No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
57655 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
880 |
6. Filter based on genotype QC (FinnGen only) |
847 |
Control definitions (FinnGen only)
- Control conditions
- not I9_AF
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Embolic stroke with flimmer
based on the number of shared cases.
Similar with more cases:
- Embolic stroke
- Ischaemic Stroke, excluding all haemorrhages
- Stroke, excluding SAH
- Stroke, including SAH
- Cerebrovascular diseases (FINNGEN)
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16896 | 8436 | 8086 |
| Only index persons | 7367 | 3543 | 3824 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.24 | 0.23 |
| Only index persons | 0.14 | 0.13 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 74.92 | 77.54 | 72.31 |
| Only index persons | 74.78 | 78.33 | 71.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 847 | 279 | 568 |
| Unadjusted period prevalence (%) | 0.23 | 0.11 | 0.29 |
| Median age at first event (years) | 72.48 | 74.10 | 71.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 878
- Matched controls
- 8786
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I48
ICD-10 Finland
Atrial fibrillation and flutter
911.9
323.0
790
86
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
323.0
317
*
B01AA03
ATC
warfarin; systemic
24.3
323.0
626
810
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
611.7
323.0
360
10
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
1095.3
323.0
739
42
207
Kela drug reimbursment
Chronic arrhythmias
160.3
323.0
442
55
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
12.9
232.4
502
819
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
14.3
217.3
421
530
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
53.2
187.7
224
56
C01AA05
ATC
digoxin; systemic
16.1
185.0
325
309
K78
ICPC
Atrial fibrillation/flutter
33.9
161.1
213
82
B01AF02
ATC
apixaban; oral
28.2
153.7
214
99
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
133.8
125
*
TFP20
NOMESCO Finland
Cardiodefibrillation
84.4
133.5
148
21
4341A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral embolism
87.2
109.5
121
16
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
193.9
100.6
103
6
C03CA01
ATC
furosemide; systemic
4.7
100.2
556
2359
C07AB07
ATC
bisoprolol; oral
4.7
99.5
616
2905
I50.9
ICD-10 Finland
Heart failure, unspecified
6.0
97.6
325
786
AA1AD
NOMESCO Finland
CT of head and brain
4.2
76.6
387
1383
I50.0
ICD-10 Finland
Congestive heart failure
6.8
72.4
202
371
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
733.4
70.0
68
*
K90
ICPC
Stroke/cerebrovascular accident
12.2
67.8
128
121
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
16.2
63.4
105
73
C07AA07
ATC
sotalol; systemic
11.7
58.5
112
108
I48.2
ICD-10 Finland
Chronic atrial fibrillation
+∞
52.6
50
*
C01BC04
ATC
flecainide; systemic
55.4
52.5
62
12
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
7.8
52.5
128
188
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
52.4
287
1029
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
12.7
50.8
93
81
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.8
50.0
250
826
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
49.4
47
*
I48.1
ICD-10 Finland
Persistent atrial fibrillation
165.1
45.2
47
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
8.3
44.9
104
140
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
5.6
44.9
142
294
C01BD01
ATC
amiodarone; systemic
24.6
43.8
62
27
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
43.2
222
739
R4120
NOMESCO Finland
Occupational therapy
6.6
40.4
109
183
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
146.7
40.1
42
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.1
38.8
170
489
B01AE07
ATC
dabigatran etexilate; oral
13.3
37.8
67
54
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
6.5
34.3
93
157
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.0
33.2
231
939
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.7
32.7
277
1272
WX892
NOMESCO Finland
Monitored bed care
4.9
32.5
114
261
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
32.4
226
916
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.6
32.3
99
195
XA800
NOMESCO Finland
Neuropsychological investigation
9.6
32.1
67
75
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
7.3
29.7
73
107
C10AA05
ATC
atorvastatin; oral
2.3
29.5
410
2416
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
10.8
29.3
57
56
C01DA14
ATC
isosorbide mononitrate; oral
2.5
29.3
292
1451
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
7.2
29.3
73
109
C03DA01
ATC
spironolactone; oral
3.4
29.2
159
538
XF404
NOMESCO Finland
Ambulatory ECG
4.2
28.6
116
306
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.0
28.6
124
348
C09AA05
ATC
ramipril; oral
2.4
28.0
318
1688
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
19.1
27.6
42
23
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.3
27.2
340
1882
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.5
26.5
98
236
I49.5
ICD-10 Finland
Sick sinus syndrome
6.8
26.0
67
105
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
18.2
25.9
40
23
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
12.0
25.7
47
41
H53.4
ICD-10 Finland
Visual field defects
9.1
25.3
54
63
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
23.9
215
995
B01AF01
ATC
rivaroxaban; oral
3.6
23.9
115
351
205
Kela drug reimbursment
Chronic hypertension
2.1
23.5
397
2472
I50.1
ICD-10 Finland
Left ventricular failure
4.3
23.4
92
235
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
23.2
327
1881
C01BA01
ATC
quinidine; oral
41.2
22.8
28
7
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.3
22.5
272
1454
M04AA01
ATC
allopurinol; systemic
2.6
22.2
187
830
AA5PD
NOMESCO Finland
CT examination of brain pefusion
16.8
21.5
34
21
Z3231
NOMESCO Finland
Registered nurse
2.2
21.3
268
1452
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
21.3
390
2480
Z3226
NOMESCO Finland
Physiotherapist
2.5
20.9
185
842
C07AB02
ATC
metoprolol; systemic
2.2
20.9
282
1574
AN1
HP
Coronary angiography
2.7
20.7
160
674
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
20.6
586
4392
ZXD05
NOMESCO Finland
Urgent procedure
2.1
20.1
284
1615
81
HP
Angiography of the heart and coronary arteries
3.0
20.0
123
449
B01AB05
ATC
enoxaparin; parenteral
2.1
19.8
272
1525
I50
ICD-10 Finland
Heart failure
6.0
19.6
55
97
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.4
19.1
188
899
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
18.9
165
740
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
9.6
18.8
38
41
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
18.7
313
1893
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
4.1
18.6
74
191
A46
ICD-10 Finland
Erysipelas
2.5
18.6
164
742
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
18.3
165
753
M10.9
ICD-10 Finland
Gout, unspecified
3.4
18.0
93
299
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.7
17.8
131
531
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
11.0
17.5
33
31
I42.0
ICD-10 Finland
Dilated cardiomyopathy
6.6
17.5
45
71
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
19.1
17.4
26
14
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.0
17.3
291
1753
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
17.3
115
440
I63
ICD-10 Finland
Cerebral infarction
12.9
17.2
30
24
C08DA01
ATC
verapamil; systemic
4.3
17.1
64
156
K91
ICPC
Cerebrovascular disease
8.5
17.1
37
45
R42
ICD-10 Finland
Dizziness and giddiness
2.1
17.1
228
1250
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.4
16.9
51
99
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
4.5
16.6
59
137
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
16.6
305
1896
C10AA01
ATC
simvastatin; oral
1.8
16.4
475
3450
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
10.7
16.3
31
30
A28
ICPC
Limited function/disability NOS
2.1
16.1
203
1082
C08CA01
ATC
amlodipine; oral
1.8
16.1
364
2428
A12BA01
ATC
potassium chloride; oral
3.0
16.0
95
337
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
8.6
15.8
34
41
R4110
NOMESCO Finland
Physiotherapy
2.0
15.6
223
1253
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
9.7
15.0
30
32
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
6.4
15.0
39
63
R06.0
ICD-10 Finland
Dyspnoea
2.0
14.8
224
1282
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.5
14.6
122
531
43499
ICD-8 Finland
Cerebral embolism, Without mention of hypertension
81.4
14.6
16
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
8.6
14.6
31
37
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
11.1
14.6
27
25
C09AA02
ATC
enalapril; systemic
1.9
14.2
248
1493
K99
ICPC
Cardiovascular disease other
5.9
14.0
39
69
Z2445
NOMESCO Finland
Psychologist
7.0
14.0
34
50
PA7BD
NOMESCO Finland
CT angiography of neck and brain
6.7
14.0
35
54
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.8
13.9
93
356
N18
ICPC
Paralysis/weakness
5.5
13.9
41
78
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.9
13.6
56
150
I63.8
ICD-10 Finland
Other cerebral infarction
8.5
13.6
29
35
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
13.5
107
452
N02BE01
ATC
paracetamol; systemic, rectal
1.8
13.3
667
5567
WX872
NOMESCO Finland
Intensive care
3.6
13.3
61
180
R04.0
ICD-10 Finland
Epistaxis
2.8
13.2
88
336
ZXE00
NOMESCO Finland
One hour or less
1.8
13.2
309
2051
L28
ICPC
Limited function/disability (L)
2.1
13.1
173
931
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.4
13.1
118
534
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
13.1
98
402
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.5
13.0
62
188
K77
ICPC
Heart failure
6.0
12.9
35
60
R4150
NOMESCO Finland
Neuropsychological rehabilitation
22.9
12.9
18
8
B01AF03
ATC
edoxaban; oral
22.9
12.9
18
8
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.8
12.8
83
312
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
12.8
311
2079
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
5.7
12.8
36
65
R1260
NOMESCO Finland
Evaluation of communicative skills
5.4
12.5
37
71
B01AC04
ATC
clopidogrel; oral
1.9
12.5
195
1121
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.4
12.2
110
499
SPAT1251
SPAT
Organisation of medication
3.6
12.1
54
156
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
27.1
12.1
16
6
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.7
12.0
85
336
Z2221
NOMESCO Finland
Medical doctor
1.9
11.9
218
1321
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.2
11.9
125
609
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
47.3
11.9
14
*
C09AA04
ATC
perindopril; oral
3.0
11.9
69
242
R53
ICD-10 Finland
Malaise and fatigue
1.9
11.8
186
1072
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.8
11.5
48
131
342
Kela drug reimbursment
Dronedarone
+∞
11.5
11
*
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
121.4
11.4
12
*
43400
ICD-8 Finland
Cerebral embolism, With hypertension (benign)
121.4
11.4
12
*
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
11.4
431
5370
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.9
11.2
69
251
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
11.2
310
2135
R47.0
ICD-10 Finland
Dysphasia and aphasia
8.2
11.1
24
30
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
11.1
142
754
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.0
11.1
64
224
TFP34
NOMESCO Finland
Electrophysiological investigation
11.3
11.1
20
18
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
9.4
11.0
22
24
C03AA03
ATC
hydrochlorothiazide; oral
2.2
11.0
114
552
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
9.0
10.8
22
25
C01BC03
ATC
propafenone; systemic
60.7
10.6
12
*
3A064
NOMESCO Finland
NA
60.7
10.6
12
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.3
10.6
97
441
N19
ICPC
Speech disorder
6.0
10.5
28
48
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
3.7
10.4
45
127
C01BD07
ATC
dronedarone; oral
+∞
10.4
10
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.3
10.4
52
165
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.9
10.4
62
223
SPAT1263
SPAT
Sampling
1.7
10.3
308
2161
C09DX04
ATC
valsartan and sacubitril; oral
23.7
10.3
14
6
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
10.1
218
1385
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
10.1
138
748
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
6.6
10.1
25
39
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
10.1
122
630
SPAT1252
SPAT
Overall medication plan or its review
2.5
10.0
82
352
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
9.9
119
612
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
9.9
246
1634
K22
ICPC
Risk factor cardiovascular disease
3.1
9.9
52
172
I25.2
ICD-10 Finland
Old myocardial infarction
2.2
9.8
108
535
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.5
9.8
76
318
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
9.8
104
509
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
3.1
9.8
52
173
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.8
162
945
C07AB03
ATC
atenolol; systemic
2.4
9.7
83
364
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.2
9.5
95
452
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
9.5
279
1937
SPAT1254
SPAT
Administration of medicine
1.9
9.4
142
797
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.7
9.4
66
259
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
9.4
127
686
S97
ICPC
Chronic ulcer skin
2.7
9.4
62
236
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
9.3
143
807
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
9.3
281
1961
B01AC07
ATC
dipyridamole; systemic
2.1
9.2
104
521
ZX120
NOMESCO Finland
Intravenous
2.3
9.2
86
397
K80
ICPC
Cardiac arrhythmia NOS
2.9
9.2
54
193
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
9.0
57
212
R4130
NOMESCO Finland
Speech therapy
4.3
8.9
32
77
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
4.3
8.9
32
77
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.7
8.8
57
216
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
8.8
63
252
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
8.8
123
674
J01DB01
ATC
cefalexin; oral
1.6
8.8
570
4766
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
8.7
71
304
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
50.4
8.7
10
*
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
5.1
8.7
26
52
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
3.5
8.7
39
115
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
8.7
69
294
R51.80
ICD-10 Finland
Headache
2.3
8.7
84
393
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.8
8.6
55
208
A10AE04
ATC
insulin glargine; parenteral
2.2
8.5
86
411
R50.9
ICD-10 Finland
Fever, unspecified
2.0
8.5
115
622
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.3
8.5
76
345
11
HP
Coronary artery bypass surgery
3.0
8.4
46
157
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.5
8.4
67
286
AS2
HP
Ventricular pacemaker insertion VVI (R)
12.9
8.4
14
11
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
8.3
119
654
AR6
HP
Catheter ablation of arrhythmia, target: atrial fibrillation
+∞
8.3
8
*
K92.1
ICD-10 Finland
Melaena
2.5
8.3
66
279
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
10.9
8.3
15
14
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.6
8.3
58
231
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.4
8.2
39
120
WX882
NOMESCO Finland
High dependency care
4.0
8.2
31
79
R02
ICPC
Shortness of breath/dyspnoea
2.1
8.2
90
446
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
8.2
141
832
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.6
8.2
57
227
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
8.1
68
298
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
8.1
284
2048
K50
ICPC
Cardiovascular, Medication/prescr/renewal
22.2
8.0
11
5
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.6
8.0
55
216
A10BA02
ATC
metformin; oral
1.6
7.9
266
1896
N06AX11
ATC
mirtazapine; oral
1.6
7.9
212
1425
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.5
7.7
57
234
XF402
NOMESCO Finland
ECG with work load test
2.0
7.7
97
507
4278A
ICD-9 Finland
Cardiac dysrhythmias, Other specified cardiac dysrhythmias[SICK SINUS-SYNDROMA]
45.3
7.7
9
*
K29
ICPC
Cardiovascular sympt/complt other
3.0
7.7
42
144
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.8
7.6
46
169
SPAT1216
SPAT
Assessment of functional ability
1.7
7.6
158
987
XF640
NOMESCO Finland
NA
3.4
7.5
35
107
C07AG02
ATC
carvedilol; oral
2.3
7.5
70
324
FPJ02
NOMESCO Finland
Revision of ventricular pacemaker generator
80.7
7.4
8
*
R00.1
ICD-10 Finland
Bradycardia, unspecified
3.1
7.4
39
131
A06AD11
ATC
lactulose; oral
1.7
7.3
184
1211
M01AH05
ATC
etoricoxib; oral
0.6
7.3
194
2698
41201
ICD-8 Finland
Chronic ischaemic heart disease, Status post infarctum cordis, cum hypertonia
11.0
7.3
13
12
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
+∞
7.3
7
*
Z50.5
ICD-10 Finland
Speech therapy
5.9
7.2
19
33
ZXA05
NOMESCO Finland
Left side
1.6
7.2
220
1528
M10.0
ICD-10 Finland
Idiopathic gout
3.2
7.2
36
117
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.9
7.1
27
70
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.1
204
1393
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
7.0
88
459
GD1LA
NOMESCO Finland
GD
7.1
7.0
16
23
-34
ICPC
Blood test
3.9
7.0
27
71
SPAT1301
SPAT
No procedures
1.5
7.0
253
1826
A02BC02
ATC
pantoprazole; systemic
1.5
6.9
474
3910
K05
ICPC
Irregular heartbeat other
4.3
6.9
24
57
C02AC05
ATC
moxonidine; oral
2.7
6.9
46
179
61
HP
Catheterization and pressure measurement of the left side of the heart
3.3
6.9
32
98
RD211
NOMESCO Finland
NA
3.0
6.9
37
126
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
13.9
6.9
11
8
T90
ICPC
Diabetes non-insulin dependent
1.6
6.9
188
1264
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
3.7
6.8
28
78
H02AB06
ATC
prednisolone; systemic
1.5
6.8
352
2740
K84
ICPC
Heart disease other
3.9
6.8
26
68
AQ2
HP
Electrophysiological electroanatomical examination
40.3
6.8
8
*
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
16.8
6.7
10
6
WX730
NOMESCO Finland
Conventional respirator
4.8
6.7
21
45
Z71.8
ICD-10 Finland
Other specified counselling
1.7
6.7
143
899
73
HP
Initial pacemaker installation
7.2
6.7
15
21
5273
FHL
Repair with flap prosthesis or graft
22.7
6.7
9
*
K83
ICPC
Heart valve disease NOS
7.9
6.6
14
18
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.9
6.6
38
134
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.1
6.6
75
379
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
6.6
122
733
C01BA03
ATC
disopyramide; systemic
8.8
6.6
13
15
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
10.1
6.5
12
12
W19
ICD-10 Finland
Unspecified fall
2.0
6.5
83
440
Z2446
NOMESCO Finland
Social worker
2.6
6.5
46
185
A04
ICPC
Weakness/tiredness general
1.8
6.5
106
611
PA6AD
NOMESCO Finland
CT of neck arteries
5.4
6.5
18
34
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.5
177
1192
N19
ICD-10 Finland
Unspecified kidney failure
2.7
6.4
42
162
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.5
6.4
14
19
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
7.5
6.4
14
19
I20.00
ICD-10 Finland
Unstable angina
2.6
6.4
43
169
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.1
6.4
33
110
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.4
6.4
51
218
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.0
6.4
19
39
N28
ICPC
Limited function/disability (N)
3.9
6.3
24
63
AQ1
HP
Conventional electrophysiological examination
11.1
6.3
11
10
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.5
6.3
46
190
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
18.1
6.3
9
5
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.6
6.3
44
176
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.7
6.2
41
159
I20.01
ICD-10 Finland
Unstable angina
2.7
6.2
40
151
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
26.8
6.2
8
*
C08DB01
ATC
diltiazem; oral
2.0
6.2
82
440
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
5.1
6.2
18
36
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.2
6.2
30
96
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.6
6.1
161
1069
I20.91
ICD-10 Finland
Angina pectoris, unspecified
4.3
6.1
21
50
WX722
NOMESCO Finland
PEEP
2.6
6.1
43
171
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.1
105
618
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.8
6.1
24
65
SPAT1229
SPAT
Assessment of need for aid
1.9
6.1
81
435
R40.0
ICD-10 Finland
Somnolence
12.6
6.1
10
8
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.1
6.1
64
312
ZXA00
NOMESCO Finland
Right side
1.5
6.0
221
1590
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.7
6.0
24
66
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
5.6
6.0
16
29
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint I9_STR_EMBOLIC_WITH_FLIMMER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STR_EMBOLIC_WITH_FLIMMER | 2.272 [1.99, 2.59] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 1978 out of 3053 females with I9_STR_EMBOLIC_WITH_FLIMMER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STR_EMBOLIC_WITH_FLIMMER | 1.913 [1.69, 2.17] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 1881 out of 3320 males with I9_STR_EMBOLIC_WITH_FLIMMER died.
Mortality risk
Mortality risk for people of age
years, who have I9_STR_EMBOLIC_WITH_FLIMMER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.212% | 0.392% |
| 5 | 1.238% | 2.458% |
| 10 | 3.16% | 6.167% |
| 15 | 6.259% | 11.018% |
| 20 | 10.935% | 18.91% |
Relationships between endpoints
↥Index endpoint: I9_STR_EMBOLIC_WITH_FLIMMER – Embolic stroke with flimmer
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data