Crohn disease (strict definition, require KELA)

K11_CD_STRICT

ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

K11_KELACROHN

1441

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Filter registries

Hospital Discharge: ICD-10 K50
Hospital discharge: ICD-9 555
Hospital discharge: ICD-8 5630
Cause of death: ICD-10 K50
Cause of death: ICD-9 555
Cause of death: ICD-8 5630

1343

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1343

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Check minimum number of events None

1343

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Include endpoints None

1343

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K11_CD_STRICT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Summary Statistics

Key figures

All Female Male
Number of individuals 1307 755 552
Unadjusted prevalence (%) 0.42 0.44 0.41
Mean age at first event (years) 40.14 39.72 40.72

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.92 [0.94, 3.89] 7.1e-2 23
15 years 0.01 1.45 [0.73, 2.89] 2.9e-1 12
5 years - - - -
1 year - - - -

Correlations

Index endpoint: K11_CD_STRICT – Crohn disease (strict definition, require KELA)
GWS hits: 3

Survival analyses between endpoints

Plot

before Crohn disease (strict definition, require KELA)
after Crohn disease (strict definition, require KELA)

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Drugs most likely to be purchased after Crohn disease (strict definition, require KELA)