Malignant neoplasm of thymus, excluding all cancers (controls excluding all cancers)

C3_THYMUS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C37&
  • Hospital discharge: ICD-9 1640
  • Cause of death: ICD-10 C37&
  • Cause of death: ICD-9 1640
  • Cancer registry: Topography ICD-O-3 C37
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

141

4. Check minimum number of events

None

141

5. Include endpoints

None

141

6. Filter based on genotype QC (FinnGen only)

141

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of thymus, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 141 64 77
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 62.20 61.56 62.73

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
99
Matched controls
989
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
+∞
52.9
46
*
C37
ICD-10 Finland
Malignant neoplasm of thymus
+∞
46.6
41
*
GEC24
NOMESCO Finland
Thoracoscopic thymectomy
+∞
45.3
40
*
D38.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thymus
+∞
44.1
39
*
8580/3-C37.9
ICD-O-3
Thymoma, NOS, of thymus
+∞
32.0
29
*
D15.0
ICD-10 Finland
Benign neoplasm: Thymus
+∞
32.0
29
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
41.8
31.5
39
15
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
19.7
28.1
45
40
130
Kela drug reimbursment
Malignant tumour
+∞
26.2
24
*
H02AB02
ATC
dexamethasone; systemic
76.9
25.6
28
5
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
21.6
20
*
GEC23
NOMESCO Finland
Transsternal thymectomy
+∞
20.5
19
*
8582/3-C37.9
ICD-O-3
Thymoma, type AB of thymus
+∞
19.4
18
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
19.4
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.5
18.7
74
281
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
18.3
17
*
GD1AD
NOMESCO Finland
Thorax CT examination
23.4
17.6
25
14
JN4BD
NOMESCO Finland
Extensive body CT
17.2
17.5
28
22
ZXC96
NOMESCO Finland
Robot assisted procedure
202.8
17.1
17
*
XX3DW
NOMESCO Finland
Time consuming IT work
21.3
15.2
22
13
WX408
NOMESCO Finland
General anesthesy, balanced
6.1
15.0
53
158
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
15.0
14
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
15.0
14
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
174.7
14.9
15
*
WF002
NOMESCO Finland
Radical radiotherapy
174.7
14.9
15
*
A03FA01
ATC
metoclopramide; systemic, rectal
7.8
14.3
36
67
A04AA02
ATC
granisetron; systemic, transdermal
161.2
13.8
14
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
47.0
13.6
16
*
B01AB05
ATC
enoxaparin; parenteral
5.7
13.3
47
136
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.9
13.0
36
76
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
12.8
12
*
GEB30
NOMESCO Finland
Mediastinotomy and excision of lesion
+∞
12.8
12
*
G70.0
ICD-10 Finland
Myasthenia gravis
148.0
12.8
13
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
148.0
12.8
13
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
11.7
11
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
11.7
11
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
11.7
11
*
A04AA01
ATC
ondansetron; systemic, rectal
29.1
11.5
15
6
WX302
NOMESCO Finland
Thoracal epidural anesthesy
20.9
11.2
16
9
N07AA02
ATC
pyridostigmine; systemic
122.4
10.6
11
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
+∞
10.6
10
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
10.6
10
*
Z51.5
ICD-10 Finland
Palliative care
44.9
10.2
12
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.9
10.1
19
21
L03AA02
ATC
filgrastim; parenteral
110.1
9.6
10
*
108
Kela drug reimbursment
Myasthenia gravis
110.1
9.6
10
*
R4110
NOMESCO Finland
Physiotherapy
4.3
9.6
43
150
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
9.5
9
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
9.5
9
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
9.5
9
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
40.8
9.2
11
*
JN4AD
NOMESCO Finland
Body CT examination
16.4
8.5
13
9
A04AD12
ATC
aprepitant; systemic
+∞
8.4
8
*
N02AA05
ATC
oxycodone; systemic
6.2
8.4
23
46
WZC30
NOMESCO Finland
Teaching
6.2
8.4
23
46
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.7
8.3
45
180
WX402
NOMESCO Finland
General anaesthesia
4.9
8.2
28
73
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
8.1
41
154
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
7.9
8.0
18
27
JN6AD
NOMESCO Finland
CT of torso and neck
86.3
7.5
8
*
8585/3-C37.9
ICD-O-3
Thymoma, type B3 of thymus
+∞
7.4
7
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
7.4
7
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
7.4
7
*
8581/3-C37.9
ICD-O-3
Thymoma, type A of thymus
+∞
7.4
7
*
116
Kela drug reimbursment
Prostate cancer
+∞
7.4
7
*
8583/3-C37.9
ICD-O-3
Thymoma, type B1 of thymus
+∞
7.4
7
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.1
6.8
16
26
TPH04
NOMESCO Finland
Cathetrisation of vein
3.8
6.8
31
106
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
15.7
6.5
10
7
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
19.6
6.4
9
5
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
28.7
6.3
8
*
C38.1
ICD-10 Finland
Malignant neoplasm: Anterior mediastinum
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
8070/3-C37.9
ICD-O-3
Squamous cell carcinoma, NOS, of thymus
+∞
6.3
6
*
D15.2
ICD-10 Finland
Benign neoplasm: Mediastinum
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.1
6.3
25
75
WW500
NOMESCO Finland
Blood transfusion
16.3
6.0
9
6

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_THYMUS_EXALLC – Malignant neoplasm of thymus, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).