≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Malignant immunoproliferative diseases

Endpoint Browser PheWeb

CD2_IMMUNOPROLIFERATIVE_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C88
  • Cause of death: ICD-10 — C88

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
C81-C96
Name in latin
Morbi immunoproliferativi maligni

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 319 124 195
Unadjusted period prevalence (%) 0.07 0.04 0.09
Median age at first event (years) 67.83 65.99 69.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
293
Matched controls
2928
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C88.0
ICD-10 Finland
Waldenström macroglobulinaemia
+∞
256.4
207
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
181.3
166.6
163
20
XW000
NOMESCO Finland
Bone marrow biopsy
79.6
128.8
142
34
9761/3-C42.0
ICD-O-3
Waldenstrom macroglobulinemia of blood
+∞
86.8
79
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
109.1
69.8
74
9
C88.9
ICD-10 Finland
Malignant immunoproliferative disease, unspecified
+∞
63.9
59
*
L03AA02
ATC
filgrastim; parenteral
344.2
57.4
56
*
A04AA01
ATC
ondansetron; systemic, rectal
33.7
50.4
66
25
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
93.7
49.9
54
7
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
49.4
46
*
JN4BD
NOMESCO Finland
Extensive body CT
18.5
49.0
78
56
H02AB02
ATC
dexamethasone; systemic
149.8
48.4
50
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
46.0
43
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
43.8
41
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
42.7
40
*
L03AA13
ATC
pegfilgrastim; parenteral
417.0
37.9
37
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
36.2
34
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
17.8
35.9
57
39
WW500
NOMESCO Finland
Blood transfusion
25.8
34.4
48
22
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
12.5
34.3
64
64
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.5
32.3
96
205
JN4AD
NOMESCO Finland
Body CT examination
15.5
31.7
53
41
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
28.6
27
*
A03FA01
ATC
metoclopramide; systemic, rectal
6.3
27.9
82
169
A04AA02
ATC
granisetron; systemic, transdermal
+∞
27.5
26
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
296.4
27.2
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
26.4
25
*
9671/3-C42.1
ICD-O-3
Lymphoplasmacytic lymphoma of bone marrow
+∞
26.4
25
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
+∞
26.4
25
*
M04AA01
ATC
allopurinol; systemic
4.8
26.2
104
302
ZX120
NOMESCO Finland
Intravenous
8.0
25.9
62
95
C88.7
ICD-10 Finland
Other malignant immunoproliferative diseases
+∞
23.2
22
*
390
Kela drug reimbursment
Ibrutinib
+∞
23.2
22
*
1512
Kela drug reimbursment
Ibrutinib
+∞
23.2
22
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
12.1
22.7
42
40
R50.9
ICD-10 Finland
Fever, unspecified
5.0
22.2
80
205
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
22.1
21
*
L01AA02
ATC
chlorambucil; oral
236.6
21.9
22
*
1XC02
NOMESCO Finland
NA
112.6
19.8
21
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
18.9
18
*
D64.9
ICD-10 Finland
Anaemia, unspecified
5.1
18.9
64
151
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
18.8
170
907
C83.01
ICD-10 Finland
Lymphoplasmacytic lymphoma
+∞
17.9
17
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
17.9
17
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
17.9
17
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
16.9
93
341
H02AB06
ATC
prednisolone; systemic
2.9
16.8
173
976
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
16.8
16
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
16.8
16
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.5
16.5
63
168
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.2
16.2
104
427
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
63.6
15.9
18
*
L01EL01
ATC
ibrutinib; oral
+∞
15.8
15
*
C83.1
ICD-10 Finland
Mantle cell lymphoma
+∞
15.8
15
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
89.9
15.7
17
*
J05AB11
ATC
valaciclovir; oral
4.1
15.3
64
185
J05AB01
ATC
aciclovir; systemic
3.4
15.2
87
326
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
14.7
14
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
157.3
14.6
15
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
21.3
14.0
20
10
C88.4
ICD-10 Finland
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lyphoma]
+∞
13.6
13
*
L01XE27
ATC
[U] ibrutinib; oral
+∞
13.6
13
*
N08.1*C88.0
ICD-10 Finland
Glomerular disorders in Waldenström's macroglobulinaemia
+∞
13.6
13
*
130
Kela drug reimbursment
Malignant tumour
+∞
13.6
13
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
146.3
13.6
14
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.6
12.8
38
76
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
+∞
12.6
12
*
116
Kela drug reimbursment
Prostate cancer
+∞
12.6
12
*
J01MA12
ATC
levofloxacin; systemic
3.2
12.5
76
292
ZX112
NOMESCO Finland
Subcutaneous
39.3
12.3
15
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
39.3
12.3
15
*
JN6AD
NOMESCO Finland
CT of torso and neck
39.3
12.3
15
*
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
13.2
12.3
21
17
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
48.7
12.0
14
*
JN4CD
NOMESCO Finland
Very extensive body CT
13.3
11.8
20
16
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
67.6
11.7
13
*
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
45.1
11.0
13
*
B03XA01
ATC
erythropoietin; parenteral
22.4
10.8
15
7
N02AA05
ATC
oxycodone; systemic
3.3
10.5
55
189
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
113.8
10.5
11
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
+∞
10.5
10
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
10.5
10
*
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
+∞
10.5
10
*
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
+∞
10.5
10
*
9591/3-C42.1
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of bone marrow
+∞
10.5
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
10.4
85
390
D70.89
ICD-10 Finland
Neutropenic splenomegaly
33.8
10.4
13
*
B03XA02
ATC
darbepoetin alfa; parenteral
11.9
10.2
18
16
J01MA14
ATC
moxifloxacin; systemic
4.0
10.0
41
115
L01AA01
ATC
cyclophosphamide; systemic
27.0
9.9
13
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
9.8
108
578
127
Kela drug reimbursment
Transplant complication
18.3
9.5
14
8
WZC30
NOMESCO Finland
Teaching
3.8
9.5
41
121
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
9.4
9
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
9.4
9
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
9.4
9
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
10.5
9.1
17
17
WW200
NOMESCO Finland
Immunization
7.9
9.1
20
27
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
37.9
9.1
11
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.7
9.0
22
35
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.9
8.8
36
101
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
8.7
35
97
A02BC02
ATC
pantoprazole; systemic
2.1
8.7
196
1422
UJF32
NOMESCO Finland
Coloscopy
2.3
8.5
90
468
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
8.4
97
526
C82.1
ICD-10 Finland
Follicular lymphoma grade II
+∞
8.4
8
*
WW300
NOMESCO Finland
Transfer of autologic stem cells
+∞
8.4
8
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
8.4
8
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
15.0
8.3
13
9
ZXE00
NOMESCO Finland
One hour or less
2.1
8.2
118
704
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.2
8.2
14
12
TAB00
NOMESCO Finland
Lumbar puncture
6.2
8.1
21
36
PJA10
NOMESCO Finland
Exploration of lymph nodes
34.3
8.1
10
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
10.5
8.1
15
15
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.2
8.1
24
49
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
8.0
115
683
A41.9
ICD-10 Finland
Sepsis, unspecified
5.1
8.0
24
50
B01AB10
ATC
tinzaparin; parenteral
5.2
7.8
23
47
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.3
7.7
38
125
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
82.0
7.4
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
7.4
63
292
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
7.3
7
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.3
7
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
7.3
7
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
7.3
7
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.2
7.3
38
131
XX3DW
NOMESCO Finland
Time consuming IT work
4.6
7.2
24
56
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
8.2
7.2
15
19
WF002
NOMESCO Finland
Radical radiotherapy
30.8
7.2
9
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.3
6.9
24
59
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
17.2
6.8
10
6
HAB40
NOMESCO Finland
Wedge excision of mammary gland
41.0
6.8
8
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
6.7
30
92
C03CA01
ATC
furosemide; systemic
2.0
6.7
115
723
Z51.5
ICD-10 Finland
Palliative care
5.0
6.7
20
42
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
6.5
115
729
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
6.5
38
142
L02AE02
ATC
leuprorelin; implant, parenteral
71.2
6.4
7
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
14.7
6.4
10
7
L04AA06
ATC
mycophenolic acid; systemic
9.6
6.3
12
13
C88.3
ICD-10 Finland
Immunoproliferative small intestinal disease
+∞
6.3
6
*
9689/3-C42.2
ICD-O-3
Splenic marginal zone B-cell lymphoma of spleen
+∞
6.3
6
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
6.3
6
*
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
+∞
6.3
6
*
L02BG04
ATC
letrozole; oral
+∞
6.3
6
*
L01BB05
ATC
fludarabine; systemic
+∞
6.3
6
*
9680/3-C77.8
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of lymph nodes of multiple regions
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
115
Kela drug reimbursment
Breast cancer
+∞
6.3
6
*
9680/3-C77.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of lymph node, NOS
+∞
6.3
6
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
+∞
6.3
6
*
1AA09
NOMESCO Finland
NA
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
6.3
6
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
6.3
6
*
C82.00
ICD-10 Finland
Follicular nodular non-Hodgkin's lymphoma, ungraded
+∞
6.3
6
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
6.2
30
98
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
6.2
100
612
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
10.3
6.1
11
11

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: CD2_IMMUNOPROLIFERATIVE_EXALLC – Malignant immunoproliferative diseases

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).