This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Leukaemia of unspecified cell type
CD2_LEUKAEMIA_NAS
leukemia: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
303 |
4. Check minimum number of eventsNone |
303 |
5. Include endpointsNone |
303 |
6. Filter based on genotype QC (FinnGen only) |
303 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF8
- Parent code in ICD-10
- C81-C96
- Name in latin
- Leuc(h)aemiae typo cellulari non specificato
Similar endpoints
↥List of similar endpoints to
Leukaemia of unspecified cell type
based on the number of shared cases.
Similar with more cases:
- Leukaemia of unspecified cell type
- Primary_lymphoid and hematopoietic malignant neoplasms
- Primary_lymphoid and hematopoietic malignant neoplasms
- Malignant neoplasm
- Malignant neoplasm, excluding all cancers (controls excluding all cancers)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 303 | 132 | 171 |
| Unadjusted period prevalence (%) | 0.06 | 0.04 | 0.08 |
| Median age at first event (years) | 62.58 | 56.99 | 66.89 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 298
- Matched controls
- 2982
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
+∞
211.5
177
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
104.8
182.1
193
51
XW000
NOMESCO Finland
Bone marrow biopsy
63.3
134.1
155
50
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
388.0
125.5
118
5
C95.9
ICD-10 Finland
Leukaemia, unspecified
+∞
93.8
85
*
WW500
NOMESCO Finland
Blood transfusion
27.0
69.4
98
53
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
26.5
63.0
89
47
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
186.8
59.3
60
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
335.6
56.2
55
*
127
Kela drug reimbursment
Transplant complication
54.6
46.0
54
12
L03AA02
ATC
filgrastim; parenteral
27.2
45.5
63
29
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
114.0
45.3
48
5
A05AA02
ATC
ursodeoxycholic acid; oral
45.7
43.6
53
14
J05AB11
ATC
valaciclovir; oral
8.5
41.0
100
167
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.1
40.2
114
238
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
11.6
40.1
79
90
A04AA01
ATC
ondansetron; systemic, rectal
11.8
38.1
74
81
L01BB02
ATC
mercaptopurine; oral
62.5
37.5
43
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.2
36.3
72
82
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
373.6
33.6
33
*
9835/3-C42.1
ICD-O-3
Precursor cell lymphoblastic leukemia, NOS, of bone marrow
184.7
32.4
33
*
ZX120
NOMESCO Finland
Intravenous
7.0
30.0
81
150
M04AA01
ATC
allopurinol; systemic
5.9
29.9
96
223
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
26.2
29.7
41
18
C95.1
ICD-10 Finland
Chronic leukaemia of unspecified cell type
+∞
28.6
27
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
296.3
27.2
27
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
41.0
26.8
33
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
26.5
101
281
R50.9
ICD-10 Finland
Fever, unspecified
5.2
26.3
93
238
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
283.8
26.1
26
*
L04AD01
ATC
ciclosporin; systemic
31.7
26.0
34
12
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
13.7
25.2
44
37
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
61.5
24.5
28
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.6
23.4
75
169
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
23.3
179
898
WW200
NOMESCO Finland
Immunization
16.7
23.2
37
25
L01XX05
ATC
hydroxycarbamide; oral
27.9
20.8
28
11
TAB00
NOMESCO Finland
Lumbar puncture
9.8
20.5
42
49
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.4
20.4
46
63
121
Kela drug reimbursment
Severe hypofunction of sexual glands
22.8
20.4
29
14
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
43.3
19.8
24
6
J02AC03
ATC
voriconazole; systemic
213.5
19.8
20
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
9.2
19.8
42
52
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
17.4
19.2
30
19
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
106.8
18.8
20
*
ZXD05
NOMESCO Finland
Urgent procedure
3.1
17.4
133
620
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.1
17.0
48
91
D64.9
ICD-10 Finland
Anaemia, unspecified
4.5
16.3
63
169
J01MA12
ATC
levofloxacin; systemic
3.5
16.3
90
329
189
Kela drug reimbursment
Imatinib
50.5
16.2
19
*
L01XE01
ATC
[U] imatinib; oral
63.6
15.9
18
*
H02AB09
ATC
hydrocortisone; systemic
10.0
15.1
30
33
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.3
14.9
36
55
B73
ICPC
Leukaemia
84.3
14.7
16
*
C92.9
ICD-10 Finland
Myeloid leukaemia, unspecified
+∞
14.7
14
*
C92.4
ICD-10 Finland
Acute promyelocytic leukaemia [PML]
+∞
14.7
14
*
JN4BD
NOMESCO Finland
Extensive body CT
4.0
14.3
62
184
D70.89
ICD-10 Finland
Neutropenic splenomegaly
25.2
14.0
19
8
A41.9
ICD-10 Finland
Sepsis, unspecified
6.8
13.8
35
57
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
+∞
13.6
13
*
J02AC04
ATC
posaconazole; systemic
+∞
13.6
13
*
Y84.8
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
146.3
13.6
14
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
6.3
12.7
34
60
Z85.6
ICD-10 Finland
Personal history of leukaemia
135.4
12.5
13
*
L04AA06
ATC
mycophenolic acid; systemic
15.2
12.5
20
14
TPH00
NOMESCO Finland
Phlebotomy
48.7
12.0
14
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.5
11.6
27
39
C92.5
ICD-10 Finland
Acute myelomonocytic leukaemia
+∞
11.5
11
*
9801/3-C42.1
ICD-O-3
Acute leukemia, NOS, of bone marrow
+∞
11.5
11
*
9811/3-C42.1
ICD-O-3
B lymphoblastic leukemia/lymphoma, NOS, of bone marrow
+∞
11.5
11
*
ZX131
NOMESCO Finland
Intrathecal
124.6
11.5
12
*
2AX04
NOMESCO Finland
NA
124.6
11.5
12
*
H02AB02
ATC
dexamethasone; systemic
3.6
11.4
55
178
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
17.9
11.3
17
10
ZX090
NOMESCO Finland
Other technic of radiotherapy
8.6
11.3
24
30
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
45.1
11.0
13
*
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
45.1
11.0
13
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.4
11.0
22
25
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
62.3
10.7
12
*
1DB06
NOMESCO Finland
NA
+∞
10.5
10
*
152
Kela drug reimbursment
Nilotinib
+∞
10.5
10
*
2089X
ICD-9 Finland
Leukaemia of unspecified cell type, Unspecified leukaemia
+∞
10.5
10
*
ZX108
NOMESCO Finland
Inhalation
33.8
10.4
13
*
ZX121
NOMESCO Finland
Central venous catheter
19.6
10.4
15
8
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
10.3
82
371
J01MA14
ATC
moxifloxacin; systemic
3.8
10.2
44
130
J05AB01
ATC
aciclovir; systemic
2.7
10.0
80
362
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
9.6
111
607
WW304
NOMESCO Finland
Transfer of stem cells from registered domestic donator
+∞
9.4
9
*
H02AB04
ATC
methylprednisolone; systemic
3.1
9.4
56
209
ZXE00
NOMESCO Finland
One hour or less
2.2
9.3
135
815
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
9.0
129
771
N02AA05
ATC
oxycodone; systemic
2.8
8.8
60
245
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
14.6
8.8
14
10
9863/3-C42.1
ICD-O-3
Chronic myeloid leukemia, NOS, of bone marrow
51.5
8.7
10
*
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
28.4
8.5
11
*
D46.2
ICD-10 Finland
Refractory anaemia with excess of blasts [RAEB]
92.5
8.5
9
*
C93.0
ICD-10 Finland
Acute monoblastic/monocytic leukaemia
+∞
8.4
8
*
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
34.4
8.1
10
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
10.5
8.1
15
15
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
8.0
89
468
A07AA02
ATC
nystatin; oral
4.0
7.8
31
85
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.2
7.8
40
136
L01EA01
ATC
imatinib; oral (bcr-abl tyrosine kinase inhibitors)
46.2
7.8
9
*
Z2446
NOMESCO Finland
Social worker
3.5
7.7
36
114
J02AC01
ATC
fluconazole; systemic
2.1
7.7
110
648
150
Kela drug reimbursment
Dasatinib
82.0
7.4
8
*
L01XE06
ATC
[U] dasatinib; systemic
82.0
7.4
8
*
2AA01
NOMESCO Finland
NA
82.0
7.4
8
*
5BA08
NOMESCO Finland
NA
13.8
7.4
12
9
A41.8
ICD-10 Finland
Other specified sepsis
8.7
7.4
15
18
212
Kela drug reimbursment
Gout
7.1
7.4
17
25
L01XE08
ATC
[U] nilotinib; oral
+∞
7.3
7
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.4
7.3
35
113
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.9
7.2
19
34
ZX114
NOMESCO Finland
Intramuscular
8.2
7.2
15
19
TPX15
NOMESCO Finland
Removal of vascular injection port
30.8
7.2
9
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
20.6
7.2
10
5
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.5
6.9
31
95
N05BA06
ATC
lorazepam; systemic, sublingual
3.8
6.9
28
79
Z51.5
ICD-10 Finland
Palliative care
3.6
6.9
30
90
316
Kela drug reimbursment
Imatinib
41.0
6.8
8
*
ZX112
NOMESCO Finland
Subcutaneous
6.1
6.7
17
29
1XC02
NOMESCO Finland
NA
23.1
6.7
9
*
C90.0
ICD-10 Finland
Multiple myeloma
9.0
6.6
13
15
1XX02
NOMESCO Finland
NA
71.3
6.4
7
*
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
71.3
6.4
7
*
WA010
NOMESCO Finland
Adjuvant whole body radiotherapy
71.3
6.4
7
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
11.4
6.3
11
10
L04AA01
ATC
[U] ciclosporin; systemic
7.3
6.3
14
20
L01EA03
ATC
nilotinib; oral
+∞
6.3
6
*
1CX01
NOMESCO Finland
NA
+∞
6.3
6
*
5AD01
NOMESCO Finland
NA
+∞
6.3
6
*
9866/3-C42.1
ICD-O-3
Acute promyelocytic leukemia, t(15;17)(q22;q11-12) of bone marrow
+∞
6.3
6
*
C92.7
ICD-10 Finland
Other myeloid leukaemia
+∞
6.3
6
*
9891/3-C42.1
ICD-O-3
Acute monocytic leukemia of bone marrow
+∞
6.3
6
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
6.3
6
*
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.9
6.1
10
8
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_LEUKAEMIA_NAS – Leukaemia of unspecified cell type
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).