No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1693 |
4. Check minimum number of eventsNone |
1693 |
5. Include endpointsNone |
1693 |
6. Filter based on genotype QC (FinnGen only) |
1693 |
Control definitions (FinnGen only)
- Control exclude
- AB1_TUBERCULOSIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Respiratory tuberculosis, not confirmed
based on the number of shared cases.
Similar with more cases:
- Respiratory tuberculosis, confirmed and not-confirmed
- Respiratory tuberculosis
- Tuberculosis
- Tuberculosis, IBD comorbidity
- Tuberculosis, wide
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26949 | 10715 | 15412 |
| Only index persons | 12955 | 6283 | 6672 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.31 | 0.43 |
| Only index persons | 0.24 | 0.23 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 49.87 | 48.85 | 50.29 |
| Only index persons | 38.41 | 38.00 | 38.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1693 | 597 | 1096 |
| Unadjusted period prevalence (%) | 0.38 | 0.20 | 0.48 |
| Median age at first event (years) | 40.84 | 33.14 | 45.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1569
- Matched controls
- 15689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
323.0
372
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
263.1
245
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
194.9
183
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
172.1
162
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
144.0
136
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
120.4
114
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
41.6
75.1
94
24
0110K
ICD-8 Finland
NA
+∞
71.4
68
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
60.8
58
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
58.7
56
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
57.7
55
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
67.1
45.4
52
8
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
44.8
286
1067
0110J
ICD-8 Finland
NA
+∞
41.9
40
*
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
41.9
40
*
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
39.7
38
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
39.2
241
870
0110A
ICD-8 Finland
NA
+∞
34.5
33
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
33.4
32
*
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
32.4
31
*
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
14.2
32.2
55
40
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
32.0
342
1686
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.3
28
*
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
29.3
28
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
29.3
28
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
28.2
27
*
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
24.0
23
*
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
23.0
22
*
R03BB04
ATC
tiotropium bromide; inhalant
2.1
21.0
257
1322
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
20.9
362
2138
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
19.4
534
3647
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.4
16.8
144
625
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.8
16.1
103
378
R03DA04
ATC
theophylline; systemic, rectal
2.2
15.9
177
866
1240
FHL
Bronchoscopy
4.9
15.7
51
107
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
38.4
15.4
19
5
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
23.6
15.1
21
9
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
14.8
253
1465
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
14.6
14
*
R03BB01
ATC
ipratropium bromide; inhalant
2.3
14.5
140
644
R03AC12
ATC
salmeterol; inhalant
2.5
14.4
115
480
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
8.2
13.8
30
37
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.6
13
*
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
13.6
13
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.2
13.2
136
644
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.0
13.1
176
936
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
12.5
12
*
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
12.5
12
*
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
12.5
12
*
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
12.5
12
*
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.3
12.1
59
181
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
10.1
12.0
23
23
H02AB06
ATC
prednisolone; systemic
1.5
11.5
687
5458
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
11.5
11
*
R03AC02
ATC
salbutamol; inhalant
1.5
11.2
663
5252
51899
ICD-8 Finland
Bronchiectasis
12.8
11.1
19
15
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
10.4
10
*
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
+∞
10.4
10
*
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
23.5
10.2
14
6
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.7
10.2
66
247
M05BA04
ATC
alendronic acid; oral
1.9
10.1
147
800
48509
ICD-8 Finland
Bronchopneumonia, unspecified
6.0
10.1
27
46
J47
ICD-10 Finland
Bronchiectasis
3.6
9.9
43
121
132
Kela drug reimbursment
Sarcoidosis
6.8
9.9
24
36
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.3
9.9
86
379
13599
ICD-8 Finland
Sarcoidosis, Unspecified
8.8
9.8
20
23
48609
ICD-8 Finland
Pneumonia, unspecified
4.8
9.8
31
65
J45.8
ICD-10 Finland
Mixed asthma
2.9
9.8
59
212
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
9.7
201
1231
A70
ICPC
Tuberculosis
100.6
9.4
10
*
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
9.4
9
*
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
5.6
9.4
26
47
J96.1
ICD-10 Finland
Chronic respiratory failure
2.7
9.3
62
234
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.4
9.0
77
337
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
8.9
240
1585
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
7.7
8.6
19
25
J01MA14
ATC
moxifloxacin; systemic
1.8
8.5
136
767
Y0499
ICD-8 Finland
Investigation of respiratory system
4.1
8.5
31
76
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.2
8.4
81
374
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
8.1
143
833
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
33.5
8.1
10
*
TGC00
NOMESCO Finland
Bronchial lavation
2.8
8.0
49
179
51109
ICD-8 Finland
Pleurisy, Sicca NUD
45.2
7.7
9
*
13597
ICD-8 Finland
Sarcoidosis, Suspecta
5.9
7.7
20
34
A98
ICPC
Health maint/preventive medicine
0.7
7.6
973
10825
0110B
ICD-8 Finland
NA
+∞
7.3
7
*
01202
ICD-8 Finland
NA
+∞
7.3
7
*
R03BB02
ATC
oxitropium bromide; inhalant
3.4
7.0
32
96
H02AB07
ATC
prednisone; oral
1.5
7.0
217
1481
D86.0
ICD-10 Finland
Sarcoidosis of lung
4.8
6.8
21
44
L04AX01
ATC
azathioprine; systemic
2.4
6.8
54
227
49300
ICD-8 Finland
Asthma, bronchiale
2.7
6.8
44
167
R03BA01
ATC
beclometasone; inhalant
1.6
6.8
199
1338
P01BA02
ATC
hydroxychloroquine; oral
1.9
6.6
96
527
R95
ICPC
Chron obstructive pulmonary disease
2.4
6.6
51
215
A02BA02
ATC
ranitidine; systemic
1.4
6.6
319
2386
R03BA02
ATC
budesonide; inhalant
1.5
6.5
218
1510
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.1
6.5
32
103
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
70.1
6.4
7
*
J01FA06
ATC
roxithromycin; oral
1.3
6.4
519
4233
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
14.4
6.4
10
7
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
6.3
97
543
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.3
6
*
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
6.3
6
*
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
6.3
6
*
A10BA02
ATC
metformin; oral
0.7
6.2
247
3283
5120A
ICD-9 Finland
Pneumothorax, Spontaneous tension pneumothorax
8.6
6.1
12
14
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
3.2
6.0
29
92
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
498
2.79
24.91
5.2
2.7
—
—
—
0
0
59
157
3.86
19.66
3.9
3.9
—
—
—
0
0
78
321
2.50
12.40
1.7
1.6
1.9
18.6
iu/ml
0.43
28
65
69
300
2.36
9.79
2.1
1.5
—
—
—
0
0
20
43
4.69
8.83
1.6
1.5
—
—
—
0
0
980
11039
0.73
8.64
5.2
5.3
2.6
2.6
mmol/l
0.95
880
9866
27
80
3.41
7.81
5.4
3.6
—
—
—
0
0
1114
12238
0.74
7.72
31.9
25.4
248.4
239.2
e9/l
4.20
1071
11791
1115
12244
0.74
7.67
32.0
25.5
7.2
6.9
e9/l
2.12
1069
11746
1115
12242
0.74
7.65
32.0
25.6
131.5
132.3
g/l
0.94
1086
11926
1115
12240
0.74
7.62
31.9
25.4
4.4
4.4
e12/l
0.56
1067
11745
956
10709
0.75
7.36
4.7
4.7
4.5
4.4
mmol/l
1.21
861
9647
31
104
3.02
7.36
1.8
1.7
—
—
—
0
0
51
222
2.34
7.29
1.6
1.4
—
—
—
0
0
1077
11845
0.75
7.12
25.5
20.7
84.6
85.5
umol/l
0.29
1077
11840
43
176
2.48
7.04
1.3
1.4
—
—
—
0
0
46
198
2.36
6.76
1.4
1.4
—
—
—
0
0
63
313
2.05
6.54
1.6
1.6
—
—
—
0
0
952
10587
0.77
6.39
4.6
4.6
1.4
1.4
mmol/l
0.37
851
9432
1091
11916
0.76
6.36
25.3
20.9
139.5
139.6
mmol/l
0.42
1060
11521
1093
11933
0.76
6.34
25.4
21.0
4.0
4.0
mmol/l
0.06
1060
11523
42
181
2.35
6.18
1.7
1.4
—
—
—
0
0
919
10243
0.78
6.14
4.1
4.2
1.3
1.3
mmol/l
0.45
813
9042
41
176
2.36
6.09
1.2
1.1
—
—
—
0
0
994
10949
0.78
5.90
4.9
5.0
6.1
6.1
mmol/l
0.32
887
9654
59
299
2.01
5.84
1.6
1.6
—
—
—
0
0
947
10453
0.79
5.48
20.7
16.7
73.4
72.3
ml/min/173m2
0.80
798
8661
954
10519
0.79
5.45
6.3
6.5
40.5
41.0
mmol/mol
0.92
863
9489
15
39
3.87
5.26
1.2
2.6
520.0
49721.0
u/ml
—
5
9
1090
11810
0.78
5.26
13.3
11.0
25.6
25.1
u/l
0.08
1038
11234
226
3006
0.71
5.23
2.7
3.3
0.9
0.8
ug/l
0.31
153
2115
889
9781
0.81
4.47
24.2
19.1
38.3
38.4
%
0.08
531
6001
349
4233
0.78
4.14
3.9
4.7
21.8
21.8
%
0.03
178
2206
217
1655
1.36
4.06
6.5
7.0
1.5
1.2
mmol/l
0.40
177
1264
216
1651
1.35
3.99
6.2
7.0
5.2
5.1
kpa
0.54
206
1561
216
1651
1.35
3.99
6.2
7.0
11.6
11.6
kpa
0.08
206
1562
43
226
1.93
3.94
1.7
1.6
—
—
—
0
0
449
5257
0.80
3.89
4.5
5.4
3.1
4.6
ug/l
1.03
387
4604
18
69
2.63
3.47
1.7
2.1
458.7
689.6
e6/l
—
10
29
28
132
2.14
3.46
1.3
1.2
27.1
15.8
u/l
0.88
23
121
939
10145
0.83
3.39
4.8
4.6
1.9
2.0
mu/l
1.83
836
8973
1056
11284
0.83
3.37
23.8
17.6
27.9
27.8
mg/l
0.05
904
9263
215
1687
1.31
3.33
2.0
1.8
—
—
—
0
0
11
32
3.45
3.33
1.2
1.3
—
—
—
0
0
293
2396
1.27
3.31
2.0
1.9
—
—
—
0
0
214
1682
1.31
3.28
1.9
1.8
—
—
—
0
0
51
302
1.71
3.24
2.0
2.3
122.3
126.0
g/l
0.57
37
228
10
28
3.59
3.20
1.9
1.4
—
—
—
0
0
77
513
1.52
3.06
1.4
1.2
265.2
209.5
u/ml
0.26
69
462
10
29
3.46
3.05
1.8
2.1
—
—
—
0
0
69
449
1.56
3.04
2.0
2.0
37.7
38.4
u/l
0.11
63
388
28
145
1.95
2.75
1.9
1.6
—
—
—
0
0
24
118
2.05
2.72
1.1
1.5
—
—
—
0
0
24
118
2.05
2.72
1.1
1.5
—
—
—
0
0
24
118
2.05
2.72
1.1
1.5
—
—
—
0
0
33
183
1.82
2.66
1.8
1.6
—
—
—
0
0
123
925
1.36
2.59
7.9
6.9
25.1
24.4
mmol/l
1.16
117
864
17
74
2.31
2.58
1.6
1.5
—
—
—
0
0
17
74
2.31
2.58
1.6
1.5
—
—
—
0
0
89
635
1.42
2.56
2.1
1.9
1.1
2.0
ug/l
0.74
75
545
58
386
1.52
2.38
2.9
3.4
25.0
25.3
mmol/l
0.15
53
331
11
40
2.76
2.37
1.1
1.2
—
—
—
0
0
25
132
1.91
2.36
1.4
1.5
—
—
—
0
0
22
111
1.99
2.36
1.5
1.5
—
—
—
0
0
833
8946
0.86
2.34
26.5
21.4
14.1
13.9
%
1.58
816
8682
356
4072
0.84
2.23
3.6
3.9
14.4
9.4
mg/mmol
0.60
220
2596
58
393
1.49
2.21
1.5
1.7
—
—
—
0
0
6
14
4.30
2.15
3.0
1.7
—
—
—
0
0
7
19
3.69
2.15
1.1
1.3
—
—
—
0
0
15
68
2.22
2.11
1.1
1.6
—
—
—
0
0
15
68
2.22
2.11
1.1
1.6
—
—
—
0
0
15
68
2.22
2.11
1.1
1.6
—
—
—
0
0
166
1349
1.26
2.02
7.5
7.8
119.5
119.4
g/l
0.02
161
1295
18
92
1.97
1.90
1.6
1.4
—
—
—
0
0
762
8161
0.88
1.89
6.1
5.0
6054.9
1965.1
e6/l
0.30
17
158
43
286
1.52
1.83
1.9
2.1
10.8
12.5
mg/l
0.61
43
261
501
5502
0.87
1.80
4.8
4.3
—
—
—
0
0
345
3891
0.86
1.79
3.2
3.1
7.1
7.2
mmol/l
0.17
282
3189
5
13
3.85
1.71
1.0
1.2
—
—
—
0
0
14
68
2.07
1.70
1.1
1.6
—
—
—
0
0
14
69
2.04
1.64
1.1
1.2
15.9
11.4
mmol/l
—
5
20
508
5542
0.88
1.62
2.2
2.1
92.3
92.3
pmol/l
0.00
262
2884
47
329
1.44
1.59
1.2
1.2
1.5
1.2
u/ml
—
9
27
44
306
1.45
1.55
1.9
1.8
—
—
—
0
0
11
51
2.16
1.50
1.1
1.7
—
—
—
0
0
11
51
2.16
1.50
1.1
1.7
—
—
—
0
0
23
139
1.66
1.48
2.8
3.5
54.1
57.0
%
0.18
13
95
48
343
1.41
1.47
1.6
1.4
—
—
—
0
0
48
343
1.41
1.47
1.6
1.4
—
—
—
0
0
59
437
1.36
1.47
5.0
3.7
3.9
4.0
mmol/l
0.67
54
401
622
6668
0.89
1.45
3.9
3.1
51.8
55.9
u/l
0.41
575
6037
11
52
2.12
1.44
1.1
1.7
—
—
—
0
0
63
825
0.75
1.41
2.1
2.2
11.1
11.8
nmol/l
0.27
55
706
18
104
1.74
1.37
1.2
1.2
—
—
u/ml
—
0
0
9
41
2.20
1.37
1.3
1.1
—
70.0
—
0
6
5
17
2.95
1.36
1.0
1.1
—
—
—
0
0
93
745
1.26
1.35
7.6
8.8
24.3
24.4
mmol/l
0.12
86
685
127
1516
0.82
1.31
4.5
4.7
30.7
33.3
%
1.52
70
967
256
2877
0.87
1.27
1.6
1.6
1.4
1.3
mmol/l
0.21
219
2352
8
35
2.29
1.27
3.4
2.4
16.9
255.7
ug/l
—
8
29
20
123
1.63
1.24
1.4
1.7
—
—
—
0
0
55
416
1.33
1.24
1.5
1.2
—
—
—
0
0
12
63
1.91
1.23
1.7
1.8
13.0
16.4
%
—
6
29
33
229
1.45
1.22
2.6
3.7
0.4
1.7
%
3.21
22
180
11
56
1.97
1.22
1.1
1.0
—
—
—
0
0
32
221
1.46
1.21
1.5
1.4
1704.1
1651.0
e6/l
0.05
22
161
14
79
1.78
1.17
1.1
1.1
—
—
—
0
0
44
325
1.36
1.16
1.2
1.2
—
—
—
0
0
38
519
0.73
1.16
1.3
1.2
88.3
149.0
iu/ml
0.99
11
182
15
87
1.73
1.15
1.0
1.1
—
—
—
0
0
44
327
1.35
1.13
1.2
1.1
—
—
—
0
0
268
2977
0.88
1.13
1.9
1.8
1143.7
1183.9
nmol/l
0.34
203
2185
7
32
2.19
1.08
1.0
1.1
—
—
—
0
0
20
129
1.56
1.05
1.4
1.7
—
—
—
0
0
7
33
2.13
1.05
1.0
1.1
—
—
—
0
0
31
220
1.42
1.05
4.5
5.6
636.8
283.6
iu/ml
—
6
33
9
46
1.96
1.03
1.0
1.2
—
—
—
0
0
5
22
2.28
1.03
1.0
2.5
1.2
1.2
mmol/l
—
5
22
7
34
2.06
1.03
1.0
1.1
—
—
—
0
0
28
196
1.44
1.02
1.5
1.4
26071.8
84511.8
e6/l
1.03
17
121
188
2121
0.87
1.01
26.5
29.7
1.5
1.5
inr
0.03
32
268
789
8249
0.92
0.99
3.9
3.8
15.2
15.1
pmol/l
0.39
695
7256
37
492
0.75
0.98
2.6
2.8
1.1
1.3
g/l
0.14
31
414
7
36
1.95
0.97
1.1
1.9
—
—
—
0
0
32
233
1.38
0.96
1.4
1.3
—
—
—
0
0
20
134
1.50
0.92
1.5
1.4
—
—
—
0
0
150
1315
1.15
0.91
2.7
2.5
4.3
6.2
ug/l
2.40
125
1111
13
79
1.65
0.88
1.0
1.0
—
—
—
0
0
8
43
1.86
0.87
1.0
1.0
—
—
—
0
0
37
281
1.32
0.87
1.9
1.4
0.2
0.2
g/l
0.45
37
270
13
80
1.63
0.84
1.2
1.3
—
—
—
0
0
6
31
1.94
0.84
1.0
1.1
—
—
—
0
0
228
2070
1.12
0.82
3.6
3.1
0.8
0.8
mmol/l
0.06
204
1915
18
121
1.49
0.82
1.1
1.3
126.9
219.1
miu/ml
—
7
41
100
858
1.18
0.82
3.7
3.7
2.4
2.0
mmol/l
0.38
69
644
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
709
7401
0.93
0.81
5.7
5.0
6.9
6.9
mmol/l
0.02
671
6970
12
73
1.65
0.81
1.2
1.1
0.5
0.8
u/ml
—
5
29
217
1967
1.12
0.81
2.5
2.5
2.2
2.3
g/l
0.33
202
1799
13
81
1.61
0.81
2.2
3.5
—
—
—
0
0
8
47
1.71
0.80
1.8
1.1
—
—
—
0
0
38
485
0.78
0.79
1.4
1.8
—
—
—
0
0
6
33
1.82
0.79
1.3
1.2
—
—
—
0
0
15
98
1.54
0.78
1.0
1.1
—
—
—
0
0
115
1003
1.16
0.78
2.0
1.6
—
—
—
0
0
23
315
0.73
0.78
1.4
1.6
8091.5
15383.5
e6/l
0.51
12
231
141
1249
1.14
0.77
6.1
6.4
11.6
11.5
mmol/l
0.02
135
1177
22
157
1.41
0.76
1.1
1.4
138.6
110.2
u/ml
—
5
25
9
53
1.70
0.75
1.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.2
1.4
—
—
—
0
0
309
3323
0.91
0.74
1.6
1.6
20.3
20.1
nmol/l
0.07
259
2791
5
25
2.00
0.72
1.0
1.1
—
—
—
0
0
5
25
2.00
0.72
1.6
1.5
—
—
—
0
0
104
908
1.15
0.71
3.8
3.7
5.1
5.2
kpa
0.44
96
828
378
3548
1.08
0.70
3.9
3.1
36.4
36.0
u/l
0.03
355
3352
105
918
1.15
0.70
4.0
3.0
57.7
59.0
ml/min/173m2
0.16
51
396
9
58
1.55
0.69
1.1
1.2
187.0
378.2
u/l
—
9
52
149
1336
1.13
0.69
4.6
3.5
1.8
2.0
mmol/l
0.24
117
1047
19
135
1.41
0.69
1.1
1.1
230.7
98.1
iu/ml
—
5
24
7
42
1.67
0.68
1.0
1.3
—
—
—
0
0
19
261
0.72
0.67
3.1
1.8
2.5
2.9
mg/l
0.19
13
206
151
1360
1.12
0.66
3.7
3.1
206.7
269.0
ng/l
1.62
141
1247
34
268
1.27
0.65
1.5
1.6
—
—
—
0
0
37
460
0.80
0.65
2.4
2.5
38.7
37.0
g/l
1.21
30
385
287
2674
1.09
0.64
4.8
4.1
197.3
303.9
ng/l
0.92
243
2300
686
6612
1.06
0.60
11.0
8.6
4.4
4.3
e9/l
0.26
612
5712
19
139
1.37
0.60
1.8
1.3
27.4
28.4
iu/l
0.05
14
115
175
1599
1.11
0.60
3.4
3.8
244.7
249.7
u/l
0.16
160
1499
455
4772
0.94
0.58
3.1
2.7
142.6
156.2
ug/l
0.55
402
4264
202
1866
1.09
0.56
2.6
2.5
21.9
21.9
%
0.01
173
1567
6
38
1.58
0.54
1.8
2.7
—
—
—
0
0
126
1144
1.11
0.51
1.4
1.3
—
—
—
0
0
9
65
1.39
0.50
1.7
1.9
—
—
—
0
0
130
1425
0.90
0.50
4.4
3.7
—
—
—
0
0
97
869
1.12
0.50
4.0
3.1
122.4
125.6
g/l
0.77
97
848
26
207
1.26
0.49
1.1
1.1
—
—
—
0
0
282
2987
0.93
0.49
3.0
2.4
—
—
—
0
0
158
1456
1.09
0.48
3.4
3.9
74.7
21.9
ug/l
0.50
135
1210
172
1593
1.09
0.47
9.6
8.7
—
—
—
0
0
21
164
1.28
0.46
1.4
2.1
55.7
30.3
u/ml
0.18
21
158
239
2247
1.07
0.46
3.2
3.0
1.5
1.2
e6/l
0.70
153
1338
7
49
1.43
0.46
1.7
1.6
—
—
—
0
0
23
183
1.26
0.45
1.1
1.1
—
—
—
0
0
30
361
0.83
0.43
1.2
1.3
—
—
—
0
0
5
31
1.61
0.43
36.8
18.8
1430.8
1628.6
nmol/l
—
5
31
124
1140
1.09
0.42
2.6
2.4
31.4
34.9
u/l
0.64
98
951
58
510
1.14
0.41
2.4
2.2
273.7
508.9
ug/l
1.09
52
478
351
3669
0.95
0.41
4.1
3.4
0.5
0.5
e6/l
0.28
287
2870
227
2141
1.07
0.41
2.6
2.5
11.9
12.0
umol/l
0.05
215
1956
14
105
1.34
0.41
1.7
1.2
—
—
—
0
0
254
2413
1.06
0.38
1.9
1.6
1.4
1.5
mg/l
0.20
200
1889
24
197
1.22
0.37
1.3
1.3
—
—
—
0
0
9
68
1.33
0.37
1.4
2.0
—
—
—
0
0
29
343
0.84
0.37
2.2
2.4
91.7
79.7
ug/min
0.06
18
206
131
1217
1.08
0.36
7.4
6.5
1.4
1.4
mmol/l
0.45
126
1159
27
226
1.20
0.36
1.6
1.2
27.2
48.8
e6/l
0.25
19
178
27
226
1.20
0.36
1.6
1.3
30.5
755.8
e6/l
0.88
20
185
13
168
0.77
0.35
1.5
1.8
191.5
216.2
pmol/l
0.61
13
154
48
542
0.88
0.34
2.4
2.6
2.8
3.2
g/l
2.19
38
419
6
86
0.70
0.33
1.2
1.1
—
91.1
—
0
8
24
284
0.84
0.31
2.1
2.8
40.1
33.8
umol/l
0.28
17
231
21
174
1.21
0.31
2.8
2.6
—
1313.8
—
0
18
914
9293
0.96
0.31
9.1
7.5
77.9
81.3
u/l
2.01
846
8614
65
590
1.11
0.31
1.9
1.9
—
—
—
0
0
7
53
1.32
0.31
2.1
1.2
—
—
—
0
0
90
973
0.92
0.30
2.0
2.1
351.3
374.2
nmol/l
0.54
79
871
535
5213
1.04
0.29
4.3
4.3
39.1
57.9
ng/l
1.60
400
4013
562
5758
0.96
0.29
4.8
4.0
0.0
0.0
estimate
0.50
104
1047
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
57
1.23
0.29
1.0
1.2
—
—
—
0
0
51
459
1.11
0.29
1.5
1.2
—
—
—
0
0
301
2903
1.04
0.27
3.3
2.7
6.1
4.7
e6/l
1.03
271
2563
73
672
1.09
0.27
4.2
2.5
1.3
1.2
%
0.43
73
667
34
385
0.88
0.27
1.6
1.5
—
—
—
0
0
251
2611
0.95
0.27
3.3
3.1
2.5
2.5
mmol/l
0.06
215
2272
15
122
1.23
0.27
1.5
1.2
3.3
4.8
u/ml
—
9
33
553
5659
0.97
0.26
5.1
4.8
34.1
34.4
g/l
0.55
496
5211
18
214
0.84
0.26
1.7
1.6
2.8
4.7
iu/l
—
8
66
10
77
1.30
0.26
1.1
1.2
—
—
—
0
0
124
1171
1.06
0.25
2.1
2.1
0.2
0.2
g/l
0.17
117
1079
191
1827
1.05
0.25
5.6
5.2
1.1
1.0
mmol/l
1.19
171
1659
10
78
1.28
0.24
1.1
1.1
—
—
—
0
0
6
83
0.72
0.24
1.8
1.3
—
—
—
0
0
6
83
0.72
0.24
1.8
1.3
—
—
—
0
0
88
940
0.93
0.24
1.8
1.7
1.7
1.6
%
0.52
76
769
15
124
1.21
0.24
1.5
1.2
1.7
5.7
u/ml
—
7
52
21
243
0.86
0.23
1.9
1.7
—
—
—
0
0
16
134
1.20
0.23
2.4
2.0
4.5
2.3
u/field
—
8
40
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
60
554
1.09
0.22
2.4
2.5
0.3
0.4
u/ml
1.07
34
326
10
79
1.27
0.22
1.0
1.3
—
—
—
0
0
10
79
1.27
0.22
1.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
584
5949
0.97
0.21
6.6
6.0
1.2
1.2
mmol/l
0.04
509
5308
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
5.0
—
—
—
0
0
659
6480
1.03
0.21
6.8
6.0
10.8
12.4
umol/l
3.72
620
6092
0
14
0.00
0.20
0.0
2.0
—
—
—
0
0
91
859
1.06
0.20
1.5
1.5
—
—
—
0
0
41
374
1.10
0.20
1.5
1.7
—
—
—
0
0
16
136
1.18
0.20
1.5
2.0
—
—
—
0
0
6
49
1.23
0.20
13.2
2.8
—
—
—
0
0
6
49
1.23
0.20
13.0
2.8
—
—
—
0
0
133
1390
0.95
0.19
2.4
2.6
6.9
9.4
umol/l
1.83
111
1220
109
1037
1.05
0.19
3.2
3.6
85.5
98.1
ng/l
1.14
93
874
6
52
1.15
0.19
1.0
1.1
—
—
—
0
0
427
4361
0.97
0.19
5.1
4.3
—
—
—
0
0
6
53
1.13
0.18
4.2
2.6
785.2
1615.3
u/ml
—
6
53
13
109
1.19
0.18
1.1
1.1
—
—
—
0
0
50
539
0.93
0.18
4.7
4.0
24.9
24.9
mmol/l
0.04
45
489
558
5675
0.98
0.18
6.2
5.4
0.0
0.0
estimate
0.00
102
1065
429
4378
0.97
0.18
3.3
3.4
2.3
2.3
mmol/l
0.32
370
3733
659
6498
1.02
0.17
7.3
6.8
1.2
1.2
mmol/l
0.65
547
5405
8
69
1.16
0.16
1.4
2.2
—
—
—
0
0
32
292
1.10
0.16
2.1
2.6
15.4
15.5
%
0.11
21
152
320
3273
0.97
0.16
3.2
2.8
3791.1
8123.4
umol/l
0.99
264
2729
128
1231
1.04
0.16
2.6
2.7
65.8
66.0
g/l
0.09
114
1102
13
151
0.86
0.15
1.5
1.4
—
—
—
0
0
262
2557
1.03
0.15
5.6
4.4
1.0
1.0
kg/l
0.18
44
414
28
255
1.10
0.15
1.4
1.4
—
—
—
0
0
13
112
1.16
0.14
1.1
1.3
—
—
—
0
0
36
334
1.08
0.13
1.4
1.6
—
—
—
0
0
560
5674
0.98
0.13
4.7
4.0
0.0
0.0
estimate
0.00
103
1075
389
3825
1.02
0.13
2.6
2.4
57.3
57.4
u/l
0.01
359
3493
113
1090
1.04
0.13
3.8
3.6
1.2
1.2
mmol/l
0.21
96
929
13
113
1.15
0.13
1.5
2.0
—
—
—
0
0
12
138
0.87
0.13
1.0
1.0
—
—
—
0
0
57
540
1.06
0.13
1.8
1.8
—
—
—
0
0
30
324
0.92
0.12
3.7
3.5
7.9
7.9
mmol/l
0.06
30
318
199
2039
0.97
0.12
1.2
1.2
1.2
1.6
u/ml
0.56
63
496
360
3542
1.02
0.12
2.3
2.2
3.0
3.1
mg/l
0.37
302
2956
479
4727
1.02
0.12
2.4
2.2
81.2
78.8
nmol/l
0.93
413
4080
32
343
0.93
0.11
3.5
3.4
1.6
1.7
mmol/l
0.30
32
336
845
8516
0.98
0.11
5.6
4.1
16.2
14.7
mm/h
1.55
773
7716
523
5288
0.98
0.10
2.4
2.4
—
—
—
0
0
50
524
0.95
0.09
2.5
3.1
147.8
8085.8
u/ml
0.87
43
446
159
1627
0.97
0.09
1.3
1.2
65.3
39.5
iu/ml
0.44
48
504
5
46
1.09
0.09
1.4
1.5
0.3
0.2
nmol/l
—
5
34
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
56
584
0.96
0.09
2.5
2.5
3.6
3.8
g/l
0.43
37
411
6
54
1.11
0.09
1.2
1.2
—
—
—
0
0
6
55
1.09
0.09
3.7
3.1
215.3
217.0
u/l
—
6
55
42
400
1.05
0.08
2.8
3.1
0.8
0.8
nmol/l
0.48
36
316
293
2970
0.98
0.08
1.7
1.8
23636815.2
10482254.8
pmol/l
0.23
220
2366
19
205
0.93
0.08
1.7
1.3
—
—
—
0
0
68
658
1.03
0.07
5.8
3.5
24.1
24.1
mmol/l
0.07
61
588
42
402
1.05
0.07
1.1
1.0
—
—
—
0
0
14
153
0.91
0.07
1.4
1.4
—
—
—
0
0
18
167
1.08
0.07
1.3
1.2
—
—
—
0
0
8
91
0.88
0.06
1.0
1.0
—
—
—
0
0
103
1008
1.02
0.06
1.3
1.4
—
—
—
0
0
14
152
0.92
0.06
1.4
1.4
—
—
—
0
0
14
152
0.92
0.06
1.4
1.4
—
—
—
0
0
14
152
0.92
0.06
1.4
1.4
—
—
—
0
0
48
496
0.97
0.05
4.2
3.5
110.1
69.8
mg/l
0.18
39
407
57
586
0.97
0.05
2.5
2.5
7.6
7.5
g/l
0.21
38
426
48
495
0.97
0.05
4.2
3.5
42.7
67.0
mg/l
1.01
39
404
394
3912
1.01
0.04
2.5
2.2
208.3
227.4
u/l
0.22
364
3633
20
189
1.06
0.04
1.5
1.2
41.0
47.6
u/ml
—
6
15
57
585
0.97
0.04
2.5
2.5
—
—
—
0
0
14
150
0.93
0.04
1.4
1.4
—
—
—
0
0
451
4485
1.01
0.04
3.5
3.2
1733.2
2006.6
ng/l
0.61
395
3863
213
2150
0.99
0.04
3.5
3.2
2.4
1.9
e6/l
0.52
126
1247
154
1557
0.99
0.03
1.3
1.2
18.4
14.5
u/ml
0.28
64
544
30
290
1.04
0.03
1.1
1.2
—
—
—
0
0
175
1763
0.99
0.02
2.3
2.3
1.8
1.8
%
0.24
148
1541
11
117
0.94
0.01
1.2
1.1
—
—
—
0
0
14
147
0.95
0.01
1.1
1.2
0.6
0.6
nmol/l
0.04
14
137
14
147
0.95
0.01
2.4
2.5
—
—
—
0
0
93
921
1.01
0.01
1.6
1.7
—
—
—
0
0
54
547
0.99
0.01
2.6
2.5
9.7
10.4
g/l
0.55
45
457
19
196
0.97
0.00
1.2
1.2
—
—
—
0
0
15
154
0.97
0.00
1.5
1.5
—
—
—
0
0
32
316
1.01
0.00
3.9
3.7
31.2
28.6
mg/l
0.13
22
213
48
484
0.99
0.00
4.1
3.5
2.2
1.7
ratio
—
6
35
316
3156
1.00
0.00
5.2
4.3
0.0
0.0
estimate
0.50
95
1004
17
167
1.02
0.00
1.8
1.3
16.9
8.6
u/l
1.09
12
131
28
283
0.99
0.00
2.0
1.6
—
—
—
0
0
35
347
1.01
0.00
1.5
1.5
237.8
270.7
ug/g
0.47
22
201
71
707
1.00
0.00
1.5
1.8
1.5
1.5
g/l
0.37
59
602
7
70
1.00
0.00
2.0
1.1
—
—
—
0
0
7
70
1.00
0.00
2.0
1.1
—
—
—
0
0
7
70
1.00
0.00
2.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
2.6
—
0
5
0
6
0.00
0.00
0.0
7.2
—
—
—
0
0
7
77
0.91
0.00
2.3
2.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
21.6
—
0
5
5
52
0.96
0.00
2.4
3.0
24.4
32.2
umol/l
—
5
37
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
0.00
2.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
6
60
1.00
0.00
1.0
1.2
—
—
—
0
0
7
69
1.01
0.00
2.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
8.0
—
74.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
7.7
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint AB1_RESP_TUBERCU_NONCONF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_NONCONF | 2.647 [2.24, 3.13] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 641 out of 1245 females with AB1_RESP_TUBERCU_NONCONF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_NONCONF | 2.682 [2.28, 3.16] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 1179 out of 1955 males with AB1_RESP_TUBERCU_NONCONF died.
Mortality risk
Mortality risk for people of age
years, who have AB1_RESP_TUBERCU_NONCONF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.247% | 0.493% |
| 5 | 1.684% | 3.329% |
| 10 | 3.933% | 8.096% |
| 15 | 6.764% | 15.062% |
| 20 | 12.124% | 24.76% |
Relationships between endpoints
↥Index endpoint: AB1_RESP_TUBERCU_NONCONF – Respiratory tuberculosis, not confirmed
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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