This is a non-core endpoint: only basic statistics are computed.
See its core counterpart CD2_IMMUNOPROLIFERATIVE_EXALLC for full statistics.
Malignant immunoproliferative diseases
CD2_IMMUNOPROLIFERATIVE
lymphoma: A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
319 |
4. Check minimum number of eventsNone |
319 |
5. Include endpointsNone |
319 |
6. Filter based on genotype QC (FinnGen only) |
319 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- C81-C96
- Name in latin
- Morbi immunoproliferativi maligni
Similar endpoints
↥List of similar endpoints to
Malignant immunoproliferative diseases
based on the number of shared cases.
Similar with more cases:
- Malignant immunoproliferative diseases
- Primary_lymphoid and hematopoietic malignant neoplasms
- Primary_lymphoid and hematopoietic malignant neoplasms
- Malignant neoplasm
- Malignant neoplasm, excluding all cancers (controls excluding all cancers)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 319 | 124 | 195 |
| Unadjusted period prevalence (%) | 0.07 | 0.04 | 0.09 |
| Median age at first event (years) | 67.83 | 65.99 | 69.00 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 293
- Matched controls
- 2930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
+∞
256.5
207
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
48.9
131.9
163
73
XW000
NOMESCO Finland
Bone marrow biopsy
41.3
111.3
142
65
9761/3-C42.0
ICD-O-3
Waldenstrom macroglobulinemia of blood
+∞
86.9
79
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
81.9
67.3
74
12
C88.9
ICD-10 Finland
Malignant immunoproliferative disease, unspecified
+∞
63.9
59
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
50.5
45.3
54
13
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
21.8
38.5
57
32
L03AA02
ATC
filgrastim; parenteral
16.2
34.0
56
42
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.2
31.3
96
213
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
26.3
29.7
41
18
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
18.6
29.7
46
29
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.3
29.3
64
85
M04AA01
ATC
allopurinol; systemic
4.9
26.6
104
298
9671/3-C42.1
ICD-O-3
Lymphoplasmacytic lymphoma of bone marrow
+∞
26.4
25
*
A04AA01
ATC
ondansetron; systemic, rectal
7.0
24.9
66
117
C88.7
ICD-10 Finland
Other malignant immunoproliferative diseases
+∞
23.2
22
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
21.2
23.2
34
18
WW500
NOMESCO Finland
Blood transfusion
9.7
23.0
48
58
1512
Kela drug reimbursment
Ibrutinib
236.9
21.9
22
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
37.0
21.5
27
8
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
54.4
21.5
25
5
R50.9
ICD-10 Finland
Fever, unspecified
4.7
20.9
80
217
390
Kela drug reimbursment
Ibrutinib
118.5
20.9
22
*
L01AA02
ATC
chlorambucil; oral
59.2
19.2
22
*
JN4BD
NOMESCO Finland
Extensive body CT
4.0
17.5
78
242
1XC02
NOMESCO Finland
NA
37.5
16.9
21
6
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
6.9
16.9
43
71
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
7.6
16.7
40
60
C83.01
ICD-10 Finland
Lymphoplasmacytic lymphoma
179.7
16.7
17
*
L03AA13
ATC
pegfilgrastim; parenteral
8.1
16.3
37
51
L01EL01
ATC
ibrutinib; oral
+∞
15.8
15
*
ZX120
NOMESCO Finland
Intravenous
4.4
15.7
62
170
H02AB06
ATC
prednisolone; systemic
2.7
14.9
173
1020
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.8
14.5
42
82
J05AB11
ATC
valaciclovir; oral
3.8
14.0
64
200
J05AB01
ATC
aciclovir; systemic
3.2
13.9
87
345
C88.4
ICD-10 Finland
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lyphoma]
+∞
13.6
13
*
N08.1*C88.0
ICD-10 Finland
Glomerular disorders in Waldenström's macroglobulinaemia
+∞
13.6
13
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.7
13.3
64
208
JN4AD
NOMESCO Finland
Body CT examination
4.1
13.0
53
149
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
12.5
12.0
21
18
L01XE27
ATC
[U] ibrutinib; oral
67.7
11.7
13
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
11.6
63
223
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
11.4
170
1083
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
13.6
10.8
18
14
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
13.6
10.8
18
14
9591/3-C42.1
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of bone marrow
+∞
10.5
10
*
L01AA01
ATC
cyclophosphamide; systemic
33.9
10.4
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
10.4
93
449
B03XA01
ATC
erythropoietin; parenteral
19.7
10.4
15
8
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
15.3
10.1
16
11
C83.1
ICD-10 Finland
Mantle cell lymphoma
17.5
10.0
15
9
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
9.8
38
102
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
9.7
108
582
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
15.7
9.6
15
10
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
31.1
9.5
12
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.1
9.3
22
33
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
37.9
9.1
11
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
19.3
9.0
13
7
C90.0
ICD-10 Finland
Multiple myeloma
11.2
8.9
16
15
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
51.5
8.7
10
*
JN6AD
NOMESCO Finland
CT of torso and neck
12.1
8.7
15
13
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
13.3
8.5
14
11
127
Kela drug reimbursment
Transplant complication
12.2
8.2
14
12
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
12.2
8.2
14
12
J01MA14
ATC
moxifloxacin; systemic
3.2
7.9
41
140
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
7.9
97
538
WW200
NOMESCO Finland
Immunization
6.2
7.8
20
34
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
7.8
82
420
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
7.8
7.8
17
23
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
46.2
7.8
9
*
J01MA12
ATC
levofloxacin; systemic
2.3
7.7
76
381
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
12.3
7.6
13
11
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
10.4
7.6
14
14
H02AB02
ATC
dexamethasone; systemic
2.8
7.5
50
202
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
82.1
7.4
8
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.1
7.4
17
25
D70.82
ICD-10 Finland
Drug-induced neutropenia
7.1
7.4
17
25
B03XA02
ATC
darbepoetin alfa; parenteral
6.5
7.4
18
29
L03AA14
ATC
lipegfilgrastim; parenteral
6.9
7.2
17
26
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
20.6
7.2
10
5
TAB00
NOMESCO Finland
Lumbar puncture
5.2
7.1
21
43
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
7.0
24
58
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.3
6.9
24
59
L04AA06
ATC
mycophenolic acid; systemic
11.3
6.9
12
11
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
17.2
6.8
10
6
WW300
NOMESCO Finland
Transfer of autologic stem cells
41.0
6.8
8
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
14.7
6.4
10
7
UJF32
NOMESCO Finland
Coloscopy
2.0
6.3
90
525
9680/3-C77.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of lymph node, NOS
+∞
6.3
6
*
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
6.3
6
*
C88.3
ICD-10 Finland
Immunoproliferative small intestinal disease
+∞
6.3
6
*
A02BC02
ATC
pantoprazole; systemic
1.9
6.2
196
1512
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
6.2
104
643
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_IMMUNOPROLIFERATIVE – Malignant immunoproliferative diseases
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).