obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3101 |
4. Check minimum number of eventsNone |
3101 |
5. Include endpoints |
3197 |
6. Filter based on genotype QC (FinnGen only) |
3197 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF12
Tuberculosis, wide
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 48519 | 21137 | 25875 |
| Only index persons | 25041 | 12800 | 12241 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.70 | 0.61 | 0.72 |
| Only index persons | 0.47 | 0.47 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 53.53 | 53.62 | 53.34 |
| Only index persons | 44.14 | 44.42 | 43.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3197 | 1262 | 1935 |
| Unadjusted period prevalence (%) | 0.69 | 0.43 | 0.85 |
| Median age at first event (years) | 46.17 | 39.74 | 50.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2947
- Matched controls
- 29481
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
323.0
372
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
292.7
276
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
259.3
245
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
208.9
198
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
192.8
183
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
170.5
162
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
39.3
153.0
195
53
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
142.9
136
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
119.6
114
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.5
110.7
592
1960
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
108.0
103
*
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
104.8
100
*
A70
ICPC
Tuberculosis
+∞
94.3
90
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.6
90.6
463
1458
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.5
75
*
0110K
ICD-8 Finland
NA
+∞
71.1
68
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
64.8
62
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
60.6
58
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
58.5
56
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
57.8
592
2829
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
57.5
55
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
38.6
53.7
68
18
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
50.1
48
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
49.3
1029
6552
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
454.5
45.4
45
*
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
44.9
43
*
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
43.9
42
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
25.5
42.9
60
24
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
41.8
40
*
01600
ICD-8 Finland
Tuberculosis of genito-urinary system, Renis
+∞
41.8
40
*
0110J
ICD-8 Finland
NA
+∞
41.8
40
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
41.0
660
3775
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
40.7
39
*
R03BB04
ATC
tiotropium bromide; inhalant
2.2
38.2
453
2275
0172A
ICD-9 Finland
Tuberculosis of other organs, Peripheral lymph nodes
+∞
37.6
36
*
A18.4
ICD-10 Finland
Tuberculosis of skin and subcutaneous tissue
+∞
37.6
36
*
H02AB06
ATC
prednisolone; systemic
1.6
35.5
1343
9956
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
35.5
34
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
34.4
33
*
A18.8
ICD-10 Finland
Tuberculosis of other specified organs
+∞
34.4
33
*
0110A
ICD-8 Finland
NA
+∞
34.4
33
*
R03DA04
ATC
theophylline; systemic, rectal
2.3
32.6
318
1455
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
32.3
31
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.6
32.2
251
1018
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
31.5
402
2075
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
9.5
31.3
65
70
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
31.3
30
*
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
16.4
31.1
50
31
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.0
30.8
184
633
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.2
28
*
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
29.2
28
*
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
294.7
28.8
29
*
R03AC12
ATC
salmeterol; inhalant
2.6
28.3
221
898
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
28.2
27
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
28.2
27
*
R03AC02
ATC
salbutamol; inhalant
1.6
27.9
1298
9922
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
27.4
473
2730
R03BB01
ATC
ipratropium bromide; inhalant
2.4
26.8
244
1074
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.1
25.9
309
1544
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
25.4
174
651
H02AB07
ATC
prednisone; oral
1.8
24.7
462
2730
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
24.0
23
*
J96.1
ICD-10 Finland
Chronic respiratory failure
3.2
23.8
127
404
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.3
23.8
233
1063
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.9
23.6
99
260
1240
FHL
Bronchoscopy
4.1
23.4
93
233
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
22.9
22
*
01718
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum periphericorum aliorum
+∞
22.9
22
*
TGC00
NOMESCO Finland
Bronchial lavation
3.5
22.9
109
319
J47
ICD-10 Finland
Bronchiectasis
4.0
22.4
90
228
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.7
22.3
157
601
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
22.1
480
2969
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
20.9
20
*
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
30.3
20.5
27
9
J01MA14
ATC
moxifloxacin; systemic
2.0
20.5
272
1416
L04AX01
ATC
azathioprine; systemic
3.0
20.4
118
399
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
19.4
1180
9310
Y3429
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other inactive tuberculosis cases
46.3
19.2
23
5
R03BA01
ATC
beclometasone; inhalant
1.8
19.1
389
2350
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.3
18.3
175
790
01500
ICD-8 Finland
Tuberculosis of bones and joints, Of vertebral column
+∞
17.7
17
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
17.7
17
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
17.7
17
*
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
181.0
17.5
18
*
J01MA12
ATC
levofloxacin; systemic
1.6
17.4
551
3754
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
50.3
17.0
20
*
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
16.7
16
*
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
6.9
16.7
41
60
N33.0*A18.1
ICD-10 Finland
Tuberculous cystitis
+∞
15.6
15
*
R04.2
ICD-10 Finland
Haemoptysis
2.4
15.5
131
554
M05BA04
ATC
alendronic acid; oral
1.8
15.2
273
1579
1370X
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,MUU JÄLKITILA]
23.5
15.1
21
9
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
45.2
15.1
18
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
14.9
284
1674
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
2.8
14.9
96
350
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.6
14.8
107
417
01909
ICD-8 Finland
Late effects of tuberculosis, Sequelae NUD o tuberculosis organorum respirationis
+∞
14.6
14
*
A19.9
ICD-10 Finland
Miliary tuberculosis, unspecified
+∞
14.6
14
*
01797
ICD-8 Finland
Tuberculosis of other organs, Suspecta
+∞
14.6
14
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
14.5
195
1019
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
5.5
13.9
40
73
R06.0
ICD-10 Finland
Dyspnoea
1.4
13.8
684
5112
M01.1*A18.0
ICD-10 Finland
Tuberculous arthritis
+∞
13.5
13
*
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
13.5
13
*
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.5
13
*
01597
ICD-8 Finland
Tuberculosis of bones and joints, Suspecta
+∞
13.5
13
*
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
8.8
13.5
28
32
N02AX02
ATC
tramadol; systemic, rectal
1.4
13.1
1092
8921
J01FA06
ATC
roxithromycin; oral
1.4
12.8
989
7974
J01AA02
ATC
doxycycline; systemic
1.3
12.7
1997
17950
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
12.6
1071
8764
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
12.5
12
*
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
13.2
12.4
21
16
R03BA02
ATC
budesonide; inhalant
1.5
12.1
411
2828
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
12.1
466
3294
132
Kela drug reimbursment
Sarcoidosis
5.5
11.9
34
62
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
11.8
866
6904
P01BA02
ATC
hydroxychloroquine; oral
1.8
11.6
193
1091
A19.0
ICD-10 Finland
Acute miliary tuberculosis of a single specified site
+∞
11.5
11
*
01510
ICD-8 Finland
Tuberculosis of bones and joints, Of hip
+∞
11.5
11
*
0151X
ICD-9 Finland
Tuberculosis of bones and joints, Hip[TUBERCULOSIS COXAE,EPÄILTY]
+∞
11.5
11
*
01588
ICD-8 Finland
Tuberculosis of bones and joints, Of other specified bones and joints
+∞
11.5
11
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.0
11.4
147
760
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
11.3
189
1071
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
35.1
11.3
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
11.2
318
2097
H02AB04
ATC
methylprednisolone; systemic
1.5
11.1
368
2519
51899
ICD-8 Finland
Bronchiectasis
8.6
11.0
23
27
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
10.9
382
2647
B90.2
ICD-10 Finland
Sequelae of tuberculosis of bones and joints
28.1
10.7
14
5
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.1
10.6
115
554
XG410
NOMESCO Finland
Flow-volume spirometry
2.1
10.6
114
544
GD1AD
NOMESCO Finland
Thorax CT examination
2.1
10.5
117
570
R03BB02
ATC
oxitropium bromide; inhalant
3.3
10.5
51
156
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
3.0
10.5
60
204
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
+∞
10.4
10
*
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
10.4
10
*
A02BA02
ATC
ranitidine; systemic
1.4
10.4
584
4435
R03AC03
ATC
terbutaline; inhalant
1.6
10.4
315
2108
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
2.9
10.4
61
213
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
3.1
10.4
54
174
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
5.1
10.3
31
61
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
10.2
188
1098
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
10.1
249
1582
13599
ICD-8 Finland
Sarcoidosis, Unspecified
5.6
10.1
28
50
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
1.9
10.0
150
817
PJA10
NOMESCO Finland
Exploration of lymph nodes
3.7
9.9
41
111
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.1
9.8
102
485
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
9.7
733
5835
48509
ICD-8 Finland
Bronchopneumonia, unspecified
4.0
9.6
37
94
13597
ICD-8 Finland
Sarcoidosis, Suspecta
5.2
9.5
28
54
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
3.4
9.4
43
126
49300
ICD-8 Finland
Asthma, bronchiale
2.4
9.4
80
345
0150X
ICD-9 Finland
Tuberculosis of bones and joints, Vertebral column[SELKÄRANKATUBERKULOOSI,EPÄILTY]
+∞
9.4
9
*
01608
ICD-8 Finland
Tuberculosis of genito-urinary system, Suspecta
+∞
9.4
9
*
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
9.4
9
*
H03.1*A18.4
ICD-10 Finland
Lupus vulgaris: of eyelid
+∞
9.4
9
*
01719
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum NUD
+∞
9.4
9
*
R05CB01
ATC
acetylcysteine; inhalant, oral
2.4
9.4
75
315
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.7
9.1
182
1090
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
2.9
9.1
54
191
J45.8
ICD-10 Finland
Mixed asthma
2.2
9.0
91
427
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
18.6
8.9
13
7
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.9
8.9
135
739
J46
ICD-10 Finland
Status asthmaticus
2.4
8.9
72
304
R03AC13
ATC
formoterol; inhalant
1.8
8.8
144
810
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
10.7
8.8
16
15
R50.9
ICD-10 Finland
Fever, unspecified
1.5
8.7
341
2415
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
8.7
402
2945
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
4.5
8.6
29
65
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
2.4
8.4
69
294
N05CD07
ATC
temazepam; oral
1.4
8.4
418
3099
Z2446
NOMESCO Finland
Social worker
1.8
8.4
149
862
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
4.8
8.4
26
54
01900
ICD-8 Finland
Late effects of tuberculosis, Bronchiectasia
+∞
8.3
8
*
01701
ICD-8 Finland
Tuberculosis of other organs, Erythema induratum tuberculosum
+∞
8.3
8
*
01930
ICD-8 Finland
Late effects of tuberculosis, Columnae vertebralis
+∞
8.3
8
*
H32.0*A18.5
ICD-10 Finland
Lupus chorioretinitis
+∞
8.3
8
*
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
01901
ICD-8 Finland
Late effects of tuberculosis, Emphysema
+∞
8.3
8
*
01931
ICD-8 Finland
Late effects of tuberculosis, Coxae
+∞
8.3
8
*
01604
ICD-8 Finland
Tuberculosis of genito-urinary system, Prostatae, vesiculae seminalis sive testis
+∞
8.3
8
*
01903
ICD-8 Finland
Late effects of tuberculosis, Fibrosis pulmonum
+∞
8.3
8
*
L04AA13
ATC
leflunomide; oral
2.5
8.3
61
245
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
4.9
8.2
25
51
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
8.1
640
5113
A06AD11
ATC
lactulose; oral
1.4
8.1
510
3935
SPAT1017
SPAT
Examination of colour vision
33.4
8.1
10
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
3.5
8.0
35
100
J01DA01
ATC
[U] cefalexin; systemic
1.2
7.9
1567
14044
J01FF01
ATC
clindamycin; systemic
1.3
7.9
593
4701
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
7.8
315
2245
A31.89
ICD-10 Finland
Other mycobacterial infections
45.1
7.7
9
*
Y3419
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Inactive pulmonary tuberculosis, which is known to have been inactive
45.1
7.7
9
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
7.7
93
471
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
2.2
7.7
72
328
A98
ICPC
Health maint/preventive medicine
0.8
7.7
1924
20720
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.7
7.5
136
797
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.7
7.4
216
3076
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
2.3
7.4
62
268
R05
ICD-10 Finland
Cough
1.4
7.3
404
3048
A19.8
ICD-10 Finland
Other miliary tuberculosis
+∞
7.3
7
*
0110B
ICD-8 Finland
NA
+∞
7.3
7
*
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
7.3
7
*
01202
ICD-8 Finland
NA
+∞
7.3
7
*
K93.0*A18.3
ICD-10 Finland
Tuberculous disease of the intestines, peritoneum and mesentery glands
+∞
7.3
7
*
1373X
ICD-9 Finland
Late effects of tuberculosis of bones and joints
+∞
7.3
7
*
A19.2
ICD-10 Finland
Acute miliary tuberculosis, unspecified
+∞
7.3
7
*
A02BC01
ATC
omeprazole; systemic
1.3
7.3
728
5996
SPAT1254
SPAT
Administration of medicine
1.4
7.2
390
2936
J43.9
ICD-10 Finland
Emphysema, unspecified
2.4
7.1
57
242
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.8
7.1
118
673
R03BA05
ATC
fluticasone; inhalant
1.4
7.0
387
2920
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.6
7.0
153
948
N02AC04
ATC
dextropropoxyphene; oral
1.7
6.9
139
838
J86.9
ICD-10 Finland
Pyothorax without fistula
3.4
6.9
31
92
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.2
6.9
66
303
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
1.8
6.8
110
619
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
2.8
6.8
40
142
Y3498
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other illnesses, accidents or surgeries
8.3
6.8
14
17
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
6.7
6.8
16
24
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
4.2
6.8
24
58
L95.8
ICD-10 Finland
Other vasculitis limited to skin
9.3
6.8
13
14
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.1
6.7
70
335
N05CF01
ATC
zopiclone; oral
1.2
6.6
872
7415
1243
FHL
Bronchoscopy and other therapeutic procedure
8.7
6.5
13
15
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
3.8
6.5
25
66
B90.8
ICD-10 Finland
Sequelae of tuberculosis of other organs
70.0
6.4
7
*
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
14.3
6.4
10
7
A10BA02
ATC
metformin; oral
0.8
6.4
498
6121
M79.3
ICD-10 Finland
Panniculitis, unspecified
8.2
6.3
13
16
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
6.3
116
684
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.4
6.3
51
218
0178X
ICD-9 Finland
Tuberculosis of other organs, Oesophagus[TUBERCULOSIS ALIORUM ORGANORUM]
+∞
6.2
6
*
01731
ICD-8 Finland
Tuberculosis of other organs, Otitis media tuberculosa
+∞
6.2
6
*
01401
ICD-8 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Peritonei et lymphonodorum mesenterii
+∞
6.2
6
*
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
6.2
6
*
A18.5
ICD-10 Finland
Tuberculosis of eye
+∞
6.2
6
*
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
6.2
6
*
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.2
6
*
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.2
6
*
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
6.2
6
*
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
6.2
6
*
I41.0*A18.8
ICD-10 Finland
Tuberculosis of myocardium
+∞
6.2
6
*
N29.1*A18.1
ICD-10 Finland
Tuberculosis of the kidney or ureter
+∞
6.2
6
*
G05.0*A17.8
ICD-10 Finland
Tuberculous meningoencephalitis
+∞
6.2
6
*
A17.8
ICD-10 Finland
Other tuberculosis of nervous system
+∞
6.2
6
*
0140X
ICD-9 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Tuberculous peritonitis[PERITONITIS TUBERCULOSA,EPÄILTY]
+∞
6.2
6
*
0130X
ICD-9 Finland
Tuberculosis of meninges and central nervous system, Tuberculous meningitis[MENINGITIS TUBERCULOSA, EPÄILTY]
+∞
6.2
6
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.6
6.2
147
927
A07AA02
ATC
nystatin; oral
1.6
6.2
158
1017
ZX136
NOMESCO Finland
Intravesicalis
3.1
6.2
31
101
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
2.9
6.1
33
113
GDA10
NOMESCO Finland
Biopsy of lung
7.7
6.1
13
17
48609
ICD-8 Finland
Pneumonia, unspecified
2.6
6.1
41
160
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
2.3
6.1
50
216
1350A
ICD-9 Finland
Sarcoidosis[SARCOIDOSIS]
4.9
6.0
18
37
Mortality – FinRegistry
↥Association
Association between endpoint AB1_TUBERCULOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TUBERCULOSIS | 1.898 [1.73, 2.09] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.167 |
During the follow-up period (1.1.1998 — 31.12.2019), 2139 out of 4624 females with AB1_TUBERCULOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TUBERCULOSIS | 2.451 [2.19, 2.74] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3252 out of 5855 males with AB1_TUBERCULOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_TUBERCULOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.197% | 0.417% |
| 5 | 1.084% | 2.623% |
| 10 | 2.86% | 6.862% |
| 15 | 5.108% | 12.978% |
| 20 | 8.989% | 20.557% |
Relationships between endpoints
↥Index endpoint: AB1_TUBERCULOSIS – Tuberculosis, wide
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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