Respiratory tuberculosis

TBC_RESP

pulmonary tuberculosis: A bacterial infection that affects the lungs and is caused by Mycobacterium tuberculosis. Most patients with tuberculosis do not have symptoms (latent tuberculosis) and are not contagious. When signs and symptoms occur (active tuberculosis), patients become contagious. The signs and symptoms include chronic cough with blood-tinged sputum, night sweats, fever, fatigue, and weight loss.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

2316

6. Filter based on genotype QC (FinnGen only)

2316

Control definitions (FinnGen only)

Control exclude
IBD_TUBERCULOSIS

Extra metadata

First used in FinnGen datafreeze
DF2

Similar endpoints

List of similar endpoints to Respiratory tuberculosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34910 13713 20113
Only index persons 17505 8163 9342
Unadjusted period prevalence (%)
Whole population 0.51 0.39 0.56
Only index persons 0.33 0.30 0.36
Median age at first event (years)
Whole population 53.02 52.55 53.15
Only index persons 42.73 41.60 43.72

-FinnGen-

Key figures

All Female Male
Number of individuals 2316 804 1512
Unadjusted period prevalence (%) 0.53 0.27 0.67
Median age at first event (years) 45.55 37.14 50.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2155
Matched controls
21549
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
323.0
372
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
294.7
276
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
260.8
245
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
209.9
198
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
193.7
183
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
171.1
162
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
143.3
136
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
39.4
121.1
154
42
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
119.9
114
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.8
98.8
486
1532
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.2
94.7
406
1128
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.6
75
*
0110K
ICD-8 Finland
NA
+∞
71.2
68
*
A70
ICPC
Tuberculosis
+∞
70.2
67
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
64.9
62
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
60.7
58
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
58.6
56
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
57.5
55
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.6
56.0
496
2240
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
50.2
48
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
+∞
47.0
45
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
46.5
803
4888
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
26.3
42.5
59
23
0110J
ICD-8 Finland
NA
+∞
41.8
40
*
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
41.8
40
*
R03BB04
ATC
tiotropium bromide; inhalant
2.5
41.0
376
1701
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
39.7
38
*
0110A
ICD-8 Finland
NA
+∞
34.5
33
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
34.5
33
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
18.1
34.1
53
30
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.0
34.0
217
787
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
33.8
506
2838
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
12.3
33.0
60
50
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
32.4
31
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.5
31.7
159
486
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
30.3
29
*
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.2
28
*
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
29.2
28
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
28.2
27
*
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
28.2
27
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
28.1
325
1621
1240
FHL
Bronchoscopy
5.4
27.6
85
163
R03DA04
ATC
theophylline; systemic, rectal
2.4
27.6
254
1135
H02AB06
ATC
prednisolone; systemic
1.7
27.0
977
7194
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
16.0
25.4
41
26
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
24.0
23
*
J01MA14
ATC
moxifloxacin; systemic
2.3
23.5
226
1032
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
23.2
352
1952
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
22.9
22
*
R03AC02
ATC
salbutamol; inhalant
1.6
22.6
944
7100
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
22.6
196
849
R03AC12
ATC
salmeterol; inhalant
2.6
22.5
168
669
R03BB01
ATC
ipratropium bromide; inhalant
2.4
22.1
198
871
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.2
21.8
251
1244
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
20.9
20
*
J96.1
ICD-10 Finland
Chronic respiratory failure
3.5
20.7
100
298
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
20.1
130
475
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
19.6
146
578
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.8
19.2
131
495
TGC00
NOMESCO Finland
Bronchial lavation
3.7
19.2
85
236
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
8.8
17.9
38
44
J47
ICD-10 Finland
Bronchiectasis
4.0
17.8
72
185
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
26.9
17.8
24
9
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.6
17.8
81
231
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
17.7
17
*
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
95.8
17.6
19
*
R04.2
ICD-10 Finland
Haemoptysis
2.8
17.1
113
419
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
3.0
16.0
94
325
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
15.3
347
2179
H02AB07
ATC
prednisone; oral
1.7
14.9
322
1994
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
25.2
14.7
20
8
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
14.6
14
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.1
14.0
75
244
J01FA06
ATC
roxithromycin; oral
1.5
14.0
749
5767
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
13.6
13
*
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.6
13
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
13.5
797
6250
J45.8
ICD-10 Finland
Mixed asthma
3.0
12.8
75
259
R03BA01
ATC
beclometasone; inhalant
1.7
12.8
283
1760
M05BA04
ATC
alendronic acid; oral
1.9
12.7
190
1038
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
12.5
12
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
12.2
141
696
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.4
11.9
102
439
R03BA02
ATC
budesonide; inhalant
1.6
11.9
305
1975
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
65.3
11.6
13
*
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
11.5
11
*
A02BA02
ATC
ranitidine; systemic
1.5
11.3
435
3105
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
11.2
834
6752
L04AX01
ATC
azathioprine; systemic
2.6
11.1
79
310
R03AC13
ATC
formoterol; inhalant
2.2
10.9
114
543
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.1
10.9
118
570
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
3.7
10.7
45
123
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.2
10.6
110
522
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
60.3
10.6
12
*
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
10.4
10
*
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
+∞
10.4
10
*
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
3.2
10.4
54
174
R03BB02
ATC
oxitropium bromide; inhalant
3.6
10.3
45
127
J01MA12
ATC
levofloxacin; systemic
1.5
10.0
387
2755
13599
ICD-8 Finland
Sarcoidosis, Unspecified
9.2
10.0
20
22
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.0
9.9
118
592
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
9.9
335
2315
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
5.7
9.8
27
48
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
20.1
9.8
14
7
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
9.6
9.8
19
20
A98
ICPC
Health maint/preventive medicine
0.7
9.7
1349
14938
R06.0
ICD-10 Finland
Dyspnoea
1.4
9.6
477
3573
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
9.5
189
1140
R05CB01
ATC
acetylcysteine; inhalant, oral
2.7
9.4
61
228
N05CD07
ATC
temazepam; oral
1.5
9.4
325
2260
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
9.4
9
*
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
9.4
9
*
J43.9
ICD-10 Finland
Emphysema, unspecified
2.9
9.3
54
187
48609
ICD-8 Finland
Pneumonia, unspecified
3.7
9.3
39
107
51899
ICD-8 Finland
Bronchiectasis
8.3
9.1
19
23
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
36.8
9.0
11
*
J01AA02
ATC
doxycycline; systemic
1.3
9.0
1454
13099
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.1
9.0
48
159
XG410
NOMESCO Finland
Flow-volume spirometry
2.2
8.9
88
409
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
8.9
289
1977
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
4.4
8.9
31
72
GD1AD
NOMESCO Finland
Thorax CT examination
2.2
8.8
87
404
A10BA02
ATC
metformin; oral
0.7
8.7
344
4599
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.6
8.4
59
232
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
8.3
8
*
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
5.8
8.3
22
38
N02AX02
ATC
tramadol; systemic, rectal
1.3
8.3
783
6497
132
Kela drug reimbursment
Sarcoidosis
4.9
8.2
25
51
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
8.2
134
759
R95
ICPC
Chron obstructive pulmonary disease
2.3
7.9
68
299
P01BA02
ATC
hydroxychloroquine; oral
1.8
7.8
128
727
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
25.1
7.6
10
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
3.3
7.6
36
111
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
3.9
7.5
29
75
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
4.1
7.5
27
66
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
3.1
7.4
38
124
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
7.4
132
770
01202
ICD-8 Finland
NA
+∞
7.3
7
*
A18.8
ICD-10 Finland
Tuberculosis of other specified organs
+∞
7.3
7
*
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
7.3
7
*
0110B
ICD-8 Finland
NA
+∞
7.3
7
*
48509
ICD-8 Finland
Bronchopneumonia, unspecified
3.7
7.2
29
79
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
7.1
515
4085
J46
ICD-10 Finland
Status asthmaticus
2.4
7.1
56
234
R03AC03
ATC
terbutaline; inhalant
1.5
7.0
230
1575
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
2.4
7.0
55
230
13597
ICD-8 Finland
Sarcoidosis, Suspecta
5.2
6.9
20
39
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
2.3
6.9
58
252
L04AA13
ATC
leflunomide; oral
2.7
6.9
45
171
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
2.8
6.8
41
149
N02AC04
ATC
dextropropoxyphene; oral
1.8
6.8
106
595
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.1
6.8
70
334
A06AD11
ATC
lactulose; oral
1.4
6.7
362
2734
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
6.5
147
2184
Z2446
NOMESCO Finland
Social worker
1.8
6.5
109
624
Y3498
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other illnesses, accidents or surgeries
10.0
6.5
12
12
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
2.6
6.5
44
173
H02AB04
ATC
methylprednisolone; systemic
1.5
6.5
251
1782
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
6.5
581
4751
A31.89
ICD-10 Finland
Other mycobacterial infections
70.0
6.4
7
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
7.4
6.4
14
19
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
4.9
6.3
19
39
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
6.3
6
*
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
6.3
6
*
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.3
6
*
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
6.3
6
*
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
6.3
6
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
6.3
6
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
6.3
6
*
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
6.3
6
*
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.3
6
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
6.2
51
221
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
3.3
6.2
29
90
5188X
ICD-9 Finland
Other diseases of lung
5.0
6.2
18
36
Y0499
ICD-8 Finland
Investigation of respiratory system
2.9
6.1
35
123
5120A
ICD-9 Finland
Pneumothorax, Spontaneous tension pneumothorax
6.7
6.0
14
21
D86.0
ICD-10 Finland
Sarcoidosis of lung
3.4
6.0
26
76

Mortality – FinRegistry

Association

Association between endpoint TBC_RESP and mortality.

Females

Parameter HR [95% CI] p-value
TBC_RESP 2.077 [1.85, 2.33] < 0.001
Birth year 0.996 [0.99, 1.0] 0.314

During the follow-up period (1.1.1998 — 31.12.2019), 1483 out of 2958 females with TBC_RESP died.

Males

Parameter HR [95% CI] p-value
TBC_RESP 2.815 [2.49, 3.19] < 0.001
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 2702 out of 4601 males with TBC_RESP died.

Mortality risk

Mortality risk for people of age

years, who have TBC_RESP.

N-year risk Females Males
1 0.237% 0.513%
5 1.239% 3.228%
10 3.108% 7.591%
15 5.846% 14.501%
20 10.563% 23.591%

Relationships between endpoints

Index endpoint: TBC_RESP – Respiratory tuberculosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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