Leiomyosarcoma, excluding all cancers (controls excluding all cancers)

C3_LEIOMYOSARCOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C48.3|C49.3|C5421
  • Cause of death: ICD-10 C48.3|C49.3|C5421
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 8890
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

314

4. Check minimum number of events

None

314

5. Include endpoints

None

314

6. Filter based on genotype QC (FinnGen only)

314

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Leiomyosarcoma, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 314 212 102
Unadjusted period prevalence (%) 0.06 0.07 0.04
Median age at first event (years) 60.36 58.51 64.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
218
Matched controls
2180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB02
ATC
dexamethasone; systemic
182.3
81.6
81
7
130
Kela drug reimbursment
Malignant tumour
+∞
75.5
68
*
C54.21
ICD-10 Finland
Leiomyosarcoma and myometrium
+∞
74.3
67
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
622.8
51.7
49
*
A03FA01
ATC
metoclopramide; systemic, rectal
12.1
48.7
101
145
128
Kela drug reimbursment
Cancers of female genital organs
+∞
47.7
44
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
47.7
44
*
JN4BD
NOMESCO Finland
Extensive body CT
20.1
45.6
71
51
A04AA01
ATC
ondansetron; systemic, rectal
44.3
44.2
54
16
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
43.2
40
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
40.9
38
*
8890/3-C54.9
ICD-O-3
Leiomyosarcoma, NOS, of corpus uteri
+∞
40.9
38
*
JN4AD
NOMESCO Finland
Body CT examination
27.8
36.5
50
23
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
78.6
35.3
39
6
8890/3-C49.2
ICD-O-3
Leiomyosarcoma, NOS, of connective, Subcutaneous and other soft tissues of lower limb and hip
+∞
34.3
32
*
N02AA05
ATC
oxycodone; systemic
8.8
33.9
82
140
A04AA02
ATC
granisetron; systemic, transdermal
390.5
33.9
33
*
Z51.5
ICD-10 Finland
Palliative care
24.6
33.1
47
24
C49.23
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of lower extremity including hip leiomyosarcoma
+∞
32.1
30
*
L03AA02
ATC
filgrastim; parenteral
+∞
32.1
30
*
B01AB10
ATC
tinzaparin; parenteral
16.7
31.8
52
40
XX3DW
NOMESCO Finland
Time consuming IT work
15.9
31.1
52
42
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
31.0
29
*
8890/3-C54.2
ICD-O-3
Leiomyosarcoma, NOS, of myometrium
+∞
31.0
29
*
159
Kela drug reimbursment
Pazopanib
+∞
27.7
26
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
27.7
26
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
26.6
25
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
26.6
25
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
25.5
24
*
C54.2
ICD-10 Finland
Malignant neoplasm: Myometrium
+∞
25.5
24
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
26.6
24.8
34
15
C48.03
ICD-10 Finland
Malignant tumor of the retroperitoneal space leiomyosarcoma
+∞
24.4
23
*
L02BG04
ATC
letrozole; oral
140.4
24.1
25
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.9
24.0
101
328
WX302
NOMESCO Finland
Thoracal epidural anesthesy
16.1
23.9
39
29
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
23.3
22
*
B01AB05
ATC
enoxaparin; parenteral
4.5
22.9
110
403
A04AD12
ATC
aprepitant; systemic
+∞
22.3
21
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
24.6
21.5
30
14
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
21.2
20
*
L01XE11
ATC
[U] pazopanib; oral
+∞
21.2
20
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
11.1
20.7
40
43
KKB10
NOMESCO Finland
Excision of retroperitoneal tumour
219.0
19.9
20
*
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
17.2
19.1
30
20
D70.82
ICD-10 Finland
Drug-induced neutropenia
57.7
18.3
21
*
JN4CD
NOMESCO Finland
Very extensive body CT
29.7
18.2
24
9
WZC30
NOMESCO Finland
Teaching
6.2
17.4
50
100
8890/3-C49.1
ICD-O-3
Leiomyosarcoma, NOS, of connective, Subcutaneous and other soft tissues of upper limb and shoulder
+∞
16.9
16
*
C49.20
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the lower extremity including the hip without histology
+∞
16.9
16
*
C49.43
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the abdomen leiomyosarcoma
+∞
16.9
16
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
183.4
16.7
17
*
LCD00
NOMESCO Finland
Hysterectomy
8.0
16.4
38
56
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
15.8
15
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
15.8
15
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
15.6
81
295
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
12.7
15.3
27
24
WW500
NOMESCO Finland
Blood transfusion
18.2
15.1
23
14
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
34.5
15.1
19
6
ZZR00
NOMESCO Finland
Flap of skin
86.0
14.8
16
*
C49.13
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of upper extremity including shoulder leiomyosarcoma
+∞
14.7
14
*
WF002
NOMESCO Finland
Radical radiotherapy
160.2
14.6
15
*
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
12.7
13.7
24
21
A79
ICPC
Malignancy NOS
+∞
13.7
13
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
19.8
13.6
20
11
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
15.1
13.6
22
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
13.5
120
630
D39.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Uterus
43.0
13.3
16
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.3
13.2
32
50
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
30.5
13.2
17
6
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
12.6
12
*
C49.29
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of lower extremity including hip other or unspecified tumor
+∞
12.6
12
*
8890/3-C49.4
ICD-O-3
Leiomyosarcoma, NOS, of connective, Subcutaneous and other soft tissues of abdomen
+∞
12.6
12
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
12.6
12
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
+∞
12.6
12
*
8890/3-C48.0
ICD-O-3
Leiomyosarcoma, NOS, of retroperitoneum
+∞
12.6
12
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
12.6
12
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
12.6
12
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
12.6
12
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
32.0
11.8
15
5
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
4.7
11.8
42
106
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
45.8
11.0
13
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
29.7
10.9
14
5
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
13.0
10.6
18
15
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.5
10.5
27
46
C49.2
ICD-10 Finland
Malignant neoplasm: Connective and soft tissue of lower limb, including hip
+∞
10.5
10
*
115
Kela drug reimbursment
Breast cancer
+∞
10.5
10
*
KAC10
NOMESCO Finland
Total nephrectomy with capsule
+∞
10.5
10
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
10.5
10
*
C49.53
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the pelvis leiomyosarcoma
+∞
10.5
10
*
C54.12
ICD-10 Finland
Adenosquamous carcinoma of the endometrium
+∞
10.5
10
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
6.4
10.0
26
45
TPH07
NOMESCO Finland
Cathetrisation of artery
4.4
9.7
36
94
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
31.6
9.5
12
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
9.4
9
*
YN1BD
NOMESCO Finland
Extensive CT examination of extremities for dose design of radiotherapy
+∞
9.4
9
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
9.4
9
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
9.4
9
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
9.4
9
*
343
Kela drug reimbursment
Pazopanib
+∞
9.4
9
*
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
+∞
9.4
9
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
9.4
9
*
8890/3-C55.9
ICD-O-3
Leiomyosarcoma, NOS, of uterus, NOS
+∞
9.4
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
9.4
9
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
4.7
9.4
32
77
WX402
NOMESCO Finland
General anaesthesia
3.5
9.1
45
152
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
19.6
9.0
13
7
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
9.0
49
176
R50.9
ICD-10 Finland
Fever, unspecified
3.4
9.0
45
153
C61
ICD-10 Finland
Malignant neoplasm of prostate
93.5
8.5
9
*
S18
ICPC
Laceration/cut
2.4
8.4
104
607
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
8.4
8
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
8.4
8
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
8.4
8
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
8.4
8
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
8.4
8
*
C54.9
ICD-10 Finland
Malignant neoplasm: Corpus uteri, unspecified
+∞
8.4
8
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
8.4
8
*
C49.03
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the head, face and neck Leiomyosarcoma
+∞
8.4
8
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
8.4
8
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
8.4
8
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
8.3
8.0
17
22
ZZA00
NOMESCO Finland
Split skin graft
9.0
8.0
16
19
ZX120
NOMESCO Finland
Intravenous
4.3
7.9
29
75
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
10.0
7.9
15
16
SPAT1153
SPAT
Removal of sutures
2.4
7.9
83
441
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
5.6
7.8
22
43
JAH00
NOMESCO Finland
Laparotomy
8.5
7.7
16
20
JN3AD
NOMESCO Finland
Abdominal CT examination
4.9
7.5
24
54
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
82.8
7.5
8
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
82.8
7.5
8
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.9
7.4
49
201
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.3
7.4
27
70
C49.83
ICD-10 Finland
Overall malignant tumor of connective tissue and other soft tissue leiomyosarcoma
+∞
7.3
7
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
7.3
7
*
X77
ICPC
Malignant neopl genital female other
+∞
7.3
7
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
7.3
7
*
C54.29
ICD-10 Finland
Unspecified uterine sarcoma
+∞
7.3
7
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
7.3
7
*
1820C
ICD-9 Finland
Malignant neoplasm of body of uterus, Corpus uteri, except isthmus[SARCOMA MYOMETRI]
+∞
7.3
7
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
7.3
7
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
7.3
7
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
16.4
7.3
11
7
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.0
7.1
22
48
D48.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Retroperitoneum
41.4
6.8
8
*
C03CA01
ATC
furosemide; systemic
2.2
6.8
85
485
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
12.8
6.7
11
9
L02AB02
ATC
medroxyprogesterone; systemic (progestogens)
71.8
6.5
7
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
71.8
6.5
7
*
SPAT1255
SPAT
Intravenous administration of medicine
4.4
6.4
22
54
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
6.4
33
115
JN6AD
NOMESCO Finland
CT of torso and neck
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
8890/3-C64.9
ICD-O-3
Leiomyosarcoma, NOS, of kidney, NOS
+∞
6.3
6
*
D77
ICPC
Malignant digestive neopl other/NOS
+∞
6.3
6
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
6.3
6
*
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
+∞
6.3
6
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
+∞
6.3
6
*
YN1AD
NOMESCO Finland
CT examination of extremities for dose design of radiotherapy
+∞
6.3
6
*
YJ1CD
NOMESCO Finland
Very extensive CT examination of abdomen for dose design of radiotherapy
+∞
6.3
6
*
C48.02
ICD-10 Finland
Malignant tumor of the retroperitoneal space liposarcoma
+∞
6.3
6
*
8890/3-C49.6
ICD-O-3
Leiomyosarcoma, NOS, of connective, Subcutaneous and other soft tissues of trunk, NOS
+∞
6.3
6
*
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
27.5
6.3
8
*
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
7.0
6.1
14
21
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
9.0
6.1
12
14
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
6.0
35
132

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
54
27.10
134.01
1.4
1.4
—
—
—
0
0
155
609
4.05
33.12
6.0
3.8
—
—
—
0
0
165
681
4.00
32.74
3.9
2.0
—
—
—
0
0
75
174
5.35
31.76
1.4
1.1
—
—
—
0
0
208
1037
3.98
30.52
5.9
3.7
—
—
—
0
0
62
127
5.84
30.05
2.3
1.5
2.4
2.8
ug/l
0.44
43
102
130
528
3.50
25.07
3.6
2.0
—
—
—
0
0
227
1312
3.64
24.20
20.0
6.4
4.1
4.2
e9/l
0.41
205
1136
164
792
3.24
23.40
2.7
1.6
—
—
—
0
0
209
1189
3.27
22.02
8.4
6.0
1.2
1.2
mmol/l
1.81
174
1026
192
1047
3.15
21.66
7.7
3.7
34.0
35.6
g/l
3.27
182
973
194
1090
3.04
20.27
8.0
5.4
1.2
1.2
mmol/l
1.03
183
957
47
125
4.25
16.34
7.7
5.9
24.5
25.7
mmol/l
1.19
47
125
57
175
3.76
16.25
3.4
4.5
1.6
0.8
%
1.42
33
36
171
987
2.61
15.54
11.4
9.9
1.3
1.3
inr
0.25
50
266
112
548
2.62
14.05
6.0
3.1
90.5
89.7
%
0.12
107
535
51
165
3.50
13.34
3.6
4.7
0.3
0.1
%
1.25
28
31
50
164
3.44
12.79
3.5
4.5
1.1
0.3
%
1.96
25
25
128
702
2.39
12.25
6.0
3.1
7.4
7.4
ph
0.54
34
108
79
346
2.71
12.17
2.1
2.0
—
—
—
0
0
66
264
2.90
12.05
7.3
8.4
0.6
1.9
mmol/l
2.66
48
214
64
261
2.82
11.23
7.5
8.6
15.9
11.6
kpa
5.28
59
252
142
838
2.27
11.23
9.3
2.1
2.4
2.4
mmol/l
0.01
133
698
251
1895
2.62
10.86
17.9
5.2
91.0
76.4
u/l
5.20
244
1728
15
20
7.83
10.65
1.5
1.3
3.2
187.7
u/ml
0.48
15
20
66
282
2.70
10.56
1.8
1.8
—
—
—
0
0
208
1459
2.26
10.47
6.5
4.4
7.0
6.7
mmol/l
0.96
202
1357
226
1642
2.34
10.43
5.9
4.5
196.0
3691.6
e6/l
—
7
25
96
496
2.35
10.23
6.0
2.2
2.5
2.4
mmol/l
1.57
88
435
45
159
3.14
10.14
3.8
4.8
0.1
3.1
%
0.48
25
28
48
181
2.95
9.66
9.4
7.4
—
—
—
0
0
102
555
2.24
9.53
17.6
4.7
—
—
—
0
0
54
221
2.74
9.34
8.5
9.3
116.9
122.3
g/l
1.32
54
216
127
767
2.10
9.01
6.0
5.4
—
—
—
0
0
165
1106
2.04
8.73
6.5
5.6
8.7
8.5
%
0.21
155
1015
160
1067
2.02
8.52
6.4
5.4
0.6
0.7
%
2.02
150
970
166
1123
2.01
8.47
6.5
5.5
22.7
27.8
%
6.95
154
1026
17
34
5.23
8.23
4.2
3.3
57.9
57.8
%
0.01
17
34
134
847
2.02
8.22
4.1
3.5
358.5
114.8
e6/l
0.46
103
588
127
794
2.01
7.99
2.8
2.1
55.6
58.8
u/l
0.29
122
721
130
820
2.00
7.97
3.8
3.3
—
—
—
0
0
162
1105
1.96
7.89
6.4
5.3
2.5
2.9
%
1.93
151
1004
117
716
2.01
7.77
3.6
2.9
90.3
165.1
e6/l
0.32
95
541
170
1190
1.93
7.56
5.9
5.1
0.6
0.6
e9/l
0.21
151
1015
162
1117
1.93
7.53
6.0
5.3
60.7
57.4
%
2.41
151
1026
16
33
5.06
7.49
4.1
2.7
3.4
4.3
e9/l
0.63
16
33
29
95
3.26
7.37
4.2
4.1
—
—
—
0
0
174
1234
1.92
7.37
6.1
5.5
0.2
0.2
e9/l
3.78
156
1074
170
1201
1.91
7.24
5.9
5.1
0.0
0.0
e9/l
1.66
153
1023
108
662
1.96
7.01
3.4
2.9
0.5
0.5
e6/l
0.11
85
487
95
558
2.01
6.96
1.4
1.3
—
—
—
0
0
87
496
2.04
6.92
2.6
2.2
7.0
6.0
e6/l
0.24
76
432
104
633
1.96
6.87
3.4
2.8
—
—
—
0
0
169
1218
1.84
6.52
6.1
5.1
1.8
1.9
e9/l
0.25
153
1059
10
15
6.85
6.35
1.1
1.0
—
—
—
0
0
81
471
1.97
6.01
3.0
2.6
488.4
532.4
mosm/kgh2o
0.89
70
393
10
9
11.43
5.83
2.3
1.3
22.9
13.7
ug/l
—
10
9
10
17
6.04
5.66
1.9
4.2
—
—
—
0
0
36
155
2.49
5.58
3.6
7.7
—
—
—
0
0
82
500
1.87
5.21
5.4
4.3
—
—
—
0
0
144
1052
1.68
4.82
15.6
8.1
0.0
0.0
e9/l
0.67
122
838
28
115
2.58
4.78
9.4
12.4
—
—
—
0
0
44
224
2.12
4.64
2.8
3.0
—
—
—
0
0
56
313
1.96
4.59
2.9
2.4
21.3
23.4
%
0.64
48
268
8
9
9.08
4.30
1.1
1.3
—
—
—
0
0
16
52
3.19
4.14
4.3
3.1
9.1
8.3
kpa
0.80
16
52
16
52
3.19
4.14
4.3
3.1
4.7
5.2
kpa
1.53
16
52
16
52
3.19
4.14
4.3
3.1
2.4
3.5
mmol/l
0.78
11
35
10
24
4.27
3.91
1.1
1.1
—
—
—
0
0
18
67
2.79
3.72
2.5
1.8
—
—
—
0
0
44
245
1.93
3.64
3.5
3.1
2.3
2.5
mmol/l
0.14
36
196
6
6
10.16
3.51
2.8
1.2
0.0
0.2
e9/l
—
6
6
45
256
1.88
3.49
3.4
3.3
—
—
—
0
0
205
1729
1.53
3.20
5.5
4.4
—
—
—
0
0
94
671
1.57
3.19
4.6
3.9
0.0
0.0
estimate
0.00
28
214
156
1243
1.51
3.19
4.1
3.7
0.0
0.0
estimate
0.00
32
218
7
12
5.94
3.03
1.1
1.9
—
—
—
0
0
7
12
5.94
3.03
3.3
1.8
5.4
3.3
nmol/l
—
7
12
157
1267
1.48
2.94
4.2
3.7
0.0
0.0
estimate
0.50
30
214
155
1248
1.48
2.94
5.3
5.1
0.0
0.0
estimate
0.00
31
212
84
596
1.56
2.90
3.0
3.5
—
—
—
0
0
7
13
5.48
2.88
1.1
1.1
—
—
—
0
0
86
616
1.55
2.85
2.0
2.2
2.9
3.1
mg/l
0.30
74
517
24
447
0.50
2.80
1.3
1.2
24.5
14.1
u/ml
0.24
13
167
72
500
1.57
2.72
4.0
4.3
21.6
224.4
ng/l
1.65
62
408
275
2518
1.74
2.71
30.4
12.7
31.0
21.6
mg/l
4.31
256
1924
24
121
2.06
2.63
1.2
1.3
—
—
—
0
0
37
219
1.78
2.55
2.2
3.9
165.9
243.4
ng/l
0.79
30
201
13
51
2.62
2.47
1.7
2.1
1.7
1.6
mg/l
0.29
13
46
131
1048
1.43
2.44
4.0
3.8
28.0
70.0
ng/l
0.70
105
749
243
2635
0.66
2.40
4.6
5.3
2.6
2.7
mmol/l
0.95
217
2414
20
99
2.09
2.31
1.2
1.2
—
—
—
0
0
49
703
0.64
2.17
1.5
1.6
1.4
1.3
mmol/l
0.19
39
593
206
1808
1.41
2.15
4.5
3.9
—
—
—
0
0
237
2562
0.69
1.98
4.1
4.7
1.5
1.5
mmol/l
1.32
210
2348
44
295
1.57
1.93
1.3
1.5
—
—
—
0
0
240
2585
0.70
1.91
4.1
4.7
4.5
4.7
mmol/l
1.66
217
2377
67
878
0.70
1.84
3.5
3.1
—
—
—
0
0
5
12
4.22
1.83
1.6
1.2
38.8
19.5
umol/l
—
5
12
32
203
1.64
1.76
1.8
1.5
—
—
—
0
0
25
148
1.75
1.76
2.6
2.2
8.5
10.9
g/l
3.90
25
137
8
30
2.71
1.73
1.9
1.7
84.4
90.0
%
—
8
30
51
363
1.48
1.72
24.2
24.2
1.7
1.3
inr
—
7
55
31
466
0.63
1.68
1.3
1.3
16.5
35.2
iu/ml
—
10
143
32
207
1.61
1.64
2.2
2.2
59.2
70.3
e9/l
0.98
25
165
5
14
3.61
1.62
1.0
1.1
—
2.5
—
0
5
38
260
1.53
1.55
1.7
2.6
10.7
7.5
ug/l
0.17
29
222
21
123
1.76
1.55
2.0
1.3
0.8
1.1
g/l
1.50
21
114
10
44
2.31
1.55
2.8
3.0
—
—
—
0
0
75
592
1.35
1.42
4.3
3.8
1.0
1.0
kg/l
—
7
86
5
17
2.97
1.36
1.0
1.5
6.9
11.9
%
—
5
17
230
2460
0.76
1.35
6.2
6.0
42.6
40.2
mmol/mol
2.19
205
2284
29
194
1.55
1.32
4.6
3.4
—
—
—
0
0
8
34
2.39
1.30
1.0
1.0
—
—
—
0
0
35
246
1.48
1.28
5.3
4.0
—
—
—
0
0
6
25
2.43
1.25
2.7
2.0
34.2
32.1
pg
—
6
25
6
25
2.43
1.25
1.0
1.2
—
—
—
0
0
5
19
2.66
1.22
1.0
1.3
—
—
—
0
0
20
125
1.64
1.21
1.7
1.3
—
—
—
0
0
5
20
2.52
1.15
2.2
1.9
—
—
—
0
0
7
31
2.29
1.11
14.7
2.6
8.2
6.7
mmol/l
—
7
22
93
783
1.27
1.10
4.9
3.9
—
—
—
0
0
68
552
1.30
1.07
1.9
1.7
2.0
1.0
mg/l
1.70
53
424
99
846
1.25
1.02
2.6
2.9
7.2
7.1
mmol/l
0.05
79
699
9
157
0.56
1.01
1.2
1.4
—
—
—
0
0
5
23
2.19
0.98
2.4
2.5
—
—
—
0
0
15
93
1.64
0.95
4.9
2.1
512.4
740.3
ug/l
0.19
15
86
7
37
1.91
0.94
1.1
1.2
—
—
—
0
0
6
27
2.25
0.94
2.0
1.2
—
—
—
0
0
68
563
1.27
0.92
1.6
1.7
496.7
453.1
pmol/l
0.29
50
460
19
127
1.53
0.91
3.0
2.0
1.2
1.1
%
0.21
19
127
8
42
1.93
0.89
1.0
1.1
—
—
—
0
0
94
811
1.23
0.88
2.7
3.0
651.6
292.8
mg/l
0.24
61
495
32
239
1.38
0.88
1.8
1.5
—
—
—
0
0
234
2459
0.81
0.85
3.8
4.3
1.3
1.3
mmol/l
0.75
205
2235
13
81
1.63
0.82
5.6
4.9
—
—
—
0
0
14
211
0.65
0.81
1.6
1.3
—
—
—
0
0
0
24
0.00
0.79
0.0
1.4
—
—
—
0
0
8
133
0.59
0.75
1.4
1.5
—
—
—
0
0
7
38
1.86
0.74
1.1
1.1
—
—
—
0
0
5
25
2.02
0.73
1.4
1.8
—
—
—
0
0
10
60
1.69
0.73
3.6
2.8
—
—
—
0
0
7
40
1.77
0.71
1.1
1.2
—
—
—
0
0
7
40
1.77
0.71
2.4
2.1
—
—
—
0
0
5
27
1.87
0.68
1.0
1.4
—
—
—
0
0
246
2557
0.82
0.68
4.5
4.8
6.2
6.0
mmol/l
0.81
220
2326
45
541
0.80
0.66
1.9
1.8
1640.1
1186.8
nmol/l
1.65
30
401
13
188
0.68
0.64
1.4
1.4
—
—
—
0
0
13
87
1.52
0.64
1.1
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
289.7
—
0
13
8
53
1.52
0.59
1.5
1.6
—
—
—
0
0
271
2632
1.22
0.54
26.8
12.3
—
—
—
0
0
6
39
1.55
0.53
4.7
1.9
63.5
61.0
%
—
6
39
14
100
1.42
0.52
4.6
4.1
23.8
25.1
mmol/l
0.62
14
94
113
1036
1.14
0.51
2.7
2.8
193.4
105.6
ug/l
2.57
104
947
73
651
1.16
0.48
2.8
2.3
333.2
10617.9
umol/l
4.04
64
559
5
85
0.58
0.46
1.2
1.5
1.2
1.2
g/l
—
5
80
18
139
1.31
0.44
4.3
4.0
—
—
—
0
0
5
32
1.57
0.42
2.0
1.3
—
—
—
0
0
15
114
1.33
0.41
4.5
3.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
0.9
—
0
15
0
15
0.00
0.41
0.0
1.7
—
3.4
—
0
9
21
259
0.80
0.41
1.9
1.7
—
—
—
0
0
9
69
1.31
0.37
3.3
3.7
—
—
—
0
0
10
135
0.73
0.37
1.6
1.5
—
—
—
0
0
49
434
1.15
0.36
1.7
1.3
2.5
2.6
g/l
0.11
29
254
210
2026
1.11
0.36
4.6
4.0
15.0
14.9
pmol/l
0.27
195
1822
6
43
1.40
0.35
2.5
2.1
3.9
4.1
mmol/l
—
6
43
6
43
1.40
0.35
2.5
2.1
103.0
105.4
mmol/l
—
6
43
6
43
1.40
0.35
1.5
1.6
—
—
—
0
0
74
677
1.12
0.34
5.0
3.5
—
—
—
0
0
6
45
1.34
0.34
1.3
1.6
—
—
—
0
0
72
659
1.12
0.33
1.4
1.5
23.2
21.2
nmol/l
0.42
60
565
6
47
1.28
0.32
3.7
1.4
—
—
—
0
0
39
344
1.15
0.31
3.3
2.7
0.7
0.8
ug/l
0.21
30
230
92
857
1.10
0.31
3.7
3.7
6.4
7.3
mg/mmol
0.15
60
521
7
56
1.26
0.29
2.6
2.6
25.4
25.3
mmol/l
—
7
47
277
2725
1.14
0.28
21.3
8.9
27.3
24.6
u/l
2.16
272
2599
12
96
1.26
0.25
9.6
6.7
—
—
—
0
0
14
169
0.82
0.24
2.9
2.9
—
—
—
0
0
21
181
1.17
0.23
1.1
1.2
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
5
42
1.19
0.21
2.6
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
10.5
—
—
—
0
0
0
11
0.00
0.21
0.0
7.1
—
25.5
—
0
11
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.4
—
13.8
—
0
10
0
12
0.00
0.21
0.0
8.4
—
0.6
—
0
12
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
5
43
1.17
0.21
2.8
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
0.8
—
0
9
0
14
0.00
0.20
0.0
2.7
—
—
—
0
0
11
90
1.23
0.19
2.5
1.6
—
—
—
0
0
200
1953
1.07
0.19
3.6
4.1
17.2
12.3
mm/h
2.38
175
1781
6
53
1.13
0.19
1.3
1.3
—
—
—
0
0
7
61
1.15
0.17
1.3
1.4
—
—
—
0
0
7
62
1.13
0.17
1.3
1.4
—
—
—
0
0
7
62
1.13
0.17
1.3
1.4
—
—
—
0
0
7
62
1.13
0.17
1.3
1.4
—
—
—
0
0
11
92
1.20
0.16
1.6
1.8
—
—
—
0
0
55
522
1.07
0.13
1.2
1.3
0.9
1.6
u/ml
0.80
16
150
18
198
0.90
0.11
1.2
1.5
—
—
—
0
0
238
2407
0.95
0.11
5.2
4.9
2.0
2.4
mu/l
0.34
217
2177
14
125
1.13
0.10
3.6
3.4
4.3
4.5
pmol/l
0.64
14
109
223
2257
0.96
0.10
30.6
14.1
37.3
39.7
%
3.44
149
1539
6
54
1.11
0.09
1.0
1.1
51.5
26.9
iu/l
—
6
44
6
55
1.09
0.09
1.5
2.2
—
—
—
0
0
5
62
0.80
0.08
1.0
1.3
—
—
—
0
0
32
303
1.06
0.08
1.7
1.7
—
—
—
0
0
7
66
1.06
0.08
1.0
1.2
4.5
3.9
mmol/l
—
7
60
8
93
0.86
0.07
1.0
1.1
—
—
—
0
0
109
1111
0.97
0.06
1.9
2.0
89.4
96.9
pmol/l
0.85
57
532
24
254
0.94
0.06
1.1
1.3
—
—
—
0
0
18
168
1.08
0.06
2.2
1.4
—
—
—
0
0
19
178
1.07
0.06
1.2
1.2
—
—
—
0
0
16
151
1.06
0.03
2.3
2.6
—
—
—
0
0
10
93
1.08
0.02
1.5
2.0
—
—
—
0
0
15
149
1.01
0.00
1.1
1.2
188.9
190.9
u/ml
0.01
15
138
35
355
0.98
0.00
1.2
1.1
—
—
—
0
0
7
74
0.94
0.00
1.0
1.3
540.3
487.6
mg/l
—
7
66
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
18.6
—
0
5
0
6
0.00
0.00
0.0
6.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
5.8
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
56
0.89
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_LEIOMYOSARCOMA_EXALLC – Leiomyosarcoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).