Respiratory tuberculosis

TBC_RESP

pulmonary tuberculosis: A bacterial infection that affects the lungs and is caused by Mycobacterium tuberculosis. Most patients with tuberculosis do not have symptoms (latent tuberculosis) and are not contagious. When signs and symptoms occur (active tuberculosis), patients become contagious. The signs and symptoms include chronic cough with blood-tinged sputum, night sweats, fever, fatigue, and weight loss.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

2329

6. Filter based on genotype QC (FinnGen only)

2236

Control definitions (FinnGen only)

Control exclude
IBD_TUBERCULOSIS

Extra metadata

First used in FinnGen datafreeze
DF2

Similar endpoints

List of similar endpoints to Respiratory tuberculosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34910 13713 20113
Only index persons 17505 8163 9342
Unadjusted period prevalence (%)
Whole population 0.51 0.39 0.56
Only index persons 0.33 0.30 0.36
Median age at first event (years)
Whole population 53.02 52.55 53.15
Only index persons 42.73 41.60 43.72

-FinnGen-

Key figures

All Female Male
Number of individuals 2236 773 1463
Unadjusted period prevalence (%) 0.53 0.27 0.67
Median age at first event (years) 45.78 37.31 50.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2329
Matched controls
23290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
307.7
304
*
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
307.7
394
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
46.6
293.4
173
40
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
276.7
260
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
227.9
215
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
213.9
202
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
1988.5
182.7
175
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.1
165.2
559
1669
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.5
159.8
462
1225
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
153.9
146
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
131.5
125
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
22.7
87.3
64
29
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
36.8
86.6
54
15
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.7
79.7
552
2431
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.6
75
*
A70
ICPC
Tuberculosis
269.4
76.9
78
*
0110K, ,
ICD-8 Finland
+∞
74.4
71
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
72.3
69
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
68.0
65
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
64.9
62
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
59.6
57
*
R03BB04
ATC
tiotropium bromide; inhalant
2.5
57.4
434
1964
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
10.4
54.8
61
60
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
54.4
52
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
51.0
922
5840
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
498.2
49.6
49
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.5
47.6
175
533
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
466.9
46.4
46
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.8
45.6
248
948
0110J, ,
ICD-8 Finland
+∞
44.9
43
*
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
12.4
44.5
44
36
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
42.8
41
*
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
41.8
40
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
39.9
559
3196
TGC00
NOMESCO Finland
Bronchial lavation
4.3
39.5
104
250
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
38.6
37
*
1240
FHL
Bronchoscopy
4.5
36.8
90
204
0110A, ,
ICD-8 Finland
+∞
35.5
34
*
R03DA04
ATC
theophylline; systemic, rectal
2.4
34.7
271
1228
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
33.7
152
523
H02AB06
ATC
prednisolone; systemic
1.7
33.6
1113
8152
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
33.4
32
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
31.7
358
1880
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
7.7
30.6
43
57
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
30.3
29
*
R03BB01
ATC
ipratropium bromide; inhalant
2.4
29.8
214
933
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.2
28
*
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
29.2
28
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
29.2
28
*
J47
ICD-10 Finland
Bronchiectasis
4.0
29.2
84
216
J01MA14
ATC
moxifloxacin; systemic
2.2
29.1
258
1231
R03AK03
ATC
[U] fenoterol and ipratropium bromide
2.1
27.6
270
1339
R03AC12
ATC
salmeterol; inhalant
2.5
27.5
182
763
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
27.1
26
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
27.1
161
641
J96.1
ICD-10 Finland
Chronic respiratory failure
3.2
27.0
112
367
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.3
26.6
220
1018
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.7
26.2
149
580
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.7
25.5
83
233
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
25.0
24
*
R03AC02
ATC
salbutamol; inhalant
1.6
24.4
1088
8347
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
24.0
23
*
R04.2
ICD-10 Finland
Haemoptysis
2.7
23.3
129
495
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
23.3
383
2267
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
34.1
21.1
27
8
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
18.8
18
*
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.7
18.7
100
377
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.0
18.4
81
275
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
17.9
400
2568
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
17.7
17
*
H02AB07
ATC
prednisone; oral
1.7
17.0
346
2164
M05BA04
ATC
alendronic acid; oral
1.9
16.4
222
1229
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.3
16.1
118
518
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
16.1
164
823
J45.8
ICD-10 Finland
Mixed asthma
2.7
16.1
86
325
R03BA01
ATC
beclometasone; inhalant
1.7
16.1
308
1894
48609
ICD-8 Finland
Pneumonia, unspecified
4.1
16.0
44
110
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
60.4
15.8
18
*
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
6.6
15.8
25
38
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
15.6
15
*
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
15.6
15
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.2
15.6
132
616
R05CB01
ATC
acetylcysteine; inhalant, oral
3.0
15.6
68
230
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
22.2
15.5
22
10
J01FA06
ATC
roxithromycin; oral
1.4
14.6
814
6336
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
14.6
14
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
5.0
14.5
31
63
GD1AD
NOMESCO Finland
Thorax CT examination
2.1
14.5
133
641
L04AX01
ATC
azathioprine; systemic
2.6
14.3
85
339
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.8
13.8
68
246
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.3
13.8
52
161
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.6
13
*
J43.9
ICD-10 Finland
Emphysema, unspecified
2.8
13.1
64
231
L04AA13
ATC
[U] leflunomide
3.1
13.1
53
172
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
3.3
12.7
47
144
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
10.5
12.7
24
23
13599
ICD-8 Finland
Sarcoidosis, Unspecified
6.0
12.6
22
37
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
70.3
12.6
14
*
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
12.5
12
*
R03BB02
ATC
oxitropium bromide; inhalant
3.2
12.3
48
152
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
2.9
12.3
57
200
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.1
12.3
122
607
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
12.3
983
8079
R03AC13
ATC
formoterol; inhalant
2.0
12.2
129
656
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
12.2
389
2700
J01MA12
ATC
levofloxacin; systemic
1.5
12.1
440
3138
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
3.0
11.9
52
177
J46
ICD-10 Finland
Status asthmaticus
2.7
11.8
64
244
48509
ICD-8 Finland
Bronchopneumonia, unspecified
4.2
11.8
31
75
P01BA02
ATC
hydroxychloroquine; oral
1.9
11.8
146
786
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
11.7
901
7341
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
2.8
11.5
57
208
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
11.5
11
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
2.8
11.3
57
210
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
11.2
215
1318
N05CD07
ATC
temazepam; oral
1.5
11.0
351
2431
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
3.6
10.9
35
98
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.9
10.9
131
698
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
21.6
10.7
15
7
XG410
NOMESCO Finland
Flow-volume spirometry
2.1
10.5
95
457
A98
ICPC
Health maint/preventive medicine
0.7
10.4
1511
16638
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
+∞
10.4
10
*
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
10.4
10
*
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
R03BA02
ATC
budesonide; inhalant
1.5
10.4
337
2343
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
10.2
158
913
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
3.8
10.0
30
80
J01AA02
ATC
doxycycline; systemic
1.4
10.0
1597
14380
A02BA02
ATC
ranitidine; systemic
1.4
9.9
462
3443
L01BA01
ATC
methotrexate; systemic
2.3
9.9
76
342
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
4.2
9.9
26
63
R03AC03
ATC
terbutaline; inhalant
1.6
9.9
257
1700
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
3.6
9.8
31
86
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
3.0
9.7
41
137
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
2.8
9.7
47
170
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
3.8
9.6
29
78
132
Kela drug reimbursment
Sarcoidosis
4.1
9.4
25
61
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
30.1
9.4
12
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
9.4
9
*
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
9.4
9
*
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
9.3
144
831
N05BA02
ATC
chlordiazepoxide; systemic
2.5
9.1
57
234
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
3.5
9.1
30
86
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
9.0
335
2391
51899
ICD-8 Finland
Bronchiectasis
8.0
8.8
19
24
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
3.2
8.8
34
108
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
4.3
8.7
22
52
A10BA02
ATC
metformin; oral
0.7
8.6
388
5123
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
8.6
373
2741
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
16.3
8.5
13
8
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
16.3
8.5
13
8
0110B, ,
ICD-8 Finland
+∞
8.3
8
*
01202, ,
ICD-8 Finland
+∞
8.3
8
*
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
8.3
8
*
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
4.1
8.3
22
54
13597
ICD-8 Finland
Sarcoidosis, Suspecta
4.2
8.2
21
50
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
2.3
8.1
62
279
N02AX02
ATC
tramadol; systemic, rectal
1.3
8.1
882
7444
R95
ICPC
Chron obstructive pulmonary disease
2.1
8.1
77
379
Y0499
ICD-8 Finland
Investigation of respiratory system
2.8
8.0
39
142
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.2
7.9
67
315
R06.0
ICD-10 Finland
Dyspnoea
1.3
7.9
564
4488
H02AB04
ATC
methylprednisolone; systemic
1.5
7.9
279
1971
L88
ICPC
Rheumatoid/seropositive arthritis
2.1
7.8
68
323
D86.0
ICD-10 Finland
Sarcoidosis of lung
3.3
7.8
28
85
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
2.2
7.8
66
311
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
3.0
7.7
32
106
51109
ICD-8 Finland
Pleurisy, Sicca NUD
15.1
7.7
12
8
J85.1
ICD-10 Finland
Abscess of lung with pneumonia
15.1
7.7
12
8
R05
ICD-10 Finland
Cough
1.4
7.6
352
2610
49300
ICD-8 Finland
Asthma, bronchiale
2.3
7.6
58
261
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
7.5
57
256
A02BC01
ATC
omeprazole; systemic
1.3
7.5
576
4628
A18.8
ICD-10 Finland
Tuberculosis of other specified organs
+∞
7.3
7
*
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
7.3
7
*
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
7.3
7
*
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
7.3
7
*
J86.9
ICD-10 Finland
Pyothorax without fistula
3.1
7.3
29
94
Z2446
NOMESCO Finland
Social worker
1.7
7.3
124
738
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
4.2
7.3
19
46
R99
ICPC
Respiratory disease other
2.6
7.3
41
161
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
3.8
7.3
21
55
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
3.1
7.2
29
95
A31.89
ICD-10 Finland
Other mycobacterial infections
30.1
7.1
9
*
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
2.2
7.0
55
251
R03AK08
ATC
formoterol and beclometasone; inhalant
2.0
7.0
70
352
R50.9
ICD-10 Finland
Fever, unspecified
1.4
7.0
296
2162
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
6.8
131
805
Y3419
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Inactive pulmonary tuberculosis, which is known to have been inactive
40.2
6.8
8
*
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
2.4
6.7
44
186
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.7
6.7
195
2800
Z22.30
ICD-10 Finland
Latent tuberculosis
22.6
6.7
9
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
6.6
71
366
I10
ICD-10 Finland
Essential (primary) hypertension
0.8
6.6
1091
12216
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
2.6
6.5
36
140
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
2.6
6.5
37
146
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.5
588
4819
A02BA03
ATC
famotidine; systemic
1.8
6.5
98
565
F10.20
ICD-10 Finland
Alcohol dependence currently independent
2.6
6.4
35
136
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.1
6.3
60
296
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
6.3
6
*
01230
ICD-8 Finland
Other respiratory tuberculosis, Tuberculous laryngitis
+∞
6.3
6
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
6.3
6
*
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.3
6
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
6.3
6
*
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.3
6
*
0116X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA, EPÄILTY]
+∞
6.3
6
*
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
2.8
6.2
29
104
J94.8
ICD-10 Finland
Other specified pleural conditions
2.3
6.1
45
201
GAC00
NOMESCO Finland
Biopsy of pleura
4.1
6.1
16
39
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
2.6
6.1
32
122
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.7
6.1
115
706
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.4
6.0
227
1621

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
102
265
3.98
34.92
6.5
2.5
—
—
—
0
0
100
289
3.57
29.37
3.4
2.5
—
—
—
0
0
309
1626
2.04
26.96
1.7
1.6
—
—
—
0
0
24
48
5.04
11.47
1.1
1.3
—
—
—
0
0
1364
15282
0.74
10.91
5.2
5.2
2.59
2.58
mmol/l
0.08
1229
13712
50
175
2.90
10.88
1.3
1.3
28.59
15.21
u/l
2.26
44
163
274
1832
1.56
10.07
2.0
1.4
—
—
—
0
0
353
2512
1.48
9.66
2.4
2.0
—
—
—
0
0
317
2223
1.49
9.31
7.1
6.8
11.45
11.64
kpa
0.21
303
2099
317
2223
1.49
9.31
7.1
6.8
5.12
5.07
kpa
0.37
302
2098
1333
14849
0.76
9.25
4.6
4.6
4.47
4.44
mmol/l
0.51
1203
13422
317
2228
1.49
9.21
7.3
6.8
1.41
1.18
mmol/l
0.49
266
1729
931
7825
1.32
9.15
8.8
5.4
0.64
0.62
e9/l
1.85
819
6672
933
7846
1.32
9.12
8.8
5.4
0.04
0.04
e9/l
0.22
824
6688
1557
16962
0.75
9.03
35.1
25.0
249.86
240.04
e9/l
5.91
1508
16362
1557
16961
0.75
9.02
35.3
25.1
39.15
39.25
%
0.25
1410
15548
1559
16971
0.75
8.91
35.3
25.2
130.81
132.71
g/l
4.89
1526
16558
1559
16969
0.75
8.88
35.1
25.1
7.31
6.94
e9/l
3.95
1506
16296
1559
16968
0.75
8.87
35.1
25.0
4.35
4.39
e12/l
2.12
1502
16295
1559
16967
0.75
8.85
34.9
24.9
30.34
30.44
pg
1.23
1524
16555
1559
16966
0.75
8.84
35.0
25.0
91.77
91.70
fl
0.21
1524
16555
180
1128
1.65
8.66
2.9
2.7
10.42
10.81
g/l
0.55
169
1023
956
8107
1.30
8.65
9.3
5.6
0.19
0.20
e9/l
0.28
855
7010
21
32
6.61
8.65
1.4
1.5
—
—
—
0
0
207
1343
1.59
8.65
4.1
4.8
—
—
—
0
0
1322
14677
0.77
8.50
4.6
4.6
1.45
1.42
mmol/l
1.18
1186
13130
179
1132
1.63
8.31
1.5
1.4
—
—
—
0
0
48
197
2.47
7.75
1.7
1.7
0.82
0.89
g/l
0.13
33
152
938
8021
1.28
7.69
8.9
5.5
1.97
1.88
e9/l
0.27
840
6997
28
86
3.28
7.66
1.5
2.1
754.43
560.75
e6/l
0.42
23
73
1285
14210
0.79
7.36
4.1
4.1
1.27
1.28
mmol/l
0.05
1141
12598
1377
15100
0.78
7.33
4.9
4.9
6.02
6.08
mmol/l
0.94
1230
13365
251
1761
1.48
7.32
1.3
1.3
553.85
492.82
titre
0.21
52
390
122
722
1.73
7.30
1.5
1.2
215.03
233.30
u/ml
0.10
109
657
1462
15891
0.79
7.05
21.7
16.6
—
—
—
0
0
68
337
2.05
7.05
1.4
1.5
37.29
31.14
g/l
2.88
63
301
862
7362
1.27
6.94
9.9
6.0
—
—
—
0
0
1515
16377
0.79
6.84
28.0
20.2
85.57
85.18
umol/l
0.11
1515
16369
315
4156
0.72
6.72
2.9
3.2
0.87
0.84
ug/l
0.15
211
2917
55
257
2.17
6.65
1.5
1.4
—
—
—
0
0
74
387
1.94
6.62
1.6
2.0
10.79
13.37
mg/l
0.95
65
353
369
2822
1.37
6.61
4.2
3.0
0.81
0.82
mmol/l
0.77
340
2608
869
7462
1.26
6.60
9.9
6.0
8.95
8.93
%
0.08
819
6905
274
1997
1.42
6.53
7.9
7.1
94.91
95.13
%
0.25
262
1917
142
902
1.61
6.52
1.9
1.8
1.48
1.54
g/l
0.07
131
812
50
229
2.21
6.36
1.4
1.5
5.83
6.51
mmol/l
0.82
45
215
26
88
2.98
6.11
1.5
1.3
1.41
0.66
u/ml
0.31
19
53
879
7609
1.25
6.09
9.5
5.9
25.85
25.92
%
0.05
827
7060
860
7431
1.25
6.05
9.5
5.7
2.84
2.81
%
0.17
808
6869
865
7482
1.25
6.02
9.2
5.6
58.34
58.67
%
0.31
815
6942
837
7217
1.25
5.98
9.5
5.7
0.66
0.64
%
0.18
789
6665
267
1968
1.40
5.97
2.1
1.7
—
—
—
0
0
1531
16440
0.80
5.92
28.0
20.6
4.01
4.01
mmol/l
0.04
1493
15881
32
124
2.60
5.88
1.6
2.0
1.45
1.12
e9/l
0.55
27
112
1529
16410
0.80
5.81
27.9
20.4
139.34
139.59
mmol/l
3.17
1494
15880
620
7303
0.79
5.57
4.5
5.3
4.37
4.42
ug/l
0.01
535
6405
1330
14458
0.81
5.55
6.1
6.3
40.54
40.92
mmol/mol
0.74
1204
13073
52
260
2.02
5.34
1.4
1.6
—
—
—
0
0
653
5532
1.25
5.34
6.3
4.4
—
—
—
0
0
243
1801
1.39
5.26
8.5
7.7
119.92
119.97
g/l
0.01
236
1753
999
8871
1.22
5.21
8.3
6.0
10.57
12.43
umol/l
7.12
953
8364
1530
16350
0.81
5.16
15.0
10.9
25.34
25.37
u/l
0.01
1469
15585
359
4464
0.77
4.94
2.9
3.2
—
—
—
0
0
75
435
1.75
4.92
2.0
2.2
119.27
127.07
g/l
1.92
52
324
1026
9174
1.21
4.89
12.5
8.6
4.43
4.34
e9/l
0.53
915
7932
30
124
2.44
4.88
2.1
1.3
—
—
—
0
0
175
1253
1.43
4.64
8.4
7.0
24.90
24.48
mmol/l
0.67
166
1195
171
1220
1.43
4.62
5.4
3.8
0.61
0.73
%
0.25
75
452
29
122
2.39
4.56
2.1
1.3
0.47
0.42
g/l
0.29
22
85
29
122
2.39
4.56
2.1
1.3
7.61
7.08
g/l
0.29
23
85
29
122
2.39
4.56
2.1
1.3
2.57
2.78
g/l
0.26
21
86
124
834
1.51
4.52
1.6
1.4
—
—
—
0
0
128
873
1.49
4.37
2.0
1.9
1.90
2.29
ug/l
0.14
111
750
55
302
1.84
4.36
1.4
1.4
1859.46
1760.33
e6/l
0.11
37
219
338
2711
1.29
4.29
2.8
2.5
2.20
2.26
g/l
1.39
312
2473
573
4896
1.23
4.19
3.8
3.1
35.72
35.41
u/l
0.04
538
4627
48
256
1.89
4.17
1.5
1.5
—
—
—
0
0
186
1376
1.38
4.11
5.4
4.0
0.78
0.92
%
0.40
88
540
478
4020
1.24
4.05
9.1
6.6
—
—
—
0
0
309
2468
1.29
4.05
6.1
5.2
1.09
1.03
mmol/l
2.10
280
2243
319
2570
1.28
3.91
2.9
2.5
21.27
21.92
%
0.32
267
2159
1315
14070
0.85
3.65
4.9
4.6
1.90
2.11
mu/l
1.60
1173
12504
184
1387
1.35
3.64
1.8
1.5
—
—
—
0
0
172
1289
1.36
3.54
5.6
4.0
0.08
0.12
%
0.41
74
455
47
264
1.80
3.53
1.2
1.3
—
—
—
0
0
172
1293
1.36
3.47
1.8
1.5
—
—
—
0
0
355
2938
1.25
3.46
2.8
2.5
11.46
12.13
umol/l
1.00
335
2699
247
1958
1.29
3.44
3.1
3.8
57.40
20.84
ug/l
0.53
208
1641
23
100
2.31
3.43
1.7
2.6
38.00
39.31
%
—
9
58
48
275
1.76
3.39
1.4
1.4
30283.04
71046.98
e6/l
0.83
28
166
139
1014
1.39
3.38
3.3
3.2
8.51
6.02
e9/l
0.29
97
775
43
242
1.79
3.23
8.3
6.4
13.83
12.24
mg/l
1.23
37
224
216
1709
1.29
3.08
6.7
6.4
11.76
11.27
mmol/l
0.40
205
1606
165
1263
1.33
2.99
1.6
1.5
—
—
—
0
0
132
986
1.36
2.83
8.5
9.7
—
—
—
0
0
52
323
1.62
2.79
3.3
3.6
0.98
1.80
%
1.43
46
278
1166
12461
0.87
2.79
32.2
22.6
330.37
331.47
g/l
3.50
1150
12270
66
437
1.53
2.71
3.8
4.0
—
—
—
0
0
388
3324
1.20
2.70
2.0
1.6
1.33
1.44
mg/l
0.30
302
2579
155
1198
1.31
2.66
5.9
4.1
0.04
0.37
%
0.79
56
374
17
73
2.34
2.65
2.9
2.5
1262.82
1420.85
u/ml
0.11
17
73
1221
12977
0.88
2.61
28.8
20.2
15.49
15.32
%
0.45
1204
12658
483
5483
0.85
2.61
3.6
3.7
14.02
9.05
mg/mmol
0.84
303
3497
1493
15651
0.87
2.58
26.3
17.3
27.91
27.62
mg/l
0.12
1297
12803
416
3602
1.19
2.57
4.9
4.1
447.53
311.74
ng/l
0.47
353
3083
78
543
1.45
2.53
3.1
3.4
24.81
25.00
mmol/l
0.15
78
532
227
1855
1.25
2.51
4.6
3.4
5.81
5.83
kpa
0.15
220
1784
453
5153
0.85
2.50
3.1
3.2
407.07
294.39
mg/l
0.24
295
3336
176
1400
1.28
2.45
1.4
1.4
—
—
—
0
0
158
1241
1.29
2.43
4.1
3.7
7.43
7.40
ph
2.17
20
152
202
1642
1.25
2.36
8.3
6.1
1.37
1.43
mmol/l
0.41
196
1589
40
244
1.65
2.35
1.5
1.4
—
—
—
0
0
202
1645
1.25
2.32
2.2
2.1
0.20
0.20
g/l
0.25
190
1516
84
1150
0.72
2.30
1.9
2.1
11.79
11.93
nmol/l
0.05
72
990
38
230
1.66
2.30
1.2
1.3
117.99
130.61
u/ml
—
9
45
159
1260
1.28
2.30
4.1
3.7
5.14
5.17
kpa
0.13
152
1184
205
1676
1.24
2.28
2.2
2.6
66.20
65.97
g/l
0.16
179
1507
224
1850
1.23
2.27
4.7
3.4
1.97
2.02
mmol/l
0.07
183
1501
35
208
1.69
2.27
1.3
1.2
—
—
—
0
0
60
407
1.49
2.25
3.0
3.0
—
—
—
0
0
193
1575
1.25
2.19
9.7
7.2
—
—
—
0
0
538
4821
1.15
2.14
2.5
2.2
3.05
3.12
mg/l
0.25
455
4032
1067
11345
0.89
2.09
4.8
4.2
—
—
—
0
0
298
2555
1.19
2.07
1.6
1.5
2.91
2.69
g/l
0.66
185
1499
21
110
1.92
2.05
3.4
2.2
—
—
—
0
0
66
467
1.43
2.02
1.2
1.2
1.22
0.92
u/ml
0.17
12
36
62
434
1.44
2.02
1.3
1.2
—
—
—
0
0
8
26
3.08
2.01
1.1
1.0
—
—
—
0
0
472
5268
0.87
1.99
3.2
3.1
6.97
7.29
mmol/l
0.82
391
4328
30
178
1.69
1.99
1.1
1.2
—
—
—
0
0
56
387
1.46
1.95
2.0
1.5
0.23
0.24
g/l
0.22
56
369
184
1519
1.23
1.91
3.9
3.5
—
—
—
0
0
22
121
1.83
1.88
2.3
2.4
—
—
—
0
0
34
213
1.61
1.85
1.1
1.1
—
—
—
0
0
66
476
1.40
1.85
3.0
3.1
7.58
7.72
kpa
0.32
66
465
947
8862
1.12
1.84
8.0
6.7
1.21
1.21
mmol/l
0.05
805
7435
580
5275
1.13
1.84
2.8
2.5
58.96
75.28
u/l
0.54
539
4833
29
464
0.62
1.81
1.4
1.4
—
—
—
0
0
8
29
2.76
1.79
6.0
4.9
—
—
—
0
0
13
260
0.50
1.78
1.4
1.8
—
—
—
0
0
110
1388
0.78
1.76
5.1
4.2
—
—
—
0
0
344
3029
1.16
1.75
3.3
2.9
1.43
1.30
e6/l
0.21
218
1786
15
74
2.03
1.75
1.0
1.0
—
—
—
0
0
20
110
1.83
1.73
1.3
1.1
250.00
143.16
titre
—
6
19
41
274
1.51
1.71
1.5
1.3
—
—
—
0
0
5
13
3.85
1.71
1.0
1.0
—
—
—
0
0
33
210
1.58
1.71
4.8
4.3
—
—
—
0
0
18
96
1.88
1.70
7.8
2.0
—
—
—
0
0
14
68
2.07
1.70
1.0
1.0
—
—
—
0
0
215
1828
1.19
1.68
3.9
3.1
225.63
271.40
ng/l
1.04
197
1680
61
443
1.39
1.67
1.2
1.2
—
—
—
0
0
18
97
1.86
1.66
5.4
2.4
—
—
—
0
0
37
244
1.52
1.65
7.9
8.7
7.36
7.56
mmol/l
0.14
31
204
211
1794
1.19
1.65
2.7
2.5
4.99
6.62
ug/l
1.58
172
1523
14
69
2.04
1.64
1.4
1.2
—
—
—
0
0
46
319
1.45
1.62
1.2
1.2
—
—
—
0
0
33
213
1.56
1.62
1.1
1.0
—
—
—
0
0
26
158
1.65
1.62
5.9
1.7
—
—
—
0
0
12
56
2.15
1.61
1.3
1.3
—
—
—
0
0
12
56
2.15
1.61
1.3
1.3
—
—
—
0
0
8
32
2.51
1.59
1.0
1.2
—
—
—
0
0
7
26
2.70
1.58
2.7
1.0
—
—
—
0
0
13
64
2.04
1.54
1.2
1.3
2.02
55.82
ug/l
—
6
30
483
5295
0.89
1.53
5.0
4.3
—
—
—
0
0
26
161
1.62
1.52
1.1
1.3
—
—
—
0
0
860
8074
1.10
1.51
7.3
5.9
1.21
1.21
mmol/l
0.34
768
7251
825
7730
1.10
1.51
5.4
4.7
33.83
34.49
g/l
2.36
744
7099
6
21
2.86
1.50
10.2
13.0
5.40
5.80
mmol/l
—
6
21
11
51
2.16
1.50
2.7
2.1
17.54
177.73
ug/l
0.48
11
43
14
72
1.95
1.48
2.1
4.2
63.00
53.52
%
0.86
14
66
20
116
1.73
1.48
1.2
1.2
—
—
—
0
0
207
1776
1.18
1.48
2.4
2.4
64.78
68.07
e9/l
0.89
160
1385
12
59
2.04
1.43
1.5
1.5
—
—
—
0
0
180
1531
1.19
1.43
3.8
2.8
4.30
4.46
kpa
0.51
172
1465
31
205
1.52
1.40
5.2
1.6
—
—
—
0
0
22
134
1.65
1.39
1.7
1.2
—
—
—
0
0
650
6040
1.11
1.39
3.7
3.2
2160.07
1981.81
ng/l
0.38
574
5174
57
426
1.35
1.35
4.8
7.8
103.62
105.51
mmol/l
1.85
52
384
57
426
1.35
1.35
4.8
7.8
11.62
11.37
mmol/l
0.14
52
384
31
207
1.50
1.35
5.2
1.6
—
—
—
0
0
0
38
0.00
1.34
0.0
1.1
—
0.71
—
0
21
78
611
1.29
1.34
5.3
6.6
1.50
1.39
mmol/l
0.19
70
541
17
98
1.74
1.31
1.1
1.2
—
—
—
0
0
8
34
2.36
1.29
1.0
1.0
—
—
—
0
0
29
194
1.50
1.27
5.4
1.6
—
—
—
0
0
30
204
1.48
1.22
5.3
1.7
—
—
—
0
0
98
800
1.23
1.22
4.7
5.5
0.88
0.88
%
0.00
93
753
352
3876
0.89
1.21
1.3
1.3
—
—
—
0
0
460
4230
1.11
1.20
5.3
3.9
87.62
83.90
%
2.61
448
4119
1227
11796
1.08
1.19
6.3
4.1
16.98
14.44
mm/h
4.85
1132
10743
97
793
1.23
1.19
6.2
4.5
—
—
—
0
0
6
26
2.31
1.18
1.7
1.3
74.67
51.27
umol/l
—
6
26
178
1542
1.17
1.18
2.6
2.3
31.80
36.35
u/l
0.97
147
1304
754
7108
1.09
1.17
4.6
4.3
39.50
59.52
ng/l
1.83
566
5462
1089
11355
0.92
1.16
4.0
3.8
15.13
15.05
pmol/l
0.45
964
10022
408
3737
1.11
1.15
4.3
3.9
—
—
—
0
0
1319
12730
1.08
1.15
10.7
7.5
79.22
81.29
u/l
0.80
1236
11856
25
166
1.51
1.15
1.1
1.5
—
—
—
0
0
50
379
1.33
1.12
1.7
2.7
30.18
34.62
umol/l
0.51
44
335
8
40
2.00
1.12
2.4
1.2
—
—
—
0
0
242
2157
1.14
1.09
1.3
1.2
—
—
—
0
0
31
218
1.43
1.09
1.3
1.3
85.32
198.62
miu/ml
1.81
13
83
268
2407
1.13
1.08
2.4
2.4
1.81
1.79
%
0.12
230
2097
69
551
1.26
1.07
3.0
1.9
21.10
21.54
s
0.38
62
500
20
129
1.56
1.05
10.5
2.5
—
—
—
0
0
665
6264
1.09
1.04
4.1
3.7
5.89
5.78
ph
0.26
31
284
563
5268
1.09
1.03
5.0
3.9
7.40
7.40
ph
0.16
98
1018
240
2148
1.13
1.03
1.3
1.2
16.29
14.11
u/ml
0.19
88
773
97
808
1.21
1.03
4.7
5.5
1.77
1.61
%
0.67
92
759
21
138
1.53
1.03
1.3
1.4
—
—
—
0
0
572
5361
1.09
1.01
2.4
2.2
231.34
243.42
u/l
0.13
531
4984
98
1167
0.83
1.01
4.2
3.2
—
—
—
0
0
95
792
1.21
1.00
1.3
1.2
—
—
—
0
0
12
68
1.77
1.00
1.8
1.4
—
—
—
0
0
108
913
1.19
0.99
4.3
3.7
—
—
—
0
0
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
32
232
1.38
0.97
1.5
1.3
24.12
26.75
iu/l
0.20
26
193
115
980
1.18
0.97
1.5
1.7
1.46
1.56
g/l
0.62
100
831
424
3931
1.10
0.96
3.3
2.7
5.55
4.70
e6/l
0.74
387
3541
28
387
0.72
0.95
1.4
1.6
—
—
—
0
0
9
52
1.73
0.92
37.6
17.7
1515.67
1529.02
nmol/l
—
9
52
248
2243
1.12
0.91
1.4
1.2
67.83
38.67
iu/ml
0.73
76
735
34
452
0.75
0.91
3.1
2.5
—
—
—
0
0
14
86
1.63
0.91
1.0
1.0
2.08
2.40
u/ml
—
6
39
185
1645
1.14
0.90
1.3
1.3
—
—
—
0
0
714
7507
0.93
0.90
2.2
2.1
90.32
92.32
pmol/l
0.51
390
3958
82
683
1.21
0.90
2.4
2.2
283.35
496.84
ug/l
1.36
76
638
6
29
2.07
0.89
1.7
1.5
—
—
—
0
0
27
194
1.40
0.88
1.2
1.2
—
—
—
0
0
35
460
0.76
0.87
1.1
1.2
—
—
—
0
0
15
95
1.58
0.87
1.5
1.1
—
—
—
0
0
28
203
1.38
0.87
4.6
1.5
—
—
—
0
0
388
4173
0.92
0.86
4.6
3.8
—
—
—
0
0
43
335
1.29
0.85
1.6
1.3
53.60
61.51
mmol/l
0.86
35
265
6
31
1.94
0.84
1.0
1.1
—
—
—
0
0
8
45
1.78
0.84
1.6
1.7
—
—
—
0
0
8
45
1.78
0.84
1.4
1.1
—
—
—
0
0
8
46
1.74
0.82
1.1
1.2
—
—
—
0
0
21
147
1.43
0.80
1.3
1.1
—
—
—
0
0
41
321
1.28
0.79
1.6
1.4
25.82
642.83
e6/l
1.15
33
265
41
321
1.28
0.79
1.6
1.3
32.19
36.79
e6/l
0.07
31
253
0
25
0.00
0.79
0.0
1.2
—
6.58
—
0
14
8
48
1.67
0.78
2.1
1.8
—
—
—
0
0
55
447
1.24
0.78
5.4
5.0
3.36
2.67
mmol/l
0.81
40
307
27
199
1.36
0.78
2.2
2.2
0.83
1.31
g/24h
0.72
15
95
87
741
1.18
0.78
4.7
4.0
24.77
24.87
mmol/l
0.10
79
670
363
3894
0.92
0.77
1.7
1.6
1.34
1.34
mmol/l
0.02
315
3192
151
1343
1.13
0.76
2.1
2.1
365.11
374.34
nmol/l
0.26
133
1204
5
24
2.09
0.74
1.6
1.5
82.86
141.38
ng/l
—
5
24
718
6867
1.07
0.74
14.7
10.2
0.00
0.00
e9/l
0.04
582
5556
9
55
1.64
0.73
1.0
1.1
—
—
—
0
0
17
117
1.46
0.71
7.5
2.9
7.42
7.42
ph
—
8
38
189
2081
0.90
0.71
4.5
4.7
32.30
33.15
%
0.40
113
1347
55
663
0.83
0.70
1.4
1.4
—
—
—
0
0
207
1887
1.11
0.70
2.6
2.6
6.08
10.17
umol/l
5.74
176
1660
311
2893
1.09
0.69
3.6
3.1
2.22
1.92
e6/l
0.35
183
1658
17
119
1.43
0.67
1.8
1.3
—
32.29
—
0
7
5
93
0.54
0.67
1.4
1.4
0.77
1.08
nmol/l
—
5
68
19
136
1.40
0.66
1.3
1.2
—
—
—
0
0
5
28
1.79
0.66
4.2
2.8
—
—
—
0
0
10
62
1.62
0.65
1.1
1.8
—
—
—
0
0
30
234
1.29
0.63
1.4
2.3
40.00
191.01
u/ml
0.42
30
229
29
226
1.29
0.61
1.2
1.2
310.19
276.14
u/ml
0.18
21
123
75
647
1.16
0.61
3.8
2.9
0.35
0.27
g/l
0.38
36
254
0
20
0.00
0.60
0.0
1.6
—
8.04
—
0
12
735
7628
0.95
0.60
3.3
2.7
—
—
—
0
0
15
105
1.43
0.60
1.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
1.84
—
0
22
674
6478
1.06
0.59
2.3
2.2
80.21
78.50
nmol/l
0.70
586
5609
0
23
0.00
0.58
0.0
1.0
—
0.51
—
0
7
33
408
0.81
0.57
1.2
1.1
—
—
—
0
0
122
1355
0.89
0.56
1.5
1.5
—
—
—
0
0
1084
11122
0.95
0.56
6.1
5.0
6114.89
2006.46
e6/l
0.46
27
211
8
55
1.46
0.56
2.5
1.4
—
—
—
0
0
21
159
1.32
0.55
1.4
1.2
—
—
—
0
0
49
414
1.19
0.53
2.8
2.6
14.76
15.77
%
1.02
31
213
563
5403
1.06
0.52
3.3
2.6
—
—
—
0
0
61
528
1.16
0.50
5.4
4.7
7.43
7.42
ph
1.32
52
469
74
651
1.14
0.50
3.1
3.4
1.88
1.77
ratio
—
8
47
22
171
1.29
0.49
1.5
1.2
2.27
5.05
u/ml
1.02
11
73
152
1395
1.10
0.49
3.7
3.6
89.91
96.54
ng/l
0.48
129
1175
26
207
1.26
0.49
1.2
1.3
—
—
—
0
0
615
5929
1.05
0.48
3.4
3.3
2.34
2.35
mmol/l
0.66
526
5081
39
463
0.84
0.47
1.9
2.2
109.85
101.61
ug/min
0.05
22
275
7
48
1.46
0.46
2.3
2.0
—
—
—
0
0
470
4505
1.05
0.46
3.3
2.9
2649.70
7315.70
umol/l
1.96
396
3838
157
1449
1.09
0.46
2.3
2.2
256.79
154.44
ug/g
0.99
124
1132
5
82
0.61
0.45
2.8
1.5
—
—
—
0
0
17
129
1.32
0.45
1.2
1.1
1.56
1.41
u/ml
—
8
60
54
468
1.16
0.45
1.5
1.5
262.74
269.47
ug/g
0.09
35
282
26
210
1.24
0.45
1.1
1.1
192.45
75.95
iu/ml
—
6
35
373
3557
1.06
0.45
5.3
4.4
1.02
1.02
kg/l
0.03
63
561
23
183
1.26
0.45
1.3
1.2
—
—
—
0
0
103
934
1.11
0.44
4.1
2.4
1.34
1.16
%
1.11
103
928
676
6549
1.05
0.44
3.3
2.8
153.77
153.96
ug/l
0.01
607
5889
102
925
1.11
0.43
2.5
2.5
10.97
20.60
au/ml
—
6
50
24
296
0.81
0.43
3.0
2.6
—
—
—
0
0
77
688
1.12
0.43
2.5
3.1
5530.28
6153.52
u/ml
0.03
66
591
90
995
0.90
0.42
1.2
1.2
—
—
—
0
0
5
32
1.56
0.42
23.2
7.1
—
—
—
0
0
90
994
0.90
0.41
4.0
3.9
—
—
—
0
0
81
728
1.12
0.41
1.3
1.2
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
—
0.23
—
0
5
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
0.18
—
0
9
26
213
1.22
0.40
1.4
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
7.2
—
0.33
—
0
17
5
34
1.47
0.40
1.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
28
232
1.21
0.40
1.1
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
2.3
—
62.16
—
0
8
16
204
0.78
0.39
2.6
2.1
—
—
—
0
0
11
80
1.38
0.38
1.2
1.0
—
—
—
0
0
44
382
1.15
0.38
3.1
3.3
2276.89
1044.66
u/ml
0.32
39
354
5
36
1.39
0.38
1.4
1.6
—
—
—
0
0
45
515
0.87
0.38
17.5
12.4
—
—
—
0
0
74
667
1.11
0.37
3.1
3.4
44.88
63.51
mg/l
1.06
59
547
21
170
1.24
0.37
1.1
1.1
—
—
—
0
0
218
2061
1.06
0.37
1.4
1.4
—
—
—
0
0
74
668
1.11
0.36
3.2
3.4
83.22
82.36
mg/l
0.00
59
550
38
328
1.16
0.36
1.1
1.2
40.72
41.80
u/l
0.03
31
284
25
299
0.83
0.35
1.2
1.3
—
—
—
0
0
13
99
1.31
0.35
1.0
1.0
—
—
—
0
0
63
565
1.12
0.35
1.6
1.4
—
—
—
0
0
32
273
1.17
0.35
2.5
3.1
—
—
—
0
0
1111
11299
0.97
0.33
5.6
4.6
—
—
—
0
0
150
1408
1.07
0.32
2.1
2.5
—
—
—
0
0
102
944
1.08
0.32
1.3
1.3
—
—
—
0
0
15
119
1.26
0.31
9.1
2.2
—
—
—
0
0
14
110
1.27
0.31
4.6
3.4
—
—
—
0
0
14
111
1.26
0.30
1.1
1.1
0.46
2.19
u/ml
—
5
39
52
468
1.11
0.29
1.6
1.6
—
—
—
0
0
40
355
1.13
0.28
2.3
1.5
—
—
—
0
0
19
158
1.20
0.28
1.6
1.2
23.58
79.88
u/ml
—
5
6
36
407
0.88
0.28
1.1
1.1
—
—
—
0
0
8
63
1.27
0.27
1.4
1.1
—
—
—
0
0
8
63
1.27
0.27
3.1
2.6
—
—
—
0
0
98
913
1.08
0.27
4.1
2.4
0.68
0.65
%
0.48
98
907
20
236
0.85
0.26
1.4
1.8
200.25
213.27
pmol/l
0.33
20
220
14
113
1.24
0.26
1.1
1.1
4.09
5.27
u/ml
—
5
50
31
352
0.88
0.26
1.0
1.1
—
—
—
0
0
5
75
0.67
0.25
1.6
3.1
—
—
—
0
0
395
3835
1.04
0.25
3.5
3.0
531.25
549.56
mosm/kgh2o
1.11
346
3287
17
142
1.20
0.24
1.8
1.3
—
—
—
0
0
12
147
0.82
0.23
1.8
2.2
396.50
631.37
ml
—
6
89
63
681
0.92
0.23
1.1
1.3
—
—
—
0
0
14
168
0.83
0.22
1.5
1.3
668898.75
83461.34
e6/l
—
8
118
633
6209
1.03
0.22
2.4
2.2
—
—
—
0
0
5
42
1.19
0.21
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
5.12
—
0
5
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
190
1827
1.04
0.21
4.2
4.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
633
6215
1.03
0.20
5.0
3.9
109.90
120.41
e6/l
0.13
488
4625
6
49
1.23
0.20
1.5
1.0
—
—
—
0
0
909
8968
1.02
0.20
18.7
19.3
1.30
1.38
inr
2.01
247
2513
79
743
1.07
0.19
2.2
2.5
10.00
10.43
g/l
0.38
64
652
11
133
0.83
0.19
1.7
1.7
8.58
10.96
%
1.23
11
133
35
318
1.10
0.18
2.6
1.9
1.57
1.71
mmol/l
0.53
35
310
15
128
1.17
0.18
2.9
3.0
—
—
—
0
0
42
456
0.92
0.18
4.1
3.5
7.66
7.79
mmol/l
0.12
42
447
43
397
1.08
0.17
4.3
2.4
—
—
—
0
0
12
101
1.19
0.16
1.2
1.0
0.18
1.12
u/ml
—
5
51
18
158
1.14
0.16
1.1
1.2
—
—
—
0
0
46
428
1.08
0.16
3.8
3.9
34.03
29.02
mg/l
0.29
28
288
28
254
1.10
0.16
1.4
1.7
3.51
4.76
mmol/24h
1.55
23
217
507
4984
1.02
0.16
4.1
3.3
0.54
0.49
e6/l
0.21
417
3907
1024
10139
1.02
0.15
6.2
4.9
6.80
6.88
mmol/l
0.51
972
9547
436
4440
0.98
0.15
1.7
1.6
19.88
19.88
nmol/l
0.00
370
3743
580
5714
1.02
0.15
3.9
3.4
—
—
—
0
0
56
527
1.06
0.15
3.1
3.1
0.78
0.84
nmol/l
0.63
48
415
50
533
0.94
0.15
1.1
1.1
—
192.82
—
0
11
7
87
0.80
0.14
1.0
1.2
137.14
137.53
nmol/l
—
7
87
15
131
1.15
0.14
1.1
1.6
—
—
—
0
0
29
268
1.08
0.12
1.4
1.4
—
—
—
0
0
27
249
1.09
0.12
1.6
1.3
12.81
9.78
u/l
0.48
20
196
52
497
1.05
0.09
3.4
3.6
—
—
—
0
0
33
311
1.06
0.09
1.5
1.6
—
—
—
0
0
19
206
0.92
0.08
1.5
1.5
70.50
65.05
%
0.29
14
135
6
56
1.07
0.08
1.2
1.3
—
0.07
g/l
—
0
7
6
58
1.03
0.08
1.2
1.3
139.17
168.39
mmol/24h
—
6
58
5
63
0.79
0.08
1.0
1.4
1.41
1.54
g/l
—
5
63
5
65
0.77
0.08
3.0
1.4
8.12
8.16
ug/l
—
5
56
49
470
1.04
0.08
1.7
1.5
—
—
—
0
0
6
74
0.81
0.07
1.0
1.1
—
—
—
0
0
484
4795
1.01
0.07
4.2
3.3
—
—
—
0
0
416
4118
1.01
0.07
3.2
2.4
—
—
—
0
0
25
235
1.06
0.07
1.2
1.4
—
—
—
0
0
7
82
0.85
0.07
2.1
1.6
11.43
16.61
nmol/l
—
7
73
8
93
0.86
0.06
3.1
1.6
—
—
—
0
0
20
187
1.07
0.06
1.5
2.0
—
—
—
0
0
9
102
0.88
0.06
1.1
1.3
—
—
—
0
0
12
109
1.10
0.06
1.0
1.2
—
—
—
0
0
43
414
1.04
0.06
1.6
1.7
8062.89
18001.42
e6/l
1.68
27
305
17
158
1.08
0.06
1.2
1.2
—
—
nmol/l
—
0
0
788
7847
1.01
0.04
4.7
4.0
0.00
0.00
estimate
1.15
152
1613
26
249
1.04
0.04
1.5
1.2
35.70
43.57
u/ml
—
7
18
405
4025
1.01
0.04
1.7
1.7
16508391.25
12743404.44
pmol/l
0.08
315
3241
784
7811
1.01
0.04
6.1
5.4
0.00
0.00
estimate
-0.00
138
1473
13
121
1.07
0.03
2.1
2.0
4.08
2.94
ug/l
0.48
13
109
56
573
0.98
0.03
4.1
4.7
—
—
—
0
0
403
4052
0.99
0.03
1.9
1.8
1142.15
1168.78
nmol/l
0.25
301
2996
789
7916
1.00
0.03
4.7
4.0
0.00
0.00
estimate
0.50
140
1434
16
169
0.95
0.03
1.1
1.2
—
—
—
0
0
929
9313
1.00
0.03
4.3
3.1
54.90
55.23
u/l
0.03
864
8465
282
2808
1.00
0.01
1.3
1.2
2.00
1.50
u/ml
0.25
79
701
150
1490
1.01
0.01
4.2
3.8
1.22
1.22
mmol/l
0.32
132
1280
88
873
1.01
0.01
3.7
2.7
—
—
—
0
0
12
115
1.04
0.00
10.7
14.8
—
—
—
0
0
20
195
1.03
0.00
3.9
3.3
—
—
—
0
0
31
305
1.02
0.00
1.5
1.7
2.63
5.07
iu/l
—
10
99
69
691
1.00
0.00
2.2
1.9
—
—
—
0
0
97
971
1.00
0.00
2.4
2.5
—
—
—
0
0
14
144
0.97
0.00
1.1
1.1
—
—
—
0
0
14
144
0.97
0.00
1.1
1.1
—
—
—
0
0
435
4345
1.00
0.00
5.2
4.3
0.00
0.00
estimate
0.50
128
1392
31
314
0.99
0.00
2.0
2.1
—
—
—
0
0
351
3509
1.00
0.00
3.5
3.1
2.46
2.46
mmol/l
0.18
302
3035
11
112
0.98
0.00
1.4
1.3
—
—
—
0
0
19
188
1.01
0.00
2.3
2.0
4.00
2.35
u/field
—
9
66
20
202
0.99
0.00
2.6
2.5
—
—
—
0
0
75
748
1.00
0.00
1.2
1.2
111.93
130.85
iu/ml
0.16
26
266
55
553
0.99
0.00
3.9
3.6
—
—
—
0
0
0
8
0.00
0.00
0.0
4.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
5
54
0.93
0.00
1.2
2.1
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.1
—
10.49
—
0
15
6
63
0.95
-0.00
1.2
1.2
83.93
234.16
iu/ml
—
6
63
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2.80
—
0
5
6
59
1.02
-0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
58
0.86
-0.00
1.4
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
3.2
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
61
610
1.00
-0.00
2.0
2.3
37.91
37.01
g/l
0.61
46
523
0
5
0.00
-0.00
0.0
1.0
—
33.00
—
0
5
6
67
0.90
-0.00
1.8
2.3
979.83
760.00
e6/l
—
6
56
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
551
5510
1.00
-0.00
4.4
3.5
65.66
88.71
e6/l
0.57
456
4346
8
80
1.00
-0.00
1.1
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint TBC_RESP and mortality.

Females

Parameter HR [95% CI] p-value
TBC_RESP 2.077 [1.85, 2.33] < 0.001
Birth year 0.996 [0.99, 1.0] 0.314

During the follow-up period (1.1.1998 — 31.12.2019), 1483 out of 2958 females with TBC_RESP died.

Males

Parameter HR [95% CI] p-value
TBC_RESP 2.815 [2.49, 3.19] < 0.001
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 2702 out of 4601 males with TBC_RESP died.

Mortality risk

Mortality risk for people of age

years, who have TBC_RESP.

N-year risk Females Males
1 0.237% 0.513%
5 1.239% 3.228%
10 3.108% 7.591%
15 5.846% 14.501%
20 10.563% 23.591%

Relationships between endpoints

Index endpoint: TBC_RESP – Respiratory tuberculosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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