anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
372 |
4. Check minimum number of eventsNone |
372 |
5. Include endpointsNone |
372 |
6. Filter based on genotype QC (FinnGen only) |
372 |
Control definitions (FinnGen only)
- Control exclude
- D3_NUTRIANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D50-D53
- Name in latin
- Aliae anaemiae nutritionales
Similar endpoints
↥List of similar endpoints to
Other nutritional anaemias
based on the number of shared cases.
Similar with more cases:
- Nutritional anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6137 | 3333 | 2692 |
| Only index persons | 3304 | 1855 | 1449 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 68.88 | 69.46 | 68.16 |
| Only index persons | 62.81 | 61.05 | 65.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 372 | 175 | 197 |
| Unadjusted period prevalence (%) | 0.07 | 0.06 | 0.09 |
| Median age at first event (years) | 63.46 | 58.15 | 68.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 343
- Matched controls
- 3440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
2738.5
252.2
213
*
D64.9
ICD-10 Finland
Anaemia, unspecified
11.1
63.3
134
186
D53.9
ICD-10 Finland
Nutritional anaemia, unspecified
+∞
60.2
56
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
56.9
53
*
B03BA03
ATC
hydroxocobalamin; parenteral
16.2
51.3
86
69
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
33.9
43.8
57
20
28199
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other and unspecified deficiency anaemia
+∞
30.7
29
*
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
+∞
29.6
28
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
26.9
149
574
B81
ICPC
Anaemia vit B12/folate deficiency
12.5
25.3
46
42
K29.4
ICD-10 Finland
Chronic atrophic gastritis
18.1
23.3
36
22
XW000
NOMESCO Finland
Bone marrow biopsy
10.6
22.9
45
48
2819X
ICD-9 Finland
Other deficiency anaemias, Unspecified deficiency anaemia
+∞
16.8
16
*
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
44.5
14.2
17
*
C03CA01
ATC
furosemide; systemic
2.4
13.1
164
951
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
21.0
12.6
18
9
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.4
11.8
35
70
WW500
NOMESCO Finland
Blood transfusion
6.2
11.6
31
54
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
20.9
11.2
16
8
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
9.8
59
221
M04AA01
ATC
allopurinol; systemic
2.7
9.8
72
306
R53
ICD-10 Finland
Malaise and fatigue
2.3
8.9
92
464
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
8.5
41
131
28198
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Alia definita
+∞
8.4
8
*
D53.8
ICD-10 Finland
Other specified nutritional anaemias
+∞
8.4
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
8.3
124
740
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.8
7.9
16
19
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
7.7
120
720
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
7.7
81
414
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
7.6
67
313
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
7.4
53
222
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.7
7.3
14
15
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.9
7.2
19
34
J01MA12
ATC
levofloxacin; systemic
2.3
7.1
73
367
R55
ICD-10 Finland
Syncope and collapse
2.6
6.9
51
217
N06AB04
ATC
citalopram; systemic
2.2
6.9
77
401
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
40.9
6.8
8
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.8
6.5
26
72
B03XA01
ATC
erythropoietin; parenteral
14.7
6.4
10
7
N19
ICD-10 Finland
Unspecified kidney failure
4.0
6.3
24
64
28110
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other vitamin B12 deficiency
+∞
6.3
6
*
UJF32
NOMESCO Finland
Coloscopy
2.0
6.2
92
535
E87.6
ICD-10 Finland
Hypokalaemia
4.6
6.1
20
46
Mortality – FinRegistry
↥Association
Association between endpoint D3_NUTRIANAEMIAOTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NUTRIANAEMIAOTHER | 2.436 [2.09, 2.84] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 1787 females with D3_NUTRIANAEMIAOTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NUTRIANAEMIAOTHER | 2.566 [2.12, 3.1] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 1608 males with D3_NUTRIANAEMIAOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_NUTRIANAEMIAOTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.188% | 0.502% |
| 5 | 1.359% | 3.048% |
| 10 | 3.342% | 7.784% |
| 15 | 6.272% | 14.518% |
| 20 | 10.55% | 24.067% |
Relationships between endpoints
↥Index endpoint: D3_NUTRIANAEMIAOTHER – Other nutritional anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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