No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
63 |
4. Check minimum number of eventsNone |
63 |
5. Include endpointsNone |
63 |
6. Filter based on genotype QC (FinnGen only) |
63 |
Control definitions (FinnGen only)
- Control exclude
- AB1_TUBERCULOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Miliary tuberculosis
based on the number of shared cases.
Similar with more cases:
- Tuberculosis
- Tuberculosis, IBD comorbidity
- Tuberculosis, wide
- Infections, IBD-co-morbidities
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1151 | 536 | 575 |
| Only index persons | 525 | 252 | 273 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.91 | 73.54 | 66.67 |
| Only index persons | 65.62 | 67.62 | 63.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 63 | 24 | 39 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 69.28 | 66.71 | 70.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 51
- Matched controls
- 508
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
18.9
17
*
A19.9
ICD-10 Finland
Miliary tuberculosis, unspecified
+∞
15.4
14
*
A19.0
ICD-10 Finland
Acute miliary tuberculosis of a single specified site
+∞
11.9
11
*
R50.9
ICD-10 Finland
Fever, unspecified
7.8
7.8
19
36
A19.2
ICD-10 Finland
Acute miliary tuberculosis, unspecified
+∞
7.5
7
*
A19.8
ICD-10 Finland
Other miliary tuberculosis
+∞
7.5
7
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
6.4
6
*
Mortality – FinRegistry
↥Association
Association between endpoint AB1TUBERCU_MILIARY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1TUBERCU_MILIARY | 2.344 [1.68, 3.27] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.142 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 196 females with AB1TUBERCU_MILIARY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1TUBERCU_MILIARY | 3.085 [2.04, 4.67] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 241 males with AB1TUBERCU_MILIARY died.
Mortality risk
Mortality risk for people of age
years, who have AB1TUBERCU_MILIARY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.247% | 0.503% |
| 5 | 1.401% | 3.278% |
| 10 | 3.368% | 8.075% |
| 15 | 6.323% | 14.981% |
| 20 | 11.127% | 24.438% |
Relationships between endpoints
↥Index endpoint: AB1TUBERCU_MILIARY – Miliary tuberculosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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