salivary gland neoplasm: ['Tumors of the SALIVARY GLANDS.']
Benign neoplasm: other/unspecified salivary gland
CD2_BENIGN_SALIVARY_NOS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
993 |
4. Check minimum number of eventsNone |
993 |
5. Include endpointsNone |
993 |
6. Filter based on genotype QC (FinnGen only) |
993 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: other/unspecified salivary gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: other/unspecified salivary gland
- Benign neoplasm of major salivary glands
- Benign neoplasm of major salivary glands
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7909 | 4345 | 3466 |
| Only index persons | 6218 | 3614 | 2604 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.10 |
| Only index persons | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 53.29 | 53.09 | 53.34 |
| Only index persons | 49.87 | 49.80 | 49.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 993 | 541 | 452 |
| Unadjusted period prevalence (%) | 0.19 | 0.18 | 0.20 |
| Median age at first event (years) | 51.51 | 48.48 | 55.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 899
- Matched controls
- 8992
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D11.70
ICD-10 Finland
Gland sublingual
+∞
323.0
345
*
ELB30
NOMESCO Finland
Excision of submandibular gland
389.8
240.5
232
8
2102A
ICD-9 Finland
Benign neoplasm of lip, oral cavity and pharynx, Major salivary glands
+∞
235.0
215
*
21020
ICD-8 Finland
Benign neoplasm of buccal cavity and pharynx, Salivary gland
+∞
222.3
204
*
4405
FHL
Partial removal of the parotid gland
1673.7
149.3
141
*
D11.9
ICD-10 Finland
Benign neoplasm: Major salivary gland, unspecified
+∞
135.9
127
*
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
27.2
101.0
141
61
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
10.1
60.2
125
141
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.6
50.1
137
237
ELB40
NOMESCO Finland
Partial parotidectomy
17.3
43.3
69
43
D11.7
ICD-10 Finland
Benign neoplasm: Other major salivary glands
+∞
43.1
41
*
EL4AT
NOMESCO Finland
Salivary gland cytology with ultrasound guidance
225.4
42.3
43
*
4404
FHL
Complete removal of the parotid gland
181.8
34.0
35
*
K11.2
ICD-10 Finland
Sialoadenitis
6.8
25.2
65
102
ELB00
NOMESCO Finland
Excision or exploration of lesion of salivary gland
44.5
21.5
26
6
4403
FHL
Submandibular gland removal
45.0
18.3
22
5
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
22.3
18.2
26
12
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
17.4
17.5
27
16
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
173.0
16.5
17
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
8.6
15.8
34
41
D11.71
ICD-10 Finland
Gland submandibular
+∞
15.7
15
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
9.7
15.5
31
33
C08.09
ICD-10 Finland
Malignant tumor of the submandibular or submaxillary gland, other or unspecified histology
81.4
14.6
16
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
14.7
14.1
23
16
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
12.6
12.2
21
17
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
11.2
12.1
22
20
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
11.8
249
1584
ELB50
NOMESCO Finland
Total parotidectomy
30.5
11.7
15
5
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.4
11.6
41
96
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
11.3
335
2353
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
18.1
10.7
16
9
C08.00
ICD-10 Finland
Malignant tumor of submandibular or submaxillary gland, not histology
+∞
10.4
10
*
4704
FHL
Neck tumor removal
32.9
10.3
13
*
K11.9
ICD-10 Finland
Disease of salivary gland, unspecified
11.4
10.1
18
16
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
12.3
9.9
17
14
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
9.6
342
2496
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.4
8.5
24
45
4402
FHL
Removal or exploration of a salivary change (eg ranula)
90.8
8.4
9
*
C08.02
ICD-10 Finland
Cystic adenocarcinoma of the submandibular or submaxillary glands
+∞
8.3
8
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
8.6
8.3
17
20
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
8.1
7.6
16
20
4701
FHL
Neck lymph node removal
25.2
7.6
10
*
ZXA00
NOMESCO Finland
Right side
1.6
7.5
246
1741
WX402
NOMESCO Finland
General anaesthesia
1.8
7.4
131
778
8200/3-C08.0
ICD-O-3
Adenoid cystic carcinoma of submandibular gland
+∞
7.3
7
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
8.9
7.1
14
16
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
16.8
6.8
10
6
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
12.3
6.6
11
9
4409
FHL
Other measure in this category
70.3
6.4
7
*
ELB99
NOMESCO Finland
Other excision of salivary gland
70.3
6.4
7
*
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
14.4
6.4
10
7
K11.70
ICD-10 Finland
Hypoptyalism
8.2
6.3
13
16
TQA05
NOMESCO Finland
Puncture of skin of head or neck
+∞
6.3
6
*
8430/3-C08.0
ICD-O-3
Mucoepidermoid carcinoma of submandibular gland
+∞
6.3
6
*
C08.90
ICD-10 Finland
Malignant tumor in unspecified large salivary gland without histology
+∞
6.3
6
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.6
6.2
41
160
ZXA05
NOMESCO Finland
Left side
1.5
6.1
231
1679
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_SALIVARY_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SALIVARY_NOS | 1.304 [1.12, 1.52] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.225 |
During the follow-up period (1.1.1998 — 31.12.2019), 403 out of 1694 females with CD2_BENIGN_SALIVARY_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SALIVARY_NOS | 1.63 [1.38, 1.93] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 1374 males with CD2_BENIGN_SALIVARY_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_SALIVARY_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.371% |
| 5 | 0.664% | 1.865% |
| 10 | 1.9% | 4.564% |
| 15 | 3.672% | 8.531% |
| 20 | 6.75% | 14.404% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_SALIVARY_NOS – Benign neoplasm: other/unspecified salivary gland
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data