No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
71 |
4. Check minimum number of eventsNone |
71 |
5. Include endpointsNone |
71 |
6. Filter based on genotype QC (FinnGen only) |
71 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Aliae arthropathiae specificae non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Other specific arthropathies
based on the number of shared cases.
Similar with more cases:
- Other specific arthropathies, wide
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 538 | 264 | 268 |
| Only index persons | 487 | 239 | 248 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 43.11 | 48.62 | 37.31 |
| Only index persons | 39.19 | 46.04 | 32.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 71 | 40 | 31 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 45.98 | 46.23 | 45.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 66
- Matched controls
- 661
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.8
ICD-10 Finland
Other specific arthropathies, not elsewhere classified
+∞
67.8
53
*
7164A
ICD-9 Finland
Other and unspecified arthropathies, Transient arthropathy
+∞
14.0
13
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
24.0
12.9
18
10
M19.0
ICD-10 Finland
Primary arthrosis of other joints
79.2
12.1
13
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
24.8
10.3
14
7
A07EC01
ATC
sulfasalazine; oral, rectal
24.8
10.3
14
7
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
17.1
9.7
15
11
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
+∞
9.6
9
*
M13.9
ICD-10 Finland
Arthritis, unspecified
19.7
9.0
13
8
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
102.3
8.6
9
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
102.3
8.6
9
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
102.3
8.6
9
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
38.5
8.3
10
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
25.8
8.3
11
5
M25.5
ICD-10 Finland
Pain in joint
6.3
8.1
23
51
P01BA02
ATC
hydroxychloroquine; oral
21.5
7.9
11
6
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
+∞
7.4
7
*
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
+∞
7.4
7
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
34.0
7.3
9
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
76.7
6.5
7
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
29.7
6.4
8
*
L88
ICPC
Rheumatoid/seropositive arthritis
29.7
6.4
8
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
11.7
6.3
11
11
Mortality – FinRegistry
↥Association
Association between endpoint M13_OTERSPECARTHR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_OTERSPECARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_OTERSPECARTHR – Other specific arthropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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