No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
927 |
4. Check minimum number of eventsNone |
927 |
5. Include endpointsNone |
927 |
6. Filter based on genotype QC (FinnGen only) |
927 |
Control definitions (FinnGen only)
- Control exclude
- AB1_TUBERCULOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Tuberculosis of other organs, strict
based on the number of shared cases.
Similar with more cases:
- Tuberculosis, wide
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14840 | 7877 | 6491 |
| Only index persons | 8037 | 4922 | 3115 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.23 | 0.18 |
| Only index persons | 0.16 | 0.18 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 54.25 | 54.45 | 54.01 |
| Only index persons | 46.80 | 48.59 | 43.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 927 | 469 | 458 |
| Unadjusted period prevalence (%) | 0.18 | 0.16 | 0.20 |
| Median age at first event (years) | 47.80 | 44.67 | 51.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 841
- Matched controls
- 8421
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
109.8
103
*
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
106.6
100
*
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
45.2
43
*
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
44.1
42
*
01600
ICD-8 Finland
Tuberculosis of genito-urinary system, Renis
+∞
42.0
40
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
39.9
39.2
49
13
0172A
ICD-9 Finland
Tuberculosis of other organs, Peripheral lymph nodes
+∞
37.8
36
*
A18.4
ICD-10 Finland
Tuberculosis of skin and subcutaneous tissue
+∞
37.8
36
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
34.6
33
*
A18.8
ICD-10 Finland
Tuberculosis of other specified organs
+∞
34.6
33
*
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
31.4
30
*
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
30.4
29
*
A70
ICPC
Tuberculosis
290.7
27.9
28
*
01718
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum periphericorum aliorum
+∞
23.0
22
*
Y3429
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other inactive tuberculosis cases
215.1
20.7
21
*
01500
ICD-8 Finland
Tuberculosis of bones and joints, Of vertebral column
+∞
17.8
17
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
17.8
17
*
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
16.7
16
*
N33.0*A18.1
ICD-10 Finland
Tuberculous cystitis
+∞
15.7
15
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
15.7
15
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
20.5
15.2
22
11
01909
ICD-8 Finland
Late effects of tuberculosis, Sequelae NUD o tuberculosis organorum respirationis
+∞
14.6
14
*
01797
ICD-8 Finland
Tuberculosis of other organs, Suspecta
+∞
14.6
14
*
1370X
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,MUU JÄLKITILA]
54.3
13.8
16
*
M01.1*A18.0
ICD-10 Finland
Tuberculous arthritis
+∞
13.6
13
*
01597
ICD-8 Finland
Tuberculosis of bones and joints, Suspecta
+∞
13.6
13
*
B90.2
ICD-10 Finland
Sequelae of tuberculosis of bones and joints
142.2
13.5
14
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
8.7
12.8
27
32
01588
ICD-8 Finland
Tuberculosis of bones and joints, Of other specified bones and joints
+∞
11.5
11
*
01510
ICD-8 Finland
Tuberculosis of bones and joints, Of hip
+∞
11.5
11
*
0151X
ICD-9 Finland
Tuberculosis of bones and joints, Hip[TUBERCULOSIS COXAE,EPÄILTY]
+∞
11.5
11
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.2
11.4
116
559
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
10.4
10
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
10.4
10
*
PJA10
NOMESCO Finland
Exploration of lymph nodes
7.2
10.3
24
34
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.3
10.1
36
86
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
10.0
133
718
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.6
9.6
42
121
H02AB07
ATC
prednisone; oral
2.0
9.5
139
774
H03.1*A18.4
ICD-10 Finland
Lupus vulgaris: of eyelid
+∞
9.4
9
*
01608
ICD-8 Finland
Tuberculosis of genito-urinary system, Suspecta
+∞
9.4
9
*
01719
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum NUD
+∞
9.4
9
*
0150X
ICD-9 Finland
Tuberculosis of bones and joints, Vertebral column[SELKÄRANKATUBERKULOOSI,EPÄILTY]
+∞
9.4
9
*
L04AX01
ATC
azathioprine; systemic
3.4
9.0
42
127
J01MA12
ATC
levofloxacin; systemic
1.8
8.8
170
1040
01701
ICD-8 Finland
Tuberculosis of other organs, Erythema induratum tuberculosum
+∞
8.3
8
*
H32.0*A18.5
ICD-10 Finland
Lupus chorioretinitis
+∞
8.3
8
*
01604
ICD-8 Finland
Tuberculosis of genito-urinary system, Prostatae, vesiculae seminalis sive testis
+∞
8.3
8
*
01930
ICD-8 Finland
Late effects of tuberculosis, Columnae vertebralis
+∞
8.3
8
*
01901
ICD-8 Finland
Late effects of tuberculosis, Emphysema
+∞
8.3
8
*
01900
ICD-8 Finland
Late effects of tuberculosis, Bronchiectasia
+∞
8.3
8
*
01903
ICD-8 Finland
Late effects of tuberculosis, Fibrosis pulmonum
+∞
8.3
8
*
01931
ICD-8 Finland
Late effects of tuberculosis, Coxae
+∞
8.3
8
*
H02AB06
ATC
prednisolone; systemic
1.5
8.1
374
2886
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
8.0
47
169
M79.3
ICD-10 Finland
Panniculitis, unspecified
18.5
7.6
11
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
7.4
95
502
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
7.3
7
*
K93.0*A18.3
ICD-10 Finland
Tuberculous disease of the intestines, peritoneum and mesentery glands
+∞
7.3
7
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
7.3
7
*
R06.0
ICD-10 Finland
Dyspnoea
1.6
7.1
216
1497
R03DA04
ATC
theophylline; systemic, rectal
2.1
7.0
75
368
R03AC12
ATC
salmeterol; inhalant
2.4
6.9
57
247
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
6.8
202
1393
C03CA01
ATC
furosemide; systemic
1.5
6.7
339
2638
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.4
6.6
30
91
R03AC02
ATC
salbutamol; inhalant
1.5
6.6
370
2939
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.5
111
653
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
8.2
6.3
13
16
H02AB04
ATC
methylprednisolone; systemic
1.8
6.3
118
712
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.3
245
1798
I41.0*A18.8
ICD-10 Finland
Tuberculosis of myocardium
+∞
6.3
6
*
N29.1*A18.1
ICD-10 Finland
Tuberculosis of the kidney or ureter
+∞
6.3
6
*
1373X
ICD-9 Finland
Late effects of tuberculosis of bones and joints
+∞
6.3
6
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
6.3
6
*
01731
ICD-8 Finland
Tuberculosis of other organs, Otitis media tuberculosa
+∞
6.3
6
*
0140X
ICD-9 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Tuberculous peritonitis[PERITONITIS TUBERCULOSA,EPÄILTY]
+∞
6.3
6
*
A18.5
ICD-10 Finland
Tuberculosis of eye
+∞
6.3
6
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
6.3
6
*
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
6.3
6
*
01401
ICD-8 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Peritonei et lymphonodorum mesenterii
+∞
6.3
6
*
0178X
ICD-9 Finland
Tuberculosis of other organs, Oesophagus[TUBERCULOSIS ALIORUM ORGANORUM]
+∞
6.3
6
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
6.2
114
683
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
12.6
6.1
10
8
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.5
6.1
46
191
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.0
350
2785
Mortality – FinRegistry
↥Association
Association between endpoint AB1_TUBERCU_OTH_ORG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TUBERCU_OTH_ORG | 1.523 [1.36, 1.71] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.42 |
During the follow-up period (1.1.1998 — 31.12.2019), 693 out of 1730 females with AB1_TUBERCU_OTH_ORG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TUBERCU_OTH_ORG | 1.85 [1.57, 2.18] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1311 males with AB1_TUBERCU_OTH_ORG died.
Mortality risk
Mortality risk for people of age
years, who have AB1_TUBERCU_OTH_ORG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | 0.383% |
| 5 | 0.859% | 2.039% |
| 10 | 2.049% | 5.092% |
| 15 | 4.14% | 9.389% |
| 20 | 7.541% | 15.862% |
Relationships between endpoints
↥Index endpoint: AB1_TUBERCU_OTH_ORG – Tuberculosis of other organs, strict
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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