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Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue

CD2_PRIMARY_LYMPHOID_HEMATOPOIETIC_NAS

lymphoma: A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C96
  • Hospital discharge: ICD-9 202
  • Hospital discharge: ICD-8 202
  • Cause of death: ICD-10 C96
  • Cause of death: ICD-9 202
  • Cause of death: ICD-8 202

2 out of 7 registries used, show all original rules.

314

4. Check minimum number of events

None

314

5. Include endpoints

None

314

6. Filter based on genotype QC (FinnGen only)

314

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
C81-C96
Name in latin
Neoplasmata maligna alia et non specificata textus lymphatici, haematopoetici et cognati

Similar endpoints

List of similar endpoints to Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 314 146 168
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 55.73 53.03 58.08

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
289
Matched controls
2887
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C96.9
ICD-10 Finland
Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified
+∞
155.7
135
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
42.7
122.1
156
77
20298
ICD-8 Finland
Other neoplasms of lymphoid tissue, Lymphomata alia
+∞
43.9
41
*
XW000
NOMESCO Finland
Bone marrow biopsy
14.7
41.7
73
65
L03AA02
ATC
filgrastim; parenteral
16.4
32.4
53
39
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
30.5
31.6
42
16
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
10.4
28.5
58
68
A03FA01
ATC
metoclopramide; systemic, rectal
4.6
27.2
115
360
C96.2
ICD-10 Finland
Malignant mast cell tumour
+∞
25.4
24
*
WW500
NOMESCO Finland
Blood transfusion
11.7
24.4
46
46
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
23.9
24.1
34
16
20199
ICD-8 Finland
Hodgkin's disease
260.7
24.0
24
*
JN4BD
NOMESCO Finland
Extensive body CT
5.2
23.9
84
212
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.6
22.9
56
88
A04AA01
ATC
ondansetron; systemic, rectal
7.1
21.0
54
91
C96.7
ICD-10 Finland
Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
+∞
20.0
19
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
28.4
19.5
26
10
Q82.2
ICD-10 Finland
Mastocytosis
107.1
18.8
20
*
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
202.6
18.8
19
*
R50.9
ICD-10 Finland
Fever, unspecified
4.2
17.7
75
222
ZX120
NOMESCO Finland
Intravenous
5.0
17.2
59
141
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
27.6
17.2
23
9
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
9.7
16.7
34
39
C81.1
ICD-10 Finland
Nodular sclerosis classical Hodgkin lymphoma
63.7
15.9
18
*
PJA10
NOMESCO Finland
Exploration of lymph nodes
20.7
15.8
23
12
1XC02
NOMESCO Finland
NA
33.7
15.0
19
6
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
10.3
14.8
29
31
M04AA01
ATC
allopurinol; systemic
3.6
14.7
77
268
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
17.3
13.7
21
13
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
14.0
12.6
21
16
9940/3-C42.1
ICD-O-3
Hairy cell leukemia, NOS, of bone marrow
+∞
12.6
12
*
20293
ICD-8 Finland
Other neoplasms of lymphoid tissue, Neoplasma benignum sive NUD medullae osseae
+∞
12.6
12
*
C91.4
ICD-10 Finland
Hairy-cell leukaemia
+∞
12.6
12
*
XX9CD
NOMESCO Finland
Very extensive complementary CT
+∞
12.6
12
*
A02BC02
ATC
pantoprazole; systemic
2.6
12.4
212
1484
N02AA05
ATC
oxycodone; systemic
3.1
12.0
73
280
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
15.5
12.0
19
13
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
11.8
58
191
C82.9
ICD-10 Finland
Follicular lymphoma, unspecified
67.8
11.7
13
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
24.1
11.7
16
7
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
6.1
11.1
30
54
D47.0
ICD-10 Finland
Histiocytic and mast cell tumours of uncertain and unknown behaviour
62.4
10.7
12
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
114.0
10.5
11
*
2024A
ICD-9 Finland
Other malignant neoplasm of lymphoid and histiocytic tissue, Leukaemic reticuloendotheliosis
+∞
10.5
10
*
H02AB02
ATC
dexamethasone; systemic
3.4
10.4
52
173
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
19.7
10.4
15
8
H02AB06
ATC
prednisolone; systemic
2.2
9.8
159
1027
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
9.8
61
235
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
22.6
9.4
13
6
C81.0
ICD-10 Finland
Nodular lymphocyte predominant Hodgkin lymphoma
+∞
9.4
9
*
20228
ICD-8 Finland
Other neoplasms of lymphoid tissue, Other primary malignant neoplasms of lymphoid tissue
+∞
9.4
9
*
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
14.3
9.3
15
11
ZXE00
NOMESCO Finland
One hour or less
2.1
8.7
132
815
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
16.9
8.6
13
8
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
34.4
8.1
10
*
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
22.8
8.1
11
5
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
19.0
7.7
11
6
JN6AD
NOMESCO Finland
CT of torso and neck
12.3
7.7
13
11
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
7.6
79
406
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
7.6
149
1003
9741/3-C42.1
ICD-O-3
Malignant mastocytosis of bone marrow
82.1
7.5
8
*
9650/3-C77.0
ICD-O-3
Hodgkin lymphoma, NOS, of lymph nodes of head, face and neck
82.1
7.5
8
*
Z2221
NOMESCO Finland
Medical doctor
2.2
7.4
90
497
WF049
NOMESCO Finland
Radiotherapy of metastasis
5.1
7.3
22
46
9591/3-C77.0
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of lymph nodes of head, face and neck
+∞
7.3
7
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
30.8
7.2
9
*
B01AB05
ATC
enoxaparin; parenteral
2.1
7.0
102
603
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
6.9
64
307
JN4AD
NOMESCO Finland
Body CT examination
3.1
6.9
38
134
L03AA13
ATC
pegfilgrastim; parenteral
4.9
6.9
21
45
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
6.6
104
633
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.4
6.5
31
100
ZX090
NOMESCO Finland
Other technic of radiotherapy
5.4
6.4
18
35
D70.82
ICD-10 Finland
Drug-induced neutropenia
7.3
6.3
14
20
9680/3-C77.8
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of lymph nodes of multiple regions
+∞
6.3
6
*
2015X
ICD-9 Finland
Hodgkin's disease, Nodular sclerosis[MORBUS HODGKIN, NODULAR SCLEROSIS, NUD]
+∞
6.3
6
*
C96.1
ICD-10 Finland
Malignant histiocytosis
+∞
6.3
6
*
2029X
ICD-9 Finland
Other malignant neoplasm of lymphoid and histiocytic tissue, Other and unspecified malignant neoplasms of lymphoid and histiocytic tissue
+∞
6.3
6
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
27.3
6.3
8
*
WF004
NOMESCO Finland
Palliative radiotherapy
6.5
6.2
15
24
WX892
NOMESCO Finland
Monitored bed care
2.9
6.1
36
136

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_PRIMARY_LYMPHOID_HEMATOPOIETIC_NAS – Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).