This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Systemic sclerosis (FG)
SYSTSCLE_FG
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
881 |
6. Filter based on genotype QC (FinnGen only) |
881 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_ENDPOINTS
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Systemic sclerosis (FG)
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 881 | 728 | 153 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.07 |
| Median age at first event (years) | 54.75 | 54.51 | 55.91 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 793
- Matched controls
- 7928
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
323.0
481
*
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
323.0
349
*
P01BA02
ATC
hydroxychloroquine; oral
111.0
323.0
424
81
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
143.3
323.0
483
85
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
67.6
271.2
309
74
C08CA05
ATC
nifedipine; systemic
35.1
257.9
344
169
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
60.4
186.5
217
49
I73.0
ICD-10 Finland
Raynaud syndrome
75.4
180.9
203
36
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
156.6
145
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
154.3
143
*
XX9XE
NOMESCO Finland
Other ultrasound examination
169.6
136.2
140
10
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
14.1
120.0
218
207
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
33.6
107.7
142
51
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
295.3
103.4
103
*
XPX04
NOMESCO Finland
Angioscopy
225.7
97.8
99
5
L88
ICPC
Rheumatoid/seropositive arthritis
78.7
97.4
109
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.8
92.2
495
2048
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
986.2
91.7
88
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.9
88.8
392
1311
L04AX01
ATC
azathioprine; systemic
15.6
79.0
134
102
L04AA06
ATC
mycophenolic acid; systemic
30.5
77.2
104
39
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.5
77.2
145
139
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.7
71.6
300
903
H02AB06
ATC
prednisolone; systemic
3.9
71.6
493
2343
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
73.9
70.8
80
12
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
158.0
69.2
72
5
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
+∞
65.5
62
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
9.5
64.7
141
177
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
62.3
59
*
XG410
NOMESCO Finland
Flow-volume spirometry
11.8
62.0
119
117
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
15.9
54.8
91
64
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
14.1
54.2
95
76
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
44.9
53.8
66
16
NH3EA
NOMESCO Finland
Feet X-ray examination with load
34.7
51.7
67
21
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
141.7
50.4
53
*
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
47.1
50.2
61
14
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
7.1
49.9
130
212
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.2
48.9
384
1816
M17.1
ICD-10 Finland
Other primary gonarthrosis
9.6
47.5
101
119
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
40.8
45.7
57
15
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
462.4
44.7
44
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
44.2
42
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.7
40.3
124
249
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.5
38.9
151
391
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
51.6
37.0
44
9
G04BE03
ATC
sildenafil; oral
40.6
36.9
46
12
C08CA02
ATC
felodipine; oral
4.8
36.4
130
308
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
26.6
36.2
50
20
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
35.9
198
694
M13.9
ICD-10 Finland
Arthritis, unspecified
11.9
34.9
65
59
R06.0
ICD-10 Finland
Dyspnoea
3.0
34.3
249
1057
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
15.8
34.1
56
38
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
6.7
33.5
89
147
M34
ICD-10 Finland
Systemic sclerosis
340.5
33.1
33
*
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
16.8
32.5
52
33
E0000UV
ATC
NA
2.5
32.4
375
2081
L04AD01
ATC
ciclosporin; systemic
17.9
31.4
49
29
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
15.0
31.1
52
37
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.0
30.9
89
163
C02KX01
ATC
bosentan; oral
+∞
30.4
29
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
13.9
29.6
51
39
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
29.3
28
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.0
29.1
126
356
A02BC02
ATC
pantoprazole; systemic
2.4
28.7
550
3851
A07EC01
ATC
sulfasalazine; oral, rectal
9.7
28.7
59
65
R4120
NOMESCO Finland
Occupational therapy
5.2
28.6
93
197
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
28.6
354
1998
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
21.0
28.5
42
21
C08CA01
ATC
amlodipine; oral
2.4
28.1
314
1677
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
27.2
221
982
N02AX02
ATC
tramadol; systemic, rectal
2.4
27.1
335
1873
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
26.8
402
2464
TGC00
NOMESCO Finland
Bronchial lavation
10.4
26.3
52
53
NF1AA
NOMESCO Finland
Hip X-ray examination
5.9
26.2
76
140
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
45.9
25.7
31
7
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
45.9
25.7
31
7
WZA10
NOMESCO Finland
Long statement of health and health related matters
18.6
25.5
39
22
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
13.2
25.1
44
35
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.8
25.0
114
336
L04AA01
ATC
[U] ciclosporin; systemic
18.4
24.1
37
21
M25.5
ICD-10 Finland
Pain in joint
2.4
24.1
249
1254
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
23.6
129
436
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
23.4
195
870
J01FF01
ATC
clindamycin; systemic
2.4
23.2
257
1334
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
+∞
23.0
22
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
31.1
22.9
30
10
SBA10
NOMESCO Finland
Measurement of excretion of saliva
19.7
22.7
34
18
L04AA13
ATC
leflunomide; oral
236.5
22.7
23
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
+∞
22.0
21
*
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
82.5
21.8
24
*
UJF32
NOMESCO Finland
Coloscopy
2.4
21.4
231
1176
A02BC01
ATC
omeprazole; systemic
2.3
21.4
248
1310
H02AB07
ATC
prednisone; oral
2.9
21.2
146
576
K74.3
ICD-10 Finland
Primary biliary cirrhosis
16.1
21.2
34
22
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
113.0
20.7
22
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
5.5
20.6
62
120
RT272
NOMESCO Finland
NA
+∞
19.9
19
*
RT172
NOMESCO Finland
NA
+∞
19.9
19
*
N03AX16
ATC
pregabalin; oral
2.4
19.8
201
988
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
107.7
19.6
21
*
M01CC01
ATC
penicillamine; oral
204.8
19.6
20
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.1
19.3
78
205
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
19.0
91
277
S18
ICPC
Laceration/cut
2.0
19.0
328
2039
M45
ICD-10 Finland
Ankylosing spondylitis
71.6
18.8
21
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.5
18.8
94
297
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.9
18.1
120
462
C03CA01
ATC
furosemide; systemic
2.2
18.1
210
1094
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.7
18.0
83
245
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
6.0
18.0
50
88
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
17.8
17
*
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
17.8
17
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
17.8
17
*
M05BA04
ATC
alendronic acid; oral
3.3
17.7
94
311
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
17.3
142
618
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
17.3
182
905
A02BC05
ATC
esomeprazole; systemic
1.9
17.3
347
2264
L99
ICPC
Musculoskeletal disease other
9.3
17.1
35
39
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.2
17.0
96
331
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.4
16.8
84
265
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
15.5
16.8
27
18
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
16.7
16
*
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
16.7
16
*
A05AA02
ATC
ursodeoxycholic acid; oral
8.2
16.7
37
47
RT160
NOMESCO Finland
NA
92.0
16.6
18
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
92.0
16.6
18
*
J01DB01
ATC
cefalexin; oral
2.1
16.5
651
5408
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.4
16.4
43
70
NG1DA
NOMESCO Finland
X-ray of knees
41.0
16.4
20
5
E000001
ATC
NA
2.2
16.2
185
950
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
16.1
95
336
GD1AD
NOMESCO Finland
Thorax CT examination
4.4
15.9
58
139
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
11.5
15.9
29
26
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
10.0
15.8
31
32
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
13.3
15.8
27
21
RT271
NOMESCO Finland
NA
+∞
15.7
15
*
C02KX04
ATC
macitentan; oral
86.8
15.6
17
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
45.9
15.1
18
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.0
14.9
237
1392
SPAT1263
SPAT
Sampling
1.9
14.9
343
2310
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
14.6
14
*
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
81.6
14.6
16
*
N02BE01
ATC
paracetamol; systemic, rectal
2.1
14.5
668
5686
RT274
NOMESCO Finland
NA
152.6
14.5
15
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
14.5
309
2022
I27.0
ICD-10 Finland
Primary pulmonary hypertension
36.8
14.5
18
5
M05BX04
ATC
denosumab; parenteral
3.8
14.4
62
173
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.4
14.4
43
83
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
14.3
114
487
ZX120
NOMESCO Finland
Intravenous
2.9
14.3
92
347
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
14.2
232
1374
A02BC03
ATC
lansoprazole; oral
1.9
14.2
246
1492
M01AC06
ATC
meloxicam; systemic, rectal
1.9
14.2
293
1891
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
54.3
13.8
16
*
B01AB05
ATC
enoxaparin; parenteral
2.0
13.7
209
1207
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
13.6
13
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
13.6
13
*
M05BA07
ATC
risedronic acid; oral
4.5
13.6
48
112
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.3
13.6
69
221
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
13.5
86
321
R13
ICD-10 Finland
Dysphagia
3.2
13.3
72
242
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
13.2
76
266
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.2
13.2
50
125
R50.9
ICD-10 Finland
Fever, unspecified
2.5
13.1
112
497
WX002
NOMESCO Finland
Sedation and analgesia
2.1
13.0
154
799
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
5.8
13.0
36
64
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
13.3
13.0
22
17
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.1
13.0
51
132
NF1DA
NOMESCO Finland
X-ray of hips
23.0
12.9
18
8
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
23.0
12.9
18
8
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
50.9
12.9
15
*
NHQ40
NOMESCO Finland
Amputation of toe
11.8
12.9
23
20
J01MA12
ATC
levofloxacin; systemic
2.1
12.9
155
809
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.2
12.8
70
236
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
12.6
310
2100
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
32.6
12.6
16
5
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
12.5
12
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
12.5
12
*
L04AB01
ATC
etanercept; parenteral
+∞
12.5
12
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
12.5
12
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.0
12.5
49
127
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.3
12.4
29
41
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
38.2
12.2
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
12.2
136
684
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
4.8
12.2
40
87
R15
ICD-10 Finland
Faecal incontinence
4.6
12.1
41
92
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.4
12.1
28
39
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
12.0
120
574
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.8
11.9
80
307
J01MA14
ATC
moxifloxacin; systemic
2.8
11.9
78
298
S97
ICPC
Chronic ulcer skin
3.9
11.8
48
128
ZXA00
NOMESCO Finland
Right side
1.9
11.7
196
1160
NDL52
NOMESCO Finland
Tenosynovectomy of hand
30.5
11.7
15
5
TEA00
NOMESCO Finland
Biopsy of lip
19.3
11.6
17
9
SPAT1254
SPAT
Administration of medicine
2.3
11.6
112
525
C02DE02
ATC
NA
10.2
11.5
22
22
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
11.5
91
384
RT231
NOMESCO Finland
NA
+∞
11.5
11
*
73409
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica NUD
+∞
11.5
11
*
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
+∞
11.5
11
*
RT310
NOMESCO Finland
NA
+∞
11.5
11
*
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
121.7
11.5
12
*
D06BX01
ATC
metronidazole; topical
2.3
11.3
113
540
J02AC01
ATC
fluconazole; systemic
1.7
11.2
364
2651
N03AX12
ATC
gabapentin; oral
2.2
11.1
114
551
SPAT1153
SPAT
Removal of sutures
1.8
11.1
232
1479
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.2
10.8
115
566
N02AA05
ATC
oxycodone; systemic
2.3
10.8
101
468
K22.7
ICD-10 Finland
Barrett oesophagus
9.0
10.8
22
25
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
10.7
535
4373
SPAT1229
SPAT
Assessment of need for aid
2.9
10.6
65
236
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
10.6
143
779
WX110
NOMESCO Finland
Local anesthesy
1.7
10.5
527
4299
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.0
10.5
41
106
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
10.5
206
1284
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
111.4
10.4
11
*
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
+∞
10.4
10
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
16.3
10.4
16
10
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.4
10.3
90
402
L12
ICPC
Hand/finger symptom/complaint
2.2
10.3
117
589
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
10.3
135
727
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.0
10.3
58
200
L28
ICPC
Limited function/disability (L)
2.2
10.2
114
571
R4190
NOMESCO Finland
Nutritional therapy
4.1
10.1
38
95
M01AH01
ATC
celecoxib; oral (coxibs)
2.0
10.1
130
693
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
10.0
93
428
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.5
10.0
82
355
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
9.9
104
508
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.8
9.9
32
69
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
17.0
9.9
15
9
K62.3
ICD-10 Finland
Rectal prolapse
6.1
9.9
26
44
D07AC01
ATC
betamethasone; topical
1.7
9.8
261
1779
J01FA06
ATC
roxithromycin; oral
1.6
9.8
320
2311
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.3
9.8
48
151
WX320
NOMESCO Finland
Spinalanesthesy
2.0
9.8
135
740
WZA90
NOMESCO Finland
Other doctors statement
1.9
9.7
167
991
J01DA01
ATC
[U] cefalexin; systemic
1.6
9.7
484
3903
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.6
9.6
68
271
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
9.6
143
805
K22.1
ICD-10 Finland
Ulcer of oesophagus
6.5
9.6
24
38
R4110
NOMESCO Finland
Physiotherapy
1.8
9.6
197
1239
XG466
NOMESCO Finland
Sleep oxymetry
4.2
9.6
35
86
B01AF01
ATC
rivaroxaban; oral
2.8
9.5
60
224
M79.6
ICD-10 Finland
Pain in limb
1.7
9.5
267
1843
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
17.8
9.4
14
8
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
30.4
9.4
12
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
9.4
226
1492
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
9.4
9
*
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
+∞
9.4
9
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
9.4
9
*
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
9.4
9
*
M34.2
ICD-10 Finland
Systemic sclerosis induced by drugs and chemicals
+∞
9.4
9
*
M33.2
ICD-10 Finland
Polymyositis
+∞
9.4
9
*
EBA10
NOMESCO Finland
Surgical removal of tooth
2.3
9.4
86
393
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
9.4
93
440
M48.0
ICD-10 Finland
Spinal stenosis
2.4
9.4
79
348
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.0
9.4
53
183
J01CA04
ATC
amoxicillin; systemic
1.7
9.3
618
5342
L95
ICPC
Osteoporosis
3.5
9.3
42
124
E000003
ATC
NA
3.4
9.3
44
135
C03DA01
ATC
spironolactone; oral
2.4
9.2
78
344
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
9.2
72
305
H03AA01
ATC
levothyroxine sodium; systemic
1.7
9.2
214
1396
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
11.6
9.1
16
14
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
9.1
254
1746
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
10.2
9.0
17
17
SAA02
NOMESCO Finland
Basic examination of mouth
1.6
9.0
478
3872
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.6
9.0
397
3073
SFA00
NOMESCO Finland
Small filling
2.1
9.0
106
546
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
9.0
60
232
NDQ20
NOMESCO Finland
Amputation of finger
18.8
8.9
13
7
L17
ICPC
Foot/toe symptom/complaint
1.7
8.9
193
1232
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.1
8.9
47
157
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.7
8.9
60
234
SPAT1312
SPAT
General health counselling
1.7
8.8
245
1682
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
8.8
67
280
SPAT1216
SPAT
Assessment of functional ability
2.0
8.8
109
573
R60.0
ICD-10 Finland
Localized oedema
2.3
8.8
80
366
J01MA02
ATC
ciprofloxacin; systemic
1.6
8.8
269
1896
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
8.7
116
625
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
8.7
319
2354
L01AA01
ATC
cyclophosphamide; systemic
50.5
8.7
10
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
3.4
8.6
40
121
A03FA02
ATC
cisapride; oral, rectal
2.4
8.6
71
309
R51.80
ICD-10 Finland
Headache
2.0
8.6
111
590
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.5
8.6
38
111
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
16.5
8.6
13
8
RF210
NOMESCO Finland
NA
4.6
8.5
28
62
R1250
NOMESCO Finland
Evaluation of functional capability
5.2
8.5
25
49
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
6.5
8.5
21
33
E000006
ATC
NA
2.5
8.5
65
272
M13.0
ICD-10 Finland
Polyarthritis, unspecified
27.8
8.5
11
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.7
8.5
57
221
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
8.4
308
2266
L04AB06
ATC
golimumab; parenteral
91.0
8.4
9
*
TNG10
NOMESCO Finland
Puncture of knee
91.0
8.4
9
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
91.0
8.4
9
*
RT171
NOMESCO Finland
NA
91.0
8.4
9
*
A07AA02
ATC
nystatin; oral
2.6
8.4
61
248
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.7
8.4
184
1177
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
12.9
8.4
14
11
M01AH02
ATC
rofecoxib; oral
2.1
8.4
93
465
NH3AE
NOMESCO Finland
Feet ultrasound examination
+∞
8.3
8
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
+∞
8.3
8
*
M35
ICD-10 Finland
Other systemic involvement of connective tissue
+∞
8.3
8
*
M43.1
ICD-10 Finland
Spondylolisthesis
3.4
8.3
38
114
E000007
ATC
NA
2.8
8.2
52
195
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.7
8.2
55
213
S09
ICPC
Infected finger/toe
4.0
8.1
31
80
318
Kela drug reimbursment
Teriparatide
33.7
8.1
10
*
GD1UN
NOMESCO Finland
Lung circulation SPECT
17.4
8.1
12
7
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.1
8.1
43
145
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.2
8.0
41
134
RJ420
NOMESCO Finland
NA
22.3
8.0
11
5
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.9
8.0
48
175
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
8.0
245
1718
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
7.3
8.0
18
25
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.6
7.9
58
237
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.1
7.9
29
72
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.0
7.9
30
77
R03AC02
ATC
salbutamol; inhalant
1.5
7.9
393
3097
K59.09
ICD-10 Finland
Constipation, unspecified
2.9
7.9
47
171
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.9
7.9
129
750
SPAT1211
SPAT
Application of soft bandage
2.3
7.8
69
311
R02
ICPC
Shortness of breath/dyspnoea
2.1
7.8
89
449
J01AA04
ATC
lymecycline; systemic
2.0
7.8
105
568
E000002
ATC
NA
2.1
7.8
89
451
M79.7
ICD-10 Finland
Fibromyalgia
4.7
7.7
25
55
NDQ48
NOMESCO Finland
Revision or amputation or exarticulation of finger
45.4
7.7
9
*
WX111
NOMESCO Finland
Local infiltration anesthesia
45.4
7.7
9
*
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.8
7.7
138
827
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
7.7
75
354
ZXA05
NOMESCO Finland
Left side
1.7
7.6
170
1090
R76.0
ICD-10 Finland
Raised antibody titre
18.6
7.6
11
6
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
7.6
168
1074
NGQ20
NOMESCO Finland
Amputation of lower leg
25.3
7.6
10
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
5.8
7.6
20
35
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
7.5
99
531
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
7.5
85
431
ADA20
NOMESCO Finland
Thoracal sympathectomy
80.8
7.4
8
*
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
7.7
7.4
16
21
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
6.1
7.4
19
32
C08DB01
ATC
diltiazem; oral
3.0
7.4
42
146
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
13.5
7.4
12
9
SPAT1255
SPAT
Intravenous administration of medicine
2.6
7.3
51
204
286
Kela drug reimbursment
Ciclosporin eye drop
+∞
7.3
7
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
7.3
7
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
7.3
7
*
73401
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica acrosclerotica
+∞
7.3
7
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
7.3
7
*
L13
ICPC
Hip symptom/complaint
1.9
7.3
103
566
WZC30
NOMESCO Finland
Teaching
2.0
7.3
98
532
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.4
7.3
57
243
SPAT1301
SPAT
No procedures
1.6
7.2
227
1595
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.7
7.2
30
84
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.9
7.2
28
74
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
7.2
117
679
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
4.5
7.2
24
55
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.0
7.2
87
452
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
20.2
7.1
10
5
SPAT1325
SPAT
Vaccination
1.6
7.1
253
1832
A02BA02
ATC
ranitidine; systemic
1.7
7.1
147
921
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
12.2
7.1
12
10
A01AB09
ATC
miconazole; local oral
2.1
7.1
78
390
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
7.1
134
815
M79.1
ICD-10 Finland
Myalgia
1.9
7.1
100
553
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
7.0
99
544
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.8
6.9
27
72
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
6.9
60
269
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
6.9
79
402
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.4
6.9
23
53
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
6.9
116
681
M01AH05
ATC
etoricoxib; oral
1.5
6.8
401
3233
M10.9
ICD-10 Finland
Gout, unspecified
4.2
6.8
24
58
R4180
NOMESCO Finland
Podiatric therapy
6.8
6.8
16
24
SBB10
NOMESCO Finland
Teeth copy
2.5
6.8
49
200
J01FA10
ATC
azithromycin; systemic
1.5
6.8
442
3642
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.5
6.8
30
89
R06AE07
ATC
cetirizine; oral
1.5
6.8
331
2565
M01AX01
ATC
nabumetone; oral
3.2
6.8
34
111
M01CB01
ATC
sodium aurothiomalate; parenteral
40.4
6.8
8
*
H05AA02
ATC
teriparatide; parenteral
40.4
6.8
8
*
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
40.4
6.8
8
*
B01AC04
ATC
clopidogrel; oral
1.9
6.8
96
532
B01AX06
ATC
[U] rivaroxaban; oral
16.9
6.8
10
6
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
4.8
6.7
21
45
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.7
118
701
J01AA02
ATC
doxycycline; systemic
1.5
6.7
596
5246
L84
ICD-10 Finland
Corns and callosities
3.4
6.7
30
90
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
6.7
247
1801
GX1K5
NOMESCO Finland
Diffusion capacity
22.7
6.7
9
*
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
6.7
682
6216
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
2.8
6.7
40
147
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
6.7
401
3244
C08CA03
ATC
isradipine; systemic
6.0
6.6
17
29
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
6.0
6.6
17
29
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.7
6.6
27
75
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
3.9
6.6
25
65
M35.7
ICD-10 Finland
Hypermobility syndrome
12.4
6.6
11
9
H26.3
ICD-10 Finland
Drug-induced cataract
12.4
6.6
11
9
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
6.6
125
761
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
2.5
6.6
49
202
Z01.9
ICD-10 Finland
Special examination, unspecified
2.5
6.6
49
202
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
6.6
96
536
-1
NOMESCO Finland
NA
1.5
6.6
233
1680
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
6.6
61
284
GD2SN
NOMESCO Finland
Lung ventilation SPECT
10.1
6.5
12
12
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
5.4
6.5
18
34
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
6.3
6.5
16
26
M47.82
ICD-10 Finland
Other spondylosis, cervical region
3.5
6.5
28
82
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
3.6
6.4
27
77
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
6.4
91
501
M06
ICD-10 Finland
Other rheumatoid arthritis
70.4
6.4
7
*
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
70.4
6.4
7
*
GX1D5
NOMESCO Finland
Flow volume spirometry
70.4
6.4
7
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
70.4
6.4
7
*
NFC00
NOMESCO Finland
Exchange of a loose part of prosthesis in hip joint
70.4
6.4
7
*
L94.3
ICD-10 Finland
Sclerodactyly
70.4
6.4
7
*
ND1AE
NOMESCO Finland
Wrist ultrasound examination
70.4
6.4
7
*
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
70.4
6.4
7
*
WZA00
NOMESCO Finland
Short statement of of health and health related matters
2.9
6.4
37
132
K76.9
ICD-10 Finland
Liver disease, unspecified
5.0
6.4
19
39
PE1AT
NOMESCO Finland
Femoral artery PTA
8.2
6.3
13
16
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
3.2
6.3
31
100
B01AC27
ATC
selexipag; oral
+∞
6.3
6
*
RJ512
NOMESCO Finland
NA
+∞
6.3
6
*
XQ844
NOMESCO Finland
Other microscope or electron microscope examination
+∞
6.3
6
*
383
Kela drug reimbursment
Selexipag
+∞
6.3
6
*
I27.1
ICD-10 Finland
Kyphoscoliotic heart disease
+∞
6.3
6
*
H02AB04
ATC
methylprednisolone; systemic
1.8
6.2
107
631
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
5.1
6.2
18
36
UJF92
NOMESCO Finland
Capsular endoscopy
5.1
6.2
18
36
WX204
NOMESCO Finland
Axillary plexus blockaced
3.4
6.2
28
85
AA1AD
NOMESCO Finland
CT of head and brain
1.6
6.2
158
1049
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.5
6.2
20
45
N02AC04
ATC
dextropropoxyphene; oral
3.5
6.2
27
80
K02.1
ICD-10 Finland
Caries of dentine
1.4
6.2
395
3221
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
6.1
73
376
J05AB01
ATC
aciclovir; systemic
1.6
6.1
163
1094
C01DA14
ATC
isosorbide mononitrate; oral
2.0
6.1
81
435
D02AX
ATC
Other emollients and protectives
3.2
6.1
30
97
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
12.6
6.1
10
8
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
12.6
6.1
10
8
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
3.2
6.1
29
92
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
10.1
6.0
11
11
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
6.0
180
1241
M70.2
ICD-10 Finland
Olecranon bursitis
4.2
6.0
21
51
TQW80
NOMESCO Finland
Local dermatologic skincare
3.7
6.0
24
66
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
6.1
6.0
15
25
H15.1
ICD-10 Finland
Episcleritis
5.6
6.0
16
29
K11.2
ICD-10 Finland
Sialoadenitis
3.0
6.0
32
110
M43.0
ICD-10 Finland
Spondylolysis
4.6
6.0
19
42
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: SYSTSCLE_FG – Systemic sclerosis (FG)
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).