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Malignant neoplasm of retroperitoneum and peritoneum

C3_RETROPERITONEUM_PERITONEUM

retroperitoneal cancer: An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C48
  • Cancer registry: Topography ICD-O-3 C48
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

239

4. Check minimum number of events

None

239

5. Include endpoints

None

239

6. Filter based on genotype QC (FinnGen only)

239

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 239 169 70
Unadjusted period prevalence (%) 0.05 0.06 0.03
Median age at first event (years) 67.51 66.99 68.76

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
213
Matched controls
2130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB02
ATC
dexamethasone; systemic
19.1
69.1
119
132
WX302
NOMESCO Finland
Thoracal epidural anesthesy
32.1
67.9
92
49
C48.89
ICD-10 Finland
Overall malignant tumor of the peritoneum and retroperitoneum other or unspecified tumor
843.2
65.6
61
*
130
Kela drug reimbursment
Malignant tumour
20.9
61.7
98
83
A03FA01
ATC
metoclopramide; systemic, rectal
12.1
58.8
142
301
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
17.6
52.9
89
83
8461/3-C48.2
ICD-O-3
High grade serous carcinoma of peritoneum, NOS
+∞
51.1
47
*
JAL30
NOMESCO Finland
Omentectomy
68.5
49.7
56
11
KKB10
NOMESCO Finland
Excision of retroperitoneal tumour
546.0
46.1
44
*
A04AA01
ATC
ondansetron; systemic, rectal
13.6
42.7
80
90
B01AB10
ATC
tinzaparin; parenteral
15.8
41.3
71
65
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
22.6
41.3
61
37
C48.02
ICD-10 Finland
Malignant tumor of the retroperitoneal space liposarcoma
+∞
39.9
37
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
16.5
38.8
65
55
R18
ICD-10 Finland
Ascites
34.0
38.5
50
19
JN4BD
NOMESCO Finland
Extensive body CT
9.3
36.8
87
147
128
Kela drug reimbursment
Cancers of female genital organs
30.6
36.0
48
20
Z51.5
ICD-10 Finland
Palliative care
12.8
32.2
60
63
C57.9
ICD-10 Finland
Malignant neoplasm: Female genital organ, unspecified
97.2
30.7
33
*
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
17.9
30.2
48
34
TPH07
NOMESCO Finland
Cathetrisation of artery
9.5
29.7
66
96
N02AA05
ATC
oxycodone; systemic
6.8
29.5
87
195
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
12.0
27.8
53
57
L03AA14
ATC
lipegfilgrastim; parenteral
23.1
27.8
40
21
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
147.3
25.2
26
*
JAL00
NOMESCO Finland
Biopsy of peritoneum
64.1
24.7
28
5
C48.09
ICD-10 Finland
Malignant tumor of the retroperitoneal space other or unspecified tumor
+∞
24.4
23
*
B01AB05
ATC
enoxaparin; parenteral
4.4
22.7
118
466
8461/3-C48.1
ICD-O-3
High grade serous carcinoma of specified parts of peritoneum
+∞
22.3
21
*
C48.00
ICD-10 Finland
Malignant tumor of the retroperitoneal space without histology
+∞
22.3
21
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.6
21.9
62
125
LCD00
NOMESCO Finland
Hysterectomy
10.2
21.5
44
53
L03AA02
ATC
filgrastim; parenteral
13.7
21.3
37
32
WW500
NOMESCO Finland
Blood transfusion
11.8
21.2
40
41
C48.0
ICD-10 Finland
Malignant neoplasm: Retroperitoneum
+∞
21.2
20
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
34.1
21.1
27
9
D48.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Retroperitoneum
85.7
21.1
23
*
L03AA13
ATC
pegfilgrastim; parenteral
10.8
20.8
41
46
JAH00
NOMESCO Finland
Laparotomy
20.8
19.7
29
16
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
26.7
19.2
26
11
JN4AD
NOMESCO Finland
Body CT examination
6.9
19.0
50
90
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
48.8
18.6
22
5
WX402
NOMESCO Finland
General anaesthesia
4.8
18.5
71
201
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.3
18.3
42
61
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
18.0
17
*
8858/3-C48.0
ICD-O-3
Dedifferentiated liposarcoma of retroperitoneum
+∞
18.0
17
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
19.1
17.9
27
16
JEA00
NOMESCO Finland
Appendectomy
8.1
17.6
41
61
A04AA02
ATC
granisetron; systemic, transdermal
8.1
17.3
40
59
ZXE20
NOMESCO Finland
More than three and less than five hours
4.9
17.3
64
173
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
14.4
17.2
29
23
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.7
17.2
107
460
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
13.8
16.9
29
24
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
18.7
16.5
25
15
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
23.3
16.4
23
11
C48.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of retroperitoneum and peritoneum
+∞
15.8
15
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.9
15.3
74
254
8850/3-C48.0
ICD-O-3
Liposarcoma, NOS, of retroperitoneum
+∞
14.8
14
*
C48.03
ICD-10 Finland
Malignant tumor of the retroperitoneal space leiomyosarcoma
+∞
14.8
14
*
JAH01
NOMESCO Finland
Laparoscopy
7.6
14.0
33
50
A04AA55
ATC
palonosetron, combinations; systemic
10.5
14.0
27
29
TPX10
NOMESCO Finland
Implantation of vascular injection port
12.7
13.7
24
21
8890/3-C48.0
ICD-O-3
Leiomyosarcoma, NOS, of retroperitoneum
+∞
12.6
12
*
C48.19
ICD-10 Finland
Malignant tumor in specified location in peritoneum other or unspecified histlogy
+∞
12.6
12
*
ZX120
NOMESCO Finland
Intravenous
5.1
12.1
40
93
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
12.1
123
690
JAL01
NOMESCO Finland
Laparoscopic biopsy of peritoneum
49.6
12.0
14
*
C57.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of female genital organs
68.9
11.7
13
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
8.4
11.5
25
33
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
9.4
11.4
23
27
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
11.4
48
143
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
5.9
11.0
31
60
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.8
10.8
31
61
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
63.2
10.7
12
*
C48.2
ICD-10 Finland
Malignant neoplasm: Peritoneum, unspecified
+∞
10.5
10
*
C48.29
ICD-10 Finland
Malignant tumor in unspecified localization in peritoneum other or unspecified histology
+∞
10.5
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
10.3
43
126
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
10.9
10.2
19
19
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.8
10.0
82
393
JN3AD
NOMESCO Finland
Abdominal CT examination
4.6
10.0
35
87
D39.10
ICD-10 Finland
Tumor of uncertain or unknown nature in the ovary without histology
7.4
9.9
23
34
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
10.8
9.7
18
18
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
9.7
82
398
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
16.0
9.7
15
10
WX306
NOMESCO Finland
Lumbar epidural anesthesy
5.8
9.6
27
52
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
10.2
9.5
18
19
WC125
NOMESCO Finland
Demanding cytostatic therapy of local tumor recidive
+∞
9.4
9
*
C48.1
ICD-10 Finland
Malignant neoplasm: Specified parts of peritoneum
+∞
9.4
9
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
5.9
9.4
26
49
A79
ICPC
Malignancy NOS
14.6
9.3
15
11
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.8
9.3
26
50
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
7.6
9.3
21
30
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
9.3
64
273
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
16.5
9.2
14
9
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
38.5
9.1
11
*
WB402
NOMESCO Finland
Demanding antibody therapy of primary tumour
38.5
9.1
11
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
19.7
9.0
13
7
KAC10
NOMESCO Finland
Total nephrectomy with capsule
25.3
9.0
12
5
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
14.9
8.8
14
10
KAC00
NOMESCO Finland
Nephrectomy
52.2
8.8
10
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
9.6
8.7
17
19
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
17.2
8.7
13
8
C56.71
ICD-10 Finland
Serous epithelial malignant tumor of the ovary
17.2
8.7
13
8
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
8.6
49
183
C48.20
ICD-10 Finland
Malignant tumor in unspecified localization in the peritoneum without histology
93.6
8.5
9
*
WC115
NOMESCO Finland
Cytostatic therapy of local tumor recidive with multiple drugs
+∞
8.4
8
*
9052/3-C48.2
ICD-O-3
Epithelioid mesothelioma, malignant of peritoneum, NOS
+∞
8.4
8
*
9680/3-C48.0
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of retroperitoneum
+∞
8.4
8
*
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
+∞
8.4
8
*
C48.80
ICD-10 Finland
Overall malignant tumor of the peritoneum and retroperitoneum without histology
+∞
8.4
8
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
8.7
8.3
17
21
A04AD12
ATC
aprepitant; systemic
9.5
8.2
16
18
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
34.8
8.1
10
*
LAF16
NOMESCO Finland
Excision of uterus, adnexes and lymph nodes for treatment of ovarian cancer
23.1
8.1
11
5
X77
ICPC
Malignant neopl genital female other
46.7
7.8
9
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
12.5
7.7
13
11
C56.00
ICD-10 Finland
Malignant tumor of the ovary without histology
19.2
7.7
11
6
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
26.1
7.6
10
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
6.4
7.6
19
32
9050/3-C48.2
ICD-O-3
Mesothelioma, malignant of peritoneum, NOS
+∞
7.3
7
*
WF001
NOMESCO Finland
Preoperative radiotherapy
16.5
7.3
11
7
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
12.6
7.2
12
10
Z51.88
ICD-10 Finland
Other specified medical care
9.3
7.2
14
16
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.9
7.2
29
83
JFB00
NOMESCO Finland
Partial resection of small intestine
10.6
7.1
13
13
JN4CD
NOMESCO Finland
Very extensive body CT
5.9
7.1
19
35
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.7
7.1
17
27
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.5
7.0
32
101
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
7.0
95
568
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
14.4
7.0
11
8
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.7
7.0
19
36
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
9.8
6.9
13
14
N02BE01
ATC
paracetamol; systemic, rectal
3.3
6.9
196
1655
R50.9
ICD-10 Finland
Fever, unspecified
2.9
6.7
41
160
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
6.6
91
541
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
14.9
6.5
10
7
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
14.9
6.5
10
7
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.6
6.4
21
49
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
11.5
6.4
11
10
XX3DW
NOMESCO Finland
Time consuming IT work
3.1
6.3
35
127
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.7
6.3
17
32
G62.0
ICD-10 Finland
Drug-induced polyneuropathy
+∞
6.3
6
*
8460/3-C48.2
ICD-O-3
Low grade serous carcinoma of peritoneum, NOS
+∞
6.3
6
*
JFB43
NOMESCO Finland
Left hemicolectomy
27.6
6.3
8
*
YJ1BD
NOMESCO Finland
Extensive CT examination of abdomen for dose design of radiotherapy
27.6
6.3
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
6.1
103
665

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_RETROPERITONEUM_PERITONEUM – Malignant neoplasm of retroperitoneum and peritoneum

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).