Liposarcoma, excluding all cancers (controls excluding all cancers)

C3_LIPOSARCOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C48.2|C49.2
  • Cause of death: ICD-10 C48.2|C49.2
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 885[0-4]|8858
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

342

4. Check minimum number of events

None

342

5. Include endpoints

None

342

6. Filter based on genotype QC (FinnGen only)

342

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 342 135 207
Unadjusted period prevalence (%) 0.07 0.05 0.09
Median age at first event (years) 62.45 59.80 64.18

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
216
Matched controls
2159
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C49.22
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the lower extremity including hip liposarcoma
+∞
67.3
61
*
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
128.0
54.9
57
6
C48.02
ICD-10 Finland
Malignant tumor of the retroperitoneal space liposarcoma
+∞
54.5
50
*
130
Kela drug reimbursment
Malignant tumour
+∞
54.5
50
*
8850/3-C49.2
ICD-O-3
Liposarcoma, NOS, of connective, Subcutaneous and other soft tissues of lower limb and hip
+∞
53.4
49
*
KKB10
NOMESCO Finland
Excision of retroperitoneal tumour
+∞
45.4
42
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
+∞
42.1
39
*
C49.20
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the lower extremity including the hip without histology
+∞
39.8
37
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
31.2
34.0
45
18
H02AB02
ATC
dexamethasone; systemic
52.5
33.1
39
9
JN4BD
NOMESCO Finland
Extensive body CT
16.0
32.3
54
44
A04AA02
ATC
granisetron; systemic, transdermal
120.0
29.5
31
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.4
29.5
145
595
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
320.8
28.5
28
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
12.5
27.4
51
52
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
307.2
27.4
27
*
D48.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Retroperitoneum
+∞
25.5
24
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.1
24.0
95
290
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
32.6
23.9
31
11
B01AB05
ATC
enoxaparin; parenteral
4.7
23.6
104
353
XX3DW
NOMESCO Finland
Time consuming IT work
12.5
23.4
43
42
8850/3-C49.6
ICD-O-3
Liposarcoma, NOS, of connective, Subcutaneous and other soft tissues of trunk, NOS
+∞
23.3
22
*
C49.29
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of lower extremity including hip other or unspecified tumor
+∞
23.3
22
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.4
23.3
121
481
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
134.3
23.1
24
*
D17.2
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
33.2
22.5
29
10
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
22.3
21
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
89.7
22.2
24
*
B01AB10
ATC
tinzaparin; parenteral
12.7
22.0
40
38
A03FA01
ATC
metoclopramide; systemic, rectal
7.0
22.0
59
110
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
21.2
20
*
8850/3-C49.1
ICD-O-3
Liposarcoma, NOS, of connective, Subcutaneous and other soft tissues of upper limb and shoulder
+∞
20.1
19
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
20.1
19
*
WX402
NOMESCO Finland
General anaesthesia
5.5
19.6
65
157
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
12.4
19.3
35
33
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
19.0
18
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.1
18.4
89
314
C49.12
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of upper extremity including shoulder liposarcoma
+∞
18.0
17
*
8858/3-C48.0
ICD-O-3
Dedifferentiated liposarcoma of retroperitoneum
+∞
18.0
17
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
18.0
17
*
C49.42
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the abdomen liposarcoma
+∞
18.0
17
*
JN4AD
NOMESCO Finland
Body CT examination
10.6
16.9
33
36
R4110
NOMESCO Finland
Physiotherapy
3.9
16.9
89
332
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
16.9
16
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
15.8
15
*
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
+∞
15.8
15
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
171.9
15.7
16
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.3
15.1
113
541
ZXE20
NOMESCO Finland
More than three and less than five hours
4.8
15.1
55
144
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
20.2
15.0
22
12
WF002
NOMESCO Finland
Radical radiotherapy
86.1
14.8
16
*
8850/3-C48.0
ICD-O-3
Liposarcoma, NOS, of retroperitoneum
+∞
14.7
14
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
14.7
14
*
L03AA02
ATC
filgrastim; parenteral
+∞
14.7
14
*
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
+∞
14.7
14
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
14.7
14
*
KAC10
NOMESCO Finland
Total nephrectomy with capsule
+∞
14.7
14
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.6
14.2
43
91
C49.2
ICD-10 Finland
Malignant neoplasm: Connective and soft tissue of lower limb, including hip
+∞
13.7
13
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
149.0
13.6
14
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
7.6
13.6
32
48
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.2
12.9
42
96
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.7
12.9
30
44
WX306
NOMESCO Finland
Lumbar epidural anesthesy
8.9
12.8
27
34
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
12.6
12
*
D17.1
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
9.3
12.2
25
30
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
11.5
12.1
22
21
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
24.5
11.8
16
7
A04AA01
ATC
ondansetron; systemic, rectal
12.8
11.6
20
17
C49.32
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the thorax liposarcoma
+∞
11.6
11
*
8850/3-C49.4
ICD-O-3
Liposarcoma, NOS, of connective, Subcutaneous and other soft tissues of abdomen
+∞
11.6
11
*
KAC00
NOMESCO Finland
Nephrectomy
+∞
11.6
11
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
11.6
11
*
C49.10
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of upper extremity including shoulder without histology
+∞
11.6
11
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.2
11.3
25
34
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
7.9
11.1
25
35
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
19.1
10.9
16
9
JN4CD
NOMESCO Finland
Very extensive body CT
15.3
10.7
17
12
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
115.4
10.5
11
*
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
115.4
10.5
11
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
115.4
10.5
11
*
Z51.5
ICD-10 Finland
Palliative care
11.5
10.5
19
18
C48.0
ICD-10 Finland
Malignant neoplasm: Retroperitoneum
+∞
10.5
10
*
C49.52
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the pelvis liposarcoma
+∞
10.5
10
*
C48.09
ICD-10 Finland
Malignant tumor of the retroperitoneal space other or unspecified tumor
+∞
10.5
10
*
A04AD12
ATC
aprepitant; systemic
+∞
10.5
10
*
8852/3-C49.2
ICD-O-3
Myxoid liposarcoma of connective, Subcutaneous and other soft tissues of lower limb and hip
+∞
10.5
10
*
N02AA05
ATC
oxycodone; systemic
3.9
10.1
43
128
N02BE01
ATC
paracetamol; systemic, rectal
3.5
10.0
192
1496
S18
ICPC
Laceration/cut
2.6
10.0
109
611
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
12.2
9.7
17
15
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
12.2
9.7
17
15
WZC30
NOMESCO Finland
Teaching
4.3
9.7
37
100
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
9.4
9.5
19
22
D17.9
ICD-10 Finland
Benign lipomatous neoplasm, unspecified
22.9
9.5
13
6
C48.00
ICD-10 Finland
Malignant tumor of the retroperitoneal space without histology
+∞
9.4
9
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
9.4
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.4
9
*
R4120
NOMESCO Finland
Occupational therapy
4.9
9.4
31
72
TPX10
NOMESCO Finland
Implantation of vascular injection port
12.3
8.7
15
13
ZXA05
NOMESCO Finland
Left side
2.6
8.7
77
379
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
17.2
8.7
13
8
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.2
8.6
49
183
ZXE00
NOMESCO Finland
One hour or less
2.4
8.5
98
553
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
93.6
8.5
9
*
JAH00
NOMESCO Finland
Laparotomy
11.4
8.4
15
14
C49.02
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the head, face and neck liposarcoma
+∞
8.4
8
*
116
Kela drug reimbursment
Prostate cancer
+∞
8.4
8
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
8.4
8
*
C49.62
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the trunk, unspecified localization liposarcoma
+∞
8.4
8
*
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
23.1
8.1
11
5
Z3226
NOMESCO Finland
Physiotherapist
2.9
8.0
54
223
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
13.7
8.0
13
10
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
10.0
7.9
15
16
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
15.8
7.8
12
8
ZX070
NOMESCO Finland
Intensity modified radiotherapy
82.8
7.5
8
*
NAR20
NOMESCO Finland
Complete excision of soft tissue tumour of spine, unspecified
82.8
7.5
8
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
82.8
7.5
8
*
ZXA00
NOMESCO Finland
Right side
2.4
7.4
74
384
8851/3-C49.2
ICD-O-3
Liposarcoma, well differentiated, NOS, of connective, Subcutaneous and other soft tissues of lower limb and hip
+∞
7.3
7
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
7.3
7
*
ZZR10
NOMESCO Finland
Flap of skin and muscle
+∞
7.3
7
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
7.3
7
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.7
7.0
19
36
L02AE02
ATC
leuprorelin; implant, parenteral
23.4
6.7
9
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
10.5
6.6
12
12
TQW99
NOMESCO Finland
Other minor procedure on skin
6.6
6.6
16
26
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.7
6.6
21
48
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
6.5
44
182
WW500
NOMESCO Finland
Blood transfusion
8.6
6.4
13
16
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
6.3
6
*
115
Kela drug reimbursment
Breast cancer
+∞
6.3
6
*
ZZR30
NOMESCO Finland
Flap of muscle
+∞
6.3
6
*
C49.19
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of upper extremity including shoulder other or unspecified tumor
+∞
6.3
6
*
8850/3-C49.5
ICD-O-3
Liposarcoma, NOS, of connective, Subcutaneous and other soft tissues of pelvis
+∞
6.3
6
*
YJ1BD
NOMESCO Finland
Extensive CT examination of abdomen for dose design of radiotherapy
+∞
6.3
6
*
C49.99
ICD-10 Finland
Malignant tumor in unspecified localization in connective tissue and soft tissue other or unspecified tumor
+∞
6.3
6
*
ZZR00
NOMESCO Finland
Flap of skin
27.6
6.3
8
*
WX320
NOMESCO Finland
Spinalanesthesy
2.4
6.2
57
282

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_LIPOSARCOMA_EXALLC – Liposarcoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).