Atrial fibrillation and flutter with reimbursement

I9_AF_REIMB

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

I9_AF

35791

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Filter registries

KELA reimbursements: KELA codes 207|351

18113

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Check pre-conditions, main-only, mode, ICD version None

18113

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Check minimum number of events None

18113

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Include endpoints None

18113

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I9_AF_REIMB

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 17629 7503 10126
Unadjusted prevalence (%) 5.71 4.32 7.50
Mean age at first event (years) 70.17 71.82 68.94

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.69 [1.42, 2.01] 1.8e-9 1366
15 years 0.00 0.80 [0.68, 0.94] 6.3e-3 496
5 years 0.00 1.35 [1.15, 1.58] 2.9e-4 350
1 year 0.00 4.84 [4.04, 5.80] 1.6e-65 282

Correlations

Index endpoint: I9_AF_REIMB – Atrial fibrillation and flutter with reimbursement
GWS hits: 39

Survival analyses between endpoints

Plot

before Atrial fibrillation and flutter with reimbursement
after Atrial fibrillation and flutter with reimbursement

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Drugs most likely to be purchased after Atrial fibrillation and flutter with reimbursement