Benign neoplasm: other/unspecified salivary gland

CD2_BENIGN_SALIVARY_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D11.7, D11.9&
  • Hospital discharge: ICD-9 2102
  • Hospital discharge: ICD-8 2102
  • Cause of death: ICD-10 D11.7, D11.9&
  • Cause of death: ICD-9 2102
  • Cause of death: ICD-8 2102

2 out of 7 registries used, show all original rules.

993

4. Check minimum number of events

None

993

5. Include endpoints

None

993

6. Filter based on genotype QC (FinnGen only)

993

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7909 4345 3466
Only index persons 6218 3614 2604
Unadjusted period prevalence (%)
Whole population 0.11 0.12 0.10
Only index persons 0.12 0.13 0.10
Median age at first event (years)
Whole population 53.29 53.09 53.34
Only index persons 49.87 49.80 49.95

-FinnGen-

Key figures

All Female Male
Number of individuals 993 541 452
Unadjusted period prevalence (%) 0.19 0.18 0.20
Median age at first event (years) 51.51 48.48 55.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
899
Matched controls
8992
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D11.70
ICD-10 Finland
Gland sublingual
+∞
323.0
345
*
ELB30
NOMESCO Finland
Excision of submandibular gland
389.8
240.5
232
8
2102A
ICD-9 Finland
Benign neoplasm of lip, oral cavity and pharynx, Major salivary glands
+∞
235.0
215
*
21020
ICD-8 Finland
Benign neoplasm of buccal cavity and pharynx, Salivary gland
+∞
222.3
204
*
4405
FHL
Partial removal of the parotid gland
1673.7
149.3
141
*
D11.9
ICD-10 Finland
Benign neoplasm: Major salivary gland, unspecified
+∞
135.9
127
*
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
27.2
101.0
141
61
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
10.1
60.2
125
141
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.6
50.1
137
237
ELB40
NOMESCO Finland
Partial parotidectomy
17.3
43.3
69
43
D11.7
ICD-10 Finland
Benign neoplasm: Other major salivary glands
+∞
43.1
41
*
EL4AT
NOMESCO Finland
Salivary gland cytology with ultrasound guidance
225.4
42.3
43
*
4404
FHL
Complete removal of the parotid gland
181.8
34.0
35
*
K11.2
ICD-10 Finland
Sialoadenitis
6.8
25.2
65
102
ELB00
NOMESCO Finland
Excision or exploration of lesion of salivary gland
44.5
21.5
26
6
4403
FHL
Submandibular gland removal
45.0
18.3
22
5
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
22.3
18.2
26
12
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
17.4
17.5
27
16
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
173.0
16.5
17
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
8.6
15.8
34
41
D11.71
ICD-10 Finland
Gland submandibular
+∞
15.7
15
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
9.7
15.5
31
33
C08.09
ICD-10 Finland
Malignant tumor of the submandibular or submaxillary gland, other or unspecified histology
81.4
14.6
16
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
14.7
14.1
23
16
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
12.6
12.2
21
17
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
11.2
12.1
22
20
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
11.8
249
1584
ELB50
NOMESCO Finland
Total parotidectomy
30.5
11.7
15
5
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.4
11.6
41
96
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
18.1
10.7
16
9
C08.00
ICD-10 Finland
Malignant tumor of submandibular or submaxillary gland, not histology
+∞
10.4
10
*
4704
FHL
Neck tumor removal
32.9
10.3
13
*
K11.9
ICD-10 Finland
Disease of salivary gland, unspecified
11.4
10.1
18
16
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
12.3
9.9
17
14
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.4
8.5
24
45
4402
FHL
Removal or exploration of a salivary change (eg ranula)
90.8
8.4
9
*
C08.02
ICD-10 Finland
Cystic adenocarcinoma of the submandibular or submaxillary glands
+∞
8.3
8
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
8.6
8.3
17
20
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
8.1
7.6
16
20
4701
FHL
Neck lymph node removal
25.2
7.6
10
*
ZXA00
NOMESCO Finland
Right side
1.6
7.5
246
1741
WX402
NOMESCO Finland
General anaesthesia
1.8
7.4
131
778
8200/3-C08.0
ICD-O-3
Adenoid cystic carcinoma of submandibular gland
+∞
7.3
7
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
8.9
7.1
14
16
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
16.8
6.8
10
6
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
12.3
6.6
11
9
ELB99
NOMESCO Finland
Other excision of salivary gland
70.3
6.4
7
*
4409
FHL
Other measure in this category
70.3
6.4
7
*
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
14.4
6.4
10
7
K11.70
ICD-10 Finland
Hypoptyalism
8.2
6.3
13
16
TQA05
NOMESCO Finland
Puncture of skin of head or neck
+∞
6.3
6
*
8430/3-C08.0
ICD-O-3
Mucoepidermoid carcinoma of submandibular gland
+∞
6.3
6
*
C08.90
ICD-10 Finland
Malignant tumor in unspecified large salivary gland without histology
+∞
6.3
6
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.6
6.2
41
160
ZXA05
NOMESCO Finland
Left side
1.5
6.1
231
1679

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
129
211
6.88
77.34
1.3
1.2
—
—
—
0
0
132
726
1.94
10.44
1.5
1.4
—
—
—
0
0
36
108
3.42
10.21
2.7
1.8
1.6
0.9
g/l
0.68
30
83
541
4567
1.41
6.42
9.3
8.9
4.2
4.2
e9/l
0.27
479
3990
396
3173
1.41
6.34
2.2
2.2
—
—
—
0
0
469
3889
1.39
6.05
6.1
5.5
0.0
0.0
e9/l
0.10
407
3344
467
3871
1.39
6.03
6.1
5.5
0.6
0.6
e9/l
0.39
405
3317
481
4019
1.38
5.86
6.3
5.7
0.2
0.2
e9/l
0.50
416
3515
431
3538
1.39
5.85
6.6
5.6
0.7
0.7
%
1.44
403
3286
474
3957
1.38
5.78
6.3
5.6
2.2
1.9
e9/l
0.42
419
3464
444
3682
1.37
5.58
6.3
5.6
57.4
57.7
%
0.19
417
3431
219
1612
1.46
5.45
4.6
4.8
—
—
—
0
0
438
3649
1.36
5.24
6.5
5.7
3.0
2.9
%
0.79
409
3380
447
3738
1.36
5.21
6.7
5.8
27.1
27.1
%
0.06
421
3457
439
3668
1.35
5.12
6.7
5.9
8.9
8.8
%
0.28
410
3416
149
1030
1.53
5.03
1.3
1.3
—
—
—
0
0
20
67
3.03
4.85
1.8
1.4
—
—
—
0
0
428
3659
1.30
3.93
5.2
4.7
35.0
35.1
g/l
0.07
405
3392
14
44
3.21
3.78
5.2
5.6
—
—
—
0
0
309
2541
1.31
3.74
2.6
2.4
56.9
56.4
u/l
0.06
286
2341
479
4185
1.28
3.61
8.1
6.7
1.2
1.2
mmol/l
0.16
409
3526
32
160
2.03
3.43
4.5
2.6
—
—
—
0
0
127
927
1.42
3.27
2.0
1.7
—
—
—
0
0
316
2652
1.28
3.20
6.0
5.5
—
—
—
0
0
300
2511
1.28
3.09
3.3
3.4
28.9
100.0
e6/l
1.78
235
1973
276
2292
1.28
3.01
3.1
3.2
0.3
0.5
e6/l
2.86
212
1767
146
1107
1.37
3.01
6.4
5.2
1.0
1.0
mmol/l
0.33
138
1012
485
4309
1.25
2.96
6.3
6.0
10.8
11.5
umol/l
1.28
461
4081
155
1192
1.36
2.93
2.2
2.0
—
—
—
0
0
605
5515
1.25
2.90
4.7
4.5
—
—
—
0
0
169
1328
1.33
2.77
3.3
3.1
0.8
0.8
mmol/l
0.20
159
1230
107
782
1.41
2.75
4.4
3.4
2.2
2.0
mmol/l
0.21
89
618
265
2213
1.27
2.74
3.0
3.2
—
—
—
0
0
105
768
1.41
2.69
2.4
2.6
5.6
7.0
ug/l
0.57
93
672
127
960
1.37
2.68
1.3
1.3
582.2
473.8
titre
0.24
27
220
335
2898
1.24
2.51
3.7
3.8
55.0
105.8
e6/l
1.15
247
2110
95
693
1.41
2.49
1.6
1.5
—
—
—
0
0
11
39
2.84
2.48
1.9
1.7
—
36.3
—
0
6
295
2522
1.24
2.46
2.4
2.2
205.1
239.0
u/l
0.32
272
2374
136
1063
1.32
2.32
5.7
6.8
104.5
104.2
mmol/l
0.41
127
1039
430
3840
1.21
2.32
6.8
5.9
1.2
1.2
mmol/l
0.13
390
3462
22
113
1.97
2.26
2.7
2.6
—
—
—
0
0
667
6223
1.22
2.25
8.3
7.5
81.3
79.8
u/l
0.27
624
5820
585
5394
1.21
2.21
4.9
4.7
1281.6
2808.4
e6/l
—
9
91
163
1316
1.29
2.20
2.8
3.0
2.4
2.3
e6/l
0.04
100
740
526
4810
1.20
2.15
5.3
4.7
7.0
6.8
mmol/l
2.11
499
4510
12
49
2.47
2.11
2.4
3.5
—
—
—
0
0
43
279
1.57
2.03
3.5
4.3
3.9
3.9
mmol/l
0.23
34
259
33
202
1.66
1.97
4.8
2.6
7.8
8.0
kpa
0.19
33
183
78
576
1.38
1.94
3.0
3.0
10.1
10.6
g/l
0.45
71
529
236
2019
1.22
1.92
7.1
6.5
—
—
—
0
0
16
78
2.07
1.91
1.4
1.1
—
—
—
0
0
418
3772
1.19
1.91
4.6
4.1
—
—
—
0
0
0
52
0.00
1.88
0.0
1.0
—
295.0
—
0
46
9
34
2.66
1.86
1.0
1.2
—
2.0
%
—
0
7
192
1614
1.24
1.84
4.6
3.9
261.5
349.9
ng/l
0.36
159
1322
29
175
1.68
1.84
2.9
2.4
16.1
16.1
%
0.02
17
88
210
1784
1.22
1.82
2.7
2.6
6.1
5.4
e6/l
0.32
177
1589
53
370
1.46
1.81
2.5
1.9
4.4
2.1
ug/l
0.35
48
331
295
2592
1.20
1.81
2.6
2.4
—
—
—
0
0
49
337
1.48
1.81
1.2
1.5
—
9.5
—
0
7
159
1314
1.25
1.78
3.1
2.5
11.5
12.7
umol/l
1.25
145
1219
87
665
1.34
1.77
4.7
3.7
98.5
87.9
ng/l
0.48
73
581
147
1206
1.26
1.75
3.0
2.5
2.3
2.3
g/l
0.51
134
1118
145
1188
1.26
1.75
28.7
26.8
1.4
1.3
inr
0.50
31
151
80
607
1.35
1.71
5.9
4.6
—
—
—
0
0
14
68
2.07
1.70
2.2
1.9
2.2
2.3
u/field
—
5
24
125
1011
1.27
1.69
7.0
7.1
5.0
5.1
kpa
1.04
117
968
125
1012
1.27
1.67
7.0
7.1
11.7
12.0
kpa
0.26
118
970
21
119
1.78
1.67
1.2
1.4
—
—
—
0
0
18
97
1.87
1.67
1.1
1.5
69.3
64.6
%
—
8
65
165
1380
1.23
1.66
1.3
1.5
2.4
2.6
g/l
0.47
95
797
93
725
1.31
1.66
9.6
6.9
10.4
10.4
mmol/l
0.02
86
690
324
2890
1.18
1.65
3.5
3.5
2.3
2.4
mmol/l
0.76
285
2498
75
567
1.35
1.65
9.7
7.1
24.8
24.7
mmol/l
0.07
67
536
125
1014
1.27
1.65
7.0
7.1
1.9
1.3
mmol/l
0.75
95
802
196
1674
1.21
1.62
2.9
2.8
536.0
551.0
mosm/kgh2o
0.45
161
1437
5
14
3.58
1.61
1.2
1.1
—
—
—
0
0
8
32
2.51
1.60
1.9
1.3
—
—
—
0
0
283
2503
1.18
1.59
4.6
4.0
7.4
7.4
ph
0.68
51
478
604
5671
1.17
1.58
4.3
4.1
—
—
—
0
0
81
624
1.32
1.58
1.6
2.7
—
—
—
0
0
94
741
1.30
1.56
2.0
3.0
65.7
66.5
g/l
0.50
89
673
59
435
1.38
1.53
2.5
2.4
—
—
—
0
0
227
1976
1.19
1.53
2.2
2.3
—
—
—
0
0
103
825
1.28
1.52
2.0
2.1
141.9
136.2
ug/g
0.05
77
653
41
284
1.46
1.50
2.9
3.9
91.9
77.6
mg/l
0.13
35
230
41
284
1.46
1.50
2.9
3.9
36.7
45.6
mg/l
0.34
35
232
293
2613
1.17
1.48
3.6
3.3
—
—
—
0
0
296
2643
1.17
1.47
4.0
3.9
10.5
9.4
mg/mmol
0.16
181
1669
288
2566
1.17
1.47
3.1
3.1
7.0
7.2
mmol/l
0.33
235
2132
664
6297
1.16
1.47
22.8
19.0
13.9
13.8
%
0.98
651
6161
40
277
1.46
1.47
2.9
3.9
1.4
1.9
ratio
—
6
25
714
6811
1.17
1.46
19.6
16.8
38.8
39.1
%
0.31
490
4537
110
893
1.26
1.46
1.7
1.7
—
—
—
0
0
280
2491
1.17
1.46
3.1
3.2
315.4
280.8
mg/l
0.05
174
1583
376
3423
1.16
1.45
11.5
9.6
0.0
0.0
e9/l
0.33
305
2803
360
3274
1.16
1.40
3.3
2.7
128.3
138.7
ug/l
0.42
330
2992
122
1011
1.24
1.36
2.5
2.4
1.9
1.8
%
0.31
107
901
114
938
1.24
1.36
1.7
1.4
—
—
—
0
0
5
17
2.95
1.36
5.0
5.9
—
—
—
0
0
110
902
1.25
1.35
6.9
7.4
95.1
95.4
%
0.21
102
870
182
1571
1.19
1.35
1.2
1.2
1.0
1.5
u/ml
0.85
41
405
266
2372
1.17
1.34
5.1
4.3
—
—
—
0
0
113
931
1.24
1.33
3.2
4.1
11.7
28.4
ug/l
0.91
94
774
87
695
1.28
1.33
6.0
7.9
—
—
—
0
0
425
3925
1.14
1.32
4.3
3.9
0.0
0.0
estimate
0.80
69
702
29
193
1.52
1.30
1.6
1.3
—
—
—
0
0
16
91
1.77
1.29
1.3
1.3
—
—
—
0
0
13
69
1.90
1.29
1.0
1.3
30.0
29.5
%
—
6
45
19
115
1.66
1.25
1.6
1.9
33.2
32.4
pg
0.45
19
115
31
213
1.47
1.21
2.6
4.1
—
—
—
0
0
382
3523
1.14
1.18
2.2
2.1
93.9
94.3
pmol/l
0.06
210
1800
20
125
1.61
1.18
1.3
1.2
9.5
10.9
u/l
0.21
13
98
418
3878
1.13
1.18
5.8
5.2
0.0
0.0
estimate
0.00
70
722
133
1134
1.20
1.14
3.3
2.5
19.9
22.4
%
1.37
117
966
27
183
1.49
1.14
2.2
2.1
131.5
128.7
g/l
0.18
22
132
16
96
1.68
1.10
1.4
1.2
—
—
—
0
0
99
824
1.22
1.09
7.1
7.9
119.3
120.3
g/l
0.20
93
799
22
144
1.54
1.09
1.5
1.2
—
—
—
0
0
15
89
1.70
1.08
1.5
1.2
—
—
—
0
0
32
228
1.42
1.07
5.1
5.0
—
—
—
0
0
7
33
2.13
1.05
3.1
2.8
1482.1
1271.0
u/ml
—
7
33
205
1827
1.15
1.04
4.5
3.9
—
—
—
0
0
35
255
1.39
1.04
1.7
1.6
—
—
—
0
0
5
22
2.28
1.03
1.0
1.2
232.6
194.6
iu/ml
—
5
22
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
414
3864
1.12
1.03
4.3
3.9
0.0
0.0
estimate
0.00
69
720
10
53
1.90
1.01
1.5
1.4
1.2
1.2
promille
—
5
42
9
48
1.88
1.00
1.2
1.6
—
—
—
0
0
68
549
1.26
1.00
4.4
3.6
7.4
7.4
ph
0.22
11
66
131
1131
1.18
1.00
1.2
1.2
—
—
—
0
0
73
595
1.24
0.99
4.8
4.2
0.3
0.6
%
0.29
20
162
620
5930
1.12
0.99
4.5
4.0
15.1
14.9
pmol/l
0.67
552
5336
89
742
1.22
0.98
2.8
3.1
289.8
230.7
ng/l
0.39
76
681
15
92
1.64
0.97
1.3
1.2
—
—
nmol/l
—
0
0
236
2135
1.14
0.97
2.7
2.7
13124.7
7204.6
umol/l
0.51
206
1815
25
174
1.45
0.96
3.6
3.6
—
—
—
0
0
148
1296
1.17
0.96
1.3
1.3
28.6
33.1
iu/ml
0.32
58
405
16
101
1.59
0.94
1.4
1.2
0.7
0.6
nmol/l
0.26
16
92
6
27
2.23
0.93
1.0
1.2
—
—
—
0
0
6
27
2.23
0.93
1.2
1.5
—
—
—
0
0
8
145
0.55
0.93
1.4
2.0
59.6
60.8
%
—
8
145
12
70
1.72
0.93
1.3
1.1
—
—
—
0
0
29
210
1.39
0.91
2.7
2.5
88.4
84.7
ug/min
0.03
19
124
22
151
1.47
0.91
1.5
1.6
—
—
—
0
0
187
1674
1.14
0.90
3.4
3.1
2.5
2.5
mmol/l
0.15
167
1478
13
79
1.65
0.88
1.6
1.3
—
—
—
0
0
26
186
1.41
0.88
1.2
1.2
—
—
—
0
0
80
670
1.21
0.87
4.6
4.0
1.4
1.0
%
0.48
24
210
611
5867
1.11
0.84
4.6
4.2
14.5
13.5
mm/h
0.78
565
5386
6
111
0.54
0.83
1.0
1.1
—
—
—
0
0
192
1733
1.13
0.83
5.1
4.3
1.0
1.0
kg/l
0.21
22
249
25
180
1.40
0.82
4.1
4.4
3.9
2.7
mmol/l
0.54
14
128
794
7738
1.13
0.82
19.3
15.6
26.3
25.2
mg/l
0.41
660
6245
11
65
1.70
0.82
1.1
1.2
2.2
1.6
nmol/l
0.89
11
57
12
73
1.65
0.82
1.7
1.2
—
—
—
0
0
350
3275
1.11
0.80
4.7
3.9
41.7
48.7
ng/l
0.24
255
2409
79
668
1.20
0.79
1.9
1.5
—
—
—
0
0
6
33
1.82
0.79
1.8
2.6
—
—
—
0
0
0
26
0.00
0.78
0.0
2.7
—
—
—
0
0
21
148
1.43
0.78
1.3
1.5
—
—
—
0
0
72
605
1.20
0.77
4.6
4.0
1.3
0.5
%
1.27
19
155
74
627
1.19
0.73
4.7
4.2
0.2
0.1
%
0.22
21
187
44
353
1.26
0.73
4.6
4.9
—
—
—
0
0
29
221
1.32
0.70
1.3
1.5
0.3
0.2
g/l
0.41
29
211
15
101
1.49
0.70
1.2
1.1
—
21.3
—
0
5
16
110
1.46
0.68
2.1
1.8
87.9
89.9
%
0.51
16
110
7
120
0.58
0.67
1.3
1.1
—
—
—
0
0
50
412
1.22
0.67
4.5
3.8
—
—
—
0
0
14
94
1.50
0.67
1.4
1.3
—
—
—
0
0
14
94
1.50
0.67
1.5
1.2
—
—
—
0
0
31
241
1.30
0.66
3.5
3.3
—
—
—
0
0
30
233
1.30
0.65
1.3
1.5
1.2
1.2
g/l
0.26
30
223
51
423
1.22
0.65
1.3
1.3
—
—
—
0
0
67
574
1.18
0.61
1.4
1.4
—
—
—
0
0
26
200
1.31
0.61
1.5
1.7
—
—
—
0
0
17
122
1.40
0.60
2.2
2.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.7
—
31.7
—
0
16
0
22
0.00
0.59
0.0
1.1
—
0.8
—
0
11
730
7127
1.09
0.59
5.4
4.8
2.0
2.1
mu/l
0.50
667
6435
0
23
0.00
0.58
0.0
1.0
—
0.7
—
0
5
0
23
0.00
0.58
0.0
1.0
—
0.3
—
0
8
20
149
1.35
0.58
2.9
2.9
—
—
—
0
0
7
115
0.61
0.58
3.4
1.3
—
—
—
0
0
169
1831
0.91
0.54
1.7
1.7
462.1
15451943.6
pmol/l
1.33
144
1495
23
294
0.78
0.54
3.0
3.2
0.5
0.3
g/l
0.58
11
114
27
214
1.27
0.53
2.0
3.1
0.7
0.8
nmol/l
0.66
18
170
6
97
0.62
0.52
3.2
1.2
—
—
—
0
0
10
67
1.50
0.49
1.8
1.2
—
—
—
0
0
184
1976
0.92
0.49
1.4
1.4
—
—
—
0
0
84
750
1.13
0.47
2.6
2.5
74.9
69.8
e9/l
0.80
69
587
7
47
1.49
0.47
1.6
1.9
—
—
—
0
0
18
137
1.32
0.47
1.7
1.5
—
—
—
0
0
50
430
1.17
0.47
4.7
3.9
—
—
—
0
0
88
790
1.13
0.46
1.8
1.6
—
—
—
0
0
61
534
1.15
0.46
5.9
9.0
94.1
93.9
%
0.13
61
529
10
69
1.45
0.44
1.1
1.0
0.5
4.4
u/ml
—
5
27
19
148
1.29
0.43
5.9
3.6
56.6
58.6
%
0.35
19
148
6
95
0.63
0.42
1.3
1.2
77.2
47.3
mu/l
—
6
86
18
140
1.29
0.42
1.1
1.4
—
—
—
0
0
226
2136
1.08
0.42
5.0
4.2
0.0
0.0
estimate
0.50
63
692
86
778
1.12
0.41
1.9
1.5
—
—
—
0
0
361
3470
1.06
0.40
11.3
9.9
1.3
1.3
inr
0.16
102
972
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
2.8
—
4451.5
—
0
17
79
712
1.12
0.40
4.2
3.5
—
—
—
0
0
18
141
1.28
0.40
5.1
3.3
4.1
4.4
e9/l
0.22
18
141
12
88
1.37
0.40
2.5
2.7
—
—
—
0
0
0
18
0.00
0.40
0.0
2.2
—
3.0
—
0
5
47
410
1.15
0.39
1.4
1.3
—
—
—
0
0
15
115
1.31
0.39
4.1
2.5
—
—
—
0
0
30
253
1.19
0.37
1.3
1.4
263.5
290.5
ug/g
0.39
21
156
8
116
0.69
0.37
1.1
1.0
—
—
—
0
0
824
8136
1.08
0.36
22.0
18.4
4.0
4.0
mmol/l
0.92
805
7894
822
8116
1.07
0.36
21.6
18.2
139.7
139.7
mmol/l
0.18
804
7886
17
212
0.80
0.36
1.2
1.1
—
—
—
0
0
41
357
1.15
0.35
1.3
1.2
—
—
—
0
0
29
245
1.19
0.35
1.2
1.2
—
—
—
0
0
9
126
0.71
0.35
2.9
1.3
—
—
—
0
0
9
126
0.71
0.35
2.9
1.3
—
—
—
0
0
62
557
1.12
0.35
3.0
3.0
—
—
—
0
0
31
361
0.85
0.34
1.6
1.6
—
—
—
0
0
202
2125
0.94
0.34
1.5
1.6
1.4
1.4
mmol/l
0.19
164
1757
6
45
1.34
0.33
2.3
3.6
—
—
—
0
0
6
45
1.34
0.33
1.2
1.1
154.8
495.5
u/l
—
6
40
20
164
1.22
0.32
1.1
1.2
—
—
—
0
0
10
74
1.35
0.32
1.1
1.8
—
—
—
0
0
6
47
1.28
0.32
26.8
11.5
—
—
—
0
0
50
447
1.12
0.31
1.3
1.2
80.0
121.1
iu/ml
0.85
15
175
224
2143
1.06
0.30
2.8
2.1
3.3
3.1
mg/l
0.48
199
1813
11
84
1.31
0.30
1.1
1.1
—
—
—
0
0
11
84
1.31
0.30
1.1
1.1
—
—
—
0
0
7
55
1.27
0.30
1.1
1.3
—
—
—
0
0
216
2065
1.06
0.30
3.9
3.6
—
—
—
0
0
23
195
1.18
0.28
1.1
1.2
440.8
499.3
mg/l
0.79
23
185
217
2081
1.05
0.27
1.6
1.6
20.9
20.5
nmol/l
0.13
187
1753
163
1554
1.06
0.25
2.9
3.1
0.8
0.8
ug/l
0.08
109
1071
9
74
1.22
0.25
1.2
1.5
—
—
—
0
0
13
105
1.24
0.25
1.5
1.5
—
—
—
0
0
181
1736
1.05
0.23
1.6
1.6
1.4
1.3
mg/l
0.21
136
1350
770
7619
1.05
0.23
5.3
4.9
6.2
6.0
mmol/l
1.91
692
6889
10
125
0.80
0.23
2.7
1.3
—
—
—
0
0
10
125
0.80
0.23
2.7
1.3
—
—
—
0
0
10
79
1.27
0.22
1.3
1.0
0.1
1.0
u/ml
—
5
30
10
79
1.27
0.22
1.0
1.1
—
—
—
0
0
75
701
1.08
0.22
2.3
2.1
355.5
376.6
nmol/l
0.34
65
637
5
42
1.19
0.21
1.0
1.2
124.2
145.7
nmol/l
—
5
42
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
1.7
—
0
12
0
12
0.00
0.21
0.0
1.0
—
0.6
—
0
5
8
101
0.79
0.21
1.0
1.1
—
—
—
0
0
87
923
0.94
0.21
2.8
2.6
4.7
8.3
umol/l
6.35
75
802
741
7333
1.04
0.21
7.2
6.1
40.7
40.3
mmol/mol
0.59
678
6739
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
6
48
1.25
0.20
6.2
2.0
—
—
—
0
0
6
49
1.23
0.20
1.0
1.2
—
—
—
0
0
6
50
1.20
0.19
1.0
1.9
—
—
—
0
0
827
8208
1.05
0.19
12.3
10.8
25.2
25.1
u/l
0.06
796
7886
89
843
1.06
0.19
6.4
4.4
—
—
—
0
0
23
259
0.89
0.18
9.2
11.4
—
—
—
0
0
7
60
1.17
0.18
1.1
1.2
—
—
—
0
0
7
60
1.17
0.18
2.3
2.5
—
—
—
0
0
39
358
1.09
0.18
1.8
1.9
—
—
—
0
0
7
62
1.13
0.17
1.9
2.0
—
—
—
0
0
10
82
1.22
0.17
1.2
1.4
—
—
—
0
0
37
341
1.09
0.16
1.9
1.4
—
—
—
0
0
29
265
1.10
0.15
10.6
6.2
1.4
1.4
mmol/l
0.08
24
235
728
7338
0.97
0.14
4.4
4.1
1.3
1.3
mmol/l
1.29
646
6643
7
86
0.81
0.14
1.6
1.2
—
—
—
0
0
275
2692
1.03
0.14
4.9
5.2
2.7
3.4
ug/l
0.58
241
2382
8
97
0.82
0.13
5.1
3.7
—
—
—
0
0
805
8004
1.03
0.12
18.0
14.8
—
—
—
0
0
12
104
1.16
0.12
1.3
1.2
—
—
—
0
0
30
279
1.08
0.11
1.1
1.1
—
—
—
0
0
176
1720
1.03
0.11
1.8
1.8
1167.9
1181.8
nmol/l
0.06
136
1291
47
446
1.06
0.10
10.1
9.3
—
—
—
0
0
31
290
1.07
0.10
1.6
1.7
—
—
—
0
0
52
498
1.05
0.09
2.3
2.2
10.0
12.5
nmol/l
1.71
47
435
48
501
0.96
0.08
1.2
1.3
—
—
—
0
0
7
66
1.06
0.08
2.0
1.1
—
—
—
0
0
7
68
1.03
0.08
1.6
1.1
—
—
—
0
0
852
8492
1.02
0.07
28.0
22.9
248.0
247.0
e9/l
0.17
831
8252
45
469
0.96
0.07
1.6
1.4
—
—
—
0
0
20
186
1.08
0.07
1.2
1.7
1.3
5.0
iu/l
—
6
53
8
78
1.03
0.07
2.3
1.4
—
—
—
0
0
7
81
0.86
0.07
6.0
3.4
—
—
—
0
0
9
87
1.03
0.07
1.2
1.3
—
—
—
0
0
8
90
0.89
0.06
1.9
2.5
—
—
—
0
0
268
2649
1.02
0.06
3.9
3.0
1816.4
1569.1
ng/l
0.34
225
2282
852
8495
1.02
0.06
27.9
22.8
91.3
91.4
fl
0.42
840
8341
852
8495
1.02
0.06
27.8
22.8
30.3
30.4
pg
0.55
840
8338
852
8496
1.02
0.06
28.0
22.9
4.4
4.4
e12/l
0.96
823
8228
852
8497
1.02
0.06
28.0
22.9
7.0
6.8
e9/l
0.81
826
8227
14
129
1.09
0.05
1.1
1.2
—
—
—
0
0
126
1239
1.02
0.05
1.3
1.3
5.0
11.7
u/ml
1.33
48
460
761
7585
1.01
0.05
4.8
4.6
1.4
1.5
mmol/l
1.75
686
6906
69
673
1.03
0.05
4.2
3.9
—
—
—
0
0
22
208
1.06
0.05
1.1
1.1
—
—
—
0
0
852
8499
1.02
0.05
28.2
23.0
132.7
133.7
g/l
1.11
841
8340
251
2486
1.01
0.05
4.8
4.0
—
—
—
0
0
18
191
0.94
0.04
2.3
2.2
—
—
—
0
0
17
180
0.94
0.04
2.1
2.6
—
—
—
0
0
21
200
1.05
0.03
1.1
1.2
—
1382.9
—
0
7
52
510
1.02
0.02
3.2
3.0
5.1
4.0
e9/l
0.84
35
382
253
2516
1.01
0.02
3.3
3.1
—
—
—
0
0
19
183
1.04
0.01
1.1
1.1
—
92.5
—
0
16
763
7640
0.99
0.01
4.9
4.7
4.6
4.6
mmol/l
0.51
691
7011
87
878
0.99
0.01
1.2
1.3
—
—
—
0
0
36
366
0.98
0.00
2.8
2.7
—
—
—
0
0
781
7816
1.00
0.00
5.6
5.2
2.7
2.7
mmol/l
0.43
711
7124
17
168
1.01
0.00
1.2
1.2
—
—
—
0
0
18
182
0.99
0.00
3.4
3.6
19.9
28.1
mg/l
0.44
12
114
45
449
1.00
0.00
1.3
1.3
—
—
—
0
0
13
129
1.01
0.00
1.2
1.4
—
—
—
0
0
55
547
1.01
0.00
1.3
1.2
—
—
—
0
0
13
135
0.96
0.00
1.8
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
5
56
0.89
0.00
3.4
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
6.0
—
0.4
—
0
6
5
51
0.98
0.00
2.8
2.4
518.8
494.1
min
—
5
34
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
9
94
0.96
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
330.6
—
0
5
5
55
0.91
0.00
1.8
1.5
—
—
—
0
0
9
94
0.96
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
8
89
0.90
0.00
1.0
1.1
1.6
1.5
g/l
—
8
81
9
94
0.96
0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
5.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
7
72
0.97
0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
7.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_SALIVARY_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_NOS 1.304 [1.12, 1.52] < 0.001
Birth year 0.995 [0.99, 1.0] 0.225

During the follow-up period (1.1.1998 — 31.12.2019), 403 out of 1694 females with CD2_BENIGN_SALIVARY_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_NOS 1.63 [1.38, 1.93] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 1374 males with CD2_BENIGN_SALIVARY_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SALIVARY_NOS.

N-year risk Females Males
1 0.084% 0.371%
5 0.664% 1.865%
10 1.9% 4.564%
15 3.672% 8.531%
20 6.75% 14.404%

Relationships between endpoints

Index endpoint: CD2_BENIGN_SALIVARY_NOS – Benign neoplasm: other/unspecified salivary gland

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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