Type 1 diabetes, strict definition, subgroup 1

T1D_STRICT1

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

not E4_DM2
and not PANCREATITIS
and KELA_DIAB_INSUL
and INSULIN_SHORTFAST
and INSULIN_INTER_AND_LONG

3336

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE<40

0

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Check minimum number of events None

0

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Include endpoints

3004

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T1D_STRICT1

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2938 1472 1466
Unadjusted prevalence (%) 0.95 0.85 1.09
Mean age at first event (years) 15.15 14.74 15.56

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 6.40 [3.41, 12.01] 7.3e-9 46
15 years 0.04 6.68 [3.40, 13.10] 3.4e-8 24
5 years - - - -
1 year - - - -

Correlations

Index endpoint: T1D_STRICT1 – Type 1 diabetes, strict definition, subgroup 1
GWS hits: 23

Survival analyses between endpoints

Plot

before Type 1 diabetes, strict definition, subgroup 1
after Type 1 diabetes, strict definition, subgroup 1

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Drugs most likely to be purchased after Type 1 diabetes, strict definition, subgroup 1