Myocardial infarction, strict

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 I21, I22
Hospital discharge: ICD-9 410
Hospital discharge: ICD-8 410
Hospital discharge: excluded ICD-10 I21.90, I21.97, I22.90, I22.97
Cause of death: ICD-10 I21, I22
Cause of death: ICD-9 410
Cause of death: ICD-8 410
Cause of death: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

20390

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Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

18963

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Check minimum number of events None

18963

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Include endpoints None

18963

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I9_MI_STRICT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Summary Statistics

Key figures

All Female Male
Number of individuals 18339 4822 13517
Unadjusted prevalence (%) 5.94 2.78 10.01
Mean age at first event (years) 65.54 69.03 64.30

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.79 [3.33, 4.31] 2.0e-90 6787
15 years 0.01 1.83 [1.63, 2.06] 7.2e-24 2320
5 years 0.00 3.21 [2.91, 3.54] <1e-100 1374
1 year 0.00 27.58 [24.53, 31.00] <1e-100 2472

Correlations

Index endpoint: I9_MI_STRICT – Myocardial infarction, strict
GWS hits: 21

Survival analyses between endpoints

Plot

before Myocardial infarction, strict
after Myocardial infarction, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Myocardial infarction, strict