Benign neoplasm of major salivary glands

CD2_BENIGN_SALIVARY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D11
  • Cause of death: ICD-10 D11

2 out of 7 registries used, show all original rules.

3456

4. Check minimum number of events

None

3456

5. Include endpoints

3853

6. Filter based on genotype QC (FinnGen only)

3853

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasmata benigna glandularum salivariarum majorum

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24561 12823 11557
Only index persons 21875 11713 10162
Unadjusted period prevalence (%)
Whole population 0.35 0.37 0.32
Only index persons 0.41 0.43 0.39
Median age at first event (years)
Whole population 58.45 58.19 58.72
Only index persons 57.54 57.27 57.85

-FinnGen-

Key figures

All Female Male
Number of individuals 3853 1999 1854
Unadjusted period prevalence (%) 0.75 0.68 0.82
Median age at first event (years) 58.20 55.57 61.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3462
Matched controls
34622
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D11.70
ICD-10 Finland
Gland sublingual
3720.9
323.0
347
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
10.7
323.0
761
888
ELB40
NOMESCO Finland
Partial parotidectomy
1452.9
323.0
1497
18
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
4503599627370496.0
323.0
2700
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
13.4
301.3
552
483
EL4AT
NOMESCO Finland
Salivary gland cytology with ultrasound guidance
188.0
252.0
261
15
2102A
ICD-9 Finland
Benign neoplasm of lip, oral cavity and pharynx, Major salivary glands
+∞
226.6
215
*
21020
ICD-8 Finland
Benign neoplasm of buccal cavity and pharynx, Salivary gland
+∞
214.8
204
*
ELB30
NOMESCO Finland
Excision of submandibular gland
67.5
211.9
245
39
ELB00
NOMESCO Finland
Excision or exploration of lesion of salivary gland
363.3
207.2
207
6
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
66.9
174.5
202
32
ELB50
NOMESCO Finland
Total parotidectomy
147.7
172.1
182
13
D11.9
ICD-10 Finland
Benign neoplasm: Major salivary gland, unspecified
705.8
138.8
136
*
4405
FHL
Partial removal of the parotid gland
151.2
137.4
145
10
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
35.0
130.0
170
51
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
118.6
1231
6219
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
14.7
115.5
199
143
C07.70
ICD-10 Finland
Malignant tumor of the superficial part of the parotid gland
125.3
112.8
121
10
K11.2
ICD-10 Finland
Sialoadenitis
7.1
101.4
262
396
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
23.8
100.9
146
64
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
5.6
70.5
216
406
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
16.0
67.9
112
72
ZXA05
NOMESCO Finland
Left side
1.9
54.8
1001
6042
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.9
54.6
186
394
ZXA00
NOMESCO Finland
Right side
1.9
50.5
1041
6521
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
28.9
50.1
68
24
D11.7
ICD-10 Finland
Benign neoplasm: Other major salivary glands
+∞
43.8
42
*
WX402
NOMESCO Finland
General anaesthesia
2.0
42.7
608
3293
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
7.3
41.5
102
143
K11.9
ICD-10 Finland
Disease of salivary gland, unspecified
14.4
39.9
68
48
4404
FHL
Complete removal of the parotid gland
391.8
39.1
39
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
12.0
39.0
72
61
EL3AT
NOMESCO Finland
Salivary gland biopsy with ultrasound guidance
74.4
39.0
44
6
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
16.9
37.6
60
36
ELB99
NOMESCO Finland
Other excision of salivary gland
361.0
36.0
36
*
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.6
35.8
274
1097
C07.71
ICD-10 Finland
Malignant tumor in the deep part of the parotid gland
181.8
34.8
36
*
J01DB01
ATC
cefalexin; oral
1.6
33.4
2684
23439
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
6.7
31.8
82
124
S04
ICPC
Lump/swelling localized
2.3
31.7
321
1484
8550/3-C07.9
ICD-O-3
Acinar cell carcinoma of parotid gland
315.6
30.9
31
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.1
30.2
97
194
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
4.9
26.5
89
187
WX110
NOMESCO Finland
Local anesthesy
1.5
26.3
2137
18063
L04.0
ICD-10 Finland
Acute lymphadenitis of face, head and neck
7.4
25.9
62
85
DWD00
NOMESCO Finland
Reoperation for superficial heamorrhage in surgery of ear, nose and larynx
32.3
24.6
32
10
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.1
24.4
139
461
8430/3-C07.9
ICD-O-3
Mucoepidermoid carcinoma of parotid gland
+∞
24.0
23
*
S18
ICPC
Laceration/cut
1.5
23.7
1342
10454
N02BE01
ATC
paracetamol; systemic, rectal
1.6
23.6
2836
25714
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
22.0
718
4929
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.9
21.8
357
2004
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.3
20.1
198
904
C08.89
ICD-10 Finland
Malignant overall tumor the large salivary glands anna or unspecified histology
73.9
19.7
22
*
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
16.5
19.6
31
19
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
21.7
19.5
28
13
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
5.3
18.1
55
105
K11.88
ICD-10 Finland
Other diseases of salivary glands
15.7
17.5
28
18
J01DA01
ATC
[U] cefalexin; systemic
1.4
17.4
1963
16951
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
11.1
17.2
32
29
R03BB04
ATC
tiotropium bromide; inhalant
1.7
17.1
341
2037
C08.94
ICD-10 Finland
Mucoepidermoid carcinoma of an unspecified large salivary gland
+∞
16.7
16
*
D11.71
ICD-10 Finland
Gland submandibular
+∞
16.7
16
*
C08.09
ICD-10 Finland
Malignant tumor of the submandibular or submaxillary gland, other or unspecified histology
90.5
16.6
18
*
TQA05
NOMESCO Finland
Puncture of skin of head or neck
27.7
16.5
22
8
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.9
16.0
65
168
C82.1
ICD-10 Finland
Follicular lymphoma grade II
6.2
15.9
42
68
C08.99
ICD-10 Finland
Malignant tumor of unspecified large salivary gland, other or unspecified histology
85.5
15.6
17
*
TPJ05
NOMESCO Finland
Needle biopsy of lymph node
38.2
15.4
19
5
B02
ICPC
Lymph gland(s) enlarged/painful
6.6
15.3
39
60
4403
FHL
Submandibular gland removal
14.0
15.0
25
18
K11.3
ICD-10 Finland
Abscess of salivary gland
18.4
14.7
22
12
TEL00
NOMESCO Finland
Needle biopsy of salivary gland
+∞
14.6
14
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
5.9
14.5
40
69
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
4.4
13.5
48
110
UDC00
NOMESCO Finland
Ear microscopy
1.8
13.5
221
1240
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
1.7
13.4
273
1642
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
13.3
327
2073
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
12.8
951
7570
Q18.0
ICD-10 Finland
Sinus, fistula and cyst of branchial cleft
7.2
12.7
30
42
C08.90
ICD-10 Finland
Malignant tumor in unspecified large salivary gland without histology
+∞
12.5
12
*
9699/3-C07.9
ICD-O-3
Marginal zone B-cell lymphoma, NOS, of parotid gland
+∞
12.5
12
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
5.0
12.4
39
79
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
12.4
1160
9550
EP1BG
NOMESCO Finland
MRI examination of soft tissue of neck with high intesity magnet
6.9
12.4
30
44
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
12.3
595
4389
SPAT1153
SPAT
Removal of sutures
1.3
12.3
960
7690
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
12.3
716
5469
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
12.0
1149
9485
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.2
11.9
123
576
K11.5
ICD-10 Finland
Sialolithiasis
3.4
11.4
54
161
J01FF01
ATC
clindamycin; systemic
1.4
11.3
784
6153
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
12.7
11.1
19
15
ZXC99
NOMESCO Finland
Other special technic in surgery
12.7
11.1
19
15
NAR20
NOMESCO Finland
Complete excision of soft tissue tumour of spine, unspecified
12.7
11.1
19
15
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
5.6
11.0
31
56
WF003
NOMESCO Finland
Adjuvant radiotherapy
2.1
10.9
117
560
EP1AE
SPAT
NA
3.5
10.8
48
137
K11.4
ICD-10 Finland
Fistula of salivary gland
60.2
10.6
12
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
4.4
10.6
37
85
A10BA02
ATC
metformin; oral
1.3
10.5
839
6718
4402
FHL
Removal or exploration of a salivary change (eg ranula)
+∞
10.4
10
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
10.4
187
1080
N02AX02
ATC
tramadol; systemic, rectal
1.3
10.3
1266
10748
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
1.9
10.3
145
773
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
7.1
10.3
24
34
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.1
1318
11274
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
3.1
10.0
54
178
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.9
10.0
138
730
ELW99
NOMESCO Finland
Other operation on salivary gland
26.1
9.8
13
5
Z72.0
ICD-10 Finland
Tobacco use
2.4
9.7
79
332
EWE00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of teeth, jaws, mouth and pharynx
13.4
9.7
16
12
C08.00
ICD-10 Finland
Malignant tumor of submandibular or submaxillary gland, not histology
55.1
9.6
11
*
A02BC02
ATC
pantoprazole; systemic
1.3
9.6
1977
17812
A07AA02
ATC
nystatin; oral
1.7
9.6
185
1093
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
3.1
9.6
50
162
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.1
9.5
100
477
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.5
9.5
297
1998
8070/3-C07.9
ICD-O-3
Squamous cell carcinoma, NOS, of parotid gland
+∞
9.4
9
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.1
9.1
49
162
C07
ICD-10 Finland
Malignant neoplasm of parotid gland
36.8
9.0
11
*
130
Kela drug reimbursment
Malignant tumour
1.6
9.0
238
1539
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.8
8.9
151
860
AAH50
NOMESCO Finland
Cranial nerve anastomosis
18.6
8.9
13
7
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
1.8
8.6
133
734
R02
ICPC
Shortness of breath/dyspnoea
1.5
8.6
321
2243
EP1DM
NOMESCO Finland
Very extensive MRI examination of soft tissue of neck with 3 Tesla magnet
11.6
8.6
15
13
K11.1
ICD-10 Finland
Hypertrophy of salivary gland
16.3
8.5
13
8
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
8.5
588
4587
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.1
8.5
45
148
EP3AT
NOMESCO Finland
Neck soft tissue biopsy with ultrasound guidance
20.1
8.5
12
6
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
1.9
8.4
125
682
ELB70
NOMESCO Finland
Excision of parotid gland neoplasm or other lesion extending into parapharyngeal space
+∞
8.3
8
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.5
8.2
271
1844
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
1.7
8.2
158
937
ELA30
NOMESCO Finland
Biopsy of salivary gland
7.5
8.1
18
24
H02AB06
ATC
prednisolone; systemic
1.2
8.1
1367
11950
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.6
8.1
229
1506
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
6.8
8.1
19
28
UDQ22
NOMESCO Finland
Microlaryngoscopy
3.8
8.0
32
85
JN4BD
NOMESCO Finland
Extensive body CT
1.5
8.0
315
2228
C03CA01
ATC
furosemide; systemic
1.3
8.0
849
7029
R03AC02
ATC
salbutamol; inhalant
1.2
7.8
1486
13153
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.2
7.7
1161
10010
J01AA02
ATC
doxycycline; systemic
1.2
7.7
2421
22571
R61.0
ICD-10 Finland
Localized hyperhidrosis
6.4
7.7
19
30
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
7.7
1410
12420
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
7.6
1981
18092
K11
ICD-10 Finland
Diseases of salivary glands
11.9
7.6
13
11
PJA10
NOMESCO Finland
Exploration of lymph nodes
2.8
7.5
45
162
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
3.4
7.5
34
101
K11.0
ICD-10 Finland
Atrophy of salivary gland
80.3
7.4
8
*
8200/3-C07.9
ICD-O-3
Adenoid cystic carcinoma of parotid gland
80.3
7.4
8
*
EP1AT
NOMESCO Finland
Punction of soft tissue of neck with ultrasound guidance
13.4
7.4
12
9
SAA03
NOMESCO Finland
Extended examination of mouth
1.2
7.3
996
8479
R4110
NOMESCO Finland
Physiotherapy
1.3
7.3
751
6180
8147/3-C07.9
ICD-O-3
Basal cell adenocarcinoma of parotid gland
+∞
7.3
7
*
C08.92
ICD-10 Finland
Coastal adenocarcinoma of unspecified salivary gland
+∞
7.3
7
*
4704
FHL
Neck tumor removal
9.4
7.3
14
15
QAA99
NOMESCO Finland
Other local destruction of skin of head or neck
5.8
7.2
19
33
C82.00
ICD-10 Finland
Follicular nodular non-Hodgkin's lymphoma, ungraded
7.3
7.2
16
22
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.4
7.1
58
248
8500/3-C07.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of parotid gland
30.1
7.1
9
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
3.3
7.1
33
100
T90
ICPC
Diabetes non-insulin dependent
1.3
7.1
657
5335
N07BA03
ATC
varenicline; oral
1.7
7.1
129
755
L28
ICPC
Limited function/disability (L)
1.4
7.1
434
3320
P01AB01
ATC
metronidazole; oral, rectal
1.2
7.0
1094
9446
XX3DW
NOMESCO Finland
Time consuming IT work
1.4
7.0
286
2036
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
7.0
1313
11563
A03FA01
ATC
metoclopramide; systemic, rectal
1.3
7.0
559
4450
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.1
6.9
72
346
G51.0
ICD-10 Finland
Bell palsy
2.1
6.9
71
338
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
3.3
6.8
32
98
D37.09
ICD-10 Finland
Lip, oral cavity and pharynx
10.9
6.8
12
11
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
6.8
784
6544
XW1XT
NOMESCO Finland
Biopsy from other organ close to skin with other quidance
40.1
6.8
8
*
C08.02
ICD-10 Finland
Cystic adenocarcinoma of the submandibular or submaxillary glands
40.1
6.8
8
*
K11.70
ICD-10 Finland
Hypoptyalism
3.8
6.7
26
68
D17.0
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck
2.4
6.7
54
229
QAE30
NOMESCO Finland
Excision and repair of surgical scar in head or neck
7.2
6.7
15
21
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
6.7
690
5678
ZZK00
NOMESCO Finland
Graft of nerve
22.5
6.7
9
*
C82.9
ICD-10 Finland
Follicular lymphoma, unspecified
5.9
6.6
17
29
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.3
6.6
525
4177
8941/3-C07.9
ICD-O-3
Carcinoma ex pleomorphic adenoma of parotid gland
70.0
6.4
7
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
2.3
6.4
55
242
104
Kela drug reimbursment
Thyroid insufficiency
1.5
6.4
191
1276
DEB00
NOMESCO Finland
Cortical mastoidectomy
14.3
6.4
10
7
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
6.4
312
2298
N30.0
ICD-10 Finland
Acute cystitis
1.4
6.3
338
2529
N02AA05
ATC
oxycodone; systemic
1.3
6.3
394
3022
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
3.5
6.3
27
78
BAA60
NOMESCO Finland
Total thyroidectomy
2.1
6.3
67
326
H03AA01
ATC
levothyroxine sodium; systemic
1.3
6.3
612
5001
C08.91
ICD-10 Finland
Adenocarcinoma of mixed cell type in unspecified large salivary gland
+∞
6.2
6
*
8502/3-C07.9
ICD-O-3
Secretory carcinoma of parotid gland
+∞
6.2
6
*
8430/3-C08.0
ICD-O-3
Mucoepidermoid carcinoma of submandibular gland
+∞
6.2
6
*
D21.0
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of head, face and neck
4.3
6.2
21
49
H92.0
ICD-10 Finland
Otalgia
1.7
6.1
115
684
ENB99
NOMESCO Finland
Other excision of pharynx and adjacent structures
12.5
6.1
10
8
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.5
6.1
196
1333
R52.9
ICD-10 Finland
Pain, unspecified
1.5
6.0
207
1426
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
2.0
6.0
74
381

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
829
748
13.85
307.65
1.4
1.2
—
—
—
0
0
610
2880
2.33
71.41
1.5
1.4
—
—
—
0
0
1769
12838
1.70
54.58
2.2
2.1
—
—
—
0
0
742
4201
1.95
52.64
1.3
1.3
—
—
—
0
0
1861
14930
1.48
30.08
6.3
5.9
57.8
57.6
%
0.19
1722
13937
1944
15774
1.47
29.38
6.2
5.8
0.0
0.0
e9/l
0.27
1670
13602
1842
14810
1.47
29.06
6.6
6.3
8.9
8.7
%
1.23
1705
13839
1790
14325
1.47
28.86
6.5
6.0
0.7
0.7
%
0.26
1658
13341
1831
14733
1.46
28.60
6.5
6.0
2.9
2.9
%
0.23
1689
13709
1931
15697
1.46
28.60
6.2
5.7
0.6
0.6
e9/l
2.05
1655
13530
1871
15153
1.46
28.04
6.6
6.1
27.0
27.3
%
0.58
1729
14074
1988
16306
1.45
27.74
6.5
6.0
0.2
0.2
e9/l
0.02
1731
14268
1967
16115
1.45
27.53
6.3
5.8
1.9
1.9
e9/l
0.14
1725
14145
2191
18323
1.45
27.46
9.7
8.9
4.3
4.2
e9/l
1.28
1925
15990
580
3781
1.63
23.61
1.9
1.8
—
—
—
0
0
1932
16353
1.36
19.38
7.8
6.9
1.2
1.2
mmol/l
0.20
1642
13759
1788
15008
1.36
18.65
4.3
4.1
—
—
—
0
0
2187
19065
1.34
17.10
5.9
4.8
6.9
6.8
mmol/l
1.43
2069
17912
1336
10871
1.35
16.44
6.2
5.8
—
—
—
0
0
1269
10245
1.36
16.44
2.6
2.5
—
—
—
0
0
1752
14858
1.33
16.20
7.1
6.0
1.2
1.2
mmol/l
0.04
1601
13432
1386
11364
1.34
16.13
4.2
3.8
90.1
103.0
e6/l
0.17
981
8174
1673
14158
1.32
15.44
5.2
4.9
35.1
35.2
g/l
0.31
1549
13148
1202
9701
1.35
15.37
4.5
4.1
7.4
7.4
ph
1.48
226
1862
2727
24747
1.35
15.25
8.7
7.7
80.0
79.1
u/l
0.34
2584
23308
106
457
2.36
14.96
2.1
1.6
1.0
0.8
g/l
0.54
81
348
80
302
2.68
14.92
1.4
1.2
—
—
—
0
0
1029
8160
1.36
14.62
4.7
4.0
88.1
88.8
%
0.36
1017
7953
1119
9001
1.34
14.44
3.5
3.2
0.3
0.5
e6/l
3.13
831
6832
57
182
3.16
14.37
6.2
6.3
—
—
—
0
0
1207
9835
1.33
14.22
3.6
3.3
42.3
101.2
e6/l
2.27
914
7602
422
2861
1.53
14.13
1.6
1.5
—
—
—
0
0
1626
13819
1.31
14.12
11.2
9.8
0.0
0.0
e9/l
0.73
1336
11316
632
4651
1.43
13.99
2.1
2.1
—
—
—
0
0
1945
16947
1.30
13.93
6.9
6.3
11.0
11.7
umol/l
1.63
1873
16084
2427
21794
1.31
13.76
4.8
4.4
—
—
—
0
0
1083
8722
1.34
13.73
3.4
3.1
—
—
—
0
0
2340
20958
1.30
13.27
5.1
4.6
3299.7
1827.3
e6/l
0.24
40
305
683
5146
1.40
13.15
3.5
3.0
2.3
2.2
e6/l
0.04
379
2829
724
5520
1.38
12.97
3.2
2.8
1.5
1.1
e6/l
0.38
420
3181
70
270
2.62
12.57
5.4
4.7
90.0
50.6
u/ml
0.26
22
77
3299
31175
1.40
12.01
18.7
15.2
24.9
24.5
mg/l
0.26
2753
25021
2563
23405
1.28
11.59
4.7
4.1
13.6
12.8
mm/h
1.62
2380
21607
1309
11030
1.28
11.43
3.7
3.4
2.3
2.4
mmol/l
0.39
1150
9562
3046
28490
1.33
11.33
5.3
4.8
2.6
2.1
mu/l
0.34
2785
25932
561
4193
1.40
11.19
8.3
6.9
104.6
104.3
mmol/l
0.76
539
4096
970
7878
1.31
11.18
2.5
2.4
—
—
—
0
0
984
8032
1.30
10.88
7.4
6.6
—
—
—
0
0
2580
23659
1.27
10.84
4.4
4.0
15.1
14.9
pmol/l
3.78
2327
21422
844
6750
1.32
10.82
4.9
4.6
—
—
—
0
0
1557
13541
1.25
10.07
10.9
9.8
1.3
1.3
inr
0.46
453
3842
568
4333
1.36
9.93
5.7
5.8
1.0
1.0
mmol/l
0.98
522
4020
1099
9189
1.27
9.90
4.9
4.3
—
—
—
0
0
2441
22430
1.24
9.14
4.3
3.9
—
—
—
0
0
678
5383
1.31
8.99
3.4
3.3
0.8
0.8
mmol/l
0.83
634
5010
2737
25505
1.25
8.86
22.4
18.3
13.9
13.8
%
2.33
2686
24917
64
285
2.27
8.55
1.6
1.4
7.2
6.9
g/l
0.19
45
199
64
285
2.27
8.55
1.6
1.4
0.4
0.4
g/l
0.35
45
199
64
285
2.27
8.55
1.6
1.4
2.7
2.9
g/l
0.49
45
197
748
6056
1.29
8.53
3.4
3.0
2.5
2.5
mmol/l
0.26
662
5317
1482
12987
1.23
8.49
2.3
2.2
77.2
78.2
nmol/l
0.60
1324
11581
327
2337
1.44
8.36
2.9
2.7
10.7
10.6
g/l
0.23
297
2124
3392
32561
1.35
8.17
21.3
17.7
4.0
4.0
mmol/l
0.71
3317
31691
3384
32482
1.34
8.07
21.2
17.6
139.6
139.7
mmol/l
0.28
3316
31658
506
3911
1.34
8.05
9.1
7.3
5.2
5.1
kpa
1.45
481
3726
506
3911
1.34
8.05
9.1
7.3
12.3
12.2
kpa
0.17
481
3724
504
3895
1.34
8.02
9.1
7.3
1.4
1.1
mmol/l
0.79
393
3041
1523
13440
1.22
8.01
2.1
2.0
93.1
94.7
pmol/l
0.58
838
6977
63
287
2.21
7.99
1.6
1.4
—
—
—
0
0
258
1778
1.48
7.98
11.1
9.4
24.5
24.3
mmol/l
0.35
239
1664
782
6422
1.27
7.91
3.0
2.8
548.0
548.5
mosm/kgh2o
0.02
656
5477
397
2971
1.37
7.78
2.6
2.4
36.4
53.9
u/l
0.55
342
2555
1716
15361
1.21
7.71
5.6
5.0
0.0
0.0
estimate
0.50
318
2906
1157
9962
1.23
7.66
2.3
2.2
185.7
233.0
u/l
1.30
1084
9318
1195
10343
1.23
7.49
4.2
4.0
9.0
9.3
mg/mmol
0.08
784
6530
369
2751
1.38
7.40
9.9
8.3
—
—
—
0
0
828
6895
1.26
7.39
2.7
2.6
4.7
5.3
e6/l
1.06
705
6054
490
3815
1.33
7.39
2.6
2.5
1.8
1.8
%
0.38
429
3361
1730
15560
1.20
7.23
4.2
3.8
0.0
0.0
estimate
1.34
308
2810
1702
15333
1.20
6.86
4.1
3.7
0.0
0.0
estimate
0.00
311
2858
398
3049
1.34
6.70
7.9
7.3
10.1
10.3
mmol/l
0.21
377
2900
401
3077
1.34
6.68
3.8
3.6
2.1
2.0
mmol/l
0.27
324
2486
449
3506
1.32
6.62
9.7
7.6
95.3
95.5
%
0.38
435
3373
1169
10206
1.21
6.53
3.3
3.2
7.4
7.5
mmol/l
0.29
972
8538
401
3090
1.33
6.49
3.9
3.6
6.0
5.8
kpa
2.29
393
2993
1127
9822
1.21
6.38
3.3
3.3
466.4
344.3
mg/l
0.35
738
6206
41
172
2.40
6.36
1.8
2.2
—
—
—
0
0
1342
11898
1.20
6.30
3.8
3.5
—
5.8
—
0
8
42
179
2.36
6.29
1.6
2.7
7.4
7.4
ph
0.63
12
59
768
6446
1.24
6.29
4.2
3.8
703.3
527.6
ng/l
0.29
634
5182
256
1847
1.41
6.25
1.7
1.9
1.3
1.4
g/l
0.60
232
1676
505
4042
1.29
6.19
1.4
1.3
663.2
523.5
titre
0.76
124
857
326
2454
1.36
6.17
4.1
4.1
1.1
0.4
%
0.34
73
623
1120
9792
1.20
6.08
3.8
3.2
—
—
—
0
0
158
1045
1.53
6.01
2.5
3.5
1.4
2.2
ratio
0.74
17
84
315
2370
1.36
5.98
1.9
2.5
—
—
—
0
0
330
2507
1.35
5.89
3.8
3.9
92.0
93.3
ng/l
0.09
277
2147
342
2613
1.34
5.87
4.1
4.1
0.2
0.2
%
0.16
89
745
356
2746
1.33
5.73
4.1
4.1
1.3
0.9
%
1.36
96
803
250
1831
1.39
5.62
3.6
3.3
4.3
4.4
pmol/l
2.03
228
1603
70
381
1.85
5.57
1.3
1.3
—
—
—
0
0
126
807
1.58
5.55
2.2
3.9
—
—
—
0
0
1119
9857
1.19
5.49
3.2
3.1
1683.6
1526.5
ng/l
0.38
976
8465
159
1078
1.50
5.42
2.6
3.6
34.5
66.2
mg/l
1.56
127
876
159
1079
1.49
5.40
2.6
3.6
64.3
111.9
mg/l
0.42
126
875
576
4764
1.25
5.34
2.6
2.5
2.3
2.3
g/l
0.36
528
4409
3420
33170
1.28
5.33
12.3
10.8
25.6
26.2
u/l
0.97
3305
31964
266
1987
1.36
5.31
1.3
1.4
—
—
—
0
0
850
7330
1.20
5.23
3.9
3.7
—
—
—
0
0
395
3131
1.29
5.22
2.5
2.2
0.2
0.2
g/l
0.80
369
2911
1154
10229
1.18
5.22
2.7
2.6
53.4
58.4
u/l
3.19
1075
9430
1444
13038
1.17
5.21
3.0
2.8
136.8
139.4
ug/l
0.13
1320
11990
373
2938
1.30
5.17
8.7
6.9
1.3
1.4
mmol/l
0.19
363
2833
1151
10207
1.18
5.17
3.7
3.3
31.3
37.3
u/l
2.14
1098
9678
614
5132
1.23
5.16
2.6
2.5
12.5
12.9
umol/l
0.66
563
4759
3416
33147
1.27
5.16
21.5
17.8
79.6
79.2
umol/l
0.23
3416
33134
892
7749
1.20
5.05
1.6
1.6
20.4
20.5
nmol/l
0.05
769
6621
542
4483
1.24
5.02
1.2
1.2
—
—
—
0
0
177
1248
1.44
4.97
1.8
2.4
10.0
10.3
g/l
0.33
153
1058
941
8227
1.19
4.95
2.3
2.2
3.1
3.0
mg/l
0.31
794
6999
261
1971
1.35
4.88
8.3
7.2
25.0
24.9
mmol/l
0.10
254
1959
143
971
1.49
4.87
3.4
3.4
—
—
—
0
0
403
3231
1.28
4.87
10.4
8.1
120.5
121.4
g/l
0.34
389
3112
3524
34364
1.30
4.85
26.8
22.3
248.6
248.1
e9/l
0.15
3434
33457
111
714
1.57
4.85
2.2
2.1
128.5
129.0
g/l
0.08
87
511
360
2851
1.29
4.80
2.1
2.7
66.3
66.3
g/l
0.05
331
2596
3525
34384
1.30
4.77
26.8
22.3
7.0
6.8
e9/l
3.73
3419
33360
3524
34379
1.29
4.72
26.8
22.3
4.5
4.5
e12/l
0.01
3415
33365
661
5621
1.21
4.67
1.5
1.5
2.5
2.5
g/l
0.18
394
3410
23
85
2.72
4.67
1.0
1.1
—
—
—
0
0
3524
34386
1.29
4.65
27.0
22.4
134.6
134.9
g/l
0.39
3477
33851
3523
34375
1.29
4.65
26.7
22.2
91.4
91.3
fl
0.53
3472
33837
323
2533
1.30
4.64
3.4
2.9
4.6
4.6
kpa
0.08
315
2445
3329
32278
1.23
4.61
16.6
14.4
—
—
—
0
0
3522
34375
1.29
4.56
26.7
22.2
30.4
30.4
pg
0.12
3472
33833
975
8606
1.18
4.54
2.6
2.7
6528.5
5387.9
umol/l
0.27
839
7436
460
3781
1.25
4.50
1.6
1.4
—
—
—
0
0
533
4455
1.23
4.47
2.8
2.6
21.0
22.8
%
2.74
462
3789
512
4265
1.23
4.43
1.7
1.7
—
—
—
0
0
796
6925
1.19
4.38
1.7
1.8
1.5
1.3
mg/l
0.92
611
5316
93
589
1.59
4.38
1.3
1.5
—
—
—
0
0
317
2501
1.29
4.37
3.9
3.9
1.2
0.6
%
1.30
65
577
108
709
1.54
4.35
2.7
2.4
15.9
16.3
%
0.40
60
351
165
1179
1.42
4.35
2.2
2.3
331.8
684.2
ug/l
1.17
157
1112
598
5083
1.21
4.23
2.1
2.1
30.2
29.8
s
0.73
586
4928
1385
12618
1.15
4.21
4.2
3.8
39.7
90.4
ng/l
0.81
981
8990
3023
29117
1.18
4.15
6.8
6.0
40.7
40.1
mmol/mol
2.63
2781
26837
380
3086
1.26
4.15
1.5
1.5
—
—
—
0
0
208
1564
1.35
4.05
3.6
3.8
24.4
24.1
mmol/l
0.55
186
1401
290
2287
1.29
4.03
5.5
4.9
—
—
—
0
0
147
1045
1.42
4.01
1.9
2.2
38.2
37.5
g/l
0.67
127
896
160
1156
1.40
3.99
1.5
1.2
0.5
1.4
u/ml
1.21
11
99
356
2885
1.26
3.96
2.6
2.5
73.9
69.7
e9/l
1.09
274
2211
2896
27875
1.16
3.70
20.1
16.2
39.5
39.5
%
0.09
2035
19179
2692
25792
1.15
3.62
24.1
19.5
331.6
332.1
g/l
2.36
2668
25579
530
4525
1.20
3.58
25.6
25.6
1.3
1.4
inr
0.32
81
632
435
3645
1.22
3.57
1.5
1.6
—
—
—
0
0
183
1385
1.34
3.46
1.2
1.2
—
—
—
0
0
599
5189
1.18
3.43
1.3
1.3
50.1
35.3
iu/ml
0.76
211
1634
16
58
2.77
3.42
1.3
1.1
—
—
—
0
0
40
216
1.86
3.40
2.1
2.1
14.7
13.7
%
0.20
20
88
34
174
1.96
3.38
1.4
1.5
—
—
—
0
0
357
2962
1.23
3.24
2.6
2.4
5.8
7.3
ug/l
1.31
315
2584
49
286
1.72
3.24
2.0
2.1
1.1
1.1
e9/l
0.25
32
175
36
192
1.88
3.19
1.7
2.1
487.0
540.3
e6/l
0.26
29
163
103
719
1.44
3.18
1.6
1.7
—
—
—
0
0
115
820
1.41
3.16
3.4
2.9
1.6
1.6
mg/l
0.17
102
747
345
2865
1.22
3.12
2.4
2.2
380.1
371.0
nmol/l
0.32
314
2616
278
2256
1.25
3.11
1.4
1.4
—
—
—
0
0
29
145
2.01
3.09
1.6
1.2
—
—
—
0
0
16
62
2.59
3.04
1.9
2.0
111.1
162.5
e6/l
—
9
28
71
464
1.54
3.03
2.5
2.8
—
—
—
0
0
139
1033
1.36
3.00
5.3
4.1
3.9
3.9
mmol/l
0.17
117
968
328
2723
1.22
2.98
4.5
3.8
1.2
1.2
mmol/l
4.14
294
2372
431
3677
1.19
2.95
3.3
2.7
8.5
8.8
umol/l
0.11
376
3206
89
615
1.46
2.92
3.4
2.8
—
—
—
0
0
105
750
1.41
2.89
3.6
3.7
—
—
—
0
0
31
164
1.90
2.85
1.1
1.3
—
—
—
0
0
416
3551
1.19
2.84
3.8
4.0
28.1
23.7
ug/l
0.10
359
2900
2118
20142
1.11
2.83
3.5
3.2
55.2
51.7
u/l
0.77
1969
18617
217
1733
1.27
2.81
3.3
2.8
0.2
0.3
e6/l
1.37
209
1688
419
3588
1.19
2.76
1.3
1.3
—
—
—
0
0
349
2943
1.20
2.72
2.6
2.9
237.0
210.1
ng/l
0.50
303
2682
172
1340
1.30
2.72
1.5
1.5
—
19.2
—
0
35
33
182
1.82
2.69
1.7
2.1
0.2
0.2
e9/l
0.19
28
161
58
374
1.56
2.66
1.4
1.5
—
—
—
0
0
101
730
1.39
2.63
1.6
1.9
3.6
4.5
iu/l
0.41
33
255
66
441
1.51
2.59
2.7
2.5
—
—
—
0
0
110
809
1.37
2.58
1.8
1.9
10.3
11.7
mg/l
1.16
102
737
192
1529
1.27
2.57
2.7
2.5
0.7
0.7
%
0.25
182
1461
47
291
1.62
2.56
1.1
1.2
—
—
—
0
0
62
411
1.52
2.53
2.4
2.4
—
—
—
0
0
19
89
2.14
2.44
1.2
1.8
—
—
—
0
0
899
8207
1.12
2.44
3.9
3.5
—
—
—
0
0
52
335
1.56
2.43
3.6
3.4
—
—
—
0
0
101
742
1.37
2.41
4.0
3.1
1.7
1.6
mmol/l
0.38
101
718
115
863
1.34
2.40
3.8
3.2
24.9
24.9
mmol/l
0.01
108
750
177
1410
1.27
2.38
5.9
5.3
1.9
1.6
%
1.32
169
1318
5
8
6.26
2.37
1.0
1.0
—
—
—
0
0
82
586
1.41
2.32
1.3
1.4
—
—
—
0
0
104
775
1.35
2.29
4.3
4.5
8.3
8.5
kpa
0.42
97
764
88
641
1.38
2.24
1.7
1.8
1.0
0.8
nmol/l
0.86
73
529
47
303
1.56
2.21
2.2
2.4
—
—
—
0
0
103
771
1.35
2.21
4.2
4.5
2.7
2.6
mmol/l
0.05
75
538
103
772
1.34
2.20
4.3
4.5
5.1
5.0
kpa
0.42
96
762
110
833
1.33
2.19
1.3
1.3
—
14.1
—
0
18
219
1807
1.22
2.18
1.5
1.3
314.4
210.2
u/ml
0.99
201
1660
28
158
1.78
2.17
1.8
2.3
—
—
—
0
0
103
774
1.34
2.16
1.2
1.2
—
—
—
0
0
94
697
1.36
2.15
4.2
3.3
7.9
7.6
mmol/l
0.42
94
675
173
1394
1.25
2.15
6.0
5.4
0.8
0.9
%
0.96
165
1304
555
4957
1.14
2.14
1.3
1.2
11.6
12.3
u/ml
0.08
213
1905
54
364
1.49
2.09
1.6
1.5
—
—
—
0
0
47
308
1.53
2.08
1.9
1.3
16.5
29.3
iu/ml
—
6
12
18
89
2.03
2.05
4.4
5.0
—
—
—
0
0
165
1333
1.25
2.02
2.9
2.7
—
—
—
0
0
18
90
2.00
2.00
1.0
1.1
—
—
—
0
0
916
8459
1.11
2.00
1.6
1.6
1.4
1.4
mmol/l
0.50
769
7071
117
908
1.30
1.99
4.2
4.2
7.4
7.4
ph
0.07
96
761
28
163
1.72
1.98
1.1
1.1
9.6
12.3
iu/ml
—
7
49
13
57
2.29
1.97
1.2
1.1
—
—
—
0
0
31
187
1.66
1.93
1.4
1.3
—
—
—
0
0
35
218
1.61
1.93
1.6
1.3
1.9
1.1
u/ml
0.30
16
105
94
711
1.33
1.92
2.7
3.1
0.8
0.8
nmol/l
0.19
71
540
46
306
1.51
1.92
1.5
1.5
—
—
—
0
0
254
2158
1.19
1.90
9.1
7.0
24.9
24.6
mmol/l
0.68
235
2008
18
92
1.96
1.89
1.0
1.0
—
—
—
0
0
14
65
2.16
1.88
1.0
1.7
—
—
—
0
0
71
517
1.38
1.86
1.2
1.2
—
—
—
0
0
71
517
1.38
1.86
1.4
1.4
93.5
119.4
u/ml
1.70
18
103
29
174
1.67
1.86
2.3
2.2
154.8
161.3
ug/min
—
5
39
79
587
1.35
1.83
1.3
1.3
54.9
62.7
mmol/l
1.17
58
471
129
1026
1.27
1.83
1.3
1.3
35.3
31.8
iu/l
0.50
108
885
10
40
2.50
1.83
1.3
1.4
44.4
42.0
umol/l
—
10
40
5
12
4.17
1.82
1.2
1.8
—
—
—
0
0
12
53
2.27
1.80
1.2
1.7
75.6
140.2
ng/l
1.83
12
53
3115
30509
1.11
1.80
5.0
4.7
6.1
6.0
mmol/l
5.30
2815
27664
47
320
1.47
1.78
1.3
1.5
29.2
30.6
%
0.09
28
197
31
192
1.62
1.77
3.8
3.6
—
—
—
0
0
87
660
1.33
1.77
1.3
1.3
10.0
10.5
u/l
0.13
67
541
35
224
1.57
1.76
1.2
1.3
13.8
12.2
mmol/l
0.41
14
68
17
88
1.94
1.74
3.3
2.2
—
—
—
0
0
100
776
1.30
1.74
1.2
1.2
—
—
—
0
0
54
380
1.43
1.74
1.6
1.4
91061.4
92116.0
e6/l
0.00
30
226
28
170
1.65
1.73
2.2
1.7
1.1
3.4
u/field
1.28
23
120
121
965
1.26
1.70
1.4
1.4
262.3
277.0
ug/g
0.35
80
567
0
47
0.00
1.70
0.0
1.2
—
90.6
—
0
32
102
798
1.29
1.68
1.7
1.6
9481.7
13479.7
e6/l
0.83
70
572
896
8335
1.10
1.67
4.7
4.2
0.0
0.0
estimate
1.28
301
2778
34
219
1.56
1.67
2.1
1.4
—
—
—
0
0
33
212
1.56
1.65
1.2
1.1
—
—
—
0
0
219
1864
1.19
1.64
1.2
1.2
124.1
147.7
iu/ml
0.39
62
681
100
783
1.28
1.64
1.5
1.2
6.1
3.2
u/ml
0.58
17
82
52
369
1.41
1.62
14.2
6.1
7.3
7.4
mmol/l
0.20
42
306
164
1362
1.21
1.61
5.9
4.6
—
—
—
0
0
83
636
1.31
1.60
1.3
1.4
—
—
—
0
0
77
584
1.32
1.60
3.3
3.0
—
—
—
0
0
102
804
1.28
1.60
2.6
2.3
63.0
108.5
ug/min
1.42
70
487
49
347
1.42
1.55
1.2
1.4
284.0
277.6
mosm/kgh2o
1.93
42
260
170
1425
1.20
1.53
2.4
1.9
2.6
2.3
ug/l
0.13
150
1254
393
3520
1.13
1.50
2.2
2.2
124.6
144.9
ug/g
0.66
304
2773
100
794
1.27
1.49
1.5
1.3
15.4
7.9
u/ml
0.31
18
141
89
697
1.28
1.48
1.4
1.3
—
—
—
0
0
63
471
1.34
1.46
1.6
1.5
31.3
32.3
g/l
0.23
55
424
215
1850
1.17
1.45
12.7
9.9
—
—
—
0
0
3196
31427
1.10
1.44
5.3
5.1
2.7
2.7
mmol/l
2.34
2923
28793
68
516
1.32
1.43
1.3
1.2
366.9
279.8
u/ml
1.06
38
315
76
587
1.30
1.42
1.4
1.5
—
—
—
0
0
239
2079
1.16
1.41
4.0
3.7
7.4
7.4
ph
0.18
46
248
148
1236
1.21
1.41
3.6
3.3
1395.6
4176.8
u/ml
0.58
131
1052
31
205
1.52
1.40
1.6
2.0
664.0
689.7
e6/l
0.08
11
86
39
271
1.44
1.39
2.3
2.1
1.7
2.0
u/field
0.26
18
103
67
511
1.32
1.38
1.1
1.3
—
—
—
0
0
46
331
1.39
1.36
1.7
1.4
—
—
—
0
0
50
365
1.37
1.36
1.4
1.3
44.5
45.4
u/ml
—
6
21
22
135
1.63
1.35
3.7
2.6
—
—
—
0
0
241
2107
1.15
1.34
4.0
3.7
5.2
5.2
kpa
0.53
229
1944
59
444
1.33
1.33
7.1
6.5
12.4
12.0
mg/l
0.27
53
415
49
359
1.37
1.32
1.6
1.4
—
—
—
0
0
104
845
1.24
1.31
4.8
4.3
—
—
—
0
0
139
1165
1.20
1.29
1.7
2.0
23.0
21.5
s
0.76
129
1032
10
48
2.09
1.27
1.0
1.0
—
—
—
0
0
15
84
1.79
1.27
1.4
1.3
38.7
451.6
ug/l
—
9
41
708
6610
1.09
1.23
3.0
3.1
0.7
0.8
ug/l
0.82
489
4496
170
1460
1.17
1.21
2.0
1.9
—
—
—
0
0
0
35
0.00
1.15
0.0
10.7
—
—
—
0
0
22
142
1.55
1.14
1.3
1.1
—
—
—
0
0
48
361
1.33
1.13
2.6
4.0
—
—
—
0
0
179
1559
1.16
1.09
1.6
1.7
1.7
1.5
g/l
1.19
151
1338
31
218
1.43
1.09
1.3
1.2
—
—
—
0
0
41
303
1.36
1.08
1.2
1.1
—
—
—
0
0
55
425
1.30
1.08
1.6
1.4
2241.6
2142.9
e6/l
0.05
37
309
7
32
2.19
1.08
1.7
1.8
3.2
3.3
mmol/l
—
7
27
56
436
1.29
1.05
1.2
1.1
0.3
1.6
u/ml
2.54
23
179
9
46
1.96
1.03
2.3
1.5
—
—
—
0
0
70
562
1.25
1.03
2.6
3.4
1.4
1.4
%
0.02
53
435
716
6741
1.08
1.02
4.8
4.2
1.0
1.0
kg/l
0.13
92
1034
356
3252
1.10
1.02
1.7
1.6
—
—
—
0
0
49
377
1.30
1.01
1.1
1.1
2.0
4.3
u/ml
1.48
24
185
23
155
1.49
1.01
1.0
1.0
—
—
—
0
0
43
325
1.33
1.00
1.4
1.3
—
—
—
0
0
7
35
2.00
1.00
2.0
1.4
—
—
—
0
0
21
139
1.51
1.00
1.1
1.2
—
—
—
0
0
677
6367
1.08
1.00
1.3
1.2
1.5
1.6
u/ml
0.13
173
1668
18
115
1.57
0.99
1.7
1.6
2.0
2.0
umol/l
0.09
18
107
9
49
1.84
0.98
1.9
1.1
—
—
—
0
0
1016
9695
1.07
0.98
4.5
4.1
—
—
—
0
0
244
2189
1.12
0.98
2.8
3.1
4.5
4.1
e9/l
0.81
172
1679
157
1796
0.87
0.97
1.5
1.6
—
—
—
0
0
670
6305
1.08
0.97
1.9
1.8
1108.5
1173.5
nmol/l
0.95
490
4740
86
712
1.21
0.97
2.3
2.7
—
—
—
0
0
3098
30556
1.07
0.95
4.7
4.5
1.4
1.5
mmol/l
8.29
2819
27988
66
535
1.24
0.92
1.5
1.4
—
—
—
0
0
47
366
1.29
0.91
1.1
1.1
0.1
1.5
u/ml
2.20
23
156
16
102
1.57
0.90
2.0
2.4
—
—
—
0
0
69
564
1.23
0.90
1.2
1.2
30.7
38.0
u/l
0.27
62
485
49
386
1.27
0.88
1.3
1.2
—
—
—
0
0
237
2140
1.11
0.87
3.8
3.0
—
—
—
0
0
26
186
1.40
0.87
1.7
1.7
—
—
—
0
0
134
1168
1.15
0.86
1.1
1.1
—
—
—
0
0
28
204
1.38
0.85
1.1
1.2
44.6
34.5
mmol/l
0.84
20
174
63
515
1.23
0.83
1.5
1.3
—
—
—
0
0
3117
30788
1.06
0.83
4.8
4.5
4.5
4.6
mmol/l
4.18
2869
28381
55
445
1.24
0.80
4.8
5.2
350.7
354.6
umol/l
0.07
44
388
0
24
0.00
0.79
0.0
4.2
—
—
—
0
0
6
33
1.82
0.79
1.3
1.2
—
640.5
—
0
9
50
402
1.25
0.78
1.2
1.5
59.8
60.9
%
0.07
29
248
24
327
0.73
0.78
1.1
1.1
—
—
—
0
0
18
123
1.47
0.77
2.2
2.1
—
—
—
0
0
82
695
1.18
0.77
1.3
1.4
21.9
26.7
e6/l
0.15
62
536
82
695
1.18
0.77
1.3
1.4
732.8
1283.7
e6/l
0.45
65
564
188
1692
1.12
0.76
4.2
3.4
—
—
—
0
0
34
261
1.31
0.76
1.0
1.1
0.8
3.8
u/ml
2.36
13
103
1187
11460
1.05
0.76
5.0
5.1
2.4
3.7
ug/l
1.81
1050
10243
16
107
1.50
0.76
1.5
1.3
3.7
3.3
mmol/l
0.17
16
97
10
59
1.70
0.75
4.0
5.9
—
—
—
0
0
23
168
1.37
0.71
2.7
3.6
—
—
—
0
0
103
897
1.15
0.71
1.2
1.2
—
—
—
0
0
5
26
1.92
0.70
1.2
1.5
—
—
—
0
0
5
26
1.92
0.70
3.2
2.8
—
—
—
0
0
5
26
1.92
0.70
6.4
5.7
—
—
—
0
0
5
26
1.92
0.70
1.0
1.1
—
—
—
0
0
25
186
1.35
0.70
2.4
2.7
37.0
39.9
%
—
8
66
186
1684
1.11
0.69
1.3
1.3
—
—
—
0
0
168
1513
1.12
0.69
4.3
3.8
—
—
—
0
0
192
1742
1.11
0.69
2.4
2.4
—
—
—
0
0
233
2135
1.10
0.69
2.5
2.4
36.1
22.9
au/ml
—
9
100
77
658
1.17
0.68
4.4
3.7
59.5
57.6
%
0.78
77
658
7
43
1.63
0.66
1.3
1.0
—
—
—
0
0
42
339
1.24
0.66
1.0
1.1
0.1
2.0
u/ml
—
7
83
211
1934
1.10
0.63
1.4
1.3
74.5
50.9
au/ml
—
8
86
21
155
1.36
0.63
2.7
3.7
—
—
—
0
0
2988
29554
1.05
0.61
4.2
4.1
1.3
1.3
mmol/l
3.20
2704
26854
81
703
1.16
0.61
4.3
3.5
21.7
28.2
mg/l
1.10
59
437
13
88
1.48
0.60
1.2
1.1
—
—
—
0
0
82
713
1.15
0.60
2.7
2.8
32.3
36.3
umol/l
0.83
69
597
84
732
1.15
0.60
2.8
3.3
2150.6
702.0
u/ml
0.53
77
669
51
426
1.20
0.60
1.2
1.3
—
—
—
0
0
15
105
1.43
0.60
1.3
1.2
—
—
—
0
0
19
255
0.74
0.59
1.1
1.0
885.4
710.5
ng/l
0.69
12
167
34
272
1.25
0.59
2.6
2.1
552.9
627.2
ml
0.54
24
174
124
1112
1.12
0.58
1.7
1.6
—
—
—
0
0
38
310
1.23
0.57
1.4
1.3
191331.6
89616.4
e6/l
0.25
28
217
6
37
1.62
0.55
1.2
1.3
—
—
—
0
0
52
612
0.85
0.55
1.5
1.7
—
—
—
0
0
12
82
1.46
0.54
1.1
1.1
—
—
—
0
0
12
82
1.46
0.54
1.1
1.1
—
—
—
0
0
12
82
1.46
0.54
1.1
1.1
—
—
—
0
0
27
213
1.27
0.53
1.2
1.1
—
—
—
0
0
27
338
0.80
0.52
1.7
2.0
—
—
—
0
0
25
196
1.28
0.52
1.1
1.1
—
—
—
0
0
11
75
1.47
0.50
1.2
1.1
—
—
—
0
0
32
261
1.23
0.49
1.4
1.6
—
—
—
0
0
48
408
1.18
0.49
1.2
1.3
—
—
nmol/l
—
0
0
29
234
1.24
0.49
1.0
1.0
0.1
0.4
u/ml
—
9
61
20
256
0.78
0.48
1.1
1.0
353.2
322.9
ng/l
0.17
12
172
23
289
0.79
0.47
1.5
1.4
—
—
—
0
0
24
299
0.80
0.46
1.5
1.5
—
—
—
0
0
23
288
0.80
0.46
1.3
1.2
—
—
—
0
0
95
1055
0.90
0.46
12.4
10.1
—
—
—
0
0
7
49
1.43
0.46
1.9
1.5
—
—
—
0
0
46
393
1.17
0.45
1.1
1.1
—
—
—
0
0
46
393
1.17
0.45
1.1
1.1
—
—
—
0
0
284
2681
1.06
0.45
4.8
4.1
—
—
—
0
0
44
375
1.18
0.45
1.0
1.1
2.2
2.6
u/ml
0.28
17
158
22
174
1.27
0.44
1.0
1.1
—
—
—
0
0
23
183
1.26
0.44
2.0
2.4
88.7
25.6
umol/l
—
5
17
98
1083
0.90
0.44
8.4
6.4
1.4
1.3
mmol/l
0.20
86
950
858
8335
1.04
0.43
1.4
1.4
—
—
—
0
0
11
78
1.41
0.43
2.0
1.9
5.3
9.2
mg/l
—
5
65
28
339
0.82
0.43
1.3
1.5
0.1
0.3
nmol/l
3.83
21
249
53
462
1.15
0.42
1.2
1.3
0.7
0.6
nmol/l
0.34
53
440
25
204
1.23
0.40
1.6
1.4
2176.0
1936.5
ml
—
9
43
7
102
0.69
0.39
1.6
1.7
—
—
—
0
0
54
611
0.88
0.38
2.1
2.0
—
—
—
0
0
215
2279
0.94
0.38
1.4
1.4
—
—
—
0
0
43
373
1.15
0.37
2.8
2.7
—
—
—
0
0
24
290
0.83
0.37
1.5
1.4
—
—
—
0
0
5
37
1.35
0.37
1.0
1.3
—
—
—
0
0
5
37
1.35
0.37
1.0
1.3
—
—
—
0
0
5
37
1.35
0.37
1.0
1.3
—
—
—
0
0
5
79
0.63
0.35
1.4
1.5
—
—
—
0
0
12
91
1.32
0.33
2.6
1.5
—
—
—
0
0
17
210
0.81
0.33
1.4
1.4
62.7
207.3
pmol/l
—
7
64
38
435
0.87
0.33
1.1
1.2
—
—
—
0
0
28
238
1.18
0.32
1.3
1.2
—
—
—
0
0
6
47
1.28
0.32
1.8
1.9
16.4
18.2
umol/l
—
6
47
14
110
1.27
0.31
2.1
1.9
55.3
50.4
ug/l
0.15
14
105
7
52
1.35
0.31
2.7
1.7
15.5
46.9
pmol/l
—
7
42
22
185
1.19
0.29
1.1
1.0
—
—
—
0
0
55
497
1.11
0.28
1.1
1.1
127.7
1237.1
iu/ml
—
10
105
41
364
1.13
0.28
2.5
2.0
—
—
—
0
0
14
172
0.81
0.27
1.1
1.3
1.1
1.2
nmol/l
—
9
135
236
2261
1.05
0.27
1.2
1.2
—
—
—
0
0
15
122
1.23
0.27
1.1
1.1
0.3
1.0
u/ml
—
6
39
61
666
0.91
0.26
2.0
2.0
—
—
—
0
0
5
72
0.69
0.26
1.4
1.2
14.8
16.7
umol/l
—
5
64
47
424
1.11
0.26
2.2
2.9
—
—
—
0
0
5
74
0.68
0.26
1.8
1.3
—
—
—
0
0
32
282
1.14
0.25
1.2
1.2
380.3
368.0
nmol/l
0.13
24
244
37
330
1.12
0.25
1.1
1.1
—
—
—
0
0
238
2287
1.04
0.24
2.0
2.2
10.9
12.6
nmol/l
2.62
210
1998
149
1567
0.95
0.24
1.5
1.5
—
—
—
0
0
19
161
1.18
0.24
1.3
1.2
182.5
368.5
u/l
1.30
19
151
61
662
0.92
0.24
2.0
1.9
—
—
—
0
0
217
2086
1.04
0.23
1.2
1.2
—
—
—
0
0
51
467
1.09
0.22
1.2
1.3
0.1
0.4
nmol/l
—
5
27
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
14
116
1.21
0.22
1.1
1.0
0.5
0.4
u/ml
—
5
29
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
31
346
0.90
0.21
1.9
1.8
—
1193.3
—
0
12
82
769
1.07
0.21
2.5
2.2
—
—
—
0
0
61
657
0.93
0.21
2.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
11.1
—
0
8
0
13
0.00
0.21
0.0
1.6
—
12.6
—
0
13
32
287
1.12
0.20
1.0
1.1
3.8
3.0
u/ml
0.15
11
110
37
335
1.11
0.20
1.2
1.4
19.6
30.1
u/l
1.47
28
273
6
49
1.22
0.20
2.2
1.6
—
—
—
0
0
89
841
1.06
0.19
1.3
1.2
115.0
96.5
titre
—
6
66
6
52
1.15
0.19
1.2
1.7
—
—
—
0
0
135
1292
1.05
0.18
4.4
4.0
25.1
24.8
mmol/l
0.70
126
1191
97
920
1.06
0.18
1.1
1.1
—
—
—
0
0
93
881
1.06
0.18
1.1
1.1
—
—
—
0
0
7
58
1.21
0.18
1.6
1.4
—
—
—
0
0
12
142
0.84
0.17
1.3
1.7
3.1
7.4
nmol/l
0.65
12
118
8
71
1.13
0.16
2.4
2.2
—
—
—
0
0
8
72
1.11
0.16
1.5
1.6
—
—
—
0
0
43
399
1.08
0.16
1.3
1.2
—
—
—
0
0
21
187
1.12
0.15
1.1
1.0
—
—
—
0
0
58
545
1.07
0.15
1.4
1.6
—
—
—
0
0
6
76
0.79
0.15
9.3
7.4
—
—
—
0
0
15
130
1.15
0.15
1.5
1.4
—
—
—
0
0
20
178
1.12
0.15
2.6
2.8
—
—
—
0
0
12
102
1.18
0.15
1.2
1.1
—
—
—
0
0
1055
10438
1.01
0.15
3.3
2.9
—
—
—
0
0
9
81
1.11
0.15
1.1
1.0
—
—
—
0
0
268
2747
0.97
0.15
3.8
3.5
—
—
—
0
0
13
112
1.16
0.14
1.2
1.1
—
—
—
0
0
66
696
0.95
0.14
1.3
1.3
148.3
213.2
miu/ml
1.06
22
307
25
227
1.10
0.14
3.0
2.5
—
—
—
0
0
41
439
0.93
0.13
1.3
1.2
5.5
5.0
u/ml
0.05
16
187
714
7053
1.02
0.13
1.8
1.7
438.0
30833045.8
pmol/l
5.46
592
5825
29
267
1.09
0.13
1.9
1.9
11.7
11.2
%
0.23
29
267
48
452
1.06
0.13
1.4
1.3
—
—
—
0
0
62
652
0.95
0.12
2.0
1.9
—
—
—
0
0
14
123
1.14
0.12
3.6
2.6
158.3
156.3
umol/l
—
9
70
65
619
1.05
0.12
1.6
2.1
6184.3
3795.9
u/l
0.26
26
252
37
346
1.07
0.12
2.6
3.4
56.2
57.0
%
0.06
24
218
14
124
1.13
0.11
2.6
2.3
—
—
—
0
0
21
192
1.09
0.10
1.9
1.6
5.3
7.4
u/l
1.27
16
167
50
475
1.05
0.10
1.1
1.1
—
—
—
0
0
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.4
9.3
682058.1
nmol/l
—
5
39
13
116
1.12
0.09
2.5
1.6
—
—
—
0
0
11
97
1.13
0.09
2.1
2.2
—
—
—
0
0
345
3403
1.02
0.08
4.8
4.5
—
—
—
0
0
70
725
0.96
0.08
1.2
1.2
—
—
—
0
0
13
117
1.11
0.08
3.0
1.9
24.4
89.6
ug/l
0.47
13
104
7
68
1.03
0.07
1.0
1.1
—
—
—
0
0
22
235
0.94
0.07
1.2
1.8
4.4
8.7
umol/l
0.96
17
158
32
304
1.05
0.07
1.2
1.1
—
—
—
0
0
12
132
0.91
0.06
1.0
1.2
—
—
—
0
0
130
1323
0.98
0.05
2.0
1.7
—
—
—
0
0
41
395
1.04
0.05
4.3
3.3
5.7
19.2
nmol/l
0.48
41
388
26
247
1.05
0.05
1.0
1.0
—
—
—
0
0
34
326
1.04
0.05
1.5
1.6
—
—
—
0
0
30
288
1.04
0.04
2.4
1.9
—
1.5
—
0
12
30
288
1.04
0.04
2.6
2.5
—
—
—
0
0
30
312
0.96
0.04
4.6
3.1
28.6
33.0
mg/l
0.14
25
235
39
379
1.03
0.03
1.5
1.4
—
—
—
0
0
39
379
1.03
0.03
1.5
1.4
—
—
—
0
0
39
379
1.03
0.03
1.5
1.4
—
—
—
0
0
31
300
1.03
0.03
1.2
1.2
—
—
—
0
0
33
320
1.03
0.03
1.6
1.8
—
—
—
0
0
18
172
1.05
0.02
1.1
1.2
135.9
136.2
nmol/l
0.01
18
172
218
2167
1.01
0.02
1.3
1.3
—
—
—
0
0
52
512
1.02
0.01
2.1
1.9
—
—
—
0
0
21
203
1.03
0.01
1.0
1.1
0.2
7.7
nmol/l
—
6
46
15
144
1.04
0.00
13.7
11.6
0.7
0.6
mmol/l
0.25
15
130
11
112
0.98
0.00
1.2
1.1
2104.2
1607.2
miu/ml
0.57
11
112
16
162
0.99
0.00
14.0
12.5
—
—
—
0
0
11
115
0.96
0.00
1.5
1.3
—
—
—
0
0
11
115
0.96
0.00
1.1
1.1
—
—
—
0
0
36
362
0.99
0.00
1.4
1.2
—
—
—
0
0
17
165
1.03
0.00
1.2
1.2
—
—
—
0
0
17
165
1.03
0.00
1.2
1.1
1.1
1.0
ratio
—
6
61
31
305
1.02
0.00
2.4
2.3
—
—
—
0
0
115
1148
1.00
0.00
3.0
3.1
0.5
0.3
g/l
0.65
55
453
11
111
0.99
0.00
1.2
1.0
—
—
—
0
0
12
121
0.99
0.00
2.3
2.4
1283.8
702.6
e6/l
—
6
90
38
379
1.00
0.00
1.5
1.4
—
—
—
0
0
78
779
1.00
0.00
8.7
7.3
10.5
11.2
mmol/l
1.54
70
695
78
779
1.00
0.00
8.7
7.3
105.3
105.1
mmol/l
0.08
70
695
10
104
0.96
0.00
2.2
2.1
—
—
—
0
0
17
166
1.02
0.00
2.0
1.6
—
—
—
0
0
21
207
1.01
0.00
2.1
1.6
—
—
—
0
0
24
243
0.99
0.00
1.3
1.4
1.2
1.2
promille
0.04
18
183
13
133
0.98
0.00
1.2
1.1
214.1
206.5
iu/ml
0.03
13
133
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
9
92
0.98
0.00
1.1
1.1
—
—
—
0
0
9
92
0.98
0.00
1.0
1.1
—
—
—
0
0
9
98
0.92
0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
2984.0
—
0
5
0
7
0.00
0.00
0.0
1.4
—
1.9
—
0
7
0
6
0.00
0.00
0.0
1.0
—
19.8
—
0
6
8
82
0.98
0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.90
0.00
1.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
49
490
1.00
0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
93
0.97
0.00
1.7
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
5.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
129.9
—
0
5
0
7
0.00
0.00
0.0
2.0
—
4.7
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
174.4
—
0
5
10
100
1.00
0.00
1.2
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_SALIVARY and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY 1.266 [1.15, 1.4] < 0.001
Birth year 0.996 [0.99, 1.0] 0.298

During the follow-up period (1.1.1998 — 31.12.2019), 1813 out of 9078 females with CD2_BENIGN_SALIVARY died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY 1.404 [1.27, 1.55] < 0.001
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 2119 out of 8404 males with CD2_BENIGN_SALIVARY died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SALIVARY.

N-year risk Females Males
1 0.116% 0.207%
5 0.742% 1.619%
10 1.878% 4.099%
15 3.653% 7.984%
20 6.59% 13.355%

Relationships between endpoints

Index endpoint: CD2_BENIGN_SALIVARY – Benign neoplasm of major salivary glands

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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