Complications following myocardial infarction

I9_MI_COMPLICATIONS

myocardial infarction: Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I23
  • Cause of death: ICD-10 I23

2 out of 7 registries used, show all original rules.

276

4. Check minimum number of events

None

276

5. Include endpoints

None

276

6. Filter based on genotype QC (FinnGen only)

264

Control definitions (FinnGen only)

Control exclude
I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I20-I25
Name in latin
Aliquae complicationes post infarctum myocardii acutum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4502 1945 2459
Only index persons 2275 934 1341
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.07
Only index persons 0.04 0.03 0.05
Median age at first event (years)
Whole population 74.10 77.64 71.22
Only index persons 72.79 77.27 69.66

-FinnGen-

Key figures

All Female Male
Number of individuals 264 71 193
Unadjusted period prevalence (%) 0.08 0.03 0.10
Median age at first event (years) 70.39 69.59 70.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
276
Matched controls
2758
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I23.0
ICD-10 Finland
Haemopericardium as current complication following acute myocardial infarction
+∞
172.6
147
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
135.2
105.5
108
13
I25.2
ICD-10 Finland
Old myocardial infarction
310.8
72.0
70
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
28.8
69.3
96
50
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
15.3
57.0
101
100
I21.9
ICD-10 Finland
Acute myocardial infarction, unspecified
+∞
48.4
45
*
I21.0
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
42.8
40
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
59.2
42.4
49
10
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
+∞
41.7
39
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
394.6
35.8
35
*
AN1
HP
Coronary angiography
15.0
34.5
59
49
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
+∞
33.0
31
*
I21.2
ICD-10 Finland
Acute transmural myocardial infarction of other sites
+∞
30.8
29
*
I23.8
ICD-10 Finland
Other current complications following acute myocardial infarction
+∞
29.7
28
*
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
+∞
29.7
28
*
I21.1
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
29.7
28
*
I23.1
ICD-10 Finland
Atrial septal defect as current complication following acute myocardial infarction
+∞
29.7
28
*
I23.2
ICD-10 Finland
Ventricular septal defect as current complication following acute myocardial infarction
+∞
29.7
28
*
I23.6
ICD-10 Finland
Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute myocardial infarction
+∞
28.6
27
*
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
36.2
27.6
35
11
81
HP
Angiography of the heart and coronary arteries
23.5
26.0
37
18
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
+∞
24.3
23
*
I21.01
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
23.2
22
*
C01DA14
ATC
isosorbide mononitrate; oral
6.0
23.1
69
144
I20.99
ICD-10 Finland
Angina pectoris, unspecified
249.8
23.0
23
*
I20.09
ICD-10 Finland
Unstable angina
+∞
22.2
21
*
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
+∞
21.1
20
*
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
+∞
20.0
19
*
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
+∞
20.0
19
*
I21.19
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
20.0
19
*
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
79.1
20.0
22
*
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
+∞
19.0
18
*
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
3.9
18.2
87
290
I21.00
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
17.9
17
*
I20.90
ICD-10 Finland
Angina pectoris, unspecified
+∞
17.9
17
*
I20.00
ICD-10 Finland
Unstable angina
+∞
16.8
16
*
I21.09
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
+∞
16.8
16
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.9
16.7
77
247
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
20.7
15.8
23
12
I20.01
ICD-10 Finland
Unstable angina
+∞
15.8
15
*
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
60.1
15.0
17
*
11
HP
Coronary artery bypass surgery
+∞
14.7
14
*
AN3
HP
Balloon angioplasty and metallic stent
+∞
14.7
14
*
B01AC04
ATC
clopidogrel; oral
4.5
14.7
55
144
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
20.5
14.5
21
11
82
HP
Single vessel balloon catheter extension
+∞
13.6
13
*
I21.90
ICD-10 Finland
Myocardial infarction (acute) UNS no detected stenosis of the coronary artery
+∞
13.6
13
*
I21.10
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
12.6
12
*
AN2
HP
Balloon angioplasty, including several vessels
+∞
12.6
12
*
AA1
HP
Conventional CABG
+∞
12.6
12
*
B01AC06
ATC
acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)
16.9
12.3
19
12
I23.5
ICD-10 Finland
Rupture of papillary muscle as current complication following acute myocardial infarction
+∞
11.5
11
*
FXG00
NOMESCO Finland
Insertion and use of IABP
+∞
11.5
11
*
FNC20
NOMESCO Finland
Aorto-coronary venous bypass with two distal anastomoses
+∞
11.5
11
*
4100X
ICD-9 Finland
Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]
+∞
11.5
11
*
B01AA03
ATC
warfarin; systemic
2.6
11.0
98
478
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
114.1
10.5
11
*
I21.11
ICD-10 Finland
Acute transmural myocardial infarction of inferior wall
+∞
10.5
10
*
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
57.0
9.7
11
*
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
103.4
9.5
10
*
FHA20
NOMESCO Finland
Closure of VSR in posteroseptal myocardial infarction
+∞
9.4
9
*
A98
ICPC
Health maint/preventive medicine
0.5
9.2
128
1811
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
+∞
8.4
8
*
AN4
HP
Balloon angioplasty and drug eluding stent
+∞
8.4
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
8.3
54
215
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.1
7.9
30
80
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
7.8
52
211
I47.2
ICD-10 Finland
Ventricular tachycardia
12.3
7.7
13
11
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
7.4
61
280
I23.3
ICD-10 Finland
Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
+∞
7.3
7
*
FNC30
NOMESCO Finland
Aorto-coronary venous bypass with three distal anastomoses
+∞
7.3
7
*
I23
ICD-10 Finland
Certain current complications following acute myocardial infarction
+∞
7.3
7
*
C08CA07
ATC
nisoldipine; oral
30.9
7.2
9
*
I25
ICD-10 Finland
Chronic ischaemic heart disease
20.7
7.2
10
5
AP1
HP
Catheterization of the left side of the heart
20.7
7.2
10
5
C09AA05
ATC
ramipril; oral
2.2
7.0
82
445
N02BE01
ATC
paracetamol; systemic, rectal
0.5
6.8
136
1809
61
HP
Catheterization and pressure measurement of the left side of the heart
23.2
6.7
9
*
ZXD00
NOMESCO Finland
Emergency procedure
7.7
6.5
14
19
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.2
6.4
23
59
FN1BT
NOMESCO Finland
Extensive endovascular dilatation of coronary (PTCA) arteries
+∞
6.3
6
*
B01AC24
ATC
ticagrelor; oral
+∞
6.3
6
*
AM2
HP
Surgery of infarction complication eg VSR, aneurysm, rupture of papillary muscle
+∞
6.3
6
*
C07AB02
ATC
metoprolol; systemic
2.2
6.1
69
365

Mortality – FinRegistry

Association

Association between endpoint I9_MI_COMPLICATIONS and mortality.

Females

Parameter HR [95% CI] p-value
I9_MI_COMPLICATIONS 2.357 [1.88, 2.95] < 0.001
Birth year 0.999 [0.99, 1.01] 0.801

During the follow-up period (1.1.1998 — 31.12.2019), 329 out of 499 females with I9_MI_COMPLICATIONS died.

Males

Parameter HR [95% CI] p-value
I9_MI_COMPLICATIONS 2.412 [1.98, 2.93] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 427 out of 704 males with I9_MI_COMPLICATIONS died.

Mortality risk

Mortality risk for people of age

years, who have I9_MI_COMPLICATIONS.

N-year risk Females Males
1 0.256% 0.471%
5 1.612% 2.737%
10 4.016% 6.797%
15 7.708% 13.221%
20 13.262% 21.439%

Relationships between endpoints

Index endpoint: I9_MI_COMPLICATIONS – Complications following myocardial infarction

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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