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Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system

C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C72
  • Cause of death: ICD-9 192
  • Cause of death: ICD-8 192
  • Cause of death: excluded ICD-9 1921|1923|1928
  • Cancer registry: Topography ICD-O-3 C72
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

67

4. Check minimum number of events

None

67

5. Include endpoints

None

67

6. Filter based on genotype QC (FinnGen only)

67

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 67 33 34
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 53.09 49.81 56.27

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
9391/3-C72.0
ICD-O-3
Ependymoma, NOS, of spinal cord
+∞
32.1
28
*
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
381.6
25.7
24
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
155.0
21.1
21
*
C72.00
ICD-10 Finland
Malignant tumor of the spinal cord without histology
+∞
18.7
17
*
C72.09
ICD-10 Finland
Malignant tumor of the spinal cord other histology
+∞
15.2
14
*
C72.01
ICD-10 Finland
Malignant tumor of the spinal cord grade II glioma
+∞
15.2
14
*
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
+∞
11.8
11
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
73.0
11.1
12
*
M03BX01
ATC
baclofen; systemic
48.6
10.4
12
*
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
9.6
9
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
+∞
9.6
9
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
43.7
9.4
11
*
D33.43
ICD-10 Finland
Spinal cord
+∞
8.5
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.5
8.5
30
90
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
16.1
7.8
12
9
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
7.4
7
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
23.4
7.4
10
5
H02AB02
ATC
dexamethasone; systemic
7.1
6.9
17
31
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
8.2
6.9
15
23
L28
ICPC
Limited function/disability (L)
5.6
6.8
21
52
N03AX16
ATC
pregabalin; oral
4.6
6.7
27
89
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
16.7
6.7
10
7
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
9.3
6.5
13
17
D33.41
ICD-10 Finland
Myxopapillary epndymoma of the spinal cord (grade I)
+∞
6.3
6
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
17.2
6.1
9
6

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS – Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).