No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1693 |
4. Check minimum number of eventsNone |
1693 |
5. Include endpointsNone |
1693 |
6. Filter based on genotype QC (FinnGen only) |
1693 |
Control definitions (FinnGen only)
- Control exclude
- AB1_TUBERCULOSIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Respiratory tuberculosis, not confirmed
based on the number of shared cases.
Similar with more cases:
- Respiratory tuberculosis, confirmed and not-confirmed
- Respiratory tuberculosis
- Tuberculosis
- Tuberculosis, IBD comorbidity
- Tuberculosis, wide
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26949 | 10715 | 15412 |
| Only index persons | 12955 | 6283 | 6672 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.31 | 0.43 |
| Only index persons | 0.24 | 0.23 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 49.87 | 48.85 | 50.29 |
| Only index persons | 38.41 | 38.00 | 38.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1693 | 597 | 1096 |
| Unadjusted period prevalence (%) | 0.38 | 0.20 | 0.48 |
| Median age at first event (years) | 40.84 | 33.14 | 45.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1569
- Matched controls
- 15689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
323.0
372
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
263.1
245
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
194.9
183
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
172.1
162
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
144.0
136
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
120.4
114
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
41.6
75.1
94
24
0110K
ICD-8 Finland
NA
+∞
71.4
68
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
60.8
58
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
58.7
56
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
57.7
55
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
67.1
45.4
52
8
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.1
44.8
286
1067
0110J
ICD-8 Finland
NA
+∞
41.9
40
*
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
41.9
40
*
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
39.7
38
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
39.2
241
870
0110A
ICD-8 Finland
NA
+∞
34.5
33
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
33.4
32
*
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
32.4
31
*
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
14.2
32.2
55
40
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
32.0
342
1686
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
29.3
28
*
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
29.3
28
*
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.3
28
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
28.2
27
*
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
24.0
23
*
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
23.0
22
*
R03BB04
ATC
tiotropium bromide; inhalant
2.1
21.0
257
1322
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
20.9
362
2138
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
19.4
534
3647
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.4
16.8
144
625
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.8
16.1
103
378
R03DA04
ATC
theophylline; systemic, rectal
2.2
15.9
177
866
1240
FHL
Bronchoscopy
4.9
15.7
51
107
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
38.4
15.4
19
5
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
23.6
15.1
21
9
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
14.8
253
1465
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
14.6
14
*
R03BB01
ATC
ipratropium bromide; inhalant
2.3
14.5
140
644
R03AC12
ATC
salmeterol; inhalant
2.5
14.4
115
480
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
8.2
13.8
30
37
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
13.6
13
*
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.6
13
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.2
13.2
136
644
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.0
13.1
176
936
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
12.5
12
*
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
12.5
12
*
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
12.5
12
*
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
12.5
12
*
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.3
12.1
59
181
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
10.1
12.0
23
23
H02AB06
ATC
prednisolone; systemic
1.5
11.5
687
5458
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
11.5
11
*
R03AC02
ATC
salbutamol; inhalant
1.5
11.2
663
5252
51899
ICD-8 Finland
Bronchiectasis
12.8
11.1
19
15
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
10.4
10
*
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
+∞
10.4
10
*
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
23.5
10.2
14
6
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.7
10.2
66
247
M05BA04
ATC
alendronic acid; oral
1.9
10.1
147
800
48509
ICD-8 Finland
Bronchopneumonia, unspecified
6.0
10.1
27
46
J47
ICD-10 Finland
Bronchiectasis
3.6
9.9
43
121
132
Kela drug reimbursment
Sarcoidosis
6.8
9.9
24
36
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.3
9.9
86
379
13599
ICD-8 Finland
Sarcoidosis, Unspecified
8.8
9.8
20
23
48609
ICD-8 Finland
Pneumonia, unspecified
4.8
9.8
31
65
J45.8
ICD-10 Finland
Mixed asthma
2.9
9.8
59
212
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
9.7
201
1231
A70
ICPC
Tuberculosis
100.6
9.4
10
*
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
9.4
9
*
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
5.6
9.4
26
47
J96.1
ICD-10 Finland
Chronic respiratory failure
2.7
9.3
62
234
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.4
9.0
77
337
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
8.9
240
1585
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
7.7
8.6
19
25
J01MA14
ATC
moxifloxacin; systemic
1.8
8.5
136
767
Y0499
ICD-8 Finland
Investigation of respiratory system
4.1
8.5
31
76
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.2
8.4
81
374
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
8.1
143
833
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
33.5
8.1
10
*
TGC00
NOMESCO Finland
Bronchial lavation
2.8
8.0
49
179
51109
ICD-8 Finland
Pleurisy, Sicca NUD
45.2
7.7
9
*
13597
ICD-8 Finland
Sarcoidosis, Suspecta
5.9
7.7
20
34
A98
ICPC
Health maint/preventive medicine
0.7
7.6
973
10825
0110B
ICD-8 Finland
NA
+∞
7.3
7
*
01202
ICD-8 Finland
NA
+∞
7.3
7
*
R03BB02
ATC
oxitropium bromide; inhalant
3.4
7.0
32
96
H02AB07
ATC
prednisone; oral
1.5
7.0
217
1481
D86.0
ICD-10 Finland
Sarcoidosis of lung
4.8
6.8
21
44
L04AX01
ATC
azathioprine; systemic
2.4
6.8
54
227
49300
ICD-8 Finland
Asthma, bronchiale
2.7
6.8
44
167
R03BA01
ATC
beclometasone; inhalant
1.6
6.8
199
1338
P01BA02
ATC
hydroxychloroquine; oral
1.9
6.6
96
527
R95
ICPC
Chron obstructive pulmonary disease
2.4
6.6
51
215
A02BA02
ATC
ranitidine; systemic
1.4
6.6
319
2386
R03BA02
ATC
budesonide; inhalant
1.5
6.5
218
1510
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.1
6.5
32
103
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
70.1
6.4
7
*
J01FA06
ATC
roxithromycin; oral
1.3
6.4
519
4233
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
14.4
6.4
10
7
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
6.3
97
543
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
6.3
6
*
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
6.3
6
*
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.3
6
*
A10BA02
ATC
metformin; oral
0.7
6.2
247
3283
5120A
ICD-9 Finland
Pneumothorax, Spontaneous tension pneumothorax
8.6
6.1
12
14
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
3.2
6.0
29
92
Mortality – FinRegistry
↥Association
Association between endpoint AB1_RESP_TUBERCU_NONCONF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_NONCONF | 2.647 [2.24, 3.13] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 641 out of 1245 females with AB1_RESP_TUBERCU_NONCONF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_NONCONF | 2.682 [2.28, 3.16] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 1179 out of 1955 males with AB1_RESP_TUBERCU_NONCONF died.
Mortality risk
Mortality risk for people of age
years, who have AB1_RESP_TUBERCU_NONCONF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.247% | 0.493% |
| 5 | 1.684% | 3.329% |
| 10 | 3.933% | 8.096% |
| 15 | 6.764% | 15.062% |
| 20 | 12.124% | 24.76% |
Relationships between endpoints
↥Index endpoint: AB1_RESP_TUBERCU_NONCONF – Respiratory tuberculosis, not confirmed
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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