age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
520090 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE>=50 Registry filters:
2 out of 7 registries used, show all original rules. |
6879 |
4. Check minimum number of eventsNone |
6879 |
5. Include endpointsNone |
6879 |
6. Filter based on genotype QC (FinnGen only) |
6879 |
Control definitions (FinnGen only)
- Control exclude
- H7_RETINOPATHYDIAB, H7_RETINASEPAR, MACULA_NAS, H7_GLAUCPRIMOPEN, H7_GLAUCCLOSEPRIM, H7_GLAUCSECTRAUMA, H7_GLAUCSECINFLAM, H7_GLAUCSECDISEASE, H7_GLAUCSECDRUG, H7_GLAUCNAS
- Control pre-conditions
- DEATH_AGE>=50
- Control conditions
- not WET_AMD_EARLY
Extra metadata
- Level in the ICD hierarchy
- 5
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
- Name in latin
- Degeneratio maculae senilis exsudativa
Similar endpoints
↥List of similar endpoints to
Wet age-related macular degeneration
based on the number of shared cases.
Similar with more cases:
- Age-related macular degeneration (whether dry or wet)
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 55712 | 35752 | 19781 |
| Only index persons | 52323 | 33890 | 18433 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.85 | 1.02 | 0.55 |
| Only index persons | 1.05 | 1.25 | 0.70 |
| Median age at first event (years) | |||
| Whole population | 79.09 | 80.01 | 77.43 |
| Only index persons | 79.02 | 79.96 | 77.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6879 | 3592 | 3287 |
| Unadjusted period prevalence (%) | 1.33 | 1.22 | 1.45 |
| Median age at first event (years) | 76.71 | 76.92 | 76.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 6093
- Matched controls
- 59800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
66.5
323.0
435
69
ZX198
NOMESCO Finland
Other local administration
84.2
323.0
539
69
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
4503599627370496.0
323.0
6085
63
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
19.0
323.0
2388
1962
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.4
323.0
2093
6291
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.2
323.0
3952
21679
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
20.7
323.0
2601
2079
XCD20
NOMESCO Finland
Photoangiography of eye
70.5
323.0
979
162
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
323.0
1642
4781
1LA05
NOMESCO Finland
NA
527.6
323.0
356
7
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
13.7
323.0
1389
1263
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
255.7
323.0
774
34
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
438.3
323.0
4408
355
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
154.3
323.0
438
30
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.4
323.0
2383
2949
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
272.2
323.0
555
22
XCK10
NOMESCO Finland
Photography of fundus of eye
8.0
323.0
1778
2934
H25.1
ICD-10 Finland
Senile nuclear cataract
2.8
303.7
3310
17968
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
299.4
287
*
S01ED51
ATC
timolol, combinations; ophthalmic
7.0
280.6
746
1164
114
Kela drug reimbursment
Glaucoma
6.1
277.9
827
1501
XCH00
NOMESCO Finland
Eye pressure measurement
8.4
255.8
601
773
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
119.2
235.4
256
22
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
51.9
232.7
283
56
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
104.9
232.3
256
25
ZXA10
NOMESCO Finland
Bilateral
2.8
220.7
1864
8236
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.4
219.7
3179
18830
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
201.3
3229
19779
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
64.8
200.4
235
37
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
19.7
195.3
303
158
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
167.3
187.4
198
12
S01EE01
ATC
latanoprost; ophthalmic
5.7
185.4
571
1059
S01EC04
ATC
brinzolamide; ophthalmic
10.6
172.0
349
342
H3601, E113
ICD-10 Finland
NA
+∞
168.3
162
*
WX140
NOMESCO Finland
Parabulbar anesthesy
5.6
165.2
515
965
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.9
159.3
1107
4204
H26.4
ICD-10 Finland
After-cataract
2.7
154.3
1218
4999
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
12.3
152.6
286
238
XCK00
NOMESCO Finland
Perimetry
4.4
148.5
581
1389
H36.01
ICD-10 Finland
Diabetic maculopathy
138.1
140.8
151
11
H35.6
ICD-10 Finland
Retinal haemorrhage
24.2
138.8
201
84
A98
ICPC
Health maint/preventive medicine
2.4
134.8
5312
44017
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
15.5
132.4
224
147
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
130.8
126
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
16.6
129.9
214
131
CKC12
NOMESCO Finland
Photocoagulation of retina
6.1
127.4
369
627
CKC10
NOMESCO Finland
Local photocoagulation of retina
9.5
126.8
271
291
ZXA05
NOMESCO Finland
Left side
2.0
117.3
2034
11972
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
7.6
114.8
282
380
H34.8
ICD-10 Finland
Other retinal vascular occlusions
5.8
114.3
343
608
ZXA00
NOMESCO Finland
Right side
1.9
110.4
2116
12867
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
73.8
108.8
125
17
H25.8
ICD-10 Finland
Other senile cataract
2.2
107.3
1288
6444
H3600, E113
ICD-10 Finland
NA
+∞
103.7
100
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
496.8
100.1
100
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
98.2
1154
5687
H40.11
ICD-10 Finland
Low pressure glaucoma
46.5
97.9
121
26
S01EC01
ATC
acetazolamide; systemic
9.4
95.4
204
219
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.4
95.1
366
852
S01ED01
ATC
timolol; ophthalmic
5.1
90.9
306
619
N02BE01
ATC
paracetamol; systemic, rectal
2.0
90.5
5177
44059
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
88.8
844
3734
H40.0
ICD-10 Finland
Glaucoma suspect
3.1
86.4
514
1715
H40.9
ICD-10 Finland
Glaucoma, unspecified
20.9
80.2
121
58
S01EE03
ATC
bimatoprost; ophthalmic
9.2
79.4
172
189
S01EE05
ATC
tafluprost; ophthalmic
5.8
79.2
235
410
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
9.4
78.7
168
180
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
5.6
78.2
241
440
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
8.8
78.0
173
198
1LA01
NOMESCO Finland
NA
+∞
76.7
74
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
5.6
75.5
231
418
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
6.7
75.0
200
303
S01EC54
ATC
brinzolamide, combinations; ophthalmic
21.8
72.0
107
49
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
16.4
68.4
112
68
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.7
67.8
204
362
H3603, E113
ICD-10 Finland
NA
+∞
67.3
65
*
J01DB01
ATC
cefalexin; oral
1.7
67.3
4465
37194
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
18.1
66.4
105
58
S01EE04
ATC
travoprost; ophthalmic
6.6
65.3
174
264
H36.00
ICD-10 Finland
Diabetic background retinopathy
31.7
64.3
86
27
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
63.8
4267
35293
S01BC03
ATC
diclofenac; ophthalmic
4.5
63.0
236
533
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
62.8
579
2496
H35.36
ICD-10 Finland
Macular cyst
11.5
58.8
112
97
H35.9
ICD-10 Finland
Retinal disorder, unspecified
15.2
57.0
96
63
XCW10
NOMESCO Finland
Assessment of vision
19.9
56.4
86
43
WX110
NOMESCO Finland
Local anesthesy
1.5
54.6
3209
25215
S01EC03
ATC
dorzolamide; ophthalmic
9.3
54.6
116
124
H35.8
ICD-10 Finland
Other specified retinal disorders
14.8
54.0
92
62
S01EX03
ATC
NA
5.5
53.5
165
302
CHD00
NOMESCO Finland
Laser trabeculoplasty
16.1
52.4
86
53
S01BC05
ATC
ketorolac; ophthalmic
2.5
52.1
452
1881
1LA04
NOMESCO Finland
NA
80.7
50.5
57
7
CS494
NOMESCO Finland
Other visual field testing
5.6
49.8
150
267
C08CA01
ATC
amlodipine; oral
1.5
49.4
2646
20178
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
482.7
49.1
49
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
47.8
1439
9542
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
47.6
46
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
13.3
46.8
83
62
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
46.6
45
*
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
58.3
44.9
53
9
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.3
44.5
235
715
CKC15
NOMESCO Finland
Panretinal photocoagulation
13.1
43.8
78
59
SPAT1263
SPAT
Sampling
1.5
42.9
2446
18715
S18
ICPC
Laceration/cut
1.5
42.7
2450
18756
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
412.7
41.9
42
*
SPAT1325
SPAT
Vaccination
1.5
41.9
2402
18366
XCH05
NOMESCO Finland
Eye pressure longterm registration
13.1
41.5
74
56
T90
ICPC
Diabetes non-insulin dependent
1.6
41.3
1439
9844
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
+∞
40.4
39
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.5
40.0
1477
10232
SPAT1301
SPAT
No procedures
1.5
38.5
2047
15329
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
38.4
2926
23514
WX002
NOMESCO Finland
Sedation and analgesia
1.6
37.6
1200
8003
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
36.2
2439
19067
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.1
35.7
206
670
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
35.1
2749
22053
CKD40
NOMESCO Finland
Endophotocoagulation of retina
5.5
35.1
107
195
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
34.3
2119
16250
H3601, E103
ICD-10 Finland
NA
+∞
34.2
33
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
9.9
34.0
69
69
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
4.5
33.8
123
272
A02BC02
ATC
pantoprazole; systemic
1.4
32.4
3700
31517
H3603, E103
ICD-10 Finland
NA
+∞
32.1
31
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.3
31.3
119
275
CA1ME
NOMESCO Finland
Ultrasound oculometry
5.6
30.8
92
164
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
30.8
1866
14186
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.5
30.7
111
244
SPAT1262
SPAT
Handing over of treatment supplies
1.5
30.4
1098
7494
H35.37
ICD-10 Finland
Macular holes
4.3
30.0
115
268
H44.0
ICD-10 Finland
Purulent endophthalmitis
22.4
29.7
43
19
L28
ICPC
Limited function/disability (L)
1.5
29.5
1245
8792
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
29.5
1822
13871
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2.9
29.0
186
650
1LA0P
NOMESCO Finland
NA
+∞
29.0
28
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.5
29.0
1370
9901
C10AA01
ATC
simvastatin; oral
1.4
28.8
3252
27374
S01ED02
ATC
betaxolol; ophthalmic
6.6
28.7
75
113
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
6.0
28.4
80
133
SPAT1312
SPAT
General health counselling
1.4
27.9
1622
12185
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
27.0
1163
8225
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.0
26.9
383
1983
M79.6
ICD-10 Finland
Pain in limb
1.4
26.7
1819
14036
J01CA04
ATC
amoxicillin; systemic
1.3
26.3
3973
34757
S01EA03
ATC
apraclonidine; ophthalmic
5.5
26.2
79
143
H35
ICD-10 Finland
Other retinal disorders
22.1
26.2
38
17
CHC05
NOMESCO Finland
Iridotomy
4.7
25.9
89
187
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.0
25.8
365
1885
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
7.2
25.7
63
87
H81
ICPC
Excessive ear wax
1.5
25.1
1113
7907
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
24.8
24
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
8.6
24.8
54
62
H35.1
ICD-10 Finland
Retinopathy of prematurity
57.2
24.8
29
5
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
24.3
1188
8597
Z71.8
ICD-10 Finland
Other specified counselling
1.5
24.2
1039
7324
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
24.2
2170
17444
H16.0
ICD-10 Finland
Corneal ulcer
2.5
24.2
194
775
A28
ICPC
Limited function/disability NOS
1.4
24.1
1337
9911
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
24.0
1666
12843
UJF32
NOMESCO Finland
Coloscopy
1.4
24.0
1564
11929
S01EB01
ATC
pilocarpine; ophthalmic
7.9
23.9
55
69
H40
ICD-10 Finland
Glaucoma
6.1
23.9
66
108
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
23.8
23
*
H3602, E113
ICD-10 Finland
NA
+∞
23.8
23
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.2
23.8
75
144
R42
ICD-10 Finland
Dizziness and giddiness
1.4
23.3
1463
11075
CKA10
NOMESCO Finland
Biopsy of vitreous body
17.8
23.2
36
20
SPAT1153
SPAT
Removal of sutures
1.4
23.2
1802
14140
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
22.8
2208
17910
A10AE04
ATC
insulin glargine; parenteral
1.7
22.8
488
2897
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.6
22.5
653
4205
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
226.5
22.5
23
*
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
22.4
2448
20193
SPAT1254
SPAT
Administration of medicine
1.4
22.3
1037
7421
SPAT1216
SPAT
Assessment of functional ability
1.4
22.3
1194
8776
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
22.2
1874
14865
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
22.2
419
2390
CH2X4
NOMESCO Finland
Optical coherence tomography (OCT) of iris and iridocorneal angle
26.9
22.0
30
11
N40
ICD-10 Finland
Hyperplasia of prostate
1.4
22.0
1474
11266
K02.1
ICD-10 Finland
Caries of dentine
1.3
21.9
2107
17047
H13
ICPC
Plugged feeling ear
1.4
21.9
1144
8367
H3600, E103
ICD-10 Finland
NA
+∞
21.7
21
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
21.7
21
*
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
21.4
2065
16695
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
216.6
21.4
22
*
XKD00
NOMESCO Finland
Uroflowmetry
1.4
21.3
1042
7521
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
4.1
21.1
82
196
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.3
20.9
1954
15708
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
49.2
20.9
25
5
AA1AD
NOMESCO Finland
CT of head and brain
1.4
20.9
1597
12449
SPAT1310
SPAT
Counselling related to known health issue
1.3
20.8
1644
12884
R03AC02
ATC
salbutamol; inhalant
1.3
20.8
2489
20727
H44.1
ICD-10 Finland
Other endophthalmitis
32.0
20.0
26
8
H02AB06
ATC
prednisolone; systemic
1.3
19.9
2572
21600
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
19.9
1591
12477
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
19.8
1589
12465
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
19.8
1276
9664
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.3
19.6
1507
11738
L03
ICPC
Low back symptom/complaint
1.4
19.6
1139
8473
T89
ICPC
Diabetes insulin dependent
2.9
19.5
119
405
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
196.9
19.4
20
*
-1
NOMESCO Finland
NA
1.4
19.1
1213
9152
EBA00
NOMESCO Finland
Extraction of tooth
1.4
19.1
1387
10696
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
19.0
1056
7788
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
18.9
1602
12657
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
18.9
2201
18188
J01AA02
ATC
doxycycline; systemic
1.3
18.9
4137
37099
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.4
18.7
1179
8881
H91.1
ICD-10 Finland
Presbycusis
1.6
18.7
569
3703
D07AC01
ATC
betamethasone; topical
1.3
18.6
1719
13746
E0000UV
ATC
NA
1.3
18.6
1886
15281
A10BA02
ATC
metformin; oral
1.3
18.5
1697
13555
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
5.8
18.3
52
89
M54.5
ICD-10 Finland
Low back pain
1.3
18.3
1465
11459
H54.1
ICD-10 Finland
Severe visual impairment, binocular
11.2
18.2
34
30
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.1
18.2
57
110
F05
ICPC
Visual disturbance other
2.3
18.1
167
719
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
18.0
2039
16749
H54.7
ICD-10 Finland
Unspecified visual loss
4.8
18.0
60
124
C10AA05
ATC
atorvastatin; oral
1.3
17.8
2412
20272
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
17.6
3010
26038
CFW99
NOMESCO Finland
Other operation on conjunctiva
+∞
17.6
17
*
N03AX16
ATC
pregabalin; oral
1.4
17.6
1192
9077
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
17.5
1005
7445
G04CA02
ATC
tamsulosin; oral
1.3
17.4
1529
12112
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
17.3
2114
17517
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
17.2
1689
13591
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.4
17.1
880
6390
R06AE07
ATC
cetirizine; oral
1.3
17.0
1830
14906
F28
ICPC
Limited function/disability (F)
4.6
16.9
59
128
C09CA01
ATC
losartan; oral
1.3
16.9
1463
11556
H54.5
ICD-10 Finland
Severe visual impairment, monocular
7.2
16.6
40
55
J01MA02
ATC
ciprofloxacin; systemic
1.3
16.6
2242
18787
A04
ICPC
Weakness/tiredness general
1.4
16.6
808
5804
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.6
16.5
468
2989
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
16.4
914
6724
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
16.4
1100
8353
CHD99
NOMESCO Finland
Other filtering operation
167.2
16.4
17
*
CHD35
NOMESCO Finland
Laser goniopuncture
167.2
16.4
17
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.4
16.3
784
5614
H20.1
ICD-10 Finland
Chronic iridocyclitis
5.1
16.3
51
99
C07AB07
ATC
bisoprolol; oral
1.3
16.1
3231
28348
R01AD09
ATC
mometasone; nasal
1.3
15.9
1691
13725
R06.0
ICD-10 Finland
Dyspnoea
1.3
15.8
1522
12184
H35.3
ICD-10 Finland
Degeneration of macula and posterior pole
13.3
15.8
27
20
H53.1
ICD-10 Finland
Subjective visual disturbances
1.8
15.8
292
1656
KMAK
NOMESCO Finland
NA
1.3
15.7
1945
16091
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.3
15.6
1213
9415
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.4
15.6
744
5321
H3601, E119
ICD-10 Finland
NA
+∞
15.5
15
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.3
15.4
1183
9160
H54.4
ICD-10 Finland
Blindness, monocular
9.5
15.4
31
32
M01AH05
ATC
etoricoxib; oral
1.3
15.4
2386
20279
H27.1
ICD-10 Finland
Dislocation of lens
5.2
15.4
47
89
R53
ICD-10 Finland
Malaise and fatigue
1.3
15.3
1249
9755
L17
ICPC
Foot/toe symptom/complaint
1.3
15.3
1287
10107
R03BB04
ATC
tiotropium bromide; inhalant
1.4
15.1
663
4665
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.4
15.1
776
5626
R5140
NOMESCO Finland
Monitoring the use of the aid
1.6
14.8
446
2893
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
1.5
14.6
533
3607
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.3
14.6
998
7586
C09AA05
ATC
ramipril; oral
1.3
14.6
1713
14047
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
20.7
14.5
21
10
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.6
14.3
415
2664
G04BD12
ATC
mirabegron; oral
1.4
14.3
660
4689
R02
ICPC
Shortness of breath/dyspnoea
1.4
14.3
693
4968
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
14.2
857
6384
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.5
14.2
581
4031
H02
ICPC
Hearing complaint
1.4
14.2
816
6029
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.4
14.1
785
5769
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
14.0
1624
13281
SPAT1229
SPAT
Assessment of need for aid
1.5
13.9
583
4060
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
13.9
1377
11032
SPAT1053
SPAT
Memory test
1.3
13.9
1269
10058
UKC02
NOMESCO Finland
Cystoscopy
1.3
13.8
1061
8204
B01AC04
ATC
clopidogrel; oral
1.3
13.8
1126
8782
A10AE05
ATC
insulin detemir; parenteral
1.8
13.7
245
1375
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
23.4
13.6
19
8
B01AF02
ATC
apixaban; oral
1.4
13.6
721
5248
SPAT1260
SPAT
Consultation of another employee
1.3
13.6
950
7242
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
10.2
13.5
26
25
Z02.7
ICD-10 Finland
Issue of medical certificate
1.6
13.5
326
2002
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
13.4
575
4024
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
2.8
13.4
87
311
H57.1
ICD-10 Finland
Ocular pain
2.3
13.4
119
508
D07AC13
ATC
mometasone; topical
1.3
13.3
1329
10659
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
4.5
13.2
46
101
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
13.2
408
2663
A10BH05
ATC
linagliptin; oral
1.6
13.2
339
2115
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.3
13.1
881
6667
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.4
13.0
750
5534
CKC99
NOMESCO Finland
Other extraocular operations on vitreous body and retina
39.3
13.0
16
*
C03CA01
ATC
furosemide; systemic
1.2
12.8
2471
21373
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.1
12.6
144
689
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.3
12.6
1606
13259
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
12.5
1616
13361
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
12.4
1431
11663
B01AB05
ATC
enoxaparin; parenteral
1.2
12.4
1713
14267
H40.8
ICD-10 Finland
Other glaucoma
19.7
12.3
18
9
S29
ICPC
Skin symptom/complaint other
1.3
12.3
846
6424
RS222
NOMESCO Finland
NA
2.6
12.3
87
330
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.4
12.2
538
3787
CKD15
NOMESCO Finland
Injection of vitreous substitute
5.7
12.1
34
59
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
2.2
12.1
123
557
C08CA13
ATC
lercanidipine; oral
1.3
12.1
839
6377
RS226
NOMESCO Finland
NA
36.9
12.1
15
*
L13
ICPC
Hip symptom/complaint
1.3
12.0
889
6829
SPAT1097
SPAT
Recording of ECG
1.3
12.0
900
6925
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.5
11.8
374
2456
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
11.7
1242
10006
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
11.7
793
6006
A10AA01
ATC
NA
2.9
11.7
70
240
A10BH01
ATC
sitagliptin; oral
1.4
11.7
518
3649
A02BC05
ATC
esomeprazole; systemic
1.2
11.7
2000
17033
G04CB02
ATC
dutasteride; oral
1.5
11.6
416
2807
WX142
NOMESCO Finland
Sub-tenon anesthesy
5.1
11.5
35
67
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
1.6
11.5
315
1998
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
0.6
11.5
212
3273
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
2.6
11.5
80
300
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
11.5
1284
10417
K85
ICPC
Elevated blood pressure
1.3
11.4
926
7199
H3601, E117
ICD-10 Finland
NA
+∞
11.4
11
*
H40.12
ICD-10 Finland
Pigmentary glaucoma
+∞
11.4
11
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
118.0
11.3
12
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
11.3
1412
11599
A10AE06
ATC
insulin degludec; parenteral
2.6
11.3
83
321
N03AX12
ATC
gabapentin; oral
1.4
11.3
717
5373
C10AA07
ATC
rosuvastatin; oral
1.3
11.2
1200
9675
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.5
11.1
400
2701
SPAT1234
SPAT
Support of social functional capacity
1.5
11.1
381
2547
C09DA06
ATC
candesartan and diuretics; oral
1.5
11.1
388
2602
H91.9
ICD-10 Finland
Hearing loss, unspecified
1.6
11.0
253
1534
N06AX11
ATC
mirtazapine; oral
1.2
11.0
1525
12675
R95
ICPC
Chron obstructive pulmonary disease
1.9
10.9
165
881
S01EA02
ATC
dipivefrine; ophthalmic
10.9
10.9
20
18
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
10.9
1085
8671
H44.2
ICD-10 Finland
Degenerative myopia
8.4
10.8
23
27
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
10.8
796
6098
J01FA10
ATC
azithromycin; systemic
1.2
10.8
2122
18284
CKC20
NOMESCO Finland
Cryopexy of undetached retina
9.0
10.8
22
24
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.2
10.8
106
475
N17
ICPC
Vertigo/dizziness
1.4
10.8
669
4995
M03BX02
ATC
tizanidine; oral
1.2
10.7
2343
20404
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.2
10.7
1432
11855
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.2
10.5
1901
16243
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.4
10.5
84
341
M48.0
ICD-10 Finland
Spinal stenosis
1.3
10.4
788
6057
SDA02
NOMESCO Finland
Parodonthologic therapy
1.3
10.4
1185
9617
CKD60
NOMESCO Finland
Anterior vitrectomy
2.6
10.4
71
265
M01AE01
ATC
ibuprofen; systemic, rectal
1.2
10.4
4157
38263
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
+∞
10.3
10
*
CK2Z4
NOMESCO Finland
Ocular fundus light imaging (OCT), angiography
+∞
10.3
10
*
H3601, E1100
ICD-10 Finland
NA
+∞
10.3
10
*
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
10.3
10
*
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
108.1
10.3
11
*
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
3.9
10.3
41
104
WX199
NOMESCO Finland
Other local analgesia
1.9
10.2
151
798
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.5
10.2
337
2233
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.4
10.2
639
4772
S21
ICPC
Skin texture symptom/complaint
1.4
10.2
621
4620
J01MA12
ATC
levofloxacin; systemic
1.3
10.2
1013
8085
D64.9
ICD-10 Finland
Anaemia, unspecified
1.3
10.2
715
5439
R05
ICPC
Cough
1.3
10.1
956
7578
R01AD08
ATC
fluticasone; nasal
1.3
10.1
1007
8037
H01.0
ICD-10 Finland
Blepharitis
1.7
10.1
185
1051
Z97.4
ICD-10 Finland
Presence of external hearing-aid
1.5
10.1
358
2413
M01AB05
ATC
diclofenac; systemic, rectal
1.2
10.0
3004
26882
C09CA06
ATC
candesartan; oral
1.3
9.8
1027
8252
G47.3
ICD-10 Finland
Sleep apnoea
1.3
9.7
713
5458
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
3.8
9.7
39
100
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
4.1
9.7
36
86
H35.4
ICD-10 Finland
Peripheral retinal degeneration
3.3
9.7
46
136
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.5
9.7
380
2615
A29
ICPC
General symptom/complaint other
1.3
9.6
627
4715
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.2
9.6
1762
15042
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
9.6
902
7146
J45.9
ICD-10 Finland
Asthma, unspecified
1.3
9.6
872
6878
M25.5
ICD-10 Finland
Pain in joint
1.3
9.6
1073
8686
S82
ICPC
Naevus/mole
1.4
9.5
509
3704
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.0
9.5
112
545
D07AB02
ATC
hydrocortisone butyrate; topical
1.2
9.5
1291
10681
D82
ICPC
Teeth/gum disease
1.3
9.5
1074
8704
CS2P4
NOMESCO Finland
Optic nerve head imaging
5.7
9.5
26
45
Z01.2
ICD-10 Finland
Dental examination
1.2
9.4
1418
11859
DFF00
NOMESCO Finland
Pure tone audiometry
1.4
9.4
468
3366
H04AA01
ATC
glucagon; nasal, parenteral
3.6
9.4
41
113
SPAT1009
SPAT
Measurement of intraocular pressure
2.5
9.4
71
280
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
4.3
9.4
33
75
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.4
9.4
491
3562
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
9.4
677
5167
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
2.5
9.4
71
281
A46
ICD-10 Finland
Erysipelas
1.3
9.4
802
6275
K86
ICPC
Hypertension uncomplicated
1.3
9.3
713
5488
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.3
9.3
846
6669
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
5.6
9.3
26
46
3625B
ICD-9 Finland
Other retinal disorders, Degeneration of macula and posterior pole[DEGENERATIO MACULAE EXSUDATIVA]
+∞
9.3
9
*
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
9.3
9
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
29.5
9.3
12
*
Z46.2
ICD-10 Finland
Fitting and adjustment of other devices related to nervous system and special senses
17.2
9.3
14
8
D07AB08
ATC
desonide; topical
1.4
9.3
480
3476
SPAT1211
SPAT
Application of soft bandage
1.4
9.3
477
3451
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
1.5
9.3
267
1718
Z01.9
ICD-10 Finland
Special examination, unspecified
1.6
9.2
256
1631
H26.2
ICD-10 Finland
Complicated cataract
3.0
9.2
53
177
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
1.4
9.2
561
4174
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
5.7
9.2
25
43
R03AK07
ATC
formoterol and budesonide; inhalant
1.3
9.1
706
5447
R33
ICD-10 Finland
Retention of urine
1.4
9.1
509
3734
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.4
9.1
502
3679
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
7.1
9.1
21
29
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.4
9.0
551
4099
CBB30
NOMESCO Finland
Excision of lesion of eyelid
1.8
9.0
163
922
H03AA01
ATC
levothyroxine sodium; systemic
1.2
9.0
1165
9577
M01AE02
ATC
naproxen; oral, rectal
1.2
9.0
2397
21155
R05
ICD-10 Finland
Cough
1.3
8.9
890
7095
L57.0
ICD-10 Finland
Actinic keratosis
1.3
8.9
707
5469
Z00.0
ICD-10 Finland
General medical examination
1.3
8.9
878
6995
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.3
8.8
671
5159
N30.0
ICD-10 Finland
Acute cystitis
1.3
8.8
797
6275
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.4
8.8
492
3615
S06.0
ICD-10 Finland
Concussion
1.4
8.7
470
3432
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
1.8
8.7
144
797
ZX120
NOMESCO Finland
Intravenous
1.4
8.7
463
3370
UJF30
NOMESCO Finland
Ileoscopy through colon
1.4
8.6
396
2815
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
8.5
697
5414
S01GX01
ATC
cromoglicic acid; ophthalmic
1.3
8.5
611
4663
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.2
8.5
1414
11927
G04CA01
ATC
alfuzosin; oral
1.3
8.5
622
4758
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
1.6
8.5
189
1143
WX290
NOMESCO Finland
Other blockade of nerve
1.2
8.4
1150
9502
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
5.1
8.4
25
48
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
5.1
8.4
25
48
R31
ICD-10 Finland
Unspecified haematuria
1.3
8.4
605
4621
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
88.5
8.3
9
*
-44
ICPC
Preventive immunization/medic
1.4
8.3
488
3612
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
1.6
8.3
197
1208
WX320
NOMESCO Finland
Spinalanesthesy
1.2
8.3
1157
9586
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.4
8.3
373
2635
3652B
ICD-9 Finland
Glaucoma, Primary angle-closure glaucoma[KROONINEN AHDASKULMAGLAUKOOMA]
+∞
8.3
8
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
1.5
8.3
303
2060
C02AC05
ATC
moxonidine; oral
1.5
8.3
253
1655
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.2
8.3
1009
8238
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.4
8.2
429
3113
I50.9
ICD-10 Finland
Heart failure, unspecified
1.2
8.2
1184
9839
K59.09
ICD-10 Finland
Constipation, unspecified
1.4
8.2
361
2538
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.3
8.2
742
5842
VALMI
NOMESCO Finland
NA
1.3
8.2
787
6246
SPAT1304
SPAT
Counselling and guidance related to ageing
1.3
8.2
571
4341
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.4
8.2
475
3510
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.4
8.1
357
2515
K78
ICPC
Atrial fibrillation/flutter
1.3
8.1
591
4522
H20.8
ICD-10 Finland
Other iridocyclitis
7.4
8.0
18
24
DAX08
NOMESCO Finland
Fitting of hearing aid
1.5
8.0
289
1958
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
16.9
8.0
12
7
C09DA01
ATC
losartan and diuretics; oral
1.3
8.0
560
4259
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.2
8.0
1164
9686
H61.2
ICD-10 Finland
Impacted cerumen
1.5
7.9
303
2076
F93
ICPC
Glaucoma
6.7
7.9
19
28
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
1.6
7.9
210
1330
R60.0
ICD-10 Finland
Localized oedema
1.3
7.9
655
5099
XJH00
NOMESCO Finland
Transanal ultrasonography
1.4
7.8
395
2850
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
5.7
7.8
21
36
207
Kela drug reimbursment
Chronic arrhythmias
1.2
7.8
1087
8996
M01AX05
ATC
glucosamine; oral
1.2
7.8
1333
11263
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.3
7.8
800
6396
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
1.6
7.8
185
1137
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
1.7
7.7
148
857
U02
ICPC
Urinary frequency/urgency
1.3
7.7
664
5189
N05BA04
ATC
oxazepam; oral
1.2
7.7
1221
10237
-31
ICPC
Medical examin/health eval partial
1.4
7.7
377
2707
R3120
NOMESCO Finland
Training in mobility skills
9.2
7.7
15
16
J05AB01
ATC
aciclovir; systemic
1.2
7.6
905
7361
E000006
ATC
NA
1.4
7.6
331
2325
Z01.8
ICD-10 Finland
Other specified special examinations
1.2
7.6
965
7907
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
7.6
443
3272
F99
ICPC
Eye/adnexa disease other
3.1
7.6
39
124
SPAT1281
SPAT
Other administrative function
1.4
7.6
359
2564
R03DC03
ATC
montelukast; oral
1.3
7.6
552
4221
L08
ICPC
Shoulder symptom/complaint
1.3
7.6
839
6771
R01AD12
ATC
fluticasone furoate; nasal
1.3
7.6
794
6364
P20
ICPC
Memory disturbance
1.2
7.5
980
8053
S01FA04
ATC
cyclopentolate; ophthalmic
2.7
7.5
49
181
M01AC06
ATC
meloxicam; systemic, rectal
1.2
7.5
1686
14607
CKD50
NOMESCO Finland
Endodiathermy of retina
6.6
7.5
18
27
SPAT1167
SPAT
Insertion of urinary catheter
1.5
7.5
227
1485
L01
ICPC
Neck symptom/complaint
1.3
7.4
526
4003
K02.2
ICD-10 Finland
Caries of cementum
1.6
7.4
202
1284
D07AD01
ATC
clobetasol; topical
1.3
7.4
654
5130
UDC00
NOMESCO Finland
Ear microscopy
1.4
7.4
325
2290
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.2
7.4
834
6744
K29
ICPC
Cardiovascular sympt/complt other
1.5
7.4
254
1704
L14
ICPC
Leg/thigh symptom/complaint
1.4
7.3
373
2697
H84
ICPC
Presbyacusis
1.5
7.3
262
1771
AN1
HP
Coronary angiography
1.2
7.3
821
6631
C08CA02
ATC
felodipine; oral
1.3
7.3
656
5157
SPAT1360
SPAT
Extensive global examination
1.4
7.3
419
3092
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.3
7.3
587
4549
H33.5
ICD-10 Finland
Other retinal detachments
3.1
7.3
37
117
CKD20
NOMESCO Finland
Removal of vitreous body substitute
3.8
7.3
29
76
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.2
7.3
1196
10064
A10AA02
ATC
NA
1.8
7.2
118
651
3708
FHL
Trabeculectomy or equivalent
+∞
7.2
7
*
H3602, E103
ICD-10 Finland
NA
+∞
7.2
7
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.3
7.2
491
3716
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.4
7.2
292
2023
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
1.7
7.2
150
892
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
10.6
7.2
13
12
WZA90
NOMESCO Finland
Other doctors statement
1.2
7.2
834
6768
D11
ICPC
Diarrhoea
1.4
7.1
354
2548
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
1.4
7.1
298
2081
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.3
7.1
507
3865
RS221
NOMESCO Finland
NA
2.3
7.1
63
274
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.4
7.1
408
3011
S97
ICPC
Chronic ulcer skin
1.4
7.1
321
2275
H29
ICPC
Ear symptom/complaint other
1.3
7.0
494
3760
KED22
NOMESCO Finland
Transurethral resection of prostate
1.4
7.0
383
2803
S22.3
ICD-10 Finland
Fracture of rib
1.4
7.0
303
2128
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.3
7.0
522
4003
H33.2
ICD-10 Finland
Serous retinal detachment
4.7
7.0
22
46
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.4
7.0
403
2977
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
1.2
6.9
891
7304
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
9.8
6.9
13
13
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
1.8
6.9
120
676
J01FA06
ATC
roxithromycin; oral
1.2
6.8
1895
16670
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
1.9
6.8
89
455
U01
ICPC
Dysuria/painful urination
1.4
6.8
331
2376
RK320
NOMESCO Finland
NA
2.4
6.8
52
210
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
1.9
6.8
97
511
R96
ICPC
Asthma
1.4
6.8
384
2825
TPH07
NOMESCO Finland
Cathetrisation of artery
1.3
6.8
538
4161
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.3
6.8
581
4540
A03
ICPC
Fever
1.3
6.8
436
3275
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.3
6.8
524
4041
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.3
6.8
717
5757
L15
ICPC
Knee symptom/complaint
1.2
6.7
949
7855
F51.0
ICD-10 Finland
Nonorganic insomnia
1.3
6.7
394
2916
SPAT1043
SPAT
Audiometry
1.3
6.7
647
5134
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
6.7
1938
17102
I48.1
ICD-10 Finland
Persistent atrial fibrillation
1.6
6.7
171
1075
H43.3
ICD-10 Finland
Other vitreous opacities
2.3
6.7
55
232
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
4.3
6.7
23
53
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.3
6.7
536
4156
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
1.7
6.7
129
753
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.3
6.6
620
4899
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.3
6.6
592
4654
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
3.0
6.6
35
115
H35.29
ICD-10 Finland
Other proliferative retinopathy
22.1
6.6
9
*
R5110
SPAT
NA
1.7
6.6
137
818
A97
ICPC
No disease
1.3
6.6
687
5505
M70.6
ICD-10 Finland
Trochanteric bursitis
1.3
6.5
609
4814
H54.0
ICD-10 Finland
Blindness, binocular
7.6
6.5
14
18
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
0.7
6.5
151
2214
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
1.3
6.5
453
3447
P01AB01
ATC
metronidazole; oral, rectal
1.2
6.5
1625
14173
RD211
NOMESCO Finland
NA
1.6
6.5
170
1078
D07XC01
ATC
betamethasone, combinations; topical
1.3
6.5
525
4075
R21
NOMESCO Finland
Counselling and guidance in rehabilitation
2.4
6.5
50
205
WZC30
NOMESCO Finland
Teaching
1.3
6.4
533
4150
S01
ICPC
Pain/tenderness of skin
1.5
6.4
188
1223
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.2
6.4
771
6277
F29
ICPC
Eye symptom/complaint other
1.4
6.4
319
2303
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
3.2
6.4
31
96
H30.8
ICD-10 Finland
Other chorioretinal inflammations
68.6
6.4
7
*
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
1.7
6.4
114
652
R52.2
ICD-10 Finland
Other chronic pain
1.6
6.3
136
816
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.2
6.3
824
6763
L05
ICPC
Flank/axilla symptom/complaint
1.4
6.3
238
1631
B01AF01
ATC
rivaroxaban; oral
1.3
6.3
658
5272
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.2
6.3
1661
14536
R39.1
ICD-10 Finland
Other difficulties with micturition
1.6
6.3
139
841
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
0.3
6.3
9
350
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
1.4
6.2
272
1916
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
1.6
6.2
147
908
M54.4
ICD-10 Finland
Lumbago with sciatica
1.3
6.2
594
4707
L12
ICPC
Hand/finger symptom/complaint
1.3
6.2
549
4309
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
1.3
6.2
401
3014
C03BA11
ATC
indapamide; oral
1.5
6.2
176
1137
F83
ICPC
Retinopathy
26.2
6.2
8
*
SXC05
NOMESCO Finland
Other oral or dental procedure
1.6
6.2
152
947
N05CF01
ATC
zopiclone; oral
1.2
6.1
1906
16893
R51.80
ICD-10 Finland
Headache
1.3
6.1
480
3714
H25.9
ICD-10 Finland
Senile cataract, unspecified
1.7
6.1
108
616
R06AX27
ATC
desloratadine; oral
1.2
6.1
729
5929
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
1.5
6.1
209
1406
R04.0
ICD-10 Finland
Epistaxis
1.3
6.1
427
3249
M02AA07
ATC
piroxicam; topical
1.2
6.1
2024
18020
U05
ICPC
Urination problems other
1.4
6.1
260
1828
N06AB10
ATC
escitalopram; oral
1.3
6.0
583
4626
D01BA02
ATC
terbinafine; oral; topical
1.2
6.0
1095
9284
4148X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Other specified forms of chronic ischaemic heart disease[MORBUS CORDIS ISCHAEMICUS ALIA,MÄÄRITTELEMÄT]
0.2
6.0
8
325
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
1.4
6.0
258
1811
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.8
6.0
36
128
N17.9
ICD-10 Finland
Acute renal failure, unspecified
1.4
6.0
227
1556
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
7.5
6.0
13
17
N06AX21
ATC
duloxetine; oral
1.3
6.0
362
2691
N05AD03
ATC
melperone; systemic
0.4
6.0
19
502
S04
ICPC
Lump/swelling localized
1.3
6.0
358
2661
F94
ICPC
Blindness
12.3
6.0
10
8
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
1.7
6.0
121
716
Mortality – FinRegistry
↥Association
Association between endpoint WET_AMD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| WET_AMD | 0.833 [0.76, 0.91] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.306 |
During the follow-up period (1.1.1998 — 31.12.2019), 11318 out of 30853 females with WET_AMD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| WET_AMD | 0.905 [0.81, 1.01] | 0.064 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 6694 out of 16881 males with WET_AMD died.
Mortality risk
Mortality risk for people of age
years, who have WET_AMD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.179% |
| 5 | 0.505% | 0.921% |
| 10 | 1.256% | 2.546% |
| 15 | 2.328% | 4.81% |
| 20 | 4.171% | 8.311% |
Relationships between endpoints
↥Index endpoint: WET_AMD – Wet age-related macular degeneration
GWS hits: 25
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data