Tuberculosis of other organs, strict

AB1_TUBERCU_OTH_ORG

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A18
  • Hospital discharge: ICD-9 0[1]
  • Hospital discharge: ICD-8 0[1]
  • Hospital discharge: excluded ICD-9 01[1-3]|018
  • Hospital discharge: excluded ICD-8 01[1-3]|018
  • Cause of death: ICD-10 A18
  • Cause of death: ICD-9 0[1]
  • Cause of death: ICD-8 0[1]
  • Cause of death: excluded ICD-9 01[1-3]|018
  • Cause of death: excluded ICD-8 01[1-3]|018

2 out of 7 registries used, show all original rules.

942

4. Check minimum number of events

None

942

5. Include endpoints

None

942

6. Filter based on genotype QC (FinnGen only)

893

Control definitions (FinnGen only)

Control exclude
AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14840 7877 6491
Only index persons 8037 4922 3115
Unadjusted period prevalence (%)
Whole population 0.21 0.23 0.18
Only index persons 0.16 0.18 0.12
Median age at first event (years)
Whole population 54.25 54.45 54.01
Only index persons 46.80 48.59 43.96

-FinnGen-

Key figures

All Female Male
Number of individuals 893 455 438
Unadjusted period prevalence (%) 0.18 0.16 0.20
Median age at first event (years) 48.72 45.67 51.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
941
Matched controls
9410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
129.2
121
*
01710
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum colli
+∞
125.9
118
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
36.4
87.4
55
16
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
52.6
50
*
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
51.5
49
*
01600
ICD-8 Finland
Tuberculosis of genito-urinary system, Renis
+∞
44.1
42
*
A18.4
ICD-10 Finland
Tuberculosis of skin and subcutaneous tissue
+∞
42.0
40
*
0172A
ICD-9 Finland
Tuberculosis of other organs, Peripheral lymph nodes
+∞
40.9
39
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
39.9
38
*
A18.8
ICD-10 Finland
Tuberculosis of other specified organs
+∞
35.6
34
*
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
35.6
34
*
A70
ICPC
Tuberculosis
181.5
34.0
35
*
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
+∞
32.5
31
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
9.2
30.9
38
43
01718
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum periphericorum aliorum
+∞
25.1
24
*
Y3429
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other inactive tuberculosis cases
+∞
22.0
21
*
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.7
21.2
50
111
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
20.9
20
*
01797
ICD-8 Finland
Tuberculosis of other organs, Suspecta
+∞
18.8
18
*
01500
ICD-8 Finland
Tuberculosis of bones and joints, Of vertebral column
+∞
18.8
18
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
18.8
18
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
39.3
18.6
23
6
N33.0*A18.1
ICD-10 Finland
Tuberculous cystitis
+∞
17.8
17
*
M01.1*A18.0
ICD-10 Finland
Tuberculous arthritis
+∞
16.7
16
*
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
16.7
16
*
1370X
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,MUU JÄLKITILA]
162.6
15.5
16
*
01909
ICD-8 Finland
Late effects of tuberculosis, Sequelae NUD o tuberculosis organorum respirationis
+∞
14.6
14
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.6
14.6
48
137
B90.2
ICD-10 Finland
Sequelae of tuberculosis of bones and joints
152.3
14.5
15
*
PJA10
NOMESCO Finland
Exploration of lymph nodes
5.8
14.2
26
46
01597
ICD-8 Finland
Tuberculosis of bones and joints, Suspecta
+∞
13.6
13
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
12.6
127
646
01608
ICD-8 Finland
Tuberculosis of genito-urinary system, Suspecta
+∞
12.5
12
*
L04AX01
ATC
azathioprine; systemic
3.4
12.5
45
137
01510
ICD-8 Finland
Tuberculosis of bones and joints, Of hip
+∞
11.5
11
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
11.5
11
*
01901
ICD-8 Finland
Late effects of tuberculosis, Emphysema
+∞
11.5
11
*
0151X
ICD-9 Finland
Tuberculosis of bones and joints, Hip[TUBERCULOSIS COXAE,EPÄILTY]
+∞
11.5
11
*
01930
ICD-8 Finland
Late effects of tuberculosis, Columnae vertebralis
+∞
11.5
11
*
01588
ICD-8 Finland
Tuberculosis of bones and joints, Of other specified bones and joints
+∞
11.5
11
*
01701
ICD-8 Finland
Tuberculosis of other organs, Erythema induratum tuberculosum
+∞
11.5
11
*
H02AB06
ATC
prednisolone; systemic
1.6
10.7
439
3343
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
+∞
10.4
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
10.2
131
726
H02AB07
ATC
prednisone; oral
1.8
9.7
152
896
01903
ICD-8 Finland
Late effects of tuberculosis, Fibrosis pulmonum
+∞
9.4
9
*
0150X
ICD-9 Finland
Tuberculosis of bones and joints, Vertebral column[SELKÄRANKATUBERKULOOSI,EPÄILTY]
+∞
9.4
9
*
H03.1*A18.4
ICD-10 Finland
Lupus vulgaris: of eyelid
+∞
9.4
9
*
H32.0*A18.5
ICD-10 Finland
Lupus chorioretinitis
+∞
9.4
9
*
R50.9
ICD-10 Finland
Fever, unspecified
1.8
9.2
141
825
J01MA12
ATC
levofloxacin; systemic
1.7
9.1
193
1240
J96.1
ICD-10 Finland
Chronic respiratory failure
3.1
8.9
36
118
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.5
8.9
54
221
C03CA01
ATC
furosemide; systemic
1.5
8.8
419
3256
M79.3
ICD-10 Finland
Panniculitis, unspecified
20.2
8.5
12
6
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
8.4
306
2238
01900
ICD-8 Finland
Late effects of tuberculosis, Bronchiectasia
+∞
8.3
8
*
01719
ICD-8 Finland
Tuberculosis of other organs, Lymphonodorum NUD
+∞
8.3
8
*
M90.0*A18.0
ICD-10 Finland
Bentuberculosis
+∞
8.3
8
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
8.3
8
*
0140X
ICD-9 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Tuberculous peritonitis[PERITONITIS TUBERCULOSA,EPÄILTY]
+∞
8.3
8
*
01604
ICD-8 Finland
Tuberculosis of genito-urinary system, Prostatae, vesiculae seminalis sive testis
+∞
8.3
8
*
01931
ICD-8 Finland
Late effects of tuberculosis, Coxae
+∞
8.3
8
*
K93.0*A18.3
ICD-10 Finland
Tuberculous disease of the intestines, peritoneum and mesentery glands
+∞
8.3
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
8.3
220
1497
C03DA01
ATC
spironolactone; oral
1.8
8.2
145
884
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
8.0
147
906
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
4.4
7.7
19
44
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
7.7
155
981
G04AB05, ,
ATC
3.1
7.7
32
107
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.7
424
3367
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
7.5
101
567
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
7.4
51
221
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.0
7.4
31
104
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
7.4
164
1065
N29.1*A18.1
ICD-10 Finland
Tuberculosis of the kidney or ureter
+∞
7.3
7
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
7.3
7
*
1373X
ICD-9 Finland
Late effects of tuberculosis of bones and joints
+∞
7.3
7
*
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
+∞
7.3
7
*
0178X
ICD-9 Finland
Tuberculosis of other organs, Oesophagus[TUBERCULOSIS ALIORUM ORGANORUM]
+∞
7.3
7
*
A18.5
ICD-10 Finland
Tuberculosis of eye
+∞
7.3
7
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.9
7.2
86
464
SPAT1254
SPAT
Administration of medicine
1.7
7.2
160
1038
P01BA02
ATC
hydroxychloroquine; oral
2.0
7.1
72
366
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
7.1
128
786
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.0
366
2859
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.9
264
1941
49300
ICD-8 Finland
Asthma, bronchiale
2.9
6.8
31
109
4701
FHL
Neck lymph node removal
40.3
6.8
8
*
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
40.3
6.8
8
*
S01AD03
ATC
aciclovir; ophthalmic
2.5
6.8
41
168
A46
ICD-10 Finland
Erysipelas
1.6
6.7
148
957
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
6.7
343
2665
R03DA04
ATC
theophylline; systemic, rectal
1.9
6.7
80
432
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
7.9
6.6
14
18
H02AB04
ATC
methylprednisolone; systemic
1.7
6.6
132
832
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.4
6.6
23
69
212
Kela drug reimbursment
Gout
2.9
6.6
30
106
R03AC12
ATC
salmeterol; inhalant
2.1
6.6
60
294
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
2.8
6.5
32
118
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
2.1
6.5
57
275
J01DA01
ATC
[U] cefalexin
1.4
6.4
541
4587
40299
ICD-8 Finland
Hypertensive heart disease
4.1
6.4
17
42
M04AA01
ATC
allopurinol; systemic
1.6
6.4
155
1027
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
11.1
6.3
11
10
I50.0
ICD-10 Finland
Congestive heart failure
1.7
6.3
118
731
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
2.8
6.3
30
109
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
6.3
6
*
01407
ICD-8 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Suspecta
+∞
6.3
6
*
01731
ICD-8 Finland
Tuberculosis of other organs, Otitis media tuberculosa
+∞
6.3
6
*
01401
ICD-8 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands, Peritonei et lymphonodorum mesenterii
+∞
6.3
6
*
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
+∞
6.3
6
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
6.3
6
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.9
6.2
28
98
R03BA01
ATC
beclometasone; inhalant
1.7
6.2
128
813
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
6.2
64
329
KCD02
NOMESCO Finland
Transurethral resection of bladder
2.6
6.0
34
135

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
109
4.29
17.15
4.0
2.6
—
—
—
0
0
24
43
5.70
12.94
1.1
1.2
—
—
—
0
0
24
45
5.45
12.34
2.3
2.4
—
—
—
0
0
49
164
3.10
11.64
1.7
2.0
11.33
13.43
mg/l
0.95
42
148
97
462
2.23
11.31
2.7
2.8
10.73
10.66
g/l
0.05
87
417
132
714
1.99
11.02
1.7
1.6
—
—
—
0
0
52
189
2.85
10.71
1.2
1.2
0.33
2.02
u/ml
—
6
14
134
756
1.90
9.85
1.4
1.3
477.71
458.10
titre
0.06
35
168
396
3064
1.50
8.35
10.1
5.6
—
—
—
0
0
74
366
2.11
7.86
1.7
1.7
1.01
1.51
g/l
1.43
62
328
10
5
20.19
7.14
1.2
1.0
—
—
—
0
0
128
785
1.73
7.09
1.8
1.4
—
—
—
0
0
26
81
3.27
7.01
1.7
1.6
0.76
0.74
g/l
0.04
17
67
145
928
1.66
6.86
6.1
7.4
1.18
1.39
mmol/l
0.25
119
717
88
487
1.89
6.84
4.3
3.8
7.40
7.39
ph
0.04
12
54
145
931
1.66
6.77
6.0
7.3
5.21
5.07
kpa
0.62
138
881
145
932
1.66
6.74
6.0
7.3
11.16
11.64
kpa
0.67
137
882
132
829
1.69
6.70
6.1
7.7
94.81
95.36
%
0.35
127
797
162
1076
1.61
6.60
2.8
2.0
—
—
—
0
0
423
3425
1.43
6.57
9.2
5.3
0.19
0.20
e9/l
0.71
373
2968
96
558
1.80
6.39
3.9
5.0
—
—
—
0
0
298
2273
1.46
6.35
5.0
4.2
—
—
—
0
0
67
348
2.00
6.27
1.8
1.9
7.82
2.34
ug/l
0.44
57
294
406
3296
1.41
6.06
8.9
5.1
0.59
0.60
e9/l
0.28
353
2816
407
3309
1.41
6.01
8.9
5.1
0.04
0.04
e9/l
1.09
356
2829
9
6
15.12
5.91
1.0
1.0
—
—
—
0
0
413
3374
1.40
5.89
9.1
5.2
1.69
1.86
e9/l
2.18
370
2953
24
81
3.01
5.72
1.5
1.4
119.29
118.19
u/ml
—
7
16
450
3749
1.38
5.63
7.6
5.8
10.90
11.81
umol/l
1.14
424
3530
34
142
2.45
5.43
1.1
1.2
2.23
2.89
u/ml
—
6
19
29
112
2.64
5.43
1.2
1.2
48.15
43.62
u/ml
—
8
12
31
124
2.55
5.41
1.5
1.2
—
—
—
0
0
130
859
1.60
5.38
2.3
1.7
—
—
—
0
0
240
1815
1.43
5.20
3.6
2.8
1526.67
9253.63
umol/l
4.50
211
1523
163
1143
1.52
5.18
4.1
3.0
0.81
0.82
mmol/l
0.41
158
1052
449
3772
1.36
5.18
8.5
6.5
1.22
1.21
mmol/l
0.07
388
3169
56
294
1.96
5.13
4.2
4.3
24.95
25.09
mmol/l
0.12
50
273
70
398
1.82
5.04
7.5
10.7
—
—
—
0
0
65
362
1.85
5.00
3.8
3.9
—
—
—
0
0
14
28
5.06
4.95
1.6
1.7
941.50
859.68
u/ml
0.08
14
28
143
985
1.53
4.93
1.3
1.2
25.78
38.62
iu/ml
1.15
45
321
23
84
2.78
4.80
1.6
1.2
264.25
298.16
u/ml
0.20
12
43
282
2223
1.38
4.75
2.7
2.4
64.64
96.63
u/l
0.41
261
2036
30
128
2.39
4.61
2.2
1.5
—
—
—
0
0
27
110
2.50
4.58
1.7
1.5
—
—
—
0
0
381
3171
1.34
4.47
10.4
5.5
25.18
26.18
%
0.98
354
2937
375
3119
1.34
4.41
9.9
5.2
60.06
58.43
%
1.66
349
2896
410
3459
1.33
4.35
7.8
5.9
1.21
1.21
mmol/l
0.01
386
3092
8
9
8.95
4.28
1.3
1.2
—
—
—
0
0
453
3888
1.32
4.22
12.1
8.3
4.56
4.27
e9/l
1.15
397
3386
57
323
1.81
4.18
3.4
2.9
—
—
—
0
0
49
265
1.90
4.16
4.0
2.9
0.37
0.26
g/l
0.48
19
91
23
91
2.57
4.15
1.6
1.4
—
—
—
0
0
372
3112
1.32
4.13
10.7
5.5
8.64
8.84
%
0.55
344
2880
8
10
8.06
4.06
1.0
1.0
—
—
—
0
0
15
48
3.16
3.94
2.1
1.3
8.61
7.89
g/l
—
9
36
15
48
3.16
3.94
2.1
1.3
2.60
2.83
g/l
—
9
36
15
48
3.16
3.94
2.1
1.3
0.57
0.46
g/l
—
9
36
166
1231
1.42
3.93
3.1
2.4
11.17
11.99
umol/l
0.85
151
1133
369
3100
1.31
3.93
10.2
5.2
2.81
2.88
%
0.17
343
2862
361
3024
1.31
3.92
10.3
5.3
0.65
0.64
%
0.02
337
2790
258
2065
1.34
3.83
2.8
2.2
3.02
3.16
mg/l
0.42
223
1725
325
2693
1.32
3.79
4.5
3.9
5.79
5.89
ph
—
7
125
35
174
2.05
3.78
2.9
1.7
13668.48
17761.95
e6/l
0.26
23
123
15
50
3.03
3.70
2.1
1.3
—
—
—
0
0
17
62
2.77
3.60
1.1
1.2
—
—
—
0
0
89
594
1.55
3.56
2.0
1.8
382.50
381.47
nmol/l
0.01
80
527
13
36
3.65
3.50
1.1
1.2
—
—
—
0
0
90
606
1.54
3.46
1.6
1.4
—
—
—
0
0
145
1076
1.41
3.42
3.2
2.4
21.48
21.14
%
0.09
118
913
96
660
1.51
3.36
8.3
7.8
—
—
—
0
0
80
529
1.56
3.34
5.0
4.0
0.19
0.12
%
0.43
37
182
277
2280
1.30
3.32
5.3
3.8
7.40
7.40
ph
0.13
56
420
560
5039
1.27
3.28
6.8
4.1
17.73
14.72
mm/h
3.19
518
4556
98
683
1.49
3.22
2.1
2.8
66.55
65.92
g/l
0.34
82
609
83
561
1.53
3.16
5.1
3.9
1.14
0.84
%
0.41
40
214
314
2651
1.28
3.05
3.7
3.2
1787.78
2008.32
ng/l
0.39
272
2278
75
500
1.54
3.04
5.3
3.8
0.74
0.56
%
0.33
34
178
7
12
5.87
3.02
1.3
1.7
93.69
88.42
ng/l
—
7
12
149
1139
1.37
2.94
3.1
2.3
2.25
2.29
g/l
0.36
133
1036
383
3331
1.25
2.86
5.6
4.4
33.91
34.58
g/l
1.30
354
3054
56
354
1.62
2.85
1.4
1.3
—
—
—
0
0
131
988
1.38
2.81
2.6
2.4
1.83
1.82
%
0.01
110
863
17
71
2.42
2.81
1.3
1.2
1.38
7.14
u/ml
—
8
28
34
188
1.84
2.78
1.8
3.9
—
—
—
0
0
83
578
1.48
2.76
2.2
2.5
—
—
—
0
0
17
72
2.39
2.73
1.2
1.3
—
—
—
0
0
25
125
2.03
2.73
1.2
1.2
3.83
3.80
mmol/l
0.04
25
116
147
1137
1.35
2.70
1.6
1.5
2.83
2.61
g/l
0.40
93
638
78
543
1.48
2.61
1.6
1.4
—
—
—
0
0
7
15
4.69
2.60
1.0
1.0
1366.14
1314.53
miu/ml
—
7
15
99
723
1.41
2.58
2.3
2.4
70.10
67.91
e9/l
0.22
72
571
6
11
5.48
2.54
1.3
1.5
—
—
—
0
0
50
319
1.60
2.49
5.6
4.4
—
—
—
0
0
29
159
1.85
2.46
4.7
4.0
—
—
—
0
0
386
3403
1.23
2.45
5.1
4.3
0.00
0.00
estimate
0.50
86
693
421
3747
1.22
2.43
17.6
19.0
1.37
1.35
inr
0.18
109
1019
42
259
1.65
2.40
1.5
1.4
—
—
—
0
0
269
2286
1.25
2.39
2.3
2.1
164.80
288.35
u/l
1.52
243
2131
5
8
6.28
2.37
5.6
2.6
—
—
—
0
0
531
4846
1.22
2.36
6.5
4.7
—
—
—
0
0
334
2909
1.23
2.36
2.7
2.2
77.39
79.02
nmol/l
0.42
299
2516
71
496
1.47
2.36
5.2
4.1
0.07
0.68
%
0.53
28
151
123
947
1.34
2.34
1.4
1.2
20.30
13.51
u/ml
0.26
43
325
587
6299
0.82
2.28
4.9
4.5
4.41
4.49
mmol/l
1.04
530
5647
23
120
1.94
2.27
1.5
1.3
—
—
—
0
0
241
2035
1.25
2.26
3.7
2.9
33.48
36.22
u/l
0.42
229
1927
146
1159
1.31
2.25
2.4
1.9
30.36
29.78
s
0.47
140
1116
197
1626
1.27
2.24
4.9
4.2
—
—
—
0
0
99
742
1.37
2.24
5.6
4.2
—
—
—
0
0
18
86
2.11
2.24
2.2
2.2
—
—
—
0
0
27
150
1.82
2.22
4.0
2.7
—
—
—
0
0
202
1678
1.26
2.18
3.6
2.6
5.12
5.49
e6/l
0.16
179
1510
39
243
1.63
2.16
4.8
7.4
1.30
1.38
mmol/l
0.29
33
214
529
4851
1.21
2.15
7.1
5.3
84.40
3164.91
e6/l
2.22
15
93
31
182
1.73
2.14
1.5
1.6
—
—
—
0
0
582
6234
0.83
2.13
4.7
4.5
1.45
1.46
mmol/l
0.43
520
5544
21
109
1.95
2.11
1.9
2.6
—
—
—
0
0
20
102
1.98
2.11
1.3
1.3
—
—
—
0
0
8
25
3.22
2.10
1.3
1.1
460.88
187.38
iu/ml
—
8
25
8
25
3.22
2.10
1.0
1.4
—
—
—
0
0
29
168
1.75
2.09
3.8
2.0
120.82
124.96
g/l
0.37
22
121
16
75
2.15
2.09
1.8
1.2
—
—
—
0
0
67
475
1.44
2.09
1.5
1.4
—
—
—
0
0
202
1686
1.25
2.09
8.3
6.3
—
—
—
0
0
102
778
1.35
2.08
4.6
3.3
1.88
2.08
mmol/l
0.25
90
626
87
647
1.38
2.07
2.3
2.0
107.80
155.37
ug/g
1.40
63
504
22
117
1.90
2.07
4.0
2.9
4.38
4.61
e9/l
0.15
22
117
88
656
1.38
2.07
4.9
3.7
—
—
—
0
0
59
409
1.47
2.06
4.0
3.0
4.43
6.48
e9/l
0.92
44
300
92
694
1.36
2.01
2.9
2.1
0.19
0.20
g/l
0.82
84
640
468
4262
1.20
2.00
5.9
4.9
6.61
6.84
mmol/l
2.06
449
3999
84
626
1.38
1.99
5.5
3.5
110.98
91.20
ng/l
0.89
76
533
27
156
1.75
1.98
4.3
2.2
14.77
15.40
%
0.30
16
72
118
927
1.31
1.97
1.3
1.2
—
—
—
0
0
7
21
3.35
1.96
1.1
1.0
—
—
—
0
0
18
91
2.00
1.96
1.1
1.1
—
—
—
0
0
88
663
1.36
1.95
3.3
2.8
3.97
4.37
kpa
1.24
83
636
611
6493
0.83
1.94
5.3
5.1
2.54
2.60
mmol/l
0.81
547
5797
5
11
4.56
1.94
1.6
1.5
—
—
—
0
0
5
11
4.56
1.94
1.8
1.9
—
—
—
0
0
304
2667
1.21
1.94
4.5
3.7
—
—
—
0
0
383
3433
1.20
1.93
5.1
4.3
0.00
0.00
estimate
0.50
78
615
34
212
1.63
1.91
2.8
1.9
21.33
21.73
s
0.26
27
191
7
22
3.20
1.88
1.1
1.0
—
—
—
0
0
57
401
1.45
1.87
1.7
1.7
1.48
1.57
g/l
0.29
51
355
228
1952
1.22
1.86
1.7
1.6
18.23
20.86
nmol/l
1.81
199
1623
377
3389
1.19
1.82
6.8
5.7
0.00
0.00
estimate
-0.00
78
628
19
101
1.90
1.81
1.2
1.2
—
—
—
0
0
22
123
1.81
1.81
5.3
3.2
59.36
60.89
%
0.22
22
123
12
53
2.28
1.81
1.0
1.1
—
—
—
0
0
7
23
3.06
1.80
2.3
2.0
—
—
—
0
0
7
23
3.06
1.80
1.1
1.1
—
25.40
—
0
5
40
264
1.54
1.79
2.0
3.7
45.45
81.28
mg/l
0.84
28
219
220
1884
1.22
1.78
5.4
4.5
0.00
0.01
estimate
0.69
72
601
40
265
1.53
1.76
2.0
3.7
27.33
51.26
mg/l
1.10
28
221
7
24
2.93
1.72
1.0
1.1
181.00
150.53
mmol/24h
—
7
24
97
757
1.31
1.72
2.6
2.6
5.89
5.54
ug/l
0.10
80
633
16
82
1.97
1.70
1.9
1.2
0.69
0.63
nmol/l
0.13
16
75
45
310
1.47
1.67
1.6
1.2
—
—
—
0
0
17
90
1.91
1.66
1.6
1.5
—
—
—
0
0
10
41
2.45
1.64
1.1
1.1
—
105.71
—
0
7
236
2053
1.20
1.62
4.4
3.3
—
—
—
0
0
17
91
1.88
1.61
1.4
1.3
—
—
—
0
0
32
208
1.56
1.56
1.4
1.5
—
—
—
0
0
45
317
1.44
1.51
2.8
2.5
10.68
10.50
g/l
0.09
34
276
16
86
1.88
1.51
4.1
4.3
—
—
—
0
0
353
3198
1.17
1.49
3.1
2.7
—
—
—
0
0
10
203
0.49
1.48
1.4
1.5
—
—
—
0
0
201
1740
1.20
1.45
1.8
1.8
71598063.02
11946078.54
pmol/l
0.39
169
1398
99
795
1.27
1.44
2.7
2.7
7.02
8.93
umol/l
1.07
88
689
6
22
2.74
1.43
1.2
1.1
—
—
—
0
0
298
2674
1.17
1.41
5.6
3.9
241.85
140.22
e6/l
0.27
221
1960
338
3064
1.16
1.40
4.9
4.2
36.73
55.16
ng/l
0.92
269
2330
22
134
1.66
1.40
1.6
1.5
—
—
—
0
0
157
1829
0.83
1.34
3.5
3.2
—
—
—
0
0
571
6021
0.87
1.32
4.4
4.1
1.28
1.26
mmol/l
0.27
505
5291
17
98
1.75
1.31
1.8
1.7
87.58
89.61
%
0.44
17
98
569
5371
1.15
1.31
11.3
7.2
82.39
80.31
u/l
0.42
543
4978
172
1483
1.20
1.30
1.9
1.6
2.35
1.33
mg/l
0.94
137
1157
16
91
1.77
1.29
1.0
1.0
—
—
—
0
0
49
362
1.37
1.29
1.4
1.3
—
—
—
0
0
5
18
2.79
1.28
1.6
1.3
—
—
—
0
0
17
277
0.61
1.24
1.3
1.4
—
—
—
0
0
9
45
2.01
1.23
1.2
1.0
—
—
—
0
0
5
19
2.64
1.21
1.2
1.2
—
—
—
0
0
261
2345
1.16
1.20
4.8
3.5
84.67
103.94
e6/l
0.16
208
1831
8
39
2.06
1.15
5.4
1.4
—
—
—
0
0
5
21
2.39
1.09
1.4
2.1
—
—
—
0
0
144
1658
0.84
1.09
1.7
1.6
1.40
1.31
mmol/l
0.74
124
1375
51
392
1.32
1.08
1.3
1.2
—
—
—
0
0
71
571
1.26
1.07
1.5
1.4
—
—
—
0
0
14
82
1.72
1.05
1.5
1.2
—
—
—
0
0
312
2865
1.13
1.03
3.6
2.7
160.67
138.59
ug/l
0.86
284
2571
503
5303
0.89
1.03
31.7
22.5
330.08
330.98
g/l
1.22
497
5235
192
1708
1.16
1.01
3.2
2.4
—
—
—
0
0
77
632
1.24
0.99
4.3
3.8
1.22
1.22
mmol/l
0.07
71
541
9
159
0.56
0.99
1.1
1.3
—
—
—
0
0
698
7208
0.88
0.99
35.6
24.8
129.58
131.64
g/l
3.00
690
7043
698
7208
0.88
0.99
35.4
24.6
7.29
6.90
e9/l
0.78
676
6943
698
7207
0.88
0.98
35.4
24.6
4.33
4.36
e12/l
0.81
677
6945
698
7207
0.88
0.98
35.2
24.5
30.23
30.36
pg
1.04
687
7042
698
7205
0.88
0.97
35.3
24.5
91.51
91.62
fl
0.24
687
7042
9
50
1.81
0.96
1.2
1.3
—
—
—
0
0
698
7204
0.88
0.96
35.4
24.6
244.60
242.24
e9/l
0.38
681
6961
698
7204
0.88
0.96
35.6
24.7
38.52
39.04
%
1.07
636
6608
655
6782
0.89
0.93
22.8
16.1
—
—
—
0
0
183
1633
1.15
0.93
4.0
3.1
515.44
539.64
mosm/kgh2o
1.00
160
1389
67
546
1.24
0.93
1.7
1.5
—
—
—
0
0
9
52
1.74
0.92
1.4
1.7
10.40
10.92
%
—
9
52
26
185
1.42
0.90
3.1
4.1
52.39
28.34
mg/l
1.32
20
123
25
177
1.42
0.89
2.8
2.5
—
—
—
0
0
37
281
1.33
0.88
2.7
2.1
—
—
—
0
0
10
56
1.79
0.88
1.3
1.2
30.40
34.13
mmol/l
—
10
50
23
161
1.44
0.87
1.1
1.1
—
—
—
0
0
282
2602
1.12
0.85
2.3
2.2
—
—
—
0
0
25
179
1.41
0.84
3.5
4.4
3.26
2.87
mmol/l
0.20
19
118
315
2930
1.11
0.82
15.0
9.7
0.00
0.00
e9/l
0.82
259
2380
23
164
1.41
0.80
1.1
1.1
—
—
—
0
0
40
314
1.29
0.77
1.3
1.4
—
—
—
0
0
194
1763
1.13
0.76
1.8
1.8
1181.13
1202.90
nmol/l
0.13
151
1293
0
28
0.00
0.76
0.0
1.5
—
173.37
—
0
28
82
699
1.19
0.76
1.3
1.3
—
—
—
0
0
233
2143
1.12
0.75
4.6
3.3
0.24
0.59
e6/l
4.51
190
1661
12
76
1.59
0.72
1.9
1.2
—
—
nmol/l
—
0
0
622
6420
0.91
0.71
5.1
4.9
5.99
6.07
mmol/l
0.85
552
5675
18
126
1.44
0.70
1.7
2.1
—
—
—
0
0
675
6937
0.90
0.70
15.5
10.6
24.04
24.19
u/l
0.08
656
6612
14
93
1.51
0.69
1.8
1.2
157551.11
102490.23
e6/l
—
9
52
13
85
1.54
0.69
1.1
1.2
—
—
—
0
0
11
69
1.60
0.68
1.3
1.3
—
—
—
0
0
15
102
1.48
0.67
1.5
1.4
—
—
—
0
0
21
153
1.38
0.67
1.4
1.1
—
65.83
—
0
12
5
28
1.79
0.66
1.6
1.3
—
—
—
0
0
5
29
1.73
0.64
4.2
3.7
—
—
—
0
0
5
29
1.73
0.64
2.0
2.2
44.71
46.91
umol/l
—
5
23
38
306
1.25
0.63
4.7
3.6
1.42
1.44
mmol/l
0.03
38
300
169
1543
1.12
0.63
6.3
4.8
1.01
1.02
kg/l
0.69
26
229
12
79
1.53
0.62
1.0
1.1
—
—
—
0
0
6
103
0.58
0.62
1.3
1.6
34.83
43.55
nmol/l
—
6
97
5
30
1.67
0.61
1.0
1.0
140.80
570.38
u/l
—
5
24
596
6142
0.92
0.60
6.7
6.4
40.87
40.99
mmol/mol
0.12
551
5551
0
20
0.00
0.60
0.0
1.7
—
—
—
0
0
10
64
1.57
0.58
2.2
1.3
718.40
114986.87
e6/l
—
5
46
281
2643
1.09
0.58
3.0
3.2
2.34
2.35
mmol/l
0.79
243
2248
10
149
0.67
0.57
1.7
1.8
—
—
—
0
0
227
2122
1.09
0.54
3.4
3.1
982.41
247.35
mg/l
0.83
146
1345
9
62
1.46
0.53
1.1
1.2
—
—
—
0
0
241
2267
1.08
0.50
3.1
2.5
—
—
—
0
0
465
4815
0.93
0.49
5.0
4.3
—
—
—
0
0
7
45
1.56
0.49
2.0
3.0
—
—
—
0
0
7
46
1.53
0.48
1.6
1.2
—
—
—
0
0
237
2232
1.08
0.48
4.7
4.3
—
—
—
0
0
7
47
1.49
0.47
1.3
14.4
—
—
—
0
0
142
1308
1.10
0.47
3.8
2.9
1.34
1.30
e6/l
0.04
94
763
10
68
1.48
0.47
4.5
3.7
14.29
34.10
mg/l
—
10
55
33
273
1.22
0.46
1.9
2.5
35.53
36.79
g/l
0.54
23
233
5
31
1.62
0.43
4.2
6.3
—
—
—
0
0
93
843
1.11
0.42
3.2
3.7
49.12
27.64
ug/l
0.22
74
702
592
6061
0.94
0.42
5.3
4.8
1.97
2.01
mu/l
0.30
534
5377
48
416
1.16
0.42
2.4
2.6
—
—
—
0
0
17
131
1.30
0.42
1.6
1.9
51.83
59.29
%
0.54
17
131
8
57
1.41
0.42
1.0
1.1
—
—
—
0
0
166
1551
1.09
0.41
4.6
4.2
642.54
213.19
ng/l
0.58
143
1322
5
33
1.52
0.41
1.8
1.8
—
—
—
0
0
8
60
1.34
0.40
1.3
1.3
—
—
—
0
0
228
2162
1.07
0.39
3.5
3.1
6.52
6.89
mmol/l
0.75
189
1765
10
71
1.41
0.39
1.1
1.1
—
—
—
0
0
543
5564
0.94
0.38
26.9
19.9
15.65
15.28
%
0.71
536
5440
5
36
1.39
0.38
1.0
1.1
153.80
133.97
nmol/l
—
5
36
19
235
0.80
0.37
1.4
1.2
—
—
—
0
0
237
2259
1.07
0.35
4.1
3.7
18.59
9.55
mg/mmol
0.92
150
1414
21
255
0.82
0.35
4.2
5.1
—
—
—
0
0
55
490
1.13
0.35
3.5
3.6
—
—
—
0
0
73
663
1.11
0.34
3.1
2.3
41.18
32.54
u/l
0.52
65
549
38
435
0.87
0.34
4.6
4.2
—
—
—
0
0
6
86
0.70
0.33
1.0
1.6
—
—
—
0
0
52
581
0.89
0.33
1.5
1.6
—
—
—
0
0
12
92
1.31
0.32
1.0
1.1
—
—
—
0
0
138
1297
1.07
0.31
1.3
1.2
2.58
1.28
u/ml
0.51
39
315
25
212
1.18
0.30
1.5
1.4
298.11
271.51
ug/g
0.24
16
121
14
112
1.25
0.28
1.4
1.4
27.26
29.26
iu/l
—
9
90
333
3233
1.05
0.26
2.2
2.1
89.96
93.71
pmol/l
0.78
180
1625
29
255
1.14
0.24
3.5
3.3
0.82
0.85
nmol/l
0.20
24
205
6
82
0.73
0.24
2.7
2.8
—
—
—
0
0
11
88
1.25
0.22
1.1
1.3
—
—
—
0
0
11
88
1.25
0.22
1.1
1.3
—
—
—
0
0
47
429
1.10
0.22
1.2
1.2
—
—
—
0
0
7
94
0.74
0.22
1.3
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
55.73
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
17.22
—
0
12
11
89
1.24
0.21
6.1
4.5
370.00
354.95
umol/l
0.15
11
80
11
89
1.24
0.21
1.1
1.3
—
—
—
0
0
11
89
1.24
0.21
1.1
1.3
—
—
—
0
0
6
48
1.25
0.20
1.5
1.6
—
—
—
0
0
6
50
1.20
0.19
1.3
1.2
—
—
—
0
0
64
598
1.08
0.19
5.2
4.0
—
—
—
0
0
400
3921
1.04
0.19
4.4
3.1
62.90
52.45
u/l
0.90
371
3550
6
51
1.18
0.19
1.2
1.1
—
—
—
0
0
6
53
1.13
0.18
1.5
1.2
—
—
—
0
0
6
53
1.13
0.18
1.0
1.2
—
—
—
0
0
11
132
0.83
0.18
1.6
2.5
—
—
—
0
0
120
1249
0.96
0.16
3.0
3.2
0.62
0.83
ug/l
2.56
81
862
8
70
1.14
0.16
1.4
2.2
—
—
—
0
0
128
1233
1.04
0.15
4.4
3.2
4.23
2.48
e6/l
0.83
81
699
6
80
0.75
0.15
9.8
3.4
—
—
—
0
0
9
82
1.10
0.15
1.1
1.3
—
—
—
0
0
11
128
0.86
0.13
4.4
2.5
—
—
—
0
0
691
6960
0.97
0.12
27.6
20.4
4.01
4.00
mmol/l
0.26
673
6737
17
189
0.90
0.12
1.4
1.2
—
—
—
0
0
11
95
1.16
0.11
1.0
1.3
161.60
216.65
miu/ml
—
5
43
18
198
0.91
0.10
4.0
2.8
—
—
—
0
0
36
339
1.06
0.10
1.1
1.2
79.33
136.26
iu/ml
—
9
121
184
1802
1.03
0.10
4.9
4.0
—
—
—
0
0
5
46
1.09
0.09
11.4
3.2
—
—
—
0
0
21
226
0.93
0.08
14.7
11.0
—
—
—
0
0
691
6944
0.98
0.08
27.5
20.3
139.24
139.55
mmol/l
2.04
675
6731
226
2227
1.02
0.08
4.8
5.4
3.30
5.31
ug/l
0.47
197
1940
494
4974
0.99
0.07
4.3
3.9
15.41
15.06
pmol/l
2.25
447
4375
86
840
1.03
0.06
1.4
1.3
—
—
—
0
0
156
1583
0.98
0.05
3.0
3.1
2.46
2.46
mmol/l
0.09
138
1374
669
6667
1.01
0.04
25.9
16.9
26.73
26.62
mg/l
0.03
590
5430
23
220
1.05
0.03
5.3
3.5
—
—
—
0
0
13
137
0.95
0.01
1.5
1.6
2.16
4.61
iu/l
—
5
43
19
188
1.01
0.00
2.2
2.3
39.86
73.47
ug/min
1.01
11
112
156
1562
1.00
0.00
1.3
1.3
—
—
—
0
0
14
139
1.01
0.00
1.1
1.2
—
—
—
0
0
18
185
0.97
0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.8
—
—
—
0
0
6
60
1.00
-0.00
3.2
2.7
—
—
—
0
0
5
57
0.88
-0.00
1.4
1.1
—
—
—
0
0
5
57
0.88
-0.00
1.4
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
1.2
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_TUBERCU_OTH_ORG and mortality.

Females

Parameter HR [95% CI] p-value
AB1_TUBERCU_OTH_ORG 1.523 [1.36, 1.71] < 0.001
Birth year 0.997 [0.99, 1.01] 0.42

During the follow-up period (1.1.1998 — 31.12.2019), 693 out of 1730 females with AB1_TUBERCU_OTH_ORG died.

Males

Parameter HR [95% CI] p-value
AB1_TUBERCU_OTH_ORG 1.85 [1.57, 2.18] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1311 males with AB1_TUBERCU_OTH_ORG died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TUBERCU_OTH_ORG.

N-year risk Females Males
1 0.092% 0.383%
5 0.859% 2.039%
10 2.049% 5.092%
15 4.14% 9.389%
20 7.541% 15.862%

Relationships between endpoints

Index endpoint: AB1_TUBERCU_OTH_ORG – Tuberculosis of other organs, strict

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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