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Malignant neoplasm of retroperitoneum and peritoneum, excluding all cancers (controls excluding all cancers)

C3_RETROPERITONEUM_PERITONEUM_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C48
  • Cause of death: ICD-10 C48
  • Cancer registry: Topography ICD-O-3 C48
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

581

4. Check minimum number of events

None

581

5. Include endpoints

None

581

6. Filter based on genotype QC (FinnGen only)

581

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of retroperitoneum and peritoneum, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 581 414 167
Unadjusted period prevalence (%) 0.12 0.14 0.07
Median age at first event (years) 66.69 66.20 67.92

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
213
Matched controls
2130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB02
ATC
dexamethasone; systemic
332.8
128.7
119
8
130
Kela drug reimbursment
Malignant tumour
+∞
112.8
98
*
A03FA01
ATC
metoclopramide; systemic, rectal
26.7
89.8
142
148
WX302
NOMESCO Finland
Thoracal epidural anesthesy
106.7
87.6
92
15
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
72.1
65
*
C48.89
ICD-10 Finland
Overall malignant tumor of the peritoneum and retroperitoneum other or unspecified tumor
+∞
67.3
61
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
843.2
65.6
61
*
JN4BD
NOMESCO Finland
Extensive body CT
33.4
65.2
87
43
A04AA01
ATC
ondansetron; systemic, rectal
41.9
64.0
80
30
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
29.1
63.9
89
51
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
58.0
53
*
JAL30
NOMESCO Finland
Omentectomy
188.6
55.9
56
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
52.3
48
*
8461/3-C48.2
ICD-O-3
High grade serous carcinoma of peritoneum, NOS
+∞
51.1
47
*
Z51.5
ICD-10 Finland
Palliative care
45.8
49.4
60
18
B01AB10
ATC
tinzaparin; parenteral
23.1
47.9
71
45
KKB10
NOMESCO Finland
Excision of retroperitoneal tumour
+∞
47.7
44
*
R18
ICD-10 Finland
Ascites
72.0
44.7
50
9
L03AA13
ATC
pegfilgrastim; parenteral
+∞
44.3
41
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
43.2
40
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
43.2
40
*
N02AA05
ATC
oxycodone; systemic
10.6
39.9
87
130
C48.02
ICD-10 Finland
Malignant tumor of the retroperitoneal space liposarcoma
+∞
39.9
37
*
L03AA02
ATC
filgrastim; parenteral
+∞
39.9
37
*
C57.9
ICD-10 Finland
Malignant neoplasm: Female genital organ, unspecified
+∞
35.4
33
*
JN4AD
NOMESCO Finland
Body CT examination
22.9
34.4
50
28
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
25.4
34.1
48
24
A04AA55
ATC
palonosetron, combinations; systemic
+∞
28.8
27
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
28.8
27
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
28.8
27
*
WX402
NOMESCO Finland
General anaesthesia
8.1
28.4
71
124
TPH07
NOMESCO Finland
Cathetrisation of artery
8.6
27.8
66
106
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
27.7
26
*
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
+∞
27.7
26
*
B01AB05
ATC
enoxaparin; parenteral
5.1
27.0
118
415
JAL00
NOMESCO Finland
Biopsy of peritoneum
106.9
26.3
28
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.2
26.0
107
348
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
281.7
25.2
25
*
WW500
NOMESCO Finland
Blood transfusion
16.7
24.8
40
29
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.7
24.5
62
108
L02BG04
ATC
letrozole; oral
76.8
24.4
27
*
C48.09
ICD-10 Finland
Malignant tumor of the retroperitoneal space other or unspecified tumor
+∞
24.4
23
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
24.4
23
*
LCD00
NOMESCO Finland
Hysterectomy
12.3
23.7
44
44
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.5
23.7
42
38
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
30.0
23.4
31
12
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
+∞
23.4
22
*
D48.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Retroperitoneum
256.4
23.1
23
*
C48.00
ICD-10 Finland
Malignant tumor of the retroperitoneal space without histology
+∞
22.3
21
*
8461/3-C48.1
ICD-O-3
High grade serous carcinoma of specified parts of peritoneum
+∞
22.3
21
*
ZXE20
NOMESCO Finland
More than three and less than five hours
6.3
21.8
64
135
C48.0
ICD-10 Finland
Malignant neoplasm: Retroperitoneum
+∞
21.2
20
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
85.7
21.1
23
*
JAH00
NOMESCO Finland
Laparotomy
25.6
21.0
29
13
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
23.7
20.6
29
14
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
40.2
20.3
25
7
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
20.1
19
*
JAH01
NOMESCO Finland
Laparoscopy
14.8
19.7
33
26
JEA00
NOMESCO Finland
Appendectomy
9.3
19.2
41
53
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.7
18.8
74
215
XX3DW
NOMESCO Finland
Time consuming IT work
11.1
18.2
35
37
8858/3-C48.0
ICD-O-3
Dedifferentiated liposarcoma of retroperitoneum
+∞
18.0
17
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
18.0
17
*
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
18.0
17
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
20.9
17.8
26
14
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
16.9
16
*
A04AD12
ATC
aprepitant; systemic
+∞
16.9
16
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
19.1
16.0
24
14
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
15.8
123
617
C48.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of retroperitoneum and peritoneum
+∞
15.8
15
*
A79
ICPC
Malignancy NOS
+∞
15.8
15
*
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
11.8
15.8
29
28
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
10.2
15.6
31
35
D39.10
ICD-10 Finland
Tumor of uncertain or unknown nature in the ovary without histology
19.7
15.5
23
13
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
15.3
82
306
C48.03
ICD-10 Finland
Malignant tumor of the retroperitoneal space leiomyosarcoma
+∞
14.8
14
*
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
+∞
14.8
14
*
JAL01
NOMESCO Finland
Laparoscopic biopsy of peritoneum
+∞
14.8
14
*
8850/3-C48.0
ICD-O-3
Liposarcoma, NOS, of retroperitoneum
+∞
14.8
14
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
160.6
14.7
15
*
ZX120
NOMESCO Finland
Intravenous
6.2
14.4
40
76
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
80.4
13.8
15
*
C57.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of female genital organs
+∞
13.7
13
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
13.7
13
*
C56.71
ICD-10 Finland
Serous epithelial malignant tumor of the ovary
+∞
13.7
13
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
13.7
13
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
13.7
13
*
JN4CD
NOMESCO Finland
Very extensive body CT
20.7
13.2
19
10
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.3
13.1
82
338
JN3AD
NOMESCO Finland
Abdominal CT examination
6.3
13.0
35
64
C48.19
ICD-10 Finland
Malignant tumor in specified location in peritoneum other or unspecified histlogy
+∞
12.6
12
*
8890/3-C48.0
ICD-O-3
Leiomyosarcoma, NOS, of retroperitoneum
+∞
12.6
12
*
KAC10
NOMESCO Finland
Total nephrectomy with capsule
+∞
12.6
12
*
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
+∞
12.6
12
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
19.5
12.3
18
10
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
12.2
48
134
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.7
12.1
43
108
R50.9
ICD-10 Finland
Fever, unspecified
4.9
12.0
41
99
WZC30
NOMESCO Finland
Teaching
5.2
11.6
37
83
WB402
NOMESCO Finland
Demanding antibody therapy of primary tumour
+∞
11.6
11
*
LAF16
NOMESCO Finland
Excision of uterus, adnexes and lymph nodes for treatment of ovarian cancer
+∞
11.6
11
*
C56.00
ICD-10 Finland
Malignant tumor of the ovary without histology
+∞
11.6
11
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
11.6
11
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
16.2
11.5
18
12
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
37.3
11.4
14
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
7.3
10.9
26
40
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
10.0
10.8
21
23
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
15.3
10.7
17
12
S18
ICPC
Laceration/cut
2.7
10.6
106
575
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
115.5
10.5
11
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
115.5
10.5
11
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
11.5
10.5
19
18
C48.2
ICD-10 Finland
Malignant neoplasm: Peritoneum, unspecified
+∞
10.5
10
*
C48.29
ICD-10 Finland
Malignant tumor in unspecified localization in peritoneum other or unspecified histology
+∞
10.5
10
*
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
+∞
10.5
10
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
10.5
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
10.4
64
256
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.1
10.4
17
13
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
42.2
10.1
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
10.0
95
496
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
10.3
10.0
19
20
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
57.7
9.7
11
*
WF004
NOMESCO Finland
Palliative radiotherapy
104.5
9.5
10
*
KAC00
NOMESCO Finland
Nephrectomy
104.5
9.5
10
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
9.4
9
*
WC125
NOMESCO Finland
Demanding cytostatic therapy of local tumor recidive
+∞
9.4
9
*
C48.1
ICD-10 Finland
Malignant neoplasm: Specified parts of peritoneum
+∞
9.4
9
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
9.4
9
*
C48.20
ICD-10 Finland
Malignant tumor in unspecified localization in the peritoneum without histology
+∞
9.4
9
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
9.4
9
*
X77
ICPC
Malignant neopl genital female other
+∞
9.4
9
*
WX306
NOMESCO Finland
Lumbar epidural anesthesy
5.3
8.9
27
57
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
8.9
49
179
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
52.2
8.8
10
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
17.2
8.7
13
8
HA1AA
NOMESCO Finland
X-ray mammography
7.2
8.6
20
30
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
28.8
8.6
11
*
JFB30
NOMESCO Finland
Right hemicolectomy
28.8
8.6
11
*
WF002
NOMESCO Finland
Radical radiotherapy
28.8
8.6
11
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
93.6
8.5
9
*
C48.80
ICD-10 Finland
Overall malignant tumor of the peritoneum and retroperitoneum without histology
+∞
8.4
8
*
YJ1BD
NOMESCO Finland
Extensive CT examination of abdomen for dose design of radiotherapy
+∞
8.4
8
*
C56.98
ICD-10 Finland
Malignant tumor of the ovary, indeterminate histology
+∞
8.4
8
*
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
+∞
8.4
8
*
C56
ICD-10 Finland
Malignant neoplasm of ovary
+∞
8.4
8
*
9052/3-C48.2
ICD-O-3
Epithelioid mesothelioma, malignant of peritoneum, NOS
+∞
8.4
8
*
A06AH03
ATC
naloxegol; oral
+∞
8.4
8
*
WC115
NOMESCO Finland
Cytostatic therapy of local tumor recidive with multiple drugs
+∞
8.4
8
*
115
Kela drug reimbursment
Breast cancer
+∞
8.4
8
*
9680/3-C48.0
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of retroperitoneum
+∞
8.4
8
*
JFB00
NOMESCO Finland
Partial resection of small intestine
15.3
8.3
13
9
N02BE01
ATC
paracetamol; systemic, rectal
3.7
8.3
196
1615
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.4
8.2
21
36
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
18.0
8.2
12
7
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
7.8
91
512
Z51.88
ICD-10 Finland
Other specified medical care
10.6
7.7
14
14
JFF10
NOMESCO Finland
Loop enterostomy
82.9
7.5
8
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
82.9
7.5
8
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
82.9
7.5
8
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.0
7.4
29
80
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
9.9
7.4
14
15
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.3
7
*
9050/3-C48.2
ICD-O-3
Mesothelioma, malignant of peritoneum, NOS
+∞
7.3
7
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
7.3
7
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
7.0
7.3
17
26
D70.82
ICD-10 Finland
Drug-induced neutropenia
31.2
7.2
9
*
A02BC02
ATC
pantoprazole; systemic
2.3
7.1
152
1111
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.6
7.1
32
100
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
7.1
94
554
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
8.0
7.0
15
20
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
17.4
6.8
10
6
JFB46
NOMESCO Finland
Resection of sigmoid colon
17.4
6.8
10
6
SPAT1109
SPAT
Analgesia with portable analgesic pump
71.9
6.5
7
*
PJA12
NOMESCO Finland
Sentinel node biopsy
71.9
6.5
7
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
71.9
6.5
7
*
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
71.9
6.5
7
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
14.9
6.5
10
7
B03XA02
ATC
darbepoetin alfa; parenteral
14.9
6.5
10
7
KA1AE
NOMESCO Finland
Kidney ultrasound examination
8.6
6.4
13
16
N02AX02
ATC
tramadol; systemic, rectal
2.1
6.3
103
655
TJA10
NOMESCO Finland
Laparocentesis
+∞
6.3
6
*
1510
Kela drug reimbursment
Niraparib
+∞
6.3
6
*
8460/3-C48.2
ICD-O-3
Low grade serous carcinoma of peritoneum, NOS
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
G62.0
ICD-10 Finland
Drug-induced polyneuropathy
+∞
6.3
6
*
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
+∞
6.3
6
*
D74
ICPC
Malignant neoplasm stomach
+∞
6.3
6
*
JAQ00
NOMESCO Finland
Extensive excision of peritoneum
+∞
6.3
6
*
3009
Kela drug reimbursment
Niraparib
+∞
6.3
6
*
JFB43
NOMESCO Finland
Left hemicolectomy
27.6
6.3
8
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
27.6
6.3
8
*

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_RETROPERITONEUM_PERITONEUM_EXALLC – Malignant neoplasm of retroperitoneum and peritoneum, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).