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This is a non-core endpoint: only basic statistics are computed.

Malignant neoplasm of oropharyng

C3_OROPHARYNG

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C10
  • Cause of death: ICD-9 146
  • Cause of death: ICD-8 146
  • Cause of death: excluded ICD-9 1460A
  • Cancer registry: Topography ICD-O-3 C10
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

60

4. Check minimum number of events

None

60

5. Include endpoints

None

60

6. Filter based on genotype QC (FinnGen only)

57

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 57 18 39
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 67.89 67.83 67.92

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
60
Matched controls
600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
58.0
46
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
+∞
47.3
39
*
A03FA01
ATC
metoclopramide; systemic, rectal
30.0
41.6
39
35
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
464.7
41.5
37
*
N02AA05
ATC
oxycodone; systemic
21.3
33.7
38
45
WF002
NOMESCO Finland
Radical radiotherapy
580.9
33.3
30
*
C10.3
ICD-10 Finland
Malignant neoplasm: Posterior wall of oropharynx
+∞
22.3
20
*
R4190
NOMESCO Finland
Nutritional therapy
90.9
21.8
23
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
21.1
19
*
8070/3-C10.9
ICD-O-3
Squamous cell carcinoma, NOS, of oropharynx, NOS
+∞
21.1
19
*
H02AB02
ATC
dexamethasone; systemic
90.5
18.0
19
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
17.5
16
*
WZC00
NOMESCO Finland
Treatment plan or consultation
9.4
17.4
38
93
A04AA01
ATC
ondansetron; systemic, rectal
54.2
16.6
19
5
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
16.4
15
*
GBB00
NOMESCO Finland
Tracheostomy
213.4
16.3
16
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
213.4
16.3
16
*
UJC01
NOMESCO Finland
Scopy of lower throat
45.1
16.0
19
6
C10.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of oropharynx
+∞
15.2
14
*
C10.0
ICD-10 Finland
Malignant neoplasm: Vallecula
+∞
14.1
13
*
A06AD11
ATC
lactulose; oral
8.7
13.2
21
35
XX3DW
NOMESCO Finland
Time consuming IT work
19.3
13.1
20
15
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
162.6
13.0
13
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
13.0
12
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
+∞
13.0
12
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
11.8
11
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
11.8
11
*
SAA03
NOMESCO Finland
Extended examination of mouth
6.1
11.0
37
126
Z51.5
ICD-10 Finland
Palliative care
24.4
10.9
15
8
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
132.2
10.8
11
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
13.3
10.8
19
20
EBA15
NOMESCO Finland
Extraction of multiple teeth
19.3
10.7
16
11
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
10.7
10
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
10.7
10
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
10.7
10
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
6.0
10.3
41
159
UDH02
NOMESCO Finland
Rhinopharyngoscopy
13.0
10.2
18
19
WX402
NOMESCO Finland
General anaesthesia
6.1
10.1
24
59
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.9
10.1
26
69
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
117.8
9.7
10
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
9.6
9
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
9.6
9
*
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
9.6
9
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
8.8
9.0
20
32
WX002
NOMESCO Finland
Sedation and analgesia
5.5
9.0
24
65
WW500
NOMESCO Finland
Blood transfusion
33.0
8.8
11
*
C10.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of oropharynx
+∞
8.5
8
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
8.5
8
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
8.5
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.0
8.5
26
79
GD1AD
NOMESCO Finland
Thorax CT examination
12.6
8.1
14
14
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.0
8.0
16
21
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
29.4
7.9
10
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
9.5
7.8
16
22
A02BC05
ATC
esomeprazole; systemic
4.6
7.8
38
163
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.6
7.5
15
20
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
+∞
7.4
7
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
7.4
7
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
7.4
7
*
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
+∞
7.4
7
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
9.1
7.3
15
21
EP1AE
NOMESCO Finland
Neck ultrasound examination
14.6
6.9
11
9
R4110
NOMESCO Finland
Physiotherapy
4.1
6.6
27
100
8070/3-C10.3
ICD-O-3
Squamous cell carcinoma, NOS, of posterior wall of oropharynx
+∞
6.4
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.4
6
*
D10.7
ICD-10 Finland
Benign neoplasm: Hypopharynx
+∞
6.4
6
*
C10.9
ICD-10 Finland
Malignant neoplasm: Oropharynx, unspecified
+∞
6.4
6
*
EBA10
NOMESCO Finland
Operative extraction of tooth
8.9
6.3
13
18
Z3226
NOMESCO Finland
Physiotherapist
4.3
6.1
20
62
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
13.0
6.0
10
9

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
13
38.89
22.23
1.4
1.2
—
—
—
0
0
42
147
7.19
12.49
2.4
1.6
—
—
—
0
0
34
123
5.07
9.01
8.2
2.3
2.38
2.35
mmol/l
0.67
34
102
32
138
3.83
6.17
2.9
1.9
—
—
—
0
0
29
121
3.70
5.80
4.8
3.8
—
—
—
0
0
20
67
3.98
5.46
2.4
2.0
—
—
—
0
0
7
5
15.56
4.69
1.3
1.4
—
—
—
0
0
43
259
3.33
4.36
15.9
6.7
4.74
4.30
e9/l
0.46
38
226
16
53
3.75
4.35
1.8
1.7
—
—
—
0
0
24
109
3.00
3.93
13.7
5.2
—
—
—
0
0
15
56
3.24
3.36
8.9
6.6
102.13
104.30
mmol/l
0.42
15
56
13
41
3.76
3.32
1.2
1.1
—
—
—
0
0
16
63
3.10
3.28
2.0
2.0
—
—
—
0
0
8
19
4.69
2.79
11.7
10.1
—
—
—
0
0
16
69
2.80
2.78
5.1
1.8
2.56
2.42
mmol/l
2.32
16
52
9
28
3.59
2.42
13.6
10.5
93.56
93.83
%
—
9
28
41
294
2.25
2.19
8.0
4.3
7.00
6.92
mmol/l
0.10
41
274
9
31
3.23
2.18
13.6
9.6
1.38
1.58
%
—
9
31
9
31
3.23
2.18
13.6
9.6
0.93
0.79
%
—
9
31
48
373
2.43
2.03
13.2
5.4
74.25
75.78
u/l
0.15
48
347
32
213
2.08
2.01
10.9
6.6
1.21
1.21
mmol/l
0.20
32
185
9
34
2.93
1.96
5.0
4.8
—
—
—
0
0
21
124
2.07
1.78
1.2
1.3
—
—
—
0
0
6
19
3.39
1.71
1.5
1.1
—
—
—
0
0
33
236
1.89
1.57
6.1
5.4
0.22
0.20
e9/l
0.33
25
206
30
209
1.87
1.54
7.1
6.2
—
—
—
0
0
9
38
2.60
1.53
13.7
9.1
—
—
—
0
0
32
229
1.85
1.50
6.3
5.4
0.63
0.59
e9/l
0.39
25
200
32
230
1.84
1.47
6.3
5.3
0.05
0.04
e9/l
0.15
25
199
32
232
1.81
1.42
6.3
5.5
1.68
1.77
e9/l
0.14
24
209
0
40
0.00
1.39
0.0
2.3
—
—
—
0
0
6
128
0.41
1.37
3.5
3.3
—
—
—
0
0
5
18
2.93
1.31
4.4
4.1
—
—
—
0
0
6
29
2.18
0.92
4.0
2.6
135.83
129.79
g/l
—
6
29
5
24
2.18
0.76
4.6
2.5
28.06
24.50
mmol/l
—
5
24
5
25
2.09
0.74
2.8
4.7
—
—
—
0
0
5
25
2.09
0.74
19.2
8.6
29.32
24.96
mmol/l
—
5
25
6
101
0.55
0.70
3.3
2.0
1.68
3.76
e6/l
—
6
85
0
20
0.00
0.61
0.0
2.9
—
—
—
0
0
15
112
1.45
0.51
2.7
2.9
—
—
—
0
0
13
97
1.43
0.44
2.5
3.8
—
—
—
0
0
5
33
1.56
0.42
2.6
1.4
—
—
—
0
0
5
33
1.56
0.42
1.0
1.3
—
—
—
0
0
14
178
0.72
0.42
2.6
3.2
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
5.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
51
531
0.74
0.39
34.2
14.7
70.31
83.76
umol/l
4.21
51
531
16
128
1.34
0.37
3.2
2.4
0.27
0.41
e6/l
0.26
11
96
14
174
0.75
0.36
4.9
3.7
—
—
—
0
0
7
51
1.42
0.33
1.3
1.4
—
—
—
0
0
15
125
1.27
0.25
3.3
2.2
—
—
—
0
0
24
212
1.22
0.25
13.2
8.1
0.02
0.00
e9/l
0.48
19
177
5
38
1.34
0.24
1.0
1.7
—
—
—
0
0
18
155
1.23
0.23
2.1
2.1
92.61
198.92
u/l
3.37
18
146
38
353
1.21
0.23
4.0
4.0
—
—
—
0
0
5
40
1.27
0.23
2.8
1.4
—
—
—
0
0
5
41
1.24
0.22
7.4
2.4
61.40
66.81
g/l
—
5
35
5
42
1.21
0.22
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
0.25
—
0
11
0
11
0.00
0.21
0.0
1.4
—
0.97
—
0
11
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
47
1.31
0.21
4.2
3.5
4.33
2.28
mmol/l
—
6
36
21
186
1.20
0.21
1.9
1.9
92.62
92.94
pmol/l
—
9
88
43
408
1.19
0.18
34.3
16.5
329.93
333.06
g/l
1.31
43
408
29
312
0.86
0.16
3.5
3.9
—
—
—
0
0
51
521
0.86
0.16
22.8
11.7
—
—
—
0
0
18
162
1.16
0.14
4.4
3.5
3301.70
75.49
mg/l
0.46
12
105
19
173
1.14
0.12
2.8
4.2
11.27
9.51
mg/mmol
0.07
12
104
16
144
1.15
0.12
3.1
2.5
5.15
485.32
e6/l
0.56
11
113
5
43
1.18
0.10
3.8
2.6
—
—
—
0
0
10
87
1.18
0.10
1.4
1.6
1071.60
1256.55
nmol/l
—
5
72
16
175
0.88
0.10
2.9
3.7
—
5.91
—
0
17
41
417
0.95
0.01
35.2
14.9
14.62
15.14
%
0.36
41
408
29
289
1.01
0.00
3.5
3.8
—
49.14
—
0
7
16
165
0.96
0.00
3.7
2.8
2.69
13.99
e6/l
4.03
11
118
0
5
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
12.62
—
0
5
5
52
0.96
-0.00
2.0
2.7
3.64
13.23
ug/l
—
5
46
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
321.40
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
74.10
—
0
8
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
4.89
—
0
9
0
9
0.00
-0.00
0.0
3.9
—
61.67
—
0
9

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_OROPHARYNG – Malignant neoplasm of oropharyng

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).