Type 2 diabetes, definitions combined

T2D

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

not E4_DM1

312402

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

45867

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T2D

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 44313 19907 24406
Unadjusted prevalence (%) 14.36 11.47 18.08
Mean age at first event (years) 60.22 59.19 61.06

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.40 [2.18, 2.65] 1.4e-70 6848
15 years 0.01 1.61 [1.47, 1.76] 1.6e-26 3477
5 years 0.00 2.55 [2.35, 2.77] <1e-100 1793
1 year 0.00 4.68 [4.12, 5.32] <1e-100 630

Correlations

Index endpoint: T2D – Type 2 diabetes, definitions combined
GWS hits: 107

Survival analyses between endpoints

Plot

before Type 2 diabetes, definitions combined
after Type 2 diabetes, definitions combined

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Drugs most likely to be purchased after Type 2 diabetes, definitions combined