Acrodermatitis continua

L12_PSORI_ACRODERM

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L40.2
  • Hospital discharge: ICD-9 6961C
  • Hospital discharge: ICD-8 68696
  • Cause of death: ICD-10 L40.2
  • Cause of death: ICD-9 6961C
  • Cause of death: ICD-8 68696

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

63

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40
Name in latin
Acrodermatitis continua (Hallopeau)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 449 266 181
Only index persons 419 250 169
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 55.60 54.91 56.85
Only index persons 55.27 54.78 55.99

-FinnGen-

Key figures

All Female Male
Number of individuals 63 40 23
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 54.53 51.82 59.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
65
Matched controls
648
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L40.2
ICD-10 Finland
Acrodermatitis continua
+∞
88.0
63
*
D05BB02
ATC
acitretin; oral
396.4
26.8
25
*
D07AD01
ATC
clobetasol; topical
23.4
26.6
44
53
D05AX52
ATC
calcipotriol, combinations; topical
40.5
25.5
32
15
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
27.7
24.5
35
26
L40.0
ICD-10 Finland
Psoriasis vulgaris
173.8
23.3
23
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
16.3
15
*
D07XC01
ATC
betamethasone, combinations; topical
14.0
15.8
29
35
E0000UV
ATC
NA
9.3
15.2
49
160
D05AX02
ATC
calcipotriol; topical
40.5
14.8
18
6
L40.5
ICD-10 Finland
Arthropathic psoriasis
95.6
14.2
15
*
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
+∞
11.8
11
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
7.5
10.8
29
63
E000001
ATC
NA
6.7
10.6
32
82
D07AC01
ATC
betamethasone; topical
5.8
10.2
40
140
L04AB04
ATC
adalimumab; parenteral
116.2
9.7
10
*
S91
ICPC
Psoriasis
+∞
9.6
9
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
9.6
9
*
L40.8
ICD-10 Finland
Other psoriasis
+∞
9.6
9
*
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
43.3
9.3
11
*
D05AX03
ATC
calcitriol; topical
102.8
8.6
9
*
L40.9
ICD-10 Finland
Psoriasis, unspecified
38.7
8.3
10
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.8
8.3
15
16
E000003
ATC
NA
15.9
8.3
13
10
L30.3
ICD-10 Finland
Infective dermatitis
18.5
7.5
11
7
D07AC13
ATC
mometasone; topical
4.4
7.3
33
123
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
10.5
6.9
13
15
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.4
6.5
17
34

Mortality – FinRegistry

Association

Association between endpoint L12_PSORI_ACRODERM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_ACRODERM.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_PSORI_ACRODERM – Acrodermatitis continua

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data