Risteys · D3_KELA

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: KELA reimbursements: KELA codes — 120 1 out of 7 registries used, show all original rules.	300
4. Check minimum number of events None	300
5. Include endpoints None	300
6. Filter based on genotype QC (FinnGen only)	300

	All	Female	Male
Number of individuals
Whole population	979	566	411
Only index persons	863	510	353
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	42.67	45.86	38.29
Only index persons	41.96	46.26	35.76

	All	Female	Male
Number of individuals	300	193	107
Unadjusted period prevalence (%)	0.06	0.07	0.05
Median age at first event (years)	44.08	45.84	40.90

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
258: Matched controls
2578

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

120

Kela drug reimbursment

Hypogammaglobulinaemia

+∞

323.0

258

J06BA01

ATC

immunoglobulins, normal human, for extravascular adm.; systemic

+∞

294.4

223

D80.1

ICD-10 Finland

Nonfamilial hypogammaglobulinaemia

+∞

188.4

157

ZX120

NOMESCO Finland

Intravenous

26.7

93.4

139

108

D80.9

ICD-10 Finland

Immunodeficiency with predominantly antibody defects, unspecified

+∞

91.2

D80.8

ICD-10 Finland

Other immunodeficiencies with predominantly antibody defects

+∞

88.8

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

49.4

80.5

6BA02

NOMESCO Finland

324.5

73.5

J01MA12

ATC

levofloxacin; systemic

13.1

68.1

143

224

D80.3

ICD-10 Finland

Selective deficiency of immunoglobulin G [IgG] subclasses

+∞

67.7

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

29.7

64.2

WW200

NOMESCO Finland

Immunization

47.5

62.0

J01MA14

ATC

moxifloxacin; systemic

18.5

61.1

100

D80.0

ICD-10 Finland

Hereditary hypogammaglobulinaemia

+∞

59.7

D83.0

ICD-10 Finland

Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

+∞

58.6

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

15.5

57.5

102

104

J18.9

ICD-10 Finland

Pneumonia, unspecified

10.0

56.3

138

266

J47

ICD-10 Finland

Bronchiectasis

108.5

55.6

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

39.6

54.1

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

43.8

53.7

D83.9

ICD-10 Finland

Common variable immunodeficiency, unspecified

+∞

51.8

GD1AA

NOMESCO Finland

Thorax X-ray examination

7.9

50.6

189

664

TPH04

NOMESCO Finland

Cathetrisation of vein

8.6

50.0

135

292

TDM10

NOMESCO Finland

Puncture of maxillary antrum

22.6

49.9

C01CA24

ATC

epinephrine; parenteral

15.3

48.6

H02AB06

ATC

prednisolone; systemic

7.3

45.4

198

803

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

13.8

43.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

8.8

42.8

106

190

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

6.6

40.9

138

382

J01.0

ICD-10 Finland

Acute maxillary sinusitis

6.7

40.4

133

355

Z01.8

ICD-10 Finland

Other specified special examinations

6.4

37.0

121

312

DMB20

NOMESCO Finland

Functional endoscopic opening of maxillary antrum

12.4

36.0

R50.9

ICD-10 Finland

Fever, unspecified

7.2

34.2

193

UDH02

NOMESCO Finland

Rhinopharyngoscopy

11.1

32.5

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

12.7

32.4

UGC12

NOMESCO Finland

Flexible bronchoscopy

13.5

32.3

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

6.2

31.8

101

242

TGC00

NOMESCO Finland

Bronchial lavation

36.1

31.4

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

17.8

29.1

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

4.8

28.3

197

1043

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

4.7

28.2

126

432

SPAT1262

SPAT

Handing over of treatment supplies

5.7

27.2

220

XG412

NOMESCO Finland

Flow-volume spirometry with bronchospasmolysis

10.8

26.7

J01FA06

ATC

roxithromycin; oral

4.3

26.6

160

715

J01MA02

ATC

ciprofloxacin; systemic

4.3

26.0

136

530

WE300

NOMESCO Finland

Profylactive therapy of malignancy with biomoidiers

275.6

25.1

A49.9

ICD-10 Finland

Bacterial infection, unspecified

8.4

25.0

J45.1

ICD-10 Finland

Nonallergic asthma

8.4

25.0

Z3231

NOMESCO Finland

Registered nurse

4.3

24.2

119

432

J01FA10

ATC

azithromycin; systemic

4.5

23.8

211

1282

J01FA15

ATC

telithromycin; oral

6.0

22.9

147

R03BB04

ATC

tiotropium bromide; inhalant

8.7

22.7

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

8.7

22.4

D83.8

ICD-10 Finland

Other common variable immunodeficiencies

+∞

22.2

WVC10

NOMESCO Finland

Subcutaneous infusion of drugs

88.0

22.1

D80.2

ICD-10 Finland

Selective deficiency of immunoglobulin A [IgA]

239.5

21.9

R01AD09

ATC

mometasone; nasal

3.7

21.8

171

897

J45.9

ICD-10 Finland

Asthma, unspecified

4.6

21.4

263

J01FF01

ATC

clindamycin; systemic

3.9

21.2

114

435

J45.0

ICD-10 Finland

Predominantly allergic asthma

6.1

21.1

127

GD1AD

NOMESCO Finland

Thorax CT examination

13.3

21.0

J01AA02

ATC

doxycycline; systemic

5.1

20.8

229

1573

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

6.6

20.8

106

R03AC02

ATC

salbutamol; inhalant

3.7

20.7

185

1055

H02AB07

ATC

prednisone; oral

5.0

20.5

192

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

8.2

20.4

A07AA02

ATC

nystatin; oral

9.1

19.5

R03AK06

ATC

salmeterol and fluticasone; inhalant

5.3

19.5

154

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

4.1

19.2

300

B29

ICPC

Lymph/immune mech sympt/complt other

75.7

19.0

ZXA10

NOMESCO Finland

Bilateral

4.3

18.9

254

XW000

NOMESCO Finland

Bone marrow biopsy

11.1

18.9

XG470

NOMESCO Finland

Measurement of diffusion capastity of the lungs

16.0

18.6

UJF30

NOMESCO Finland

Ileoscopy through colon

6.0

18.4

109

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

9.2

18.3

A41.9

ICD-10 Finland

Sepsis, unspecified

16.2

18.1

TAB00

NOMESCO Finland

Lumbar puncture

9.4

17.7

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

3.2

17.6

172

989

R03DC03

ATC

montelukast; oral

3.9

17.6

288

J01FA09

ATC

clarithromycin; systemic

3.3

17.5

125

575

Z2221

NOMESCO Finland

Medical doctor

3.4

17.4

110

461

JN4BD

NOMESCO Finland

Extensive body CT

5.3

17.3

127

H04.10

ICD-10 Finland

Dry eye syndrome

5.6

17.3

113

R59.1

ICD-10 Finland

Generalized enlarged lymph nodes

53.9

17.2

J05AB01

ATC

aciclovir; systemic

3.8

17.1

294

J46

ICD-10 Finland

Status asthmaticus

14.8

16.9

J06BA02

ATC

immunoglobulins, normal human, for intravascular adm.; systemic

+∞

16.9

M36.8*D80.1

ICD-10 Finland

Systemic disorders of connective tissue in hypogammaglobulinaemia

+∞

16.9

R03AK04

ATC

salbutamol and sodium cromoglicate; inhalant

96.4

16.8

J32.4

ICD-10 Finland

Chronic pansinusitis

15.9

16.2

R03BA02

ATC

budesonide; inhalant

3.8

16.2

261

Z3226

NOMESCO Finland

Physiotherapist

3.7

16.0

287

D84.18

ICD-10 Finland

Other specified defect in the complement system

+∞

15.8

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.5

15.8

161

WZC30

NOMESCO Finland

Teaching

4.3

15.7

184

J05AB11

ATC

valaciclovir; oral

4.3

15.7

184

DM1AD

NOMESCO Finland

CT of paranasal sinuses and face area

9.5

15.5

R01AD08

ATC

fluticasone; nasal

3.1

15.4

115

534

J02AC01

ATC

fluconazole; systemic

3.0

15.4

141

747

ZXE10

NOMESCO Finland

More than one and less than three hours

3.0

15.2

122

593

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

5.7

15.1

WX408

NOMESCO Finland

General anesthesy, balanced

3.1

14.8

105

465

XQ800

NOMESCO Finland

Prick test

5.4

14.8

R03BB01

ATC

ipratropium bromide; inhalant

13.7

14.7

D80.6

ICD-10 Finland

Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia

+∞

14.7

XF400

NOMESCO Finland

ECG with 12 standard connections

4.0

14.7

206

J22

ICD-10 Finland

Unspecified acute lower respiratory infection

7.8

14.7

R03AL02

ATC

salbutamol and ipratropium bromide; inhalant

38.5

14.6

UJF32

NOMESCO Finland

Coloscopy

3.4

14.6

314

ZX110

NOMESCO Finland

Intracutaneous

158.6

14.6

XG410

NOMESCO Finland

Flow-volume spirometry

8.1

14.6

R05

ICD-10 Finland

Cough

3.5

14.5

276

C03CA01

ATC

furosemide; systemic

3.8

14.3

217

N03AX16

ATC

pregabalin; oral

3.3

14.1

328

B28

ICPC

Limited function/disability (B)

56.6

14.0

H02AB09

ATC

hydrocortisone; systemic

9.2

14.0

J13

ICD-10 Finland

Pneumonia due to Streptococcus pneumoniae

79.5

13.7

ZXE00

NOMESCO Finland

One hour or less

2.8

13.6

133

715

L03AA02

ATC

filgrastim; parenteral

11.4

13.6

J31.0

ICD-10 Finland

Chronic rhinitis

5.5

13.6

ZXE20

NOMESCO Finland

More than three and less than five hours

4.1

13.6

167

J84.8

ICD-10 Finland

Other specified interstitial pulmonary diseases

22.7

13.5

J01DB01

ATC

cefalexin; oral

4.2

13.4

235

1829

ZX121

NOMESCO Finland

Central venous catheter

42.5

13.3

A01AB09

ATC

miconazole; local oral

5.5

13.2

N02AX02

ATC

tramadol; systemic, rectal

2.7

13.1

126

667

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

6.4

13.1

ZX108

NOMESCO Finland

Inhalation

24.0

13.1

R03BA08

ATC

ciclesonide; inhalant

4.5

13.0

124

EP1AE

NOMESCO Finland

Neck ultrasound examination

6.2

12.8

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

4.0

12.7

159

TNE25

NOMESCO Finland

Drill biopsy of bone marrow, pelvis

33.9

12.7

GD1CG

NOMESCO Finland

Extensive examination of lungs and pleura with high intensity magnet

73.6

12.7

R03DA04

ATC

theophylline; systemic, rectal

8.7

12.7

R4110

NOMESCO Finland

Physiotherapy

2.9

12.6

430

D84.9

ICD-10 Finland

Immunodeficiency, unspecified

+∞

12.6

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

2.7

12.5

114

577

R01AD05

ATC

budesonide; nasal

4.7

12.5

108

M05BA04

ATC

alendronic acid; oral

6.1

12.3

R03AC12

ATC

salmeterol; inhalant

7.7

12.2

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

2.8

12.2

468

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

14.3

12.2

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

3.9

12.1

155

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

7.5

12.0

R59.0

ICD-10 Finland

Localized enlarged lymph nodes

8.4

12.0

A02BC03

ATC

lansoprazole; oral

2.9

11.9

412

N02AA05

ATC

oxycodone; systemic

4.0

11.7

142

J45.8

ICD-10 Finland

Mixed asthma

9.0

11.6

J01DA06

ATC

[U] cefuroxime; systemic

3.4

11.5

213

Z31.5

ICD-10 Finland

Genetic counselling

5.1

11.3

GD1DG

NOMESCO Finland

Extremely extensive MRI examination of pleura with high field magnet

45.4

11.0

P01AB01

ATC

metronidazole; oral, rectal

2.5

11.0

123

689

R06AE07

ATC

cetirizine; oral

2.5

11.0

146

893

J32.9

ICD-10 Finland

Chronic sinusitis, unspecified

18.8

10.9

ZXA00

NOMESCO Finland

Right side

2.8

10.8

389

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.5

10.7

113

609

J01DA01

ATC

[U] cefalexin; systemic

2.5

10.6

180

1241

D83.1

ICD-10 Finland

Common variable immunodeficiency with predominant immunoregulatory T-cell disorders

+∞

10.5

SPAT1255

SPAT

Intravenous administration of medicine

5.5

10.5

D69.3

ICD-10 Finland

Idiopathic thrombocytopenic purpura

19.8

10.4

H02AB04

ATC

methylprednisolone; systemic

3.3

10.3

199

ZXA05

NOMESCO Finland

Left side

2.8

10.3

346

C10AC01

ATC

colestyramine; oral

13.9

10.3

R03BA05

ATC

fluticasone; inhalant

2.9

10.2

284

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

8.2

10.1

NEA10

NOMESCO Finland

Exploration of soft tissue of pelvis, percutaneous

41.8

10.1

R06.0

ICD-10 Finland

Dyspnoea

2.8

10.0

323

Z01.1

ICD-10 Finland

Examination of ears and hearing

3.5

9.9

163

A40.3

ICD-10 Finland

Sepsis due to Streptococcus pneumoniae

21.0

9.9

J84.9

ICD-10 Finland

Interstitial pulmonary disease, unspecified

14.1

9.8

ZXD10

NOMESCO Finland

Scheduled procedure

2.4

9.8

116

657

XA800

NOMESCO Finland

Neuropsychological investigation

5.2

9.7

ZXD05

NOMESCO Finland

Urgent procedure

2.5

9.7

517

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

6.0

9.7

UDQ12

NOMESCO Finland

Flexible laryngoscopy

5.7

9.5

WX882

NOMESCO Finland

High dependency care

8.6

9.5

R03BA01

ATC

beclometasone; inhalant

3.1

9.5

210

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

4.3

9.5

D59.1

ICD-10 Finland

Other autoimmune haemolytic anaemias

31.3

9.5

4730A

ICD-9 Finland

Chronic sinusitis, Maxillary

11.3

9.4

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

10.1

9.4

Z2446

NOMESCO Finland

Social worker

4.1

9.3

J10.1

ICD-10 Finland

Influenza with other respiratory manifestations, seasonal influenza virus identified

14.4

9.3

A46

ICD-10 Finland

Erysipelas

3.7

9.3

130

A03FA01

ATC

metoclopramide; systemic, rectal

2.7

9.2

322

R03AC13

ATC

formoterol; inhalant

5.2

9.2

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.0

9.2

217

XX6XT

NOMESCO Finland

Other intravascular therapy with radiological guidance

38.1

9.1

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.9

9.1

231

WW500

NOMESCO Finland

Blood transfusion

7.3

9.0

DNB20

NOMESCO Finland

Endoscopic ethmoidectomy

6.8

9.0

50301

ICD-8 Finland

Chronic sinusitis, Maxillaris NUD

25.1

9.0

A07AA09

ATC

vancomycin; oral

25.1

9.0

J01.4

ICD-10 Finland

Acute pansinusitis

25.1

9.0

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.7

8.9

299

ZX114

NOMESCO Finland

Intramuscular

10.0

8.9

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.8

8.8

249

DM1AI

NOMESCO Finland

Cone beam CT of paranasal sinus

8.7

A02BC02

ATC

pantoprazole; systemic

2.2

8.7

167

1162

M04AA01

ATC

allopurinol; systemic

3.9

8.7

103

E0000UV

ATC

2.2

8.7

121

728

JN3BD

NOMESCO Finland

Extensive abdominal CT

3.5

8.6

132

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

3.2

8.6

174

A02BC01

ATC

omeprazole; systemic

2.5

8.6

366

GCA98

NOMESCO Finland

Other bronchoscopic procedure on bronchus

28.6

8.6

PJD41

NOMESCO Finland

Excision of cervical lymph nodes

20.9

8.5

ZX112

NOMESCO Finland

Subcutaneous

8.3

8.5

R01AD12

ATC

fluticasone furoate; nasal

2.3

8.5

104

588

L30.9

ICD-10 Finland

Dermatitis, unspecified

2.8

8.5

260

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.3

8.4

105

598

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.5

8.4

129

D84.19

ICD-10 Finland

Unspecified defect in the complement system

+∞

8.4

D86.0

ICD-10 Finland

Sarcoidosis of lung

+∞

8.4

D86.2

ICD-10 Finland

Sarcoidosis of lung with sarcoidosis of lymph nodes

+∞

8.4

2790B

ICD-9 Finland

Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI A]

+∞

8.4

D81.0

ICD-10 Finland

Severe combined immunodeficiency [SCID] with reticular dysgenesis

+∞

8.4

Q79.6

ICD-10 Finland

Ehlers-Danlos syndrome

+∞

8.4

WX002

NOMESCO Finland

Sedation and analgesia

2.7

8.3

256

R01AD01

ATC

beclometasone; nasal

2.8

8.3

224

H65.2

ICD-10 Finland

Chronic serous otitis media

15.1

8.3

A41.8

ICD-10 Finland

Other specified sepsis

15.1

8.3

B03BA03

ATC

hydroxocobalamin; parenteral

7.2

8.2

K52.9

ICD-10 Finland

Noninfective gastroenteritis and colitis, unspecified

5.9

8.2

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

10.5

8.1

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

3.7

8.1

104

R03AC03

ATC

terbutaline; inhalant

2.8

8.1

220

JN3DE

NOMESCO Finland

Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation

34.5

8.1

R03AK11

ATC

formoterol and fluticasone; inhalant

7.7

8.1

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.7

8.1

105

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

5.8

8.0

R03AK07

ATC

formoterol and budesonide; inhalant

2.5

8.0

331

R01BA52

ATC

pseudoephedrine, combinations; oral

2.2

8.0

552

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.8

8.0

100

N02BE01

ATC

paracetamol; systemic, rectal

2.7

8.0

223

1816

D06AX01

ATC

fusidic acid; topical (antibiotics for topical use)

3.4

7.9

130

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.2

7.9

152

H66.0

ICD-10 Finland

Acute suppurative otitis media

3.5

7.8

119

R1250

NOMESCO Finland

Evaluation of functional capability

7.8

C83.31

ICD-10 Finland

Diffuse lymphoma with large B cells

15.6

7.8

R01AD58

ATC

fluticasone, combinations; inhalant, nasal

2.4

7.8

390

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.4

7.7

347

D72.8

ICD-10 Finland

Other specified disorders of white blood cells

19.1

7.7

E27.3

ICD-10 Finland

Drug-induced adrenocortical insufficiency

19.1

7.7

UDM02

NOMESCO Finland

Sinoscopy

9.3

7.7

212

Kela drug reimbursment

Gout

25.9

7.6

J96.0

ICD-10 Finland

Acute respiratory failure

25.9

7.6

WD135

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

25.9

7.6

J01DA08

ATC

[U] cefaclor; oral

2.9

7.6

182

K51.9

ICD-10 Finland

Ulcerative colitis, unspecified

7.5

7.6

A06AD11

ATC

lactulose; oral

3.4

7.6

122

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

3.2

7.6

134

ZXD31

NOMESCO Finland

Major difficulties in performing procedure

5.9

7.5

ZYC01

NOMESCO Finland

Remote contact by phone

5.2

7.5

K90.9

ICD-10 Finland

Intestinal malabsorption, unspecified

82.4

7.5

JN4AD

NOMESCO Finland

Body CT examination

4.1

7.5

TPX10

NOMESCO Finland

Implantation of vascular injection port

6.6

7.4

2790C

ICD-9 Finland

Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI ALIA]

+∞

7.3

27510

ICD-8 Finland

Plasma protein abnormalities, Hypogammaglobulinaemia

+∞

7.3

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.8

7.3

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.6

7.3

J01CA04

ATC

amoxicillin; systemic

2.6

7.3

224

1857

RD210

NOMESCO Finland

8.3

7.2

5BA08

NOMESCO Finland

31.0

7.2

C91.1

ICD-10 Finland

Chronic lymphocytic leukaemia of B-cell type

20.7

7.2

J15.8

ICD-10 Finland

Other bacterial pneumonia

20.7

7.2

D07AB08

ATC

desonide; topical

3.0

7.2

151

K29.3

ICD-10 Finland

Chronic superficial gastritis

9.2

7.1

D07AB02

ATC

hydrocortisone butyrate; topical

2.2

7.1

461

R03AK03

ATC

[D] fenoterol & other drugs for obstructive airway dis; inhalant

6.7

7.1

ZXE30

NOMESCO Finland

More than five and less than seven hours

5.1

7.0

R06AE09

ATC

levocetirizine; oral

2.6

7.0

245

WX892

NOMESCO Finland

Monitored bed care

3.6

7.0

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

3.9

7.0

A28

ICPC

Limited function/disability NOS

3.4

6.9

107

PJ2AE

NOMESCO Finland

Lymphnode ultrasound examination

11.4

6.9

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

9.7

6.9

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

9.7

6.9

WD115

NOMESCO Finland

Multiple cystostatic therapy of methastized malignancy

9.7

6.9

L04AA06

ATC

mycophenolic acid; systemic

9.7

6.9

A04AA01

ATC

ondansetron; systemic, rectal

3.9

6.8

R81

ICPC

Pneumonia

7.5

6.8

N06AX21

ATC

duloxetine; oral

2.9

6.8

162

N03AX11

ATC

topiramate; oral

5.8

6.7

J05AH02

ATC

oseltamivir; oral

23.2

6.7

B99

ICPC

Blood/lymph/spleen disease other

23.2

6.7

A87.9

ICD-10 Finland

Viral meningitis, unspecified

23.2

6.7

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

8.2

6.7

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

2.2

6.7

441

1XC02

NOMESCO Finland

12.7

6.6

N05BA01

ATC

diazepam; systemic, rectal

2.7

6.6

186

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

6.5

6.6

Z50.1

ICD-10 Finland

Other physical therapy

4.7

6.5

XF404

NOMESCO Finland

Ambulatory ECG

3.6

6.5

Z71.8

ICD-10 Finland

Other specified counselling

2.2

6.5

389

ZY010

NOMESCO Finland

Hospital outpatient

3.7

6.5

J32.8

ICD-10 Finland

Other chronic sinusitis

71.5

6.5

C82.9

ICD-10 Finland

Follicular lymphoma, unspecified

71.5

6.5

D73.1

ICD-10 Finland

Hypersplenism

71.5

6.5

R51.80

ICD-10 Finland

Headache

2.6

6.4

214

127

Kela drug reimbursment

Transplant complication

8.5

6.4

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

7.3

6.3

ZX109

NOMESCO Finland

Instruction on medicine inhalation technique

18.6

6.3

Z94.8

ICD-10 Finland

Other transplanted organ and tissue status

18.6

6.3

G40.9

ICD-10 Finland

Epilepsy, unspecified

5.6

6.3

D84.1

ICD-10 Finland

Defects in the complement system

+∞

6.3

C81.9

ICD-10 Finland

Hodgkin lymphoma, unspecified

+∞

6.3

C91.0

ICD-10 Finland

Acute lymphoblastic leukaemia [ALL]

+∞

6.3

D81.1

ICD-10 Finland

Severe combined immunodeficiency [SCID] with low T- and B-cell numbers

+∞

6.3

3XA02

NOMESCO Finland

+∞

6.3

D89.89

ICD-10 Finland

Other specified disorders involving the immune mechanism, not elsewhere classified

+∞

6.3

C83.9

ICD-10 Finland

Non-follicular (diffuse) lymphoma, unspecified

27.4

6.3

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

3.2

6.3

110

A07EA06

ATC

budesonide; oral, local oral

4.9

6.2

ZXD20

NOMESCO Finland

Day surgery

2.6

6.2

199

N03AX12

ATC

gabapentin; oral

2.6

6.2

199

R03AK08

ATC

formoterol and beclometasone; inhalant

4.6

6.2

J01DC02

ATC

cefuroxime; systemic

3.6

6.2

L04AX01

ATC

azathioprine; systemic

4.4

6.2

D70.89

ICD-10 Finland

Neutropenic splenomegaly

12.9

6.1

PJA10

NOMESCO Finland

Exploration of lymph nodes

12.9

6.1

TQW99

NOMESCO Finland

Other minor procedure on skin

5.4

6.1

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.0

6.1

129

A02BC05

ATC

esomeprazole; systemic

2.0

6.1

109

701

SAA04

NOMESCO Finland

Special inverstigation of mouth

3.8

6.1

N03AX09

ATC

lamotrigine; oral

4.1

6.1

NAME	D3_KELA_IMMUDEF
CONTROL_EXCLUDE	D3_IMMUNEMECHANISM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	120
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
D3_KELA_IMMUDEF	5.013 [3.21, 7.83]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.595

N-year risk	Females	Males
1	0.44%	No data
5	3.202%	No data
10	7.618%	No data
15	14.22%	No data
20	23.763%	No data

Kela reimbursement Agammaglobulinemia (D80-84)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints