No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
728 |
4. Check minimum number of eventsNone |
728 |
5. Include endpointsNone |
728 |
6. Filter based on genotype QC (FinnGen only) |
728 |
Control definitions (FinnGen only)
- Control exclude
- AB1_TUBERCULOSIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Respiratory tuberculosis, confirmed
based on the number of shared cases.
Similar with more cases:
- Respiratory tuberculosis, bacteriologically and histologically confirmed
- Respiratory tuberculosis, confirmed and not-confirmed
- Respiratory tuberculosis
- Tuberculosis
- Tuberculosis, IBD comorbidity
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10043 | 3678 | 6041 |
| Only index persons | 5568 | 2240 | 3328 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.11 | 0.17 |
| Only index persons | 0.11 | 0.08 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 65.07 | 68.60 | 63.07 |
| Only index persons | 58.70 | 59.64 | 58.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 728 | 236 | 492 |
| Unadjusted period prevalence (%) | 0.17 | 0.08 | 0.22 |
| Median age at first event (years) | 62.16 | 54.36 | 65.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 681
- Matched controls
- 6811
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
313.5
276
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
218.9
198
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.5
85.4
232
440
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.7
74
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.6
74.6
195
341
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
66.5
67.2
77
13
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
64.6
61
*
A70
ICPC
Tuberculosis
630.3
59.6
58
*
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
50.6
48
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
478.1
45.8
45
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
65.4
37.6
43
7
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
+∞
34.7
33
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
34.7
33
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
32.7
310
1582
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.4
31.9
182
659
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
30.4
29
*
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
28.3
27
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.3
26.2
84
176
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.4
26.2
144
500
R03BB04
ATC
tiotropium bromide; inhalant
3.2
24.0
141
511
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
5.4
21.8
68
138
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
20.9
20
*
1240
FHL
Bronchoscopy
9.0
18.9
40
47
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
18.8
18
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.8
18.7
82
234
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
39.6
18.6
23
6
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
17.8
17
*
H02AB06
ATC
prednisolone; systemic
2.0
17.7
339
2222
J01MA14
ATC
moxifloxacin; systemic
3.2
17.4
98
341
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.5
16.8
61
146
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
16.3
312
2024
R04.2
ICD-10 Finland
Haemoptysis
4.7
16.3
56
127
J96.1
ICD-10 Finland
Chronic respiratory failure
5.6
15.1
44
83
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.3
14.7
45
90
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.2
14.2
54
136
TGC00
NOMESCO Finland
Bronchial lavation
5.5
14.0
41
78
J47
ICD-10 Finland
Bronchiectasis
7.6
13.9
32
44
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
13.6
166
883
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
13.6
13
*
R03DA04
ATC
theophylline; systemic, rectal
2.9
13.6
89
339
R03AC02
ATC
salbutamol; inhalant
1.9
13.5
323
2218
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
9.3
12.8
26
29
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
12.8
66
215
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.7
12.3
54
155
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.0
11.5
69
248
R03BB01
ATC
ipratropium bromide; inhalant
2.9
11.3
69
251
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
11.2
133
693
H02AB07
ATC
prednisone; oral
2.2
11.0
125
637
J01FA06
ATC
roxithromycin; oral
1.8
11.0
264
1783
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
10.9
291
2027
R03AC12
ATC
salmeterol; inhalant
3.0
10.7
61
214
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
10.4
10
*
XG410
NOMESCO Finland
Flow-volume spirometry
3.7
10.3
45
129
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
40.7
10.0
12
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
9.8
141
790
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
9.5
121
646
GD1AD
NOMESCO Finland
Thorax CT examination
3.3
9.0
44
139
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
8.9
122
671
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.0
8.8
27
56
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.9
8.7
52
189
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
8.6
113
610
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.6
175
1104
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.3
8.6
83
393
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.2
8.4
42
135
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
8.3
8
*
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
+∞
8.3
8
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
8.3
8
*
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
+∞
8.3
8
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
8.3
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
8.2
139
822
R05
ICD-10 Finland
Cough
1.9
8.1
120
679
F10.25
ICD-10 Finland
Alcohol dependence continuous use
6.9
8.1
19
28
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
5.3
7.9
23
45
P15
ICPC
Chronic alcohol abuse
6.2
7.9
20
33
J01MA12
ATC
levofloxacin; systemic
1.8
7.8
147
904
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
18.6
7.6
11
6
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
4.1
7.5
28
71
SPAT1254
SPAT
Administration of medicine
1.9
7.4
111
630
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
7.3
7
*
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
7.3
7
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
7.3
7
*
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
7.3
7
*
R03BA01
ATC
beclometasone; inhalant
2.0
7.0
95
517
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.8
188
1289
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
4.2
6.6
23
56
A31.89
ICD-10 Finland
Other mycobacterial infections
70.5
6.4
7
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
6.4
71
359
F10.20
ICD-10 Finland
Alcohol dependence currently independent
5.3
6.4
18
35
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
9.4
6.3
12
13
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.3
6
*
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
6.3
6
*
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
6.3
6
*
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
6.3
6
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
6.3
6
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
6.3
6
*
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
6.3
6
*
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
7.1
6.2
14
20
N05BA02
ATC
chlordiazepoxide; systemic
3.7
6.2
25
69
R99
ICPC
Respiratory disease other
4.7
6.1
19
41
GAC00
NOMESCO Finland
Biopsy of pleura
10.1
6.0
11
11
N05CD07
ATC
temazepam; oral
1.8
6.0
111
672
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
195
194
13.36
181.34
7.2
2.8
—
—
—
0
0
103
56
21.26
132.19
13.0
3.7
—
—
—
0
0
89
135
7.37
57.33
2.9
1.3
—
—
—
0
0
51
79
6.87
31.92
1.1
1.1
—
—
—
0
0
23
10
23.72
31.58
1.7
1.2
—
—
—
0
0
56
129
4.62
22.86
1.8
1.6
1.4
0.1
iu/ml
3.14
19
32
25
24
10.75
22.78
8.4
4.5
—
—
—
0
0
47
94
5.28
22.62
1.5
1.4
—
—
—
0
0
41
77
5.58
21.12
1.6
1.4
—
—
—
0
0
51
130
4.14
18.27
1.8
1.5
—
—
—
0
0
29
48
6.25
16.96
1.4
1.5
—
—
—
0
0
47
129
3.83
15.21
1.9
1.5
—
—
—
0
0
20
25
8.20
14.95
1.2
1.2
—
—
—
0
0
36
83
4.51
14.66
1.6
1.4
—
—
—
0
0
28
52
5.56
14.58
1.4
1.3
16.0
14.5
u/l
0.35
28
47
33
72
4.75
14.36
1.5
1.5
—
—
—
0
0
153
825
2.08
13.36
4.8
3.3
0.8
0.8
mmol/l
1.17
147
764
329
2291
1.80
13.14
11.5
5.5
58.1
58.5
%
0.22
311
2136
333
2330
1.79
13.06
12.0
5.7
26.3
26.1
%
0.09
312
2157
371
2696
1.77
12.64
11.0
6.2
9.9
12.1
umol/l
4.65
362
2544
23
42
5.62
12.18
1.3
1.2
1.7
—
iu/ml
—
7
0
48
157
3.20
11.92
1.7
1.6
—
212.5
—
0
8
25
51
5.04
11.76
1.9
1.8
—
—
—
0
0
26
56
4.78
11.49
1.8
1.7
—
—
—
0
0
35
99
3.66
10.87
1.9
1.5
—
—
—
0
0
131
716
2.01
10.87
6.5
5.4
1.1
1.0
mmol/l
0.83
122
644
166
988
1.88
10.70
2.5
1.8
—
—
—
0
0
373
2822
1.66
10.13
15.3
8.6
4.4
4.3
e9/l
0.40
333
2461
51
190
2.81
10.11
1.7
2.0
44.0
37.6
u/l
1.26
42
164
15
27
5.65
8.05
1.8
1.7
—
—
—
0
0
15
27
5.65
8.05
1.8
1.7
—
—
—
0
0
15
27
5.65
8.05
1.8
1.7
—
—
—
0
0
20
47
4.35
7.98
1.8
1.6
—
—
—
0
0
20
47
4.35
7.98
1.8
1.6
—
—
—
0
0
20
47
4.35
7.98
1.8
1.6
—
—
—
0
0
132
808
1.77
7.57
3.3
2.4
2.1
2.3
g/l
1.37
121
736
141
882
1.74
7.50
3.2
2.4
10.6
12.3
umol/l
2.40
132
803
13
22
6.00
7.40
1.9
1.8
—
—
—
0
0
13
22
6.00
7.40
1.9
1.8
—
—
—
0
0
126
771
1.77
7.22
3.3
2.5
20.2
22.3
%
0.90
104
658
116
696
1.79
7.10
2.4
1.8
—
—
—
0
0
13
23
5.74
7.08
1.9
1.7
—
—
—
0
0
14
27
5.27
6.99
1.9
1.7
—
—
—
0
0
52
235
2.31
6.97
1.7
1.2
125.4
343.2
u/ml
1.22
46
211
72
371
2.04
6.96
2.1
1.6
—
—
—
0
0
85
468
1.92
6.81
1.7
2.6
66.3
66.1
g/l
0.10
72
417
309
2385
1.51
6.77
8.4
5.9
1.2
1.2
mmol/l
0.91
283
2128
39
157
2.57
6.71
1.6
1.6
—
—
—
0
0
114
692
1.77
6.69
2.3
1.8
—
—
—
0
0
99
576
1.83
6.69
2.7
4.3
23.3
29.6
ug/l
0.13
81
495
25
79
3.24
6.62
1.8
1.4
—
—
—
0
0
108
648
1.78
6.59
8.8
7.1
5.1
5.1
kpa
0.03
103
614
298
2306
1.49
6.34
6.1
4.7
33.3
34.8
g/l
3.88
270
2129
32
120
2.74
6.32
1.2
2.0
12.1
13.2
mg/l
0.24
23
106
107
648
1.76
6.32
8.8
7.2
1.2
1.3
mmol/l
0.09
91
493
13
26
5.07
6.24
1.6
1.9
—
—
—
0
0
215
1570
1.52
5.97
3.7
3.0
32.8
34.4
u/l
0.27
204
1495
21
65
3.30
5.76
1.9
1.5
—
—
—
0
0
36
151
2.46
5.72
1.4
1.6
—
—
—
0
0
24
82
2.99
5.62
1.3
1.2
2117.6
1355.8
e6/l
0.87
16
53
325
2602
1.45
5.62
9.1
6.7
1.2
1.2
mmol/l
0.79
285
2155
425
3593
1.44
5.38
7.6
3.9
18.1
14.1
mm/h
3.84
400
3237
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
42
197
2.20
5.20
2.2
2.8
0.3
0.3
u/ml
0.03
22
105
83
495
1.76
5.17
2.4
2.1
0.2
0.2
g/l
0.24
78
453
83
495
1.76
5.17
7.4
6.9
11.4
11.2
mmol/l
0.10
78
466
451
3873
1.43
5.12
14.0
7.5
80.6
80.6
u/l
0.00
433
3589
195
1437
1.49
5.07
2.9
2.1
3.1
3.1
mg/l
0.18
166
1213
51
266
1.99
4.81
6.1
4.0
24.8
24.1
mmol/l
0.91
45
239
17
52
3.32
4.77
4.3
2.5
—
—
—
0
0
84
515
1.71
4.75
10.1
8.1
120.7
120.5
g/l
0.02
79
495
13
33
3.99
4.73
1.5
1.8
721.4
737.7
e6/l
—
7
15
85
526
1.70
4.65
4.5
3.7
5.8
5.8
kpa
0.18
80
508
21
75
2.85
4.58
1.3
1.2
33850.3
28127.2
e6/l
0.07
12
43
10
21
4.81
4.54
2.3
2.0
1630.8
890.0
u/ml
—
10
21
78
475
1.72
4.52
2.0
1.8
1.7
1.6
%
0.89
67
405
210
1603
1.44
4.48
2.9
2.4
60.5
55.9
u/l
1.15
197
1481
46
241
1.97
4.31
2.7
1.8
—
—
—
0
0
83
524
1.66
4.22
4.7
3.7
2.4
2.0
mmol/l
0.53
64
410
60
347
1.79
4.17
5.1
3.9
1.3
2.0
mmol/l
0.57
50
261
67
404
1.73
4.04
1.8
1.7
—
—
—
0
0
22
87
2.58
4.00
1.5
1.4
—
—
—
0
0
41
217
1.94
3.76
2.3
1.7
—
—
—
0
0
22
90
2.49
3.75
1.1
1.1
—
—
—
0
0
13
40
3.29
3.64
1.3
1.3
—
—
—
0
0
14
46
3.08
3.54
1.4
1.1
—
—
—
0
0
15
52
2.92
3.48
1.2
1.4
—
—
—
0
0
26
120
2.21
3.42
1.3
3.1
24.2
35.2
umol/l
1.73
21
97
222
1782
1.35
3.38
4.1
3.1
2911.4
2054.9
ng/l
1.32
200
1520
29
142
2.09
3.31
1.6
1.3
—
—
—
0
0
29
142
2.09
3.31
1.6
1.3
—
—
—
0
0
139
1043
1.41
3.17
2.1
1.7
1.3
1.4
mg/l
0.06
107
822
142
1073
1.40
3.11
5.2
4.0
910.5
278.5
ng/l
0.99
121
904
6
8
7.55
3.06
1.3
1.4
—
—
—
0
0
10
29
3.48
3.05
1.1
1.3
—
—
—
0
0
99
705
1.47
2.99
1.4
1.3
65.6
37.1
iu/ml
0.45
32
223
14
52
2.73
2.90
1.9
1.8
—
—
—
0
0
198
1596
1.33
2.87
2.4
2.1
310.1
274.1
u/l
0.17
185
1492
149
1150
1.37
2.87
2.0
1.8
1113.2
1158.2
nmol/l
0.25
111
856
25
123
2.07
2.84
2.0
2.0
114.5
128.2
g/l
1.23
13
93
65
429
1.57
2.81
2.2
2.0
383.1
380.3
nmol/l
0.04
57
388
7
15
4.70
2.60
1.7
1.3
—
—
—
0
0
19
87
2.22
2.59
1.4
1.3
4.3
3.9
mmol/l
0.35
19
80
244
2050
1.29
2.58
3.8
2.7
199.4
158.6
ug/l
0.92
226
1855
54
349
1.59
2.57
1.8
1.5
—
—
—
0
0
93
675
1.43
2.56
1.3
1.3
19.2
14.1
u/ml
0.19
26
263
352
3095
1.27
2.56
7.2
4.8
6.6
6.8
mmol/l
0.92
334
2898
433
4734
0.79
2.49
5.1
5.0
2.5
2.6
mmol/l
1.32
393
4260
343
3016
1.26
2.46
5.4
3.1
59.7
52.8
u/l
0.62
320
2775
12
45
2.69
2.46
1.3
1.5
—
—
—
0
0
12
45
2.69
2.46
1.3
1.5
—
—
—
0
0
12
45
2.69
2.46
1.3
1.5
—
—
—
0
0
12
45
2.69
2.46
1.3
1.5
—
—
—
0
0
9
27
3.36
2.40
2.0
1.4
—
—
—
0
0
9
28
3.24
2.31
2.0
1.4
—
—
—
0
0
10
35
2.88
2.31
1.0
1.0
—
—
—
0
0
5
9
5.58
2.21
1.2
1.4
—
—
—
0
0
10
36
2.80
2.21
1.1
1.5
—
—
—
0
0
10
36
2.80
2.21
2.0
1.4
—
—
—
0
0
10
36
2.80
2.21
1.1
1.5
—
—
—
0
0
418
4560
0.80
2.20
4.7
4.5
1.5
1.4
mmol/l
1.22
377
4110
8
24
3.36
2.18
4.8
4.1
114.2
90.4
nmol/l
—
8
24
7
19
3.71
2.15
1.3
1.4
—
—
—
0
0
7
19
3.71
2.15
1.0
1.0
—
—
—
0
0
30
175
1.74
2.12
1.4
3.7
27.8
33.7
mg/l
0.82
24
141
30
175
1.74
2.12
1.4
3.6
50.3
100.8
mg/l
0.76
23
141
152
1230
1.30
2.11
3.7
2.4
—
—
—
0
0
424
4607
0.81
2.09
4.6
4.5
4.4
4.5
mmol/l
0.63
383
4183
21
110
1.94
2.07
1.5
1.5
—
—
—
0
0
12
50
2.42
2.03
1.2
1.6
—
—
—
0
0
196
2305
0.80
2.02
4.3
5.2
6.5
5.3
ug/l
0.11
173
2020
10
38
2.65
2.01
1.2
1.3
—
—
—
0
0
69
497
1.43
2.01
3.9
3.1
261.3
237.4
ng/l
0.16
60
450
23
127
1.84
1.96
2.6
2.0
—
—
—
0
0
165
1362
1.27
1.96
3.4
2.8
367.8
7370.7
umol/l
5.43
140
1153
152
1835
0.78
1.95
4.1
4.5
22.7
21.7
%
0.38
76
925
35
220
1.62
1.91
1.7
2.5
3.6
3.8
g/l
0.34
19
155
35
220
1.62
1.91
1.7
2.5
—
—
—
0
0
35
220
1.62
1.91
1.7
2.5
7.7
7.5
g/l
0.26
19
161
16
303
0.52
1.89
1.4
1.8
—
—
—
0
0
252
2191
1.23
1.88
5.1
4.0
42.0
44.9
ng/l
0.19
187
1628
33
206
1.63
1.86
1.8
2.6
3.2
3.2
g/l
0.06
19
158
78
583
1.38
1.86
3.2
2.6
4.8
9.4
umol/l
4.80
68
516
5
12
4.19
1.82
1.2
1.2
—
—
—
0
0
15
73
2.08
1.81
1.8
2.6
28.2
23.5
mg/l
—
5
18
209
1788
1.24
1.81
3.4
3.4
2.3
2.3
mmol/l
0.55
173
1533
9
35
2.59
1.80
1.3
1.1
—
—
—
0
0
9
35
2.59
1.80
1.3
1.1
—
—
—
0
0
8
29
2.78
1.79
1.3
1.2
—
—
—
0
0
37
241
1.56
1.77
1.1
1.2
138.1
144.4
iu/ml
0.03
14
85
16
81
2.00
1.76
1.5
1.3
35.9
224.5
miu/ml
—
7
33
9
36
2.52
1.74
1.3
1.1
—
—
—
0
0
9
36
2.52
1.74
1.3
1.1
—
—
—
0
0
9
36
2.52
1.74
1.3
1.1
—
—
—
0
0
116
931
1.29
1.72
3.9
3.1
1.3
1.1
e6/l
0.12
73
554
11
48
2.31
1.71
2.0
1.4
—
—
—
0
0
227
1973
1.22
1.68
2.4
2.2
78.3
77.0
nmol/l
0.24
205
1726
8
31
2.60
1.66
1.6
1.2
—
82.0
—
0
5
30
189
1.61
1.65
1.4
2.9
0.4
1.0
g/l
0.68
19
161
432
4637
0.83
1.65
5.0
4.8
5.9
6.1
mmol/l
1.37
387
4130
6
20
3.02
1.58
1.0
1.3
28.2
22.5
%
—
6
10
22
129
1.73
1.58
1.7
1.4
330.4
277.4
ug/g
0.48
15
69
106
1303
0.78
1.56
3.3
3.1
0.8
0.8
ug/l
0.36
71
891
16
85
1.90
1.56
1.3
1.2
—
—
—
0
0
411
4415
0.84
1.51
4.1
4.0
1.2
1.3
mmol/l
0.96
367
3954
6
21
2.87
1.51
15.0
14.1
698.7
913.5
nmol/l
—
6
21
6
21
2.87
1.51
28.0
19.1
1483.8
1516.2
nmol/l
—
6
21
28
178
1.60
1.51
1.4
2.6
36.5
36.7
g/l
0.04
17
146
287
2573
1.19
1.50
3.3
2.7
—
—
—
0
0
20
116
1.74
1.50
1.7
1.7
8040.0
16596.5
e6/l
0.94
15
89
15
81
1.87
1.41
1.3
1.1
355.1
279.1
u/ml
—
9
41
35
240
1.48
1.37
1.3
1.3
—
34.4
—
0
16
5
17
2.95
1.36
2.0
2.7
84.4
97.3
%
—
5
17
109
896
1.25
1.35
4.0
3.3
1.6
1.6
e6/l
0.03
64
523
30
200
1.52
1.34
1.8
2.6
10.5
10.5
g/l
0.03
20
169
66
509
1.33
1.33
2.6
2.6
6.7
6.9
ug/l
0.04
50
441
224
1983
1.19
1.33
4.7
3.4
—
—
—
0
0
142
1209
1.22
1.28
3.4
2.6
4.4
4.4
e6/l
0.03
125
1055
21
130
1.63
1.28
1.9
2.1
—
—
—
0
0
27
178
1.54
1.28
1.3
1.2
—
—
—
0
0
256
2300
1.17
1.27
5.6
4.2
—
—
—
0
0
8
35
2.30
1.27
2.0
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
16
93
1.74
1.22
4.8
3.0
4.4
4.7
e9/l
0.18
16
93
5
19
2.64
1.22
1.4
1.8
38.6
55.1
ug/l
—
5
19
18
109
1.67
1.19
1.2
1.4
—
—
—
0
0
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
10
51
1.97
1.11
4.4
3.3
7.6
6.9
nmol/l
—
10
51
16
96
1.68
1.11
5.7
3.6
59.2
60.2
%
0.13
16
96
61
481
1.29
1.08
3.4
2.4
32.9
34.7
u/l
0.18
54
399
38
280
1.38
1.06
2.2
1.9
—
—
—
0
0
5
22
2.28
1.03
1.2
1.1
—
—
—
0
0
42
317
1.34
1.02
2.2
2.0
—
—
—
0
0
424
4474
0.87
1.01
5.8
6.2
40.6
40.7
mmol/mol
0.06
386
4077
31
223
1.41
1.00
1.4
1.3
—
—
—
0
0
29
400
0.71
1.00
1.6
2.3
13.9
12.5
nmol/l
0.38
24
348
97
822
1.21
0.94
28.0
27.4
1.5
1.4
inr
—
9
99
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
364
3412
1.13
0.94
6.2
4.8
6216.8
3100.2
e6/l
—
10
68
24
167
1.45
0.93
1.3
2.8
0.0
0.0
g/l
0.50
19
150
489
5095
0.88
0.90
33.7
19.3
87.4
84.9
umol/l
0.38
489
5090
11
63
1.76
0.90
1.2
1.4
—
—
—
0
0
143
1615
0.86
0.90
4.2
4.0
14.2
9.8
mg/mmol
0.47
92
1045
6
30
2.01
0.87
1.7
3.2
—
—
—
0
0
6
30
2.01
0.87
1.3
2.6
—
—
—
0
0
11
64
1.73
0.86
1.2
1.5
—
—
—
0
0
11
64
1.73
0.86
1.2
1.5
—
—
—
0
0
11
64
1.73
0.86
1.2
1.5
—
—
—
0
0
173
1552
1.15
0.86
4.5
3.4
0.6
0.5
e6/l
0.10
138
1200
18
120
1.51
0.86
1.9
1.3
—
—
—
0
0
11
65
1.70
0.82
1.2
1.4
—
—
—
0
0
11
65
1.70
0.82
1.2
1.4
—
—
—
0
0
17
115
1.49
0.77
3.9
2.2
13.5
15.7
%
—
9
60
9
54
1.67
0.74
1.1
1.1
—
—
—
0
0
491
5089
0.89
0.74
18.9
10.5
24.4
25.7
u/l
1.16
482
4861
488
5057
0.89
0.72
34.0
19.3
139.0
139.6
mmol/l
5.26
483
4891
5
26
1.93
0.70
1.0
1.3
—
—
—
0
0
5
26
1.93
0.70
1.0
1.3
—
—
—
0
0
489
5063
0.90
0.70
34.2
19.5
4.0
4.0
mmol/l
0.18
483
4894
21
153
1.38
0.67
1.3
2.9
0.0
0.0
g/l
0.00
16
139
19
136
1.41
0.67
1.7
1.3
—
—
—
0
0
48
395
1.23
0.66
4.6
4.0
95.1
91.0
ng/l
0.11
42
347
71
609
1.18
0.65
1.4
1.4
—
—
—
0
0
12
79
1.53
0.63
1.1
1.1
—
—
—
0
0
15
104
1.45
0.63
1.3
1.6
774.0
282.9
mu/l
0.77
15
94
10
63
1.60
0.62
1.7
1.8
—
—
—
0
0
21
156
1.36
0.61
1.3
2.9
0.0
0.0
g/l
0.00
16
139
5
30
1.67
0.61
2.6
2.5
—
—
—
0
0
74
641
1.17
0.61
9.6
8.2
—
—
—
0
0
15
105
1.44
0.60
1.8
2.0
—
—
—
0
0
143
1568
0.89
0.60
3.5
3.1
6.6
7.5
mmol/l
1.96
123
1294
257
2413
1.10
0.59
4.5
3.9
0.0
0.0
estimate
0.00
44
469
257
2414
1.10
0.59
6.0
5.4
0.0
0.0
estimate
0.00
44
466
129
1167
1.13
0.59
1.6
1.8
445.2
5981540.9
pmol/l
0.50
107
953
0
23
0.00
0.58
0.0
1.0
—
1.1
—
0
15
13
89
1.47
0.58
1.5
1.2
—
—
—
0
0
19
141
1.36
0.57
3.7
2.4
7.2
7.7
kpa
0.96
19
127
10
65
1.55
0.55
1.1
1.0
—
—
—
0
0
22
168
1.32
0.55
7.5
3.2
3.8
3.9
mmol/l
0.91
22
155
119
1080
1.12
0.52
4.7
4.3
1.0
1.0
kg/l
0.08
21
164
45
383
1.19
0.48
2.7
3.1
56.1
60.4
ml/min/173m2
0.35
23
163
12
85
1.42
0.47
1.4
1.5
—
—
—
0
0
258
2449
1.08
0.46
4.5
4.0
0.0
0.0
estimate
0.50
45
453
413
4262
0.93
0.44
31.0
17.7
37.9
39.1
%
1.30
255
2822
9
127
0.71
0.43
1.3
1.8
55.1
43.6
nmol/l
—
9
120
70
623
1.14
0.43
4.4
4.6
33.8
32.1
%
0.45
49
398
5
31
1.62
0.43
6.4
3.0
21.4
68.2
u/ml
—
5
31
5
32
1.57
0.42
1.0
1.3
—
—
—
0
0
5
33
1.52
0.41
8.4
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
3.2
—
—
—
0
0
0
17
0.00
0.40
0.0
3.2
—
—
—
0
0
19
150
1.27
0.40
2.9
2.7
1.6
1.8
mg/l
0.27
19
136
144
1347
1.09
0.37
1.9
1.6
18.4
20.3
nmol/l
0.97
125
1136
15
117
1.29
0.35
2.5
1.5
—
—
—
0
0
113
1055
1.08
0.31
3.8
3.3
2.5
2.5
mmol/l
0.38
96
914
17
138
1.24
0.30
3.3
3.9
38.7
30.9
mg/l
—
7
93
10
75
1.34
0.30
5.6
4.0
358.3
342.9
umol/l
—
10
64
65
594
1.10
0.29
4.9
3.7
—
—
—
0
0
19
158
1.21
0.28
1.2
1.2
—
—
—
0
0
10
76
1.32
0.28
1.2
1.3
—
—
—
0
0
230
2217
1.05
0.26
2.5
2.1
85.6
92.6
pmol/l
1.60
143
1182
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
8.3
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
423
4304
0.96
0.21
5.0
4.4
1.8
2.0
mu/l
1.93
379
3827
0
13
0.00
0.21
0.0
2.0
—
2.3
—
0
6
7
60
1.17
0.18
1.4
1.1
—
—
—
0
0
18
157
1.15
0.17
1.2
1.2
—
—
—
0
0
95
905
1.06
0.17
1.3
1.2
4.4
1.5
u/ml
0.44
20
218
445
4509
0.97
0.16
26.5
15.6
77.3
75.5
ml/min/173m2
0.75
377
3737
13
111
1.17
0.16
1.2
1.3
—
—
—
0
0
7
86
0.81
0.14
1.4
1.4
—
—
—
0
0
10
85
1.18
0.12
1.9
1.4
—
—
—
0
0
11
126
0.87
0.11
2.2
1.9
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
2.0
—
0
18
20
186
1.08
0.07
2.1
2.7
166.8
51.3
u/ml
0.47
20
178
31
326
0.95
0.07
4.1
2.8
0.2
0.3
e6/l
0.47
31
319
13
141
0.92
0.05
1.5
2.5
130.5
92.8
ug/min
—
6
87
343
3452
0.99
0.04
4.3
3.6
15.1
14.9
pmol/l
0.47
306
3049
132
1336
0.99
0.03
5.2
4.1
0.0
0.0
estimate
0.50
41
447
188
1896
0.99
0.03
4.6
4.2
—
—
—
0
0
44
432
1.02
0.01
1.4
1.4
—
—
—
0
0
19
197
0.96
0.01
1.0
1.0
—
—
—
0
0
488
4876
1.00
0.00
32.2
16.6
27.2
26.8
mg/l
0.11
438
3960
120
1202
1.00
0.00
1.7
1.6
1.2
1.4
mmol/l
0.84
106
996
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.4
2.4
—
—
—
0
0
9
91
0.99
0.00
1.2
1.9
202.6
225.8
pmol/l
—
9
83
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
27.3
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_RESP_TUBERCU_CONF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_CONF | 2.229 [1.96, 2.54] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 994 out of 2033 females with AB1_RESP_TUBERCU_CONF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_CONF | 2.551 [2.23, 2.92] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1865 out of 3273 males with AB1_RESP_TUBERCU_CONF died.
Mortality risk
Mortality risk for people of age
years, who have AB1_RESP_TUBERCU_CONF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.496% |
| 5 | 0.995% | 2.92% |
| 10 | 2.597% | 6.619% |
| 15 | 5.126% | 11.95% |
| 20 | 9.257% | 20.013% |
Relationships between endpoints
↥Index endpoint: AB1_RESP_TUBERCU_CONF – Respiratory tuberculosis, confirmed
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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