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Crystal arthropathies, rheuma endpoint

RHEUMA_CHRYSTAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

641

6. Filter based on genotype QC (FinnGen only)

641

Control definitions (FinnGen only)

Control exclude
RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 641 312 329
Unadjusted period prevalence (%) 0.13 0.11 0.15
Median age at first event (years) 71.55 71.37 71.71

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
572
Matched controls
5718
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M11.2
ICD-10 Finland
Other chondrocalcinosis
+∞
323.0
348
*
M13.9
ICD-10 Finland
Arthritis, unspecified
93.8
201.2
217
37
M17.1
ICD-10 Finland
Other primary gonarthrosis
41.8
184.9
234
93
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
68.3
126.6
144
28
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
667.5
114.2
109
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
25.0
111.8
162
89
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
24.4
108.4
158
88
M11.9
ICD-10 Finland
Crystal arthropathy, unspecified
+∞
106.7
99
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
63.1
93.6
108
21
M11.8
ICD-10 Finland
Other specified crystal arthropathies
+∞
93.3
87
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
32.0
92.8
124
49
H02AB06
ATC
prednisolone; systemic
6.3
89.2
408
1626
P01BA02
ATC
hydroxychloroquine; oral
31.2
75.4
101
39
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
74.6
70
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
47.0
72.3
88
22
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
27.2
70.5
98
43
M10.9
ICD-10 Finland
Gout, unspecified
15.5
68.6
117
93
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
243.8
64.6
65
*
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
97.4
56.1
61
7
N02AX02
ATC
tramadol; systemic, rectal
4.0
52.9
330
1457
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
8.8
47.6
108
147
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
47.6
45
*
L15
ICPC
Knee symptom/complaint
5.3
47.2
167
416
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
29.5
45.3
61
23
M25.5
ICD-10 Finland
Pain in joint
4.3
44.4
203
652
A07EC01
ATC
sulfasalazine; oral, rectal
16.3
41.5
68
47
M01AX05
ATC
glucosamine; oral
4.2
40.4
181
562
N02BE01
ATC
paracetamol; systemic, rectal
5.6
40.0
529
3919
N02AJ06
ATC
codeine and paracetamol; systemic
3.6
40.0
245
994
NF1AA
NOMESCO Finland
Hip X-ray examination
8.6
39.4
90
122
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
39.3
337
1749
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.1
39.2
93
134
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
66.2
37.7
43
7
M01AH05
ATC
etoricoxib; oral
3.1
37.3
341
1826
M11.1
ICD-10 Finland
Familial chondrocalcinosis
+∞
36.9
35
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
36.9
35
*
M79.6
ICD-10 Finland
Pain in limb
3.3
36.7
251
1090
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.5
34.6
139
382
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
53.6
33.9
40
8
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
37.6
33.3
42
12
M10.0
ICD-10 Finland
Idiopathic gout
21.3
33.2
49
25
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
33.2
289
1454
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
16.0
33.0
54
37
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
32.8
124
319
B01AB05
ATC
enoxaparin; parenteral
3.3
32.6
219
916
J01DB01
ATC
cefalexin; oral
3.6
32.1
487
3512
TNG10
NOMESCO Finland
Puncture of knee
174.7
32.0
33
*
M04AA01
ATC
allopurinol; systemic
4.4
31.1
125
340
M09AX01
ATC
hyaluronic acid; parenteral
11.8
31.0
58
54
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
8.0
30.7
72
101
A02BC02
ATC
pantoprazole; systemic
2.9
30.3
412
2683
SPAT1263
SPAT
Sampling
2.8
30.1
302
1628
M35.3
ICD-10 Finland
Polymyalgia rheumatica
17.5
29.9
47
29
212
Kela drug reimbursment
Gout
+∞
29.4
28
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
109.0
28.9
31
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
5.5
28.5
89
184
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
28.4
27
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
28.4
27
*
L90
ICPC
Osteoarthrosis of knee
9.2
28.1
60
72
S18
ICPC
Laceration/cut
2.7
27.9
290
1572
NG2AA
NOMESCO Finland
Patella X-ray examination
152.4
27.9
29
*
L88
ICPC
Rheumatoid/seropositive arthritis
40.0
27.4
34
9
NG1DA
NOMESCO Finland
X-ray of knees
63.1
26.2
30
5
SPAT1153
SPAT
Removal of sutures
2.8
26.0
232
1134
L04AA13
ATC
leflunomide; oral
272.2
25.9
26
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.4
25.8
147
530
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
5.6
25.6
79
160
M01AH01
ATC
celecoxib; oral (coxibs)
3.5
25.5
134
455
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
37.5
25.5
32
9
M11.0
ICD-10 Finland
Hydroxyapatite deposition disease
+∞
25.2
24
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.8
24.9
89
213
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
6.4
24.6
67
116
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
6.1
24.5
69
125
N03AX16
ATC
pregabalin; oral
3.0
24.4
166
678
WX320
NOMESCO Finland
Spinalanesthesy
3.3
24.3
140
507
A46
ICD-10 Finland
Erysipelas
3.4
24.1
136
486
C03CA01
ATC
furosemide; systemic
2.6
24.0
260
1403
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
90.7
23.9
26
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
5.0
23.6
80
180
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.6
23.0
70
139
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
17.4
23.0
36
22
R50.9
ICD-10 Finland
Fever, unspecified
3.6
22.9
117
386
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.5
22.5
230
1194
B01AA03
ATC
warfarin; systemic
2.6
22.3
203
985
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
65.2
22.0
25
*
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
83.4
21.8
24
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.8
21.8
64
122
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
21.2
193
932
B01AF01
ATC
rivaroxaban; oral
4.1
21.2
89
248
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.1
20.6
126
471
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
13.2
20.6
36
29
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
20.5
231
1246
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
49.9
20.3
24
5
R06.0
ICD-10 Finland
Dyspnoea
2.6
19.7
184
891
N02AA05
ATC
oxycodone; systemic
3.0
19.3
124
479
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.7
19.2
91
280
N03AX12
ATC
gabapentin; oral
3.2
18.9
112
407
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
+∞
18.8
18
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
24.7
18.8
26
11
M13.0
ICD-10 Finland
Polyarthritis, unspecified
103.4
18.7
20
*
M48.0
ICD-10 Finland
Spinal stenosis
3.2
18.6
107
381
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
18.5
214
1156
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.7
18.5
150
668
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.1
18.3
110
405
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
5.3
18.1
57
118
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
54.3
18.1
21
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
17.8
17
*
NFB50
NOMESCO Finland
Primary total prosthetic replacement of hip joint using cement
185.4
17.6
18
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
17.5
142
629
NH3EA
NOMESCO Finland
Feet X-ray examination with load
25.0
17.4
24
10
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
21.7
17.4
25
12
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
17.4
192
1007
ACC51
NOMESCO Finland
Release of median nerve
4.8
17.1
59
135
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
22.7
17.0
24
11
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
16.9
203
1106
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
65.3
16.8
19
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.3
16.7
207
1142
M01AC06
ATC
meloxicam; systemic, rectal
2.2
16.1
202
1118
M13.8
ICD-10 Finland
Other specified arthritis
49.0
16.1
19
*
M15
ICD-10 Finland
Polyarthrosis
5.8
15.8
45
83
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
+∞
15.7
15
*
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
10.5
15.6
30
30
M02AA07
ATC
piroxicam; topical
2.1
15.6
231
1371
WX111
NOMESCO Finland
Local infiltration anesthesia
164.3
15.6
16
*
SPAT1211
SPAT
Application of soft bandage
3.5
15.3
76
242
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
15.3
162
821
J01FF01
ATC
clindamycin; systemic
2.3
15.2
169
878
H02AB04
ATC
methylprednisolone; systemic
2.9
15.0
98
380
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.7
14.9
51
116
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
19.0
14.8
22
12
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
14.7
111
467
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
+∞
14.6
14
*
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
+∞
14.6
14
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
14.6
14
*
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
14.5
240
1481
M17.5
ICD-10 Finland
Other secondary gonarthrosis
153.7
14.5
15
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
153.7
14.5
15
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.1
14.5
86
311
1220
FHL
Arthroscopy
6.4
14.5
38
63
X58
ICD-10 Finland
Exposure to other specified factors
3.2
14.5
82
288
L28
ICPC
Limited function/disability (L)
2.6
14.4
121
543
1221
FHL
Arthroscopy and meniscus surgery
7.7
14.4
33
45
SPAT1310
SPAT
Counselling related to known health issue
2.1
14.3
198
1133
SPAT1216
SPAT
Assessment of functional ability
2.5
14.2
129
604
SPAT1260
SPAT
Consultation of another employee
2.5
14.2
126
582
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
14.1
139
675
L17
ICPC
Foot/toe symptom/complaint
2.3
14.1
161
842
J01CA04
ATC
amoxicillin; systemic
2.1
14.0
425
3315
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.7
14.0
62
180
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
54.7
13.9
16
*
NF1DA
NOMESCO Finland
X-ray of hips
24.5
13.9
19
8
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
14.0
13.8
23
17
N06AA09
ATC
amitriptyline; systemic
3.1
13.7
78
275
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
4.5
13.7
49
117
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
77.0
13.6
15
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.4
13.6
130
623
B01AX06
ATC
[U] rivaroxaban; oral
35.0
13.6
17
5
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
8.4
13.5
29
36
I50.9
ICD-10 Finland
Heart failure, unspecified
2.4
13.4
126
598
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
13.2
120
557
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
6.7
13.1
33
52
WZA00
NOMESCO Finland
Short statement of of health and health related matters
6.4
13.1
34
56
H02AB07
ATC
prednisone; oral
2.7
13.1
96
397
R60.0
ICD-10 Finland
Localized oedema
2.8
12.8
85
331
M01AH02
ATC
rofecoxib; oral
2.8
12.7
90
363
M54.5
ICD-10 Finland
Low back pain
2.1
12.6
170
951
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.5
12.5
59
181
M10
ICD-10 Finland
Gout
5.1
12.4
39
81
SPAT1229
SPAT
Assessment of need for aid
3.1
12.4
70
244
M01AE02
ATC
naproxen; oral, rectal
1.9
12.4
282
1928
SAA02
NOMESCO Finland
Basic examination of mouth
1.9
12.3
300
2103
SPAT1254
SPAT
Administration of medicine
2.4
12.2
114
535
L01
ICPC
Neck symptom/complaint
2.8
12.2
84
332
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
12.0
111
519
M01AB05
ATC
diclofenac; systemic, rectal
1.9
12.0
342
2526
L12
ICPC
Hand/finger symptom/complaint
2.6
11.9
92
391
M03BX02
ATC
tizanidine; oral
1.9
11.9
306
2178
SPAT1202
SPAT
Intra-articular injection
6.1
11.6
31
53
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
11.5
69
249
207
Kela drug reimbursment
Chronic arrhythmias
2.2
11.5
125
635
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.5
11.5
53
160
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
11.4
98
441
AA1AD
NOMESCO Finland
CT of head and brain
2.0
11.4
169
974
L89
ICPC
Osteoarthrosis of hip
12.1
11.4
20
17
C07AB07
ATC
bisoprolol; oral
1.8
11.4
318
2312
SPAT1204
SPAT
Arthrocentesis
35.8
11.3
14
*
Z94.0
ICD-10 Finland
Kidney transplant status
17.5
11.2
17
10
M47.82
ICD-10 Finland
Other spondylosis, cervical region
5.4
11.2
33
64
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.3
11.2
110
529
J01MA12
ATC
levofloxacin; systemic
2.2
11.1
127
658
Z01.2
ICD-10 Finland
Dental examination
2.0
11.1
190
1160
X59
ICD-10 Finland
Exposure to unspecified factor
2.3
10.9
107
515
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
10.9
184
1113
M01AX17
ATC
nimesulide; oral
2.1
10.8
150
841
S80.0
ICD-10 Finland
Contusion of knee
4.2
10.8
41
104
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.6
10.8
84
359
Z00.0
ICD-10 Finland
General medical examination
2.2
10.8
118
596
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
28.6
10.8
14
5
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.8
10.7
253
1727
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.6
10.6
79
328
L13
ICPC
Hip symptom/complaint
2.5
10.6
88
389
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
10.6
379
2959
L20
ICPC
Joint symptom/complaint NOS
5.8
10.6
29
52
ZXA05
NOMESCO Finland
Left side
2.0
10.5
158
914
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
10.5
89
396
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
10.5
108
531
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.8
10.5
68
260
NGC00
NOMESCO Finland
Exchange of a loose part of prosthesis in knee joint
112.0
10.4
11
*
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
10.4
10
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
10.4
188
1165
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.5
10.2
48
147
L08
ICPC
Shoulder symptom/complaint
2.2
10.1
112
569
J01MA02
ATC
ciprofloxacin; systemic
1.8
10.1
232
1557
E0000UV
ATC
NA
1.9
10.1
208
1348
H25.8
ICD-10 Finland
Other senile cataract
2.3
10.1
99
476
L04AA01
ATC
[U] ciclosporin; systemic
14.9
10.0
16
11
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.9
10.0
40
107
K78
ICPC
Atrial fibrillation/flutter
2.6
10.0
78
333
WX110
NOMESCO Finland
Local anesthesy
1.8
9.9
340
2590
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
5.8
9.9
27
48
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
5.0
9.9
31
65
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
9.9
100
488
J01DA01
ATC
[U] cefalexin; systemic
1.8
9.8
339
2583
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.7
9.8
27
49
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.7
9.8
68
272
ZXA00
NOMESCO Finland
Right side
1.9
9.7
160
955
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
11.6
9.6
17
15
NG1AD
NOMESCO Finland
Knee CT examination
15.4
9.6
15
10
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.5
9.5
43
128
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
5.7
9.5
26
47
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
6.0
9.5
25
43
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
101.6
9.4
10
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
30.6
9.4
12
*
P01AB01
ATC
metronidazole; oral, rectal
1.8
9.4
204
1337
L04AB01
ATC
etanercept; parenteral
+∞
9.4
9
*
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
9.3
213
1420
A11CC03
ATC
alfacalcidol; systemic
6.6
9.3
23
36
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
4.7
9.2
30
66
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
6.1
9.1
24
41
L11
ICPC
Wrist symptom/complaint
3.2
9.1
47
155
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
8.5
9.1
19
23
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
9.1
107
558
L03
ICPC
Low back symptom/complaint
2.0
9.1
132
748
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
4.5
9.1
31
72
M10.3
ICD-10 Finland
Gout due to impairment of renal function
37.3
9.0
11
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
9.0
247
1737
M19.9
ICD-10 Finland
Arthrosis, unspecified
4.2
9.0
33
82
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.9
9.0
168
1047
B01AF02
ATC
apixaban; oral
2.4
8.9
82
379
L16
ICPC
Ankle symptom/complaint
2.8
8.9
57
218
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
10.9
8.8
16
15
M79.7
ICD-10 Finland
Fibromyalgia
9.7
8.8
17
18
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.7
8.8
233
1620
UKC02
NOMESCO Finland
Cystoscopy
2.0
8.7
116
636
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.7
8.7
37
105
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.5
8.7
39
116
N06AX21
ATC
duloxetine; oral
2.8
8.7
56
215
M19.8
ICD-10 Finland
Other specified arthrosis
4.6
8.7
29
66
M79.1
ICD-10 Finland
Myalgia
2.6
8.6
65
273
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.0
8.6
129
740
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.1
8.6
32
81
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.6
8.6
38
112
WZA90
NOMESCO Finland
Other doctors statement
2.1
8.5
109
588
S97
ICPC
Chronic ulcer skin
3.2
8.5
44
146
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.8
8.5
35
97
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
8.5
95
485
D07AC01
ATC
betamethasone; topical
1.8
8.4
189
1242
A98
ICPC
Health maint/preventive medicine
2.1
8.4
512
4570
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.9
8.4
33
88
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
6.0
8.4
22
38
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.0
8.4
22
38
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
8.3
8
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
8.3
8
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
8.3
8
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
4.9
8.3
26
55
M19.2
ICD-10 Finland
Other secondary arthrosis
11.0
8.3
15
14
A02BC01
ATC
omeprazole; systemic
1.8
8.3
167
1058
A03
ICPC
Fever
2.3
8.3
76
352
205
Kela drug reimbursment
Chronic hypertension
1.7
8.3
203
1372
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
14.7
8.2
13
9
M25.4
ICD-10 Finland
Effusion of joint
14.7
8.2
13
9
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
4.8
8.2
26
56
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
7.7
8.2
18
24
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.4
8.1
23
44
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
6.4
8.1
20
32
R02
ICPC
Shortness of breath/dyspnoea
2.2
8.1
81
391
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
22.4
8.0
11
5
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
22.4
8.0
11
5
UJF32
NOMESCO Finland
Coloscopy
1.8
8.0
157
985
R03AC02
ATC
salbutamol; inhalant
1.7
8.0
256
1866
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
7.9
65
284
M05BA04
ATC
alendronic acid; oral
2.6
7.9
57
234
SPAT1301
SPAT
No procedures
1.7
7.8
192
1291
M25.0
ICD-10 Finland
Haemarthrosis
9.6
7.8
15
16
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
7.8
49
184
M01AB55
ATC
diclofenac, combinations; oral
2.7
7.8
51
198
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.2
7.8
23
46
L04AX01
ATC
azathioprine; systemic
5.2
7.8
23
46
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.0
7.7
44
155
PAW37
NOMESCO Finland
Biopsy of temporal artery
45.6
7.7
9
*
NK4EA
NOMESCO Finland
Joint X-ray examintion with load or wrench not elsewhere classified
45.6
7.7
9
*
M01AB01
ATC
indometacin; systemic, rectal
2.7
7.7
52
203
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
7.6
102
556
SPAT1262
SPAT
Handing over of treatment supplies
1.9
7.6
118
683
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.1
7.6
85
433
A01
ICPC
Pain general/multiple sites
2.7
7.6
52
207
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
7.6
80
395
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.9
7.6
30
81
B01AB04
ATC
dalteparin; parenteral
3.5
7.6
34
102
M23.3
ICD-10 Finland
Other meniscus derangements
10.2
7.6
14
14
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.4
7.5
64
288
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
6.1
7.4
19
32
R53
ICD-10 Finland
Malaise and fatigue
1.9
7.4
125
746
WX204
NOMESCO Finland
Axillary plexus blockaced
5.0
7.3
22
45
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
9.5
7.3
14
15
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
+∞
7.3
7
*
M45
ICD-10 Finland
Ankylosing spondylitis
+∞
7.3
7
*
ND1AE
NOMESCO Finland
Wrist ultrasound examination
+∞
7.3
7
*
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
7.3
7
*
M16.5
ICD-10 Finland
Other post-traumatic coxarthrosis
+∞
7.3
7
*
A04
ICPC
Weakness/tiredness general
2.1
7.3
83
426
SPAT1312
SPAT
General health counselling
1.7
7.3
167
1097
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
16.0
7.2
11
7
SPAT1325
SPAT
Vaccination
1.7
7.2
210
1480
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
7.2
53
220
H02.4
ICD-10 Finland
Ptosis of eyelid
4.1
7.2
26
65
S83.2
ICD-10 Finland
Tear of meniscus, current
3.5
7.2
32
96
L04AA06
ATC
mycophenolic acid; systemic
8.1
7.1
15
19
W19
ICD-10 Finland
Unspecified fall
2.4
7.1
61
275
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.8
7.0
45
172
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.5
7.0
55
236
C03DA01
ATC
spironolactone; oral
2.1
7.0
77
389
M70.6
ICD-10 Finland
Trochanteric bursitis
2.3
7.0
65
302
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
7.0
444
3829
N06AX11
ATC
mirtazapine; oral
1.7
6.9
164
1085
127
Kela drug reimbursment
Transplant complication
7.7
6.9
15
20
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
6.9
92
503
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.3
6.9
24
58
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.1
6.9
25
63
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
5.1
6.9
20
40
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.5
6.8
53
224
RF410
NOMESCO Finland
NA
11.1
6.8
12
11
ZZH31
NOMESCO Finland
Bone allograft, small pieces
40.5
6.8
8
*
NFH30
NOMESCO Finland
Reduction of dislocation prosthesis of hip joint, closed
40.5
6.8
8
*
S06.0
ICD-10 Finland
Concussion
2.3
6.8
61
281
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
6.8
314
2483
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.6
6.7
236
1735
K02.1
ICD-10 Finland
Caries of dentine
1.6
6.7
242
1795
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
6.7
53
229
J01EA01
ATC
trimethoprim; systemic
1.7
6.7
146
942
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
6.7
56
250
NH1AD
NOMESCO Finland
Ankle and foot CT
6.5
6.7
16
25
M54.8
ICD-10 Finland
Other dorsalgia
4.0
6.7
25
65
WX002
NOMESCO Finland
Sedation and analgesia
1.9
6.6
107
626
SPAT1104
SPAT
Monitoring of emergency patient
2.6
6.6
46
185
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.5
6.6
49
204
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
6.5
127
790
I50.0
ICD-10 Finland
Congestive heart failure
2.3
6.5
60
280
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.1
6.5
34
115
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
6.5
175
1197
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
6.5
211
1521
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.5
6.5
28
82
A12AA04
ATC
calcium carbonate; oral
5.8
6.5
17
30
K03.64
ICD-10 Finland
Dental calculus supragingival
1.8
6.5
109
646
M02AA10
ATC
ketoprofen; topical
1.9
6.5
92
515
-1
NOMESCO Finland
NA
1.7
6.4
141
909
9255
FHL
Joint auger removal
14.5
6.4
10
7
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.4
6.4
51
222
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.9
6.4
98
562
RD211
NOMESCO Finland
NA
3.4
6.4
29
89
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
6.4
113
682
N18.8
ICD-10 Finland
Other chronic renal failure
3.9
6.3
24
63
SPAT1053
SPAT
Memory test
1.8
6.3
122
755
N02AC04
ATC
dextropropoxyphene; oral
3.2
6.3
31
101
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.3
235
1749
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.6
6.3
26
74
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
6.3
51
225
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
4.2
6.3
22
54
M17.4
ICD-10 Finland
Other secondary gonarthrosis, bilateral
+∞
6.3
6
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
+∞
6.3
6
*
M11
ICD-10 Finland
Other crystal arthropathies
+∞
6.3
6
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
6.3
6
*
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
+∞
6.3
6
*
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
+∞
6.3
6
*
ZXA10
NOMESCO Finland
Bilateral
1.8
6.2
112
677
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
27.0
6.2
8
*
318
Kela drug reimbursment
Teriparatide
27.0
6.2
8
*
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.2
79
424
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.6
6.2
240
1804
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
3.7
6.2
25
70
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.7
6.1
128
813
M01AX01
ATC
nabumetone; oral
3.4
6.1
27
81
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.6
6.1
41
163
R60.9
ICD-10 Finland
Oedema, unspecified
3.0
6.1
33
115
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.6
6.1
247
1873
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
6.1
76
404
ZX120
NOMESCO Finland
Intravenous
2.2
6.1
59
282
A07AA09
ATC
vancomycin; oral
10.2
6.1
11
11
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
10.2
6.1
11
11
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
3.4
6.0
27
82
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.7
6.0
140
917

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: RHEUMA_CHRYSTAL – Crystal arthropathies, rheuma endpoint

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).