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Respiratory tuberculosis, bacteriologically and histologically confirmed

TBC_RESP_HISTOBACT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A15
  • Hospital discharge: ICD-9 011.[A|B]|012.[A|B]
  • Cause of death: ICD-10 A15
  • Cause of death: ICD-9 011.[A|B]|012.[A|B]

2 out of 7 registries used, show all original rules.

758

4. Check minimum number of events

None

758

5. Include endpoints

None

758

6. Filter based on genotype QC (FinnGen only)

758

Control definitions (FinnGen only)

Control exclude
TBC_RESP

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
A15-A19
Name in latin
Tuberculosis respiratoria bacteriologice et histologice confirmata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 758 247 511
Unadjusted period prevalence (%) 0.18 0.08 0.23
Median age at first event (years) 61.75 54.29 65.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
707
Matched controls
7068
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
312.3
276
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
218.3
198
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.5
86.4
234
439
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.6
74
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.4
73.2
195
347
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
65.6
62
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
40.9
61.5
77
21
A70
ICPC
Tuberculosis
628.1
59.6
58
*
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
50.6
48
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
+∞
47.4
45
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
76.0
38.4
43
6
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
37.8
316
1520
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
34.7
33
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
34.7
33
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.5
33.8
186
655
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
30.4
29
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.7
28.8
87
170
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
28.3
27
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.3
25.5
146
519
R03BB04
ATC
tiotropium bromide; inhalant
3.2
24.4
145
529
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.5
22.1
83
205
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
20.9
20
*
1240
FHL
Bronchoscopy
8.4
20.8
46
58
J01MA14
ATC
moxifloxacin; systemic
3.3
19.0
101
336
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
18.8
18
*
H02AB06
ATC
prednisolone; systemic
2.1
18.7
354
2314
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.8
18.7
64
144
R04.2
ICD-10 Finland
Haemoptysis
5.2
17.9
57
118
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
17.8
17
*
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
29.6
17.5
23
8
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.1
16.8
68
180
TGC00
NOMESCO Finland
Bronchial lavation
6.7
16.2
41
64
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.8
15.8
45
82
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
15.2
320
2123
J96.1
ICD-10 Finland
Chronic respiratory failure
5.5
14.9
44
84
R03DA04
ATC
theophylline; systemic, rectal
2.9
14.4
92
346
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.2
14.3
55
139
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
14.2
172
909
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
13.6
13
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.2
12.9
72
245
R03AC02
ATC
salbutamol; inhalant
1.8
12.7
335
2354
0120B
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, HISTOLOGISESTI VARMENNETTU]
+∞
12.5
12
*
J47
ICD-10 Finland
Bronchiectasis
6.0
11.9
32
55
R03AC12
ATC
salmeterol; inhalant
3.2
11.8
62
205
H02AB07
ATC
prednisone; oral
2.2
11.6
129
650
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
11.3
136
711
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
7.5
11.3
26
36
J01FA06
ATC
roxithromycin; oral
1.8
11.2
275
1865
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
11.2
68
246
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
10.5
300
2121
R03BB01
ATC
ipratropium bromide; inhalant
2.8
10.5
69
265
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
10.4
10
*
R05
ICD-10 Finland
Cough
2.1
9.7
126
675
XG410
NOMESCO Finland
Flow-volume spirometry
3.4
9.6
45
137
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.0
9.5
55
194
GD1AD
NOMESCO Finland
Thorax CT examination
3.5
9.5
44
133
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
30.4
9.4
12
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
9.4
9
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
9.4
9
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
8.9
126
697
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
8.8
116
626
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.2
8.7
86
410
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
8.7
143
838
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
8.6
122
675
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.5
179
1135
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.8
8.5
27
58
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
8.3
8
*
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
8.3
8
*
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
14.7
8.2
13
9
J01MA12
ATC
levofloxacin; systemic
1.8
7.9
148
907
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
18.6
7.6
11
6
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.0
7.5
43
151
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.6
7.5
52
207
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.9
7.3
28
73
A31.89
ICD-10 Finland
Other mycobacterial infections
+∞
7.3
7
*
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
7.3
7
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
7.2
194
1318
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
30.3
7.2
9
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.0
71
343
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
4.5
7.0
23
52
5188X
ICD-9 Finland
Other diseases of lung
13.9
6.9
11
8
F10.25
ICD-10 Finland
Alcohol dependence continuous use
5.4
6.8
19
36
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
40.4
6.8
8
*
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
40.4
6.8
8
*
J01AA02
ATC
doxycycline; systemic
1.5
6.7
496
4260
R99
ICPC
Respiratory disease other
5.2
6.7
19
37
SPAT1254
SPAT
Administration of medicine
1.8
6.6
113
672
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
70.4
6.4
7
*
GDB10
NOMESCO Finland
Wedge resection of lung
70.4
6.4
7
*
R03AC03
ATC
terbutaline; inhalant
1.9
6.4
88
481
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.3
140
900
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
6.3
6
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
6.3
6
*
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
6.3
6
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
6.3
6
*
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
6.3
6
*
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.3
6
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
26.9
6.2
8
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
6.2
31
102
R03BA01
ATC
beclometasone; inhalant
1.8
6.1
99
573
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
6.8
6.1
14
21

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: TBC_RESP_HISTOBACT – Respiratory tuberculosis, bacteriologically and histologically confirmed

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).