No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
137 |
4. Check minimum number of eventsNone |
137 |
5. Include endpointsNone |
137 |
6. Filter based on genotype QC (FinnGen only) |
137 |
Control definitions (FinnGen only)
- Control exclude
- D3_APLASTICANDOTHANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D64
- Name in latin
- Aliae anaemia sideroblasticae
Similar endpoints
↥List of similar endpoints to
Other sideroblastic anaemias
based on the number of shared cases.
Similar with more cases:
- Other anaemias
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1579 | 915 | 635 |
| Only index persons | 1006 | 616 | 390 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 71.02 | 71.37 | 70.40 |
| Only index persons | 65.44 | 64.99 | 66.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 137 | 67 | 70 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 66.35 | 63.51 | 69.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 126
- Matched controls
- 1258
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D64.3
ICD-10 Finland
Other sideroblastic anaemias
+∞
147.5
111
*
D64.9
ICD-10 Finland
Anaemia, unspecified
70.1
55.4
62
17
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
13.0
19.2
35
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.0
15.7
68
239
B82
ICPC
Anaemia other/unspecified
27.6
15.7
21
9
28500
ICD-8 Finland
Other and unspecified anaemias, Hypochromic anaemia with iron loading
+∞
11.6
11
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
19.4
11.6
17
10
ZX120
NOMESCO Finland
Intravenous
7.0
11.1
28
49
UJF92
NOMESCO Finland
Capsular endoscopy
26.0
10.5
14
6
WW500
NOMESCO Finland
Blood transfusion
11.0
10.2
19
20
XW000
NOMESCO Finland
Bone marrow biopsy
14.0
9.1
15
12
D50.8
ICD-10 Finland
Other iron deficiency anaemias
53.8
8.8
10
*
UJF32
NOMESCO Finland
Coloscopy
3.3
8.1
49
202
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.6
7.9
20
35
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.9
6.9
10
6
A02BC02
ATC
pantoprazole; systemic
2.8
6.7
92
613
D64.0
ICD-10 Finland
Hereditary sideroblastic anaemia
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint D3_SIDEROANAMIEAOTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SIDEROANAMIEAOTHER | 2.545 [1.95, 3.32] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 565 females with D3_SIDEROANAMIEAOTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SIDEROANAMIEAOTHER | 2.558 [1.77, 3.69] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 213 out of 380 males with D3_SIDEROANAMIEAOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_SIDEROANAMIEAOTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.607% |
| 5 | 1.237% | 3.073% |
| 10 | 2.959% | 8.425% |
| 15 | 5.515% | 15.674% |
| 20 | 9.1% | 26.053% |
Relationships between endpoints
↥Index endpoint: D3_SIDEROANAMIEAOTHER – Other sideroblastic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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