Ulcerative ileocolitis

ULCERILEO

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K51.1
  • Cause of death: ICD-10 K51.1

2 out of 7 registries used, show all original rules.

1638

4. Check minimum number of events

None

1638

5. Include endpoints

None

1638

6. Filter based on genotype QC (FinnGen only)

1638

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Ileocolitis ulcerosa [chronica]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7929 3602 4295
Only index persons 7575 3493 4082
Unadjusted period prevalence (%)
Whole population 0.11 0.10 0.12
Only index persons 0.14 0.13 0.16
Median age at first event (years)
Whole population 41.83 40.60 42.72
Only index persons 41.12 40.19 41.92

-FinnGen-

Key figures

All Female Male
Number of individuals 1638 856 782
Unadjusted period prevalence (%) 0.32 0.29 0.34
Median age at first event (years) 42.23 39.28 45.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1519
Matched controls
15191
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
323.0
470
*
UJF30
NOMESCO Finland
Ileoscopy through colon
30.3
323.0
745
468
H02AB06
ATC
prednisolone; systemic
13.7
323.0
1292
4457
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
323.0
307
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
323.0
305
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6344.7
323.0
1030
5
A07EA06
ATC
budesonide; oral, local oral
351.0
323.0
571
26
K51.5
ICD-10 Finland
Left sided colitis
4503599627370496.0
323.0
1172
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
1289.2
323.0
309
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
323.0
636
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
323.0
1515
*
A07EA02
ATC
hydrocortisone; rectal
509.7
323.0
694
25
UJF32
NOMESCO Finland
Coloscopy
41.7
323.0
1271
1662
L04AX01
ATC
azathioprine; systemic
187.2
323.0
929
127
A07EC02
ATC
mesalazine; oral, rectal
2660.0
323.0
1372
53
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
1412
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
323.0
344
*
K50.8
ICD-10 Finland
Other Crohn disease
3325.5
305.7
285
*
K51
ICD-10 Finland
Ulcerative colitis
1690.5
294.6
277
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.3
260.3
827
2126
H02AB07
ATC
prednisone; oral
9.5
247.7
587
946
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
241.2
225
*
A07EC01
ATC
sulfasalazine; oral, rectal
12.0
231.4
462
533
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
12.9
230.4
442
469
L01BB02
ATC
mercaptopurine; oral
237.2
221.1
223
11
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
211.5
198
*
J01MA02
ATC
ciprofloxacin; systemic
5.3
198.0
936
3535
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
196.2
184
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
188.5
177
*
P01AB01
ATC
metronidazole; oral, rectal
5.0
187.7
956
3827
D94
ICPC
Chronic enteritis/ulcerative colitis
2012.4
179.8
171
*
A07EA01
ATC
prednisolone; rectal
446.2
163.8
161
*
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
50.4
160.4
194
44
ZX120
NOMESCO Finland
Intravenous
8.1
153.5
382
605
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
1553.2
146.3
140
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.6
145.3
656
2144
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
101.7
134.8
147
16
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
134.4
127
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
100.3
125.4
137
15
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
118.3
112
*
K83.0
ICD-10 Finland
Cholangitis
44.8
118.1
146
36
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
116.1
110
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
90.8
113.1
125
15
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.9
108.2
230
269
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
105.8
493
1564
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
95.9
91
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
16.9
95.6
156
102
4AA12
NOMESCO Finland
NA
492.3
94.4
93
*
WX002
NOMESCO Finland
Sedation and analgesia
4.0
92.6
453
1473
A05AA02
ATC
ursodeoxycholic acid; oral
20.9
90.2
136
71
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.5
85.0
279
601
A07EC03
ATC
olsalazine; oral
+∞
84.1
80
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
83.2
742
3713
H02AB09
ATC
hydrocortisone; systemic
15.3
82.7
140
100
A02BC02
ATC
pantoprazole; systemic
3.0
82.5
1078
6871
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
82.0
78
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.7
80.1
419
1416
JFH10
NOMESCO Finland
Total colectomy and ileostomy
270.3
76.2
77
*
L04AB04
ATC
adalimumab; parenteral
14.0
73.5
129
100
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
72.5
69
*
JFF10
NOMESCO Finland
Loop enterostomy
59.2
71.6
84
15
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
71.4
68
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.3
70.8
164
217
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
22.2
69.3
102
49
ZXE00
NOMESCO Finland
One hour or less
2.6
67.5
743
4056
4AB02
NOMESCO Finland
NA
125.9
67.5
72
6
L04AD01
ATC
ciclosporin; systemic
13.8
67.5
119
93
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.3
65.9
272
732
UJF92
NOMESCO Finland
Capsular endoscopy
16.3
59.8
98
64
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.7
59.4
183
358
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
54.4
510
2459
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
54.2
296
1000
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
53.2
408
1740
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
16.5
52.9
86
55
A07DA03
ATC
loperamide; oral
7.8
52.6
126
174
Z93.2
ICD-10 Finland
Ileostomy status
76.8
52.4
59
8
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.7
51.4
252
779
J01MA12
ATC
levofloxacin; systemic
3.0
50.5
335
1297
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.7
49.7
239
725
C10AC01
ATC
colestyramine; oral
10.5
49.1
98
99
N02AX02
ATC
tramadol; systemic, rectal
2.3
47.3
676
3977
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
13.5
46.5
82
64
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
46.3
603
3387
Z2221
NOMESCO Finland
Medical doctor
2.4
45.1
506
2633
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
49.8
44.1
53
11
K50
ICD-10 Finland
Crohn disease [regional enteritis]
+∞
44.0
42
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
43.7
214
655
WVA20
NOMESCO Finland
Medicine administration
9.4
43.6
92
103
K56.7
ICD-10 Finland
Ileus, unspecified
16.1
43.5
71
46
1370
FHL
Colonoscopy, whole colon
48.9
43.1
52
11
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
42.9
41
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
42.1
259
941
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
41.9
40
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
15.8
41.3
68
45
WX402
NOMESCO Finland
General anaesthesia
2.7
41.0
329
1416
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
55.0
40.7
48
9
JF1BD
NOMESCO Finland
Very extensive small bowel CT
53.8
39.7
47
9
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
39.7
602
3559
3AC01
NOMESCO Finland
NA
15.4
39.1
65
44
JFF13
NOMESCO Finland
Terminal enterostomy
88.5
39.0
43
5
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
38.7
37
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
16.0
38.5
63
41
JF2AB
NOMESCO Finland
Colongraphy with X-ray
44.0
38.3
47
11
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.9
38.3
132
290
UJK12
NOMESCO Finland
Peroral cholangioscopy
64.7
38.3
44
7
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.5
37.8
92
130
UJK02
NOMESCO Finland
ERCP
9.0
37.1
80
93
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
36.3
368
1786
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
36.1
599
3635
4AA33
NOMESCO Finland
NA
+∞
35.6
34
*
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
35.6
34
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
9.3
35.1
74
83
R50.9
ICD-10 Finland
Fever, unspecified
2.7
34.3
263
1090
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
34.1
159
464
B01AB05
ATC
enoxaparin; parenteral
2.2
33.6
448
2457
Z93
ICD-10 Finland
Artificial opening status
51.3
33.6
40
8
ZXD05
NOMESCO Finland
Urgent procedure
2.1
33.5
521
3053
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
15.4
33.3
55
37
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.6
32.5
78
108
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
32.4
31
*
UJG02
NOMESCO Finland
Proctoscopy
8.9
32.4
70
82
K60.3
ICD-10 Finland
Anal fistula
7.8
32.3
76
102
A02BC01
ATC
omeprazole; systemic
2.2
32.2
425
2317
L04AA01
ATC
[U] ciclosporin; systemic
10.6
32.1
63
62
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
48.6
31.7
38
8
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
32.4
31.4
41
13
JHA00
NOMESCO Finland
Anal or perianal incision
9.3
31.3
66
74
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
308.3
29.9
30
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.9
29.8
130
358
JAH00
NOMESCO Finland
Laparotomy
7.4
29.8
72
101
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
15.3
29.7
49
33
L04AC05
ATC
ustekinumab; parenteral
37.9
29.4
37
10
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.3
29.0
79
131
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
28.2
27
*
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
65.3
28.0
32
5
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
7.7
27.3
64
86
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
+∞
27.2
26
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
4.7
26.8
94
210
JHD00
NOMESCO Finland
Anal dilatation
15.8
26.5
43
28
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.6
25.8
92
209
B01AB10
ATC
tinzaparin; parenteral
3.4
25.8
130
403
A07AA09
ATC
vancomycin; oral
12.5
25.1
45
37
Z3231
NOMESCO Finland
Registered nurse
2.0
24.9
414
2434
L04AB06
ATC
golimumab; parenteral
14.4
24.9
42
30
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
24.8
192
791
SPAT1262
SPAT
Handing over of treatment supplies
2.3
24.6
268
1318
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
57.0
24.1
28
5
3042
Kela drug reimbursment
NA
+∞
24.0
23
*
253
Kela drug reimbursment
NA
+∞
24.0
23
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.7
24.0
84
188
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.5
23.8
63
101
A02BC05
ATC
esomeprazole; systemic
1.8
23.6
580
3892
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.4
23.3
86
203
JFB00
NOMESCO Finland
Partial resection of small intestine
8.2
22.8
51
64
B03BA03
ATC
hydroxocobalamin; parenteral
4.4
22.6
85
204
K92.1
ICD-10 Finland
Melaena
4.2
22.6
88
219
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
45.7
22.4
27
6
Z94.4
ICD-10 Finland
Liver transplant status
52.8
22.1
26
5
6419
FHL
Other measure in this category
223.1
21.6
22
*
K61.0
ICD-10 Finland
Anal abscess
6.3
21.6
58
95
J01DB01
ATC
cefalexin; oral
1.8
21.2
1219
10442
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.4
21.1
105
323
TJF80
NOMESCO Finland
Ostomy education
13.6
21.0
36
27
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
+∞
20.9
20
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
20.7
319
1807
E86
ICD-10 Finland
Volume depletion
6.7
20.7
53
82
C05AA08
ATC
fluocortolone; rectal, topical
2.2
20.3
222
1087
N02BE01
ATC
paracetamol; systemic, rectal
1.8
20.2
1242
10758
1490
FHL
Sigmoideoscopy (fiberscope)
36.3
19.9
25
7
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
36.3
19.9
25
7
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
19.8
263
1400
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
18.0
19.6
30
17
M05BA04
ATC
alendronic acid; oral
3.3
19.3
99
312
3005
Kela drug reimbursment
Tofacitinib
34.8
18.9
24
7
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
13.6
18.8
32
24
H02AB04
ATC
methylprednisolone; systemic
2.1
18.7
220
1110
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.9
18.7
117
422
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
192.3
18.6
19
*
UJD02
NOMESCO Finland
Gastroscopy
3.6
18.5
84
240
UJF34
NOMESCO Finland
Left colonoscopy
15.3
18.5
30
20
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
18.2
188
895
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
18.1
117
430
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
53.2
18.0
21
*
N03AX16
ATC
pregabalin; oral
1.9
17.9
324
1931
K56.0
ICD-10 Finland
Paralytic ileus
12.1
17.8
32
27
JJC00
NOMESCO Finland
Allogenic transplantation of liver
67.4
17.7
20
*
K76.9
ICD-10 Finland
Liver disease, unspecified
7.6
17.7
41
55
JFA70
NOMESCO Finland
Suture of small intestine
29.2
17.4
23
8
ZXC86
NOMESCO Finland
Use of endoscopic device
17.2
17.4
27
16
A02BC03
ATC
lansoprazole; oral
1.8
17.3
381
2420
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.4
17.3
63
148
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
8.5
16.7
36
43
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
16.7
16
*
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
+∞
16.7
16
*
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
35.5
16.7
21
6
A03CA02
ATC
clidinium and psycholeptics; oral
3.4
16.0
78
237
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.2
15.9
86
282
E0000UV
ATC
NA
1.6
15.8
547
3933
RD210
NOMESCO Finland
NA
5.3
15.8
48
93
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.5
15.7
30
29
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
15.6
15
*
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
+∞
15.6
15
*
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
5.8
15.6
44
78
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
86.0
15.6
17
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
19.4
15.6
23
12
JWW96
NOMESCO Finland
Other reoperation in gastroenterological surgery
161.6
15.5
16
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
15.4
140
624
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
15.3
97
351
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.4
15.3
134
588
A07AA02
ATC
nystatin; oral
3.2
15.3
82
268
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
15.2
586
4318
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
15.2
133
580
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
15.2
272
1607
M13.9
ICD-10 Finland
Arthritis, unspecified
2.6
15.1
115
467
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
15.0
97
359
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
6.6
15.0
38
59
UJF02
NOMESCO Finland
Peroral enteroscopy
15.2
14.9
24
16
WW200
NOMESCO Finland
Immunization
3.8
14.9
64
176
Z2446
NOMESCO Finland
Social worker
2.5
14.8
116
477
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
14.6
14
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
14.5
257
1510
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
14.5
104
409
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
14.3
643
4898
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
6.2
14.3
38
63
B81
ICPC
Anaemia vit B12/folate deficiency
4.2
14.2
54
133
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
14.2
458
3213
Z3226
NOMESCO Finland
Physiotherapist
1.8
14.2
249
1461
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
14.1
135
620
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
7.6
13.9
32
43
D06BX01
ATC
metronidazole; topical
2.1
13.9
156
770
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
53.8
13.8
16
*
WX110
NOMESCO Finland
Local anesthesy
1.5
13.7
1017
8638
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.4
13.6
49
115
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
13.6
13
*
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
13.6
13
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
13.5
106
440
R4110
NOMESCO Finland
Physiotherapy
1.7
13.4
345
2272
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
13.3
111
476
K85
ICD-10 Finland
Acute pancreatitis
6.2
13.2
35
58
D07AC01
ATC
betamethasone; topical
1.6
13.0
451
3209
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
28.6
13.0
17
6
K62.4
ICD-10 Finland
Stenosis of anus and rectum
22.7
12.9
18
8
K83.1
ICD-10 Finland
Obstruction of bile duct
7.8
12.9
29
38
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
8.6
12.8
27
32
R11
ICD-10 Finland
Nausea and vomiting
2.4
12.7
113
501
D18
ICPC
Change in faeces/bowel movements
4.6
12.6
43
96
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
12.6
520
3852
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
+∞
12.5
12
*
6410
FHL
Panprococolectomy and ileostomy
+∞
12.5
12
*
L04AA29
ATC
tofacitinib; oral
20.2
12.5
18
9
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.1
12.4
69
232
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.2
12.4
132
634
JF1AD
NOMESCO Finland
Small bowel CT
11.7
12.3
22
19
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
12.2
214
1249
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
37.9
12.2
15
*
R4190
NOMESCO Finland
Nutritional therapy
3.5
12.2
56
164
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.5
12.2
42
95
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
18.2
12.1
18
10
WX600
NOMESCO Finland
Single shot through catheter
4.1
12.0
46
115
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
6.9
11.9
29
43
A07AA11
ATC
rifaximin; oral
47.0
11.9
14
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
11.8
106
470
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
14.8
11.8
19
13
A02BA02
ATC
ranitidine; systemic
1.8
11.7
225
1355
K74.3
ICD-10 Finland
Primary biliary cirrhosis
12.6
11.6
20
16
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.5
11.6
54
160
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
19.1
11.6
17
9
JHD30
NOMESCO Finland
Incomplete incision of fistula-in-ano
19.1
11.6
17
9
J02AC01
ATC
fluconazole; systemic
1.5
11.6
546
4143
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.9
11.5
68
239
5552A
ICD-9 Finland
Regional enteritis, Small intestine with large intestine
+∞
11.5
11
*
L04AA33
ATC
vedolizumab; parenteral
+∞
11.5
11
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
15.2
11.3
18
12
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
4.7
11.2
37
80
J05AB11
ATC
valaciclovir; oral
1.9
11.1
173
968
S02.51
ICD-10 Finland
Fracture of tooth, open
2.0
11.0
148
783
K59.1
ICD-10 Finland
Functional diarrhoea
3.0
10.9
63
218
-44
ICPC
Preventive immunization/medic
2.3
10.8
105
485
6525
FHL
Enterostomy occlusion
60.4
10.6
12
*
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
60.4
10.6
12
*
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.2
10.6
109
518
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
11.3
10.6
19
17
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.4
10.5
49
146
JFA76
NOMESCO Finland
Closure of fistula of small intestine
110.8
10.4
11
*
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
110.8
10.4
11
*
JF1DM
NOMESCO Finland
Very extensive MRI of small bowel (more than 1.5 T)
+∞
10.4
10
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
10.3
184
1080
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
18.9
10.3
15
8
UJH02
NOMESCO Finland
Anoscopy
2.7
10.2
66
247
S18
ICPC
Laceration/cut
1.5
10.1
513
3926
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.0
10.0
39
100
Z93.3
ICD-10 Finland
Colostomy status
9.2
10.0
20
22
SPAT1324
SPAT
Screening procedure
0.5
10.0
97
1750
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
6.1
10.0
26
43
JHD20
NOMESCO Finland
Incision of fistula-in-ano
5.8
10.0
27
47
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
40.3
10.0
12
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.6
9.9
71
282
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.2
9.9
96
443
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
9.9
73
293
L88
ICD-10 Finland
Pyoderma gangrenosum
16.8
9.9
15
9
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.8
9.7
61
223
M45
ICD-10 Finland
Ankylosing spondylitis
3.3
9.7
47
145
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
9.7
124
648
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
9.6
89
404
XJW99
NOMESCO Finland
Other investigative procedure on digestive system
11.4
9.6
17
15
H20.1
ICD-10 Finland
Chronic iridocyclitis
5.5
9.5
27
50
R01AD12
ATC
fluticasone furoate; nasal
1.5
9.5
430
3209
M81.4
ICD-10 Finland
Drug-induced osteoporosis
17.6
9.4
14
8
JN4BD
NOMESCO Finland
Extensive body CT
2.0
9.4
124
655
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
+∞
9.4
9
*
5550A
ICD-9 Finland
Regional enteritis, Small intestine
+∞
9.4
9
*
JWF00
NOMESCO Finland
Reoperation for insufficiency of anastomosis or suture in gastroenterological surgery
+∞
9.4
9
*
D50.8
ICD-10 Finland
Other iron deficiency anaemias
5.4
9.4
27
51
D07AC13
ATC
mometasone; topical
1.5
9.4
376
2730
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
8.1
9.3
20
25
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
8.1
9.3
20
25
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
8.1
9.3
20
25
J01FA10
ATC
azithromycin; systemic
1.4
9.3
821
6937
J05AB01
ATC
aciclovir; systemic
1.6
9.2
267
1799
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
9.2
837
7104
K61.1
ICD-10 Finland
Rectal abscess
13.8
9.2
15
11
Z01.2
ICD-10 Finland
Dental examination
1.4
9.2
572
4537
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
9.2
1148
12490
-1
SPAT
NA
2.7
9.1
61
231
S01FA04
ATC
cyclopentolate; ophthalmic
5.4
9.1
26
49
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
3.6
9.1
39
110
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.3
8.9
79
348
N05CF01
ATC
zopiclone; oral
1.5
8.9
376
2758
WW500
NOMESCO Finland
Blood transfusion
2.9
8.9
53
189
-69
ICPC
Other reason for encounter NEC
2.8
8.9
56
206
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
8.8
293
2038
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
8.7
8.8
18
21
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.5
8.7
289
2010
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
14.1
8.7
14
10
JFB20
NOMESCO Finland
Ileocaecal resection
14.1
8.7
14
10
ZY010
NOMESCO Finland
Hospital outpatient
2.3
8.7
81
370
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
8.7
116
614
K91.8
ICD-10 Finland
Other postprocedural disorders of digestive system, not elsewhere classified
50.3
8.7
10
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
8.6
634
5159
WX723
NOMESCO Finland
CPAP therapy
2.6
8.6
60
236
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
4.4
8.4
29
67
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
8.4
928
8083
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
90.5
8.4
9
*
Z90.4
ICD-10 Finland
Acquired absence of other parts of digestive tract
90.5
8.4
9
*
K63.2
ICD-10 Finland
Fistula of intestine
90.5
8.4
9
*
B02.9
ICD-10 Finland
Zoster without complication
2.5
8.4
65
271
127
Kela drug reimbursment
Transplant complication
3.7
8.4
35
97
JFH31
NOMESCO Finland
Laparoscopic total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
8.3
8
*
5589X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis, Other and unspecified non-infectious gastro-enteritis and colitis
+∞
8.3
8
*
4AC05
NOMESCO Finland
NA
+∞
8.3
8
*
D07AD01
ATC
clobetasol; topical
1.7
8.3
191
1209
K30
ICD-10 Finland
Functional dyspepsia
1.8
8.3
134
761
A01AB09
ATC
miconazole; local oral
2.0
8.3
97
490
J01DA01
ATC
[U] cefalexin; systemic
1.4
8.2
856
7375
R15
ICD-10 Finland
Faecal incontinence
3.9
8.2
32
84
M25.5
ICD-10 Finland
Pain in joint
1.5
8.1
362
2678
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
8.2
8.1
17
21
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
8.2
8.1
17
21
JFK00
NOMESCO Finland
Division of adhesive band in intestinal obstruction
33.5
8.1
10
*
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
17.3
8.1
12
7
L04AA06
ATC
mycophenolic acid; systemic
3.3
8.1
38
116
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
8.0
211
1385
5604
FHL
Vascular preparation or cannulation in the operating room
22.1
8.0
11
5
Z43.2
ICD-10 Finland
Attention to ileostomy
22.1
8.0
11
5
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
8.0
162
987
JG1JB
NOMESCO Finland
Defekography with X-ray
7.3
8.0
18
25
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.9
8.0
31
81
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.4
7.9
65
280
SPAT1263
SPAT
Sampling
1.4
7.9
532
4249
N06AA09
ATC
amitriptyline; systemic
1.9
7.9
114
624
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.3
7.9
37
113
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
8.5
7.8
16
19
S29
ICPC
Skin symptom/complaint other
1.6
7.7
197
1281
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.8
7.7
47
172
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.4
7.6
26
60
D07AB08
ATC
desonide; topical
1.8
7.6
139
821
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
11.9
7.6
13
11
TAB24
NOMESCO Finland
Implantation of epidural injection gate
25.1
7.6
10
*
D11
ICPC
Diarrhoea
1.7
7.5
153
934
D07XC01
ATC
betamethasone, combinations; topical
1.7
7.5
146
880
A02BA03
ATC
famotidine; systemic
2.9
7.5
44
157
R05
ICD-10 Finland
Cough
1.6
7.4
222
1499
WX419
NOMESCO Finland
Other general anesthesy
4.2
7.4
26
62
SPAT1125
SPAT
Stoma care and guidance
5.3
7.4
21
40
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.5
7.4
55
225
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.4
492
3913
D70.89
ICD-10 Finland
Neutropenic splenomegaly
4.7
7.3
23
49
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.0
7.3
87
440
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
10.9
7.3
13
12
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
7.3
7
*
6408
FHL
Colectomy and ileostomy
+∞
7.3
7
*
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
7.3
7
*
JFH01
NOMESCO Finland
Laparoscopic colectomy with ileorectal anastomosis
+∞
7.3
7
*
5563A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctosigmoiditis
+∞
7.3
7
*
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
7.3
43
154
RS221
NOMESCO Finland
NA
3.9
7.3
28
73
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
6.3
7.2
18
29
TJG20
NOMESCO Finland
Transanal irrigation
15.8
7.2
11
7
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
7.2
55
229
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.6
7.2
50
196
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.7
7.2
46
172
K60.4
ICD-10 Finland
Rectal fistula
20.1
7.1
10
5
K75.4
ICD-10 Finland
Autoimmune hepatitis
20.1
7.1
10
5
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.1
7.1
80
399
WX320
NOMESCO Finland
Spinalanesthesy
1.5
7.1
264
1874
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
5.1
7.1
21
42
NG1DA
NOMESCO Finland
X-ray of knees
4.1
7.1
26
65
N02AA05
ATC
oxycodone; systemic
1.7
7.0
139
844
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
7.0
161
1018
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
7.0
126
741
SPAT1255
SPAT
Intravenous administration of medicine
2.0
6.9
80
403
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.9
113
644
K85.8
ICD-10 Finland
Other acute pancreatitis
7.6
6.9
15
20
SAD02
NOMESCO Finland
Assessment of need for oral health care, extensive
2.2
6.8
65
299
Z01.9
ICD-10 Finland
Special examination, unspecified
2.2
6.8
68
322
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
6.8
345
2609
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
6.1
6.8
17
28
JH1CM
NOMESCO Finland
Perianal extensive MRI with 3 Tesla magnet
40.2
6.8
8
*
5781B
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[HAEMORRHAGIA EX ANO]
40.2
6.8
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.8
131
790
J01FF01
ATC
clindamycin; systemic
1.4
6.7
329
2471
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
6.7
89
474
JHD96
NOMESCO Finland
Other incision of anal sphincter
22.6
6.7
9
*
L52
ICD-10 Finland
Erythema nodosum
6.5
6.6
16
25
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
3.1
6.6
33
107
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
8.7
6.6
13
15
WX610
NOMESCO Finland
Patient controlled analgesia
4.8
6.5
20
42
B07.9
ICD-10 Finland
Verruca simplex
2.4
6.5
52
220
J01MA01
ATC
ofloxacin; systemic
1.9
6.5
95
524
J01AA02
ATC
doxycycline; systemic
1.3
6.5
1031
9300
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
6.5
368
2838
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
6.5
81
422
1380
FHL
Colonoscopy, left side
70.1
6.4
7
*
K83
ICD-10 Finland
Other diseases of biliary tract
70.1
6.4
7
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
70.1
6.4
7
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.4
423
3347
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.3
283
2088
XX3DW
NOMESCO Finland
Time consuming IT work
1.7
6.3
113
667
6437
FHL
Rectum resection and sphincter-sparing through-anastomosis
+∞
6.3
6
*
JFG70
NOMESCO Finland
Conversion of continent ileostomy to conventional ileostomy
+∞
6.3
6
*
E000003
ATC
NA
2.1
6.2
66
320
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.2
1000
9002
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.0
6.2
79
412
A06AC51
ATC
ispaghula, combinations; systemic
2.2
6.2
61
285
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
6.2
390
3053
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
26.8
6.2
8
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.0
6.2
33
112
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.0
6.2
33
112
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.2
818
7155
ZX114
NOMESCO Finland
Intramuscular
3.6
6.2
26
74
EAV
NOMESCO Finland
NA
3.3
6.2
29
90
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.8
6.2
36
129
JKA20
NOMESCO Finland
Cholecystectomy
3.0
6.1
33
113
S02.5
ICD-10 Finland
Fracture of tooth
2.7
6.1
40
153
R03AC02
ATC
salbutamol; inhalant
1.3
6.1
680
5807
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
6.1
326
2483
E87.5
ICD-10 Finland
Hyperkalaemia
4.7
6.1
19
41
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
6.1
229
1631
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
3.7
6.1
24
65
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
6.0
50
219
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.3
6.0
52
231
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
2.8
6.0
35
125

Mortality – FinRegistry

Association

Association between endpoint ULCERILEO and mortality.

Females

Parameter HR [95% CI] p-value
ULCERILEO 1.556 [1.35, 1.8] < 0.001
Birth year 0.994 [0.98, 1.0] 0.237

During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 3374 females with ULCERILEO died.

Males

Parameter HR [95% CI] p-value
ULCERILEO 1.401 [1.24, 1.58] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 558 out of 4020 males with ULCERILEO died.

Mortality risk

Mortality risk for people of age

years, who have ULCERILEO.

N-year risk Females Males
1 0.146% 0.272%
5 0.768% 1.692%
10 2.104% 4.381%
15 4.226% 8.036%
20 7.32% 12.983%

Relationships between endpoints

Index endpoint: ULCERILEO – Ulcerative ileocolitis

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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