Malignant neoplasm of oropharynx, excluding all cancers (controls excluding all cancers)

C3_OROPHARYNG_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C10
  • Hospital discharge: ICD-9 146
  • Hospital discharge: ICD-8 146
  • Cause of death: ICD-10 C10
  • Cause of death: ICD-9 146
  • Cause of death: ICD-8 146
  • Cause of death: excluded ICD-9 1460A
  • Cancer registry: Topography ICD-O-3 C10
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

169

4. Check minimum number of events

None

169

5. Include endpoints

None

169

6. Filter based on genotype QC (FinnGen only)

169

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of oropharynx, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 169 56 113
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 64.23 61.26 65.70

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
50
Matched controls
498
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
47.8
38
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
388.8
34.5
31
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
710.7
34.3
30
*
WF002
NOMESCO Finland
Radical radiotherapy
563.2
30.2
27
*
A03FA01
ATC
metoclopramide; systemic, rectal
36.6
24.7
34
27
N02AA05
ATC
oxycodone; systemic
33.4
23.5
33
27
R4190
NOMESCO Finland
Nutritional therapy
68.7
22.6
25
7
8070/3-C10.9
ICD-O-3
Squamous cell carcinoma, NOS, of oropharynx, NOS
+∞
21.4
19
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
21.4
19
*
C10.3
ICD-10 Finland
Malignant neoplasm: Posterior wall of oropharynx
+∞
18.9
17
*
H02AB02
ATC
dexamethasone; systemic
250.2
17.7
17
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
16.6
15
*
UJC01
NOMESCO Finland
Scopy of lower throat
+∞
16.6
15
*
A04AA01
ATC
ondansetron; systemic, rectal
54.5
15.7
18
5
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
15.4
14
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
14.2
13
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
14.2
13
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
24.9
12.3
17
10
C10.0
ICD-10 Finland
Malignant neoplasm: Vallecula
+∞
10.8
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
8.2
10.7
31
83
XX3DW
NOMESCO Finland
Time consuming IT work
23.0
10.7
15
9
EBA15
NOMESCO Finland
Extraction of large number of teeth
27.0
10.5
14
7
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
34.2
10.4
13
5
C10.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of oropharynx
+∞
9.7
9
*
GBB00
NOMESCO Finland
Tracheostomy
30.8
9.4
12
5
SAA03
NOMESCO Finland
Extended examination of mouth
6.4
8.8
34
124
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
18.9
8.8
13
9
WF003
NOMESCO Finland
Adjuvant radiotherapy
107.4
8.7
9
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
+∞
8.6
8
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
8.6
8
*
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
+∞
8.6
8
*
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
8.6
8
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
30.5
7.9
10
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
93.4
7.6
8
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
7.5
7
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
7.5
7
*
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
7.5
7
*
C10.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of oropharynx
+∞
7.5
7
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
+∞
7.5
7
*
R4110
NOMESCO Finland
Physiotherapy
5.6
7.1
25
76
A02BC05
ATC
esomeprazole; systemic
5.2
7.0
34
144
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
8.8
7.0
15
23
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
26.8
6.9
9
*
WX402
NOMESCO Finland
General anaesthesia
6.6
6.7
18
39
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
8.8
6.6
14
21
Z51.5
ICD-10 Finland
Palliative care
21.4
6.5
9
5
WW500
NOMESCO Finland
Blood transfusion
31.0
6.4
8
*
JN4BD
NOMESCO Finland
Extensive body CT
12.4
6.4
11
11
8070/3-C10.3
ICD-O-3
Squamous cell carcinoma, NOS, of posterior wall of oropharynx
+∞
6.4
6
*
Z3226
NOMESCO Finland
Physiotherapist
5.5
6.2
20
54
A06AD11
ATC
lactulose; oral
6.2
6.1
17
38
R13
ICD-10 Finland
Dysphagia
13.5
6.1
10
9

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_OROPHARYNG_EXALLC – Malignant neoplasm of oropharynx, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).