No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
86 |
4. Check minimum number of eventsNone |
86 |
5. Include endpointsNone |
86 |
6. Filter based on genotype QC (FinnGen only) |
86 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Hydrarthrosis intermittens
Similar endpoints
↥List of similar endpoints to
Intermittent hydrarthrosis
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 323 | 250 |
| Only index persons | 546 | 312 | 234 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.37 | 44.04 | 40.33 |
| Only index persons | 41.74 | 43.43 | 39.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 86 | 49 | 37 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 43.94 | 42.36 | 46.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 77
- Matched controls
- 770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.4
ICD-10 Finland
Intermittent hydrarthrosis
+∞
71.3
57
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
40.6
21.9
27
10
M17.1
ICD-10 Finland
Other primary gonarthrosis
45.2
20.9
25
8
7193F
ICD-9 Finland
Other and unspecified disorder of joint, Palindromic rheumatism[HYDRARTHROSIS INTERMITTENS, POLVI]
+∞
19.6
18
*
M25.4
ICD-10 Finland
Effusion of joint
+∞
19.6
18
*
M13.9
ICD-10 Finland
Arthritis, unspecified
231.0
18.4
18
*
A07EC01
ATC
sulfasalazine; oral, rectal
47.1
17.8
21
6
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
15.1
14
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
183.4
15.0
15
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
38.4
14.7
18
6
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
30.9
14.6
19
8
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
35.7
13.6
17
6
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
12.9
12
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
12.9
12
*
P01BA02
ATC
hydroxychloroquine; oral
33.1
12.6
16
6
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
23.7
12.2
17
9
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
36.6
12.2
15
5
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
140.1
11.8
12
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
51.4
11.3
13
*
M25.5
ICD-10 Finland
Pain in joint
6.5
10.8
32
76
L15
ICPC
Knee symptom/complaint
7.3
10.7
28
56
1220
FHL
Arthroscopy
46.6
10.3
12
*
M01AH05
ATC
etoricoxib; oral
4.7
9.4
55
266
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
8.5
8
*
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
+∞
8.5
8
*
L04AA13
ATC
leflunomide; oral
+∞
8.5
8
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
10.9
7.1
13
14
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
44.1
6.9
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
44.1
6.9
8
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
44.1
6.9
8
*
N02AX02
ATC
tramadol; systemic, rectal
3.5
6.4
38
166
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
29.3
6.4
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
6.3
6
*
1222
FHL
Arthroscopy and synovial surgery
+∞
6.3
6
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
6.3
6
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
+∞
6.3
6
*
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
+∞
6.3
6
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
14.1
6.3
10
8
L03
ICPC
Low back symptom/complaint
4.1
6.2
26
85
B01AF01
ATC
rivaroxaban; oral
9.2
6.1
12
15
Mortality – FinRegistry
↥Association
Association between endpoint M13_INTERHYDRARTHR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_INTERHYDRARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_INTERHYDRARTHR – Intermittent hydrarthrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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