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Respiratory TBC, ICD-8 codes not specifying whether confirmed bacteriologically or histologically

TBC_RESP_ICD8

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-8 011|012
  • Cause of death: ICD-8 011|012

2 out of 7 registries used, show all original rules.

1189

4. Check minimum number of events

None

1189

5. Include endpoints

None

1189

6. Filter based on genotype QC (FinnGen only)

1189

Control definitions (FinnGen only)

Control exclude
TBC_RESP

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1189 451 738
Unadjusted period prevalence (%) 0.26 0.15 0.33
Median age at first event (years) 35.98 29.26 40.08

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1106
Matched controls
11061
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
323.0
372
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
266.8
245
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
196.9
183
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
145.1
136
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
121.1
114
*
0110K
ICD-8 Finland
NA
+∞
71.6
68
*
0110J
ICD-8 Finland
NA
+∞
41.9
40
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
50.1
40.1
48
10
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
25.7
38.7
54
22
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
20.3
38.7
58
30
0110A
ICD-8 Finland
NA
+∞
34.6
33
*
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
29.3
28
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
28.2
27
*
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
24.0
23
*
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
23.0
22
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
16.7
214
1133
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
57.5
14.8
17
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
12.3
242
1489
R03BB04
ATC
tiotropium bromide; inhalant
1.9
11.0
161
889
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.4
11.0
95
419
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
28.3
10.7
14
5
48509
ICD-8 Finland
Bronchopneumonia, unspecified
8.1
10.6
23
29
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
13599
ICD-8 Finland
Sarcoidosis, Unspecified
9.2
10.0
20
22
R03AC12
ATC
salmeterol; inhalant
2.5
9.9
80
341
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
55.5
9.7
11
*
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
10.1
9.5
18
18
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
100.9
9.4
10
*
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
17.7
9.4
14
8
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
9.4
9
*
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.6
9.1
39
110
48609
ICD-8 Finland
Pneumonia, unspecified
4.8
9.1
29
62
51899
ICD-8 Finland
Bronchiectasis
10.1
8.5
16
16
132
Kela drug reimbursment
Sarcoidosis
7.4
8.5
19
26
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
5.3
8.3
24
46
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.8
8.2
139
810
13597
ICD-8 Finland
Sarcoidosis, Suspecta
7.3
8.0
18
25
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
7.9
166
1032
R03DA04
ATC
theophylline; systemic, rectal
1.9
7.7
111
609
R03BB01
ATC
ipratropium bromide; inhalant
2.1
7.7
87
436
0110B
ICD-8 Finland
NA
+∞
7.3
7
*
01202
ICD-8 Finland
NA
+∞
7.3
7
*
R03AC02
ATC
salbutamol; inhalant
1.4
7.1
460
3700
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
16.8
6.7
10
6
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
6.5
6.6
16
25
49300
ICD-8 Finland
Asthma, bronchiale
2.9
6.6
36
125
R03BA02
ATC
budesonide; inhalant
1.6
6.4
164
1074
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
6.3
6
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
6.3
6
*
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.3
6
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
6.3
6
*
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
1.7
6.1
114
685
Y3498
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other illnesses, accidents or surgeries
12.6
6.1
10
8
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
4.9
6.1
18
37
J47
ICD-10 Finland
Bronchiectasis
3.1
6.0
30
98

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: TBC_RESP_ICD8 – Respiratory TBC, ICD-8 codes not specifying whether confirmed bacteriologically or histologically

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).