Finngen Rheumatological endpoints

RHEUMA_ENDPOINTS

rheumatic disease: Inflammatory and degenerative diseases of connective tissue structures, such as arthritis.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 70670 41087 29583
Unadjusted prevalence (%) 22.90 23.68 21.91
Mean age at first event (years) 55.83 54.64 57.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.32 [1.19, 1.46] 7.7e-8 7000
15 years 0.01 0.93 [0.85, 1.02] 1.3e-1 3403
5 years 0.00 1.60 [1.47, 1.74] 1.1e-27 1643
1 year 0.00 2.96 [2.61, 3.37] 1.4e-62 588

Cumulative Incidence

Correlations

Index endpoint: RHEUMA_ENDPOINTS – Finngen Rheumatological endpoints
GWS hits: 13

Survival analyses between endpoints

Plot

before Finngen Rheumatological endpoints
after Finngen Rheumatological endpoints

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Finngen Rheumatological endpoints