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Respiratory tuberculosis, confirmed and not-confirmed

AB1_RESP_TUBERCU

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

2316

6. Filter based on genotype QC (FinnGen only)

2316

Control definitions (FinnGen only)

Control exclude
AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Respiratory tuberculosis, confirmed and not-confirmed based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 2316 804 1512
Unadjusted period prevalence (%) 0.53 0.27 0.67
Median age at first event (years) 45.55 37.14 50.03

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2155
Matched controls
21550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
323.0
372
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
3017.2
292.3
276
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
260.8
245
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
209.9
198
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
193.7
183
*
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
171.1
162
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
143.3
136
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
50.1
127.1
154
33
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
119.9
114
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.3
97.1
406
1104
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.7
96.0
486
1565
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.6
75
*
0110K
ICD-8 Finland
NA
+∞
71.2
68
*
A70
ICPC
Tuberculosis
342.3
66.9
67
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
64.9
62
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
60.7
58
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
58.6
56
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.6
57.6
496
2211
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
57.5
55
*
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
50.2
48
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
+∞
47.0
45
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
35.6
45.8
59
17
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
38.8
42.0
53
14
0110J
ICD-8 Finland
NA
+∞
41.8
40
*
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
41.8
40
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
41.6
803
5047
R03BB04
ATC
tiotropium bromide; inhalant
2.4
40.2
376
1716
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
39.7
38
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.0
34.5
217
780
0110A
ICD-8 Finland
NA
+∞
34.5
33
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
33.9
506
2835
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
331.9
33.0
33
*
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
11.8
32.4
60
52
0120X
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, EPÄILTY]
+∞
32.4
31
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.4
31.3
159
491
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
30.3
29
*
1240
FHL
Bronchoscopy
5.9
29.7
85
149
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
29.2
28
*
01104
ICD-8 Finland
Pulmonary tuberculosis, Tuberculoma pulmonum
+∞
29.2
28
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
28.4
325
1614
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
28.2
27
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
28.2
27
*
R03DA04
ATC
theophylline; systemic, rectal
2.4
27.9
254
1131
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
19.0
27.0
41
22
01297
ICD-8 Finland
Other respiratory tuberculosis, Suspecta
+∞
24.0
23
*
R03BB01
ATC
ipratropium bromide; inhalant
2.5
24.0
198
834
H02AB06
ATC
prednisolone; systemic
1.6
23.9
977
7345
R03AC12
ATC
salmeterol; inhalant
2.7
23.7
168
650
J47
ICD-10 Finland
Bronchiectasis
5.3
23.2
72
140
01109
ICD-8 Finland
Pulmonary tuberculosis, Unspecified
+∞
22.9
22
*
J01MA14
ATC
moxifloxacin; systemic
2.3
22.8
226
1045
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
22.7
352
1968
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.2
22.4
251
1227
TGC00
NOMESCO Finland
Bronchial lavation
4.2
22.0
85
208
R03AC02
ATC
salbutamol; inhalant
1.6
22.0
944
7136
J96.1
ICD-10 Finland
Chronic respiratory failure
3.6
21.6
100
287
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
20.9
20
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.3
20.5
196
890
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
20.0
130
477
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.8
19.6
131
486
R04.2
ICD-10 Finland
Haemoptysis
3.0
19.5
113
384
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
40.5
19.5
24
6
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
19.1
146
588
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.8
18.8
81
220
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
17.7
17
*
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
8.6
17.7
38
45
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
95.8
17.6
19
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
15.4
347
2175
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
2.9
15.3
94
333
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
14.6
14
*
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
14.6
14
*
R03BA01
ATC
beclometasone; inhalant
1.7
14.0
283
1713
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
13.6
13
*
0118X
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, EPÄILTY]
+∞
13.6
13
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.5
13.3
102
415
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.0
13.0
75
256
J01FA06
ATC
roxithromycin; oral
1.4
12.8
749
5844
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
12.5
12
*
H02AB07
ATC
prednisone; oral
1.6
12.1
322
2105
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
3.4
11.5
54
160
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
11.5
11
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
11.4
797
6388
J45.8
ICD-10 Finland
Mixed asthma
2.7
11.3
75
281
M05BA04
ATC
alendronic acid; oral
1.8
11.1
190
1090
48609
ICD-8 Finland
Pneumonia, unspecified
4.4
11.1
39
90
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.6
11.1
48
134
51120
ICD-8 Finland
Pleurisy, Other specified forms of effusion, except tuberculous
11.2
11.0
20
18
R03AC13
ATC
formoterol; inhalant
2.2
11.0
114
539
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
43.5
10.9
13
*
51899
ICD-8 Finland
Bronchiectasis
12.0
10.8
19
16
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.1
10.8
118
572
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
10.8
141
733
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
5.2
10.4
31
60
01103
ICD-8 Finland
Pulmonary tuberculosis, Bronchialis
+∞
10.4
10
*
0112X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, EPÄILTY]
+∞
10.4
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
10.3
834
6815
R03BA02
ATC
budesonide; inhalant
1.6
10.3
305
2048
J43.9
ICD-10 Finland
Emphysema, unspecified
3.1
10.2
54
176
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
10.2
335
2305
132
Kela drug reimbursment
Sarcoidosis
6.5
10.0
25
39
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
7.6
9.9
22
29
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
9.9
289
1930
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.0
9.9
118
595
R03BB02
ATC
oxitropium bromide; inhalant
3.4
9.8
45
133
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
9.6
9.8
19
20
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
5.1
9.7
29
57
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
5.5
9.5
27
50
03199
ICD-8 Finland
Other diseases due to Mycobacteria, Other and unspecified
100.4
9.4
10
*
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
9.4
9
*
01292
ICD-8 Finland
Other respiratory tuberculosis, Lymphonodorum tracheobronchialium et mediastini
+∞
9.4
9
*
A98
ICPC
Health maint/preventive medicine
0.7
9.3
1349
14908
48509
ICD-8 Finland
Bronchopneumonia, unspecified
4.9
9.3
29
60
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.0
9.1
110
560
5111B
ICD-9 Finland
Pleurisy, With effusion, with mention of a bacterial cause other than tuberculosis[PLEURITIS EXSUDATIVA ALIA DEFINITA]
24.1
8.9
12
5
J01AA02
ATC
doxycycline; systemic
1.3
8.9
1454
13108
L04AX01
ATC
azathioprine; systemic
2.3
8.8
79
353
J01MA12
ATC
levofloxacin; systemic
1.4
8.8
387
2828
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
8.5
147
2307
R95
ICPC
Chron obstructive pulmonary disease
2.4
8.4
68
288
R06.0
ICD-10 Finland
Dyspnoea
1.4
8.4
477
3649
Y3419
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Inactive pulmonary tuberculosis, which is known to have been inactive
+∞
8.3
8
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
8.3
8
*
A16.8
ICD-10 Finland
Other respiratory tuberculosis, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
3.0
8.3
45
152
A02BA02
ATC
ranitidine; systemic
1.4
8.2
435
3283
J46
ICD-10 Finland
Status asthmaticus
2.7
8.2
56
214
R03AC03
ATC
terbutaline; inhalant
1.6
8.1
230
1526
XG410
NOMESCO Finland
Flow-volume spirometry
2.1
8.0
88
430
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.5
7.8
59
242
J94.9
ICD-10 Finland
Pleural condition, unspecified
5.9
7.7
20
34
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
25.1
7.6
10
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
7.6
134
779
GD1AD
NOMESCO Finland
Thorax CT examination
2.0
7.5
87
434
A10BA02
ATC
metformin; oral
0.7
7.5
344
4497
N05BA02
ATC
chlordiazepoxide; systemic
2.6
7.5
50
193
13599
ICD-8 Finland
Sarcoidosis, Unspecified
5.6
7.4
20
36
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.6
7.3
189
1224
N05CD07
ATC
temazepam; oral
1.4
7.3
325
2374
A18.8
ICD-10 Finland
Tuberculosis of other specified organs
+∞
7.3
7
*
0110B
ICD-8 Finland
NA
+∞
7.3
7
*
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
7.3
7
*
01202
ICD-8 Finland
NA
+∞
7.3
7
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
9.4
7.3
14
15
R05CB01
ATC
acetylcysteine; inhalant, oral
2.3
7.2
61
267
N02AX02
ATC
tramadol; systemic, rectal
1.3
7.1
783
6598
P01BA02
ATC
hydroxychloroquine; oral
1.8
7.1
128
749
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
4.5
7.1
23
51
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
10.0
7.0
13
13
49300
ICD-8 Finland
Asthma, bronchiale
2.5
7.0
53
219
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
2.4
6.9
55
231
Y3498
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other illnesses, accidents or surgeries
11.0
6.8
12
11
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
5.3
6.8
19
36
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
4.7
6.7
21
45
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
3.5
6.7
29
84
D86.0
ICD-10 Finland
Sarcoidosis of lung
3.8
6.7
26
69
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
2.7
6.6
41
153
A07EC01
ATC
sulfasalazine; oral, rectal
1.7
6.6
132
802
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
4.8
6.5
20
42
F10.25
ICD-10 Finland
Alcohol dependence continuous use
3.6
6.5
27
76
A06AD11
ATC
lactulose; oral
1.4
6.4
362
2756
A31.89
ICD-10 Finland
Other mycobacterial infections
70.0
6.4
7
*
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
2.7
6.4
42
160
5120A
ICD-9 Finland
Pneumothorax, Spontaneous tension pneumothorax
7.4
6.4
14
19
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
2.5
6.4
46
186
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
3.8
6.4
25
67
L04AA13
ATC
leflunomide; oral
2.5
6.3
45
180
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
5.2
6.3
18
35
Z2446
NOMESCO Finland
Social worker
1.8
6.3
109
634
1243
FHL
Bronchoscopy and other therapeutic procedure
9.3
6.3
12
13
F10.20
ICD-10 Finland
Alcohol dependence currently independent
3.0
6.3
33
111
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.3
515
4156
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
6.3
6
*
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.3
6
*
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
6.3
6
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
6.3
6
*
01105
ICD-8 Finland
Pulmonary tuberculosis, Disseminata pulmonum
+∞
6.3
6
*
A16.4
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, without mention of bacteriological or histological confirmation
+∞
6.3
6
*
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
6.3
6
*
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
6.3
6
*
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
6.3
6
*
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
6.3
6
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
3.4
6.2
27
79
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.7
6.2
38
141
R50.9
ICD-10 Finland
Fever, unspecified
1.5
6.2
238
1687
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
10.0
6.0
11
11

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: AB1_RESP_TUBERCU – Respiratory tuberculosis, confirmed and not-confirmed

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).