≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Personality and behavioural disorders due to brain disease, damage and dysfunction

EFO MESH Endpoint Browser PheWeb

F5_PERSBEHORG

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F07
  • Hospital discharge: ICD-9 — 310
  • Hospital discharge: ICD-8 — 293
  • Cause of death: ICD-10 — F07
  • Cause of death: ICD-9 — 310
  • Cause of death: ICD-8 — 293

2 out of 7 registries used, show all original rules.

556

4. Check minimum number of events

None

556

5. Include endpoints

None

556

6. Filter based on genotype QC (FinnGen only)

556

Control definitions (FinnGen only)

Control exclude
F5_ORGANIC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F04-F09
Name in latin
Perturbationes personae et modi se gerendi a morbo, laesione sive dysfunctione cerebri inductae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7855 2589 5124
Only index persons 5216 1732 3484
Unadjusted period prevalence (%)
Whole population 0.12 0.07 0.14
Only index persons 0.11 0.06 0.13
Median age at first event (years)
Whole population 53.93 56.68 52.32
Only index persons 49.75 51.79 48.73

-FinnGen-

Key figures

All Female Male
Number of individuals 556 196 360
Unadjusted period prevalence (%) 0.13 0.07 0.16
Median age at first event (years) 50.47 46.88 52.43

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
511
Matched controls
5104
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F07.9
ICD-10 Finland
Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction
+∞
170.6
154
*
F07.2
ICD-10 Finland
Postconcussional syndrome
+∞
145.9
133
*
F07.8
ICD-10 Finland
Other organic personality and behavioural disorders due to brain disease, damage and dysfunction
+∞
108.2
100
*
N05AX08
ATC
risperidone; systemic
17.7
93.5
154
121
N03AG01
ATC
valproic acid; systemic, rectal
16.4
85.0
144
119
T90.5
ICD-10 Finland
Sequelae of intracranial injury
77.3
85.0
95
15
F07.0
ICD-10 Finland
Organic personality disorder
+∞
74.8
70
*
N05AH04
ATC
quetiapine; oral
7.3
65.0
181
358
N05AH03
ATC
olanzapine; systemic
13.6
61.8
112
103
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
9.8
60.2
131
173
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
11.7
57.8
113
121
G40.9
ICD-10 Finland
Epilepsy, unspecified
16.7
53.0
87
62
N06AB04
ATC
citalopram; systemic
5.1
51.8
204
592
S06.2
ICD-10 Finland
Diffuse brain injury
45.8
50.1
61
15
F03
ICD-10 Finland
Unspecified dementia
49.1
47.4
57
13
N05AA02
ATC
levomepromazine; systemic
13.5
45.8
82
71
F32.9
ICD-10 Finland
Depressive episode, unspecified
6.3
45.4
134
271
N05BA01
ATC
diazepam; systemic, rectal
5.4
41.6
141
334
N05AD01
ATC
haloperidol; systemic
14.8
41.5
71
55
S06.3
ICD-10 Finland
Focal brain injury
28.0
38.9
53
21
F05.9
ICD-10 Finland
Delirium, unspecified
+∞
36.9
35
*
N05CD07
ATC
temazepam; oral
5.1
36.5
129
316
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
+∞
35.8
34
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
12.0
35.3
66
62
N03AF01
ATC
carbamazepine; oral, rectal
8.3
34.4
80
112
AA1AD
NOMESCO Finland
CT of head and brain
3.7
33.3
184
677
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
32.6
31
*
N03AF02
ATC
oxcarbazepine; oral
11.4
32.4
62
61
N05BA04
ATC
oxazepam; oral
3.6
31.9
179
665
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
16.6
31.1
50
33
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
15.1
31.0
52
38
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.4
29.6
83
151
N05BA06
ATC
lorazepam; systemic, sublingual
7.6
29.5
72
108
T36
ICD-10 Finland
Poisoning by systemic antibiotics
9.0
29.3
64
80
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
6.8
29.2
77
129
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
16.0
28.8
47
32
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
6.2
28.8
82
152
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
6.0
28.8
84
161
N06AX11
ATC
mirtazapine; oral
3.2
28.7
203
882
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
5.6
27.6
86
178
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
29.6
27.0
36
13
XA800
NOMESCO Finland
Neuropsychological investigation
7.4
26.5
65
98
N03AB02
ATC
phenytoin; systemic
39.0
26.5
33
9
N03AX09
ATC
lamotrigine; oral
8.5
25.5
57
74
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.2
24.9
70
127
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
24.7
131
452
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
10.1
24.3
49
53
N06DA03
ATC
rivastigmine; oral, transdermal
91.1
23.9
26
*
N03AX14
ATC
levetiracetam; systemic
10.4
23.8
47
49
F60.9
ICD-10 Finland
Personality disorder, unspecified
29.8
23.4
31
11
N06DX01
ATC
memantine; oral
56.8
23.3
27
5
F05.8
ICD-10 Finland
Other delirium
+∞
23.1
22
*
F07.1
ICD-10 Finland
Postencephalitic syndrome
+∞
23.1
22
*
N05CF01
ATC
zopiclone; oral
2.7
22.5
206
1017
A28
ICPC
Limited function/disability NOS
3.6
22.3
112
367
N06DA02
ATC
donepezil; oral
40.6
21.9
27
7
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
21.8
191
916
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
27.8
21.6
29
11
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
7.6
21.5
51
73
R41.0
ICD-10 Finland
Disorientation, unspecified
10.8
21.2
41
41
183
Kela drug reimbursment
Lamotrigin and topiramate
25.5
21.1
29
12
N06AB03
ATC
fluoxetine; oral
3.8
20.7
97
299
S06.0
ICD-10 Finland
Concussion
4.1
20.6
87
245
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
13.9
20.0
34
26
N06AX16
ATC
venlafaxine; oral
3.6
19.9
98
314
G30.1
ICD-10 Finland
Alzheimer disease with late onset
22.7
19.7
28
13
N05BE01
ATC
buspirone; oral
9.5
19.5
40
45
F06.7
ICD-10 Finland
Mild cognitive disorder
27.2
19.3
26
10
N05BA09
ATC
clobazam; oral
35.8
19.0
24
7
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.3
19.0
75
198
N03AX18
ATC
lacosamide; systemic
72.6
18.8
21
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.5
18.7
69
170
N06AB10
ATC
escitalopram; oral
3.0
18.7
123
487
Z2445
NOMESCO Finland
Psychologist
6.2
18.5
51
90
3101A
ICD-9 Finland
Specific nonpsychotic mental disorders following organic brain damage, Organic personality syndrome
+∞
17.8
17
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
185.9
17.6
18
*
N03AE01
ATC
clonazepam; systemic
5.3
17.3
54
111
F10.20
ICD-10 Finland
Alcohol dependence currently independent
9.5
17.2
35
39
N06AB06
ATC
sertraline; oral
3.7
16.8
79
242
R53
ICD-10 Finland
Malaise and fatigue
2.7
16.6
127
549
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
16.6
164
816
V49.9
ICD-10 Finland
Car occupant [any] injured in unspecified traffic accident
6.4
16.3
43
72
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.6
16.1
78
245
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.4
16.1
49
98
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
21.8
16.1
23
11
N05AF03
ATC
chlorprothixene; systemic
7.8
15.7
36
49
F06.8
ICD-10 Finland
Other specified mental disorders due to brain damage and dysfunction and to physical disease
+∞
15.7
15
*
W19
ICD-10 Finland
Unspecified fall
3.5
15.5
76
241
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
15.5
68
197
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
7.3
15.4
37
54
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.2
15.4
60
156
N05AX12
ATC
aripiprazole; systemic
6.7
15.3
39
62
N05AD03
ATC
melperone; systemic
13.6
15.3
26
20
N07BB01
ATC
disulfiram; oral
5.4
15.3
46
91
N04AA02
ATC
biperiden; systemic
10.5
15.1
29
29
X59
ICD-10 Finland
Exposure to unspecified factor
2.6
15.0
123
551
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
4.3
14.9
57
145
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
10.2
14.9
29
30
85190
ICD-8 Finland
Cerebral laceration and contusion, Late effect
58.4
14.9
17
*
29350
ICD-8 Finland
Psychosis associated with other cerebral condition, Brain trauma
+∞
14.6
14
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
9.8
14.6
29
31
L28
ICPC
Limited function/disability (L)
2.9
14.6
97
381
Z2446
NOMESCO Finland
Social worker
4.1
14.6
59
159
G40
ICD-10 Finland
Epilepsy
17.6
14.4
22
13
A06AD11
ATC
lactulose; oral
2.7
14.4
108
457
N05BA02
ATC
chlordiazepoxide; systemic
7.4
14.0
33
47
F06.2
ICD-10 Finland
Organic delusional [schizophrenia-like] disorder
+∞
13.6
13
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
6.2
13.4
36
62
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.5
13.3
39
75
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
13.3
60
178
N05AN01
ATC
lithium; oral
9.1
13.1
27
31
F10.25
ICD-10 Finland
Alcohol dependence continuous use
9.1
13.1
27
31
N05AB03
ATC
perphenazine; systemic, rectal
5.5
13.0
38
73
N03AX16
ATC
pregabalin; oral
2.4
13.0
131
649
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
51.3
12.9
15
*
N06AX21
ATC
duloxetine; oral
3.3
12.9
67
222
N06AX03
ATC
mianserin; oral
4.8
12.9
43
96
S01.0
ICD-10 Finland
Open wound of scalp
3.4
12.6
62
197
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
17.9
12.6
19
11
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
25.0
12.5
17
7
F06.32
ICD-10 Finland
Organic depression
132.9
12.5
13
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
8.3
12.5
27
34
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
12.4
103
461
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.3
12.3
64
212
85100
ICD-8 Finland
Cerebral laceration and contusion, Without mention of open intracranial wound
38.5
12.3
15
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
27.4
12.1
16
6
N05AC02
ATC
thioridazine; oral
9.6
12.1
24
26
P20
ICPC
Memory disturbance
3.4
12.1
61
198
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
12.0
100
446
N05AF05
ATC
zuclopenthixol; systemic
15.1
11.9
19
13
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
66.4
11.6
13
*
S06.9
ICD-10 Finland
Intracranial injury, unspecified
23.5
11.6
16
7
F06.39
ICD-10 Finland
Organic mood syndrome UNS
+∞
11.5
11
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
11.4
79
315
F10.09
ICD-10 Finland
Alcohol intoxication UNS
7.9
11.3
25
33
R40.2
ICD-10 Finland
Coma, unspecified
13.1
11.2
19
15
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
8.3
11.2
24
30
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
11.5
11.1
20
18
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
11.5
11.1
20
18
F22.0
ICD-10 Finland
Delusional disorder
9.5
11.1
22
24
T74.1
ICD-10 Finland
Physical abuse
9.1
10.9
22
25
N06AX05
ATC
trazodone; oral
7.0
10.8
26
39
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
18.3
10.8
16
9
N05CD02
ATC
nitrazepam; oral
7.8
10.8
24
32
34599
ICD-8 Finland
Epilepsy, Other and unspecified
28.7
10.8
14
5
ZXD35
NOMESCO Finland
Usual procedure
5.7
10.7
30
55
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
22.0
10.7
15
7
N05AB01
ATC
dixyrazine; systemic
9.5
10.6
21
23
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
14.6
10.5
17
12
29399
ICD-8 Finland
Psychosis associated with other cerebral condition, Other and unspecified cerebral condition
+∞
10.4
10
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
10.4
58
200
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
10.9
10.3
19
18
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
10.1
70
280
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
6.9
10.0
24
36
M03BX01
ATC
baclofen; systemic
12.5
9.9
17
14
N03AX11
ATC
topiramate; oral
7.2
9.9
23
33
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
26.6
9.8
13
5
N06AB08
ATC
fluvoxamine; oral
6.6
9.7
24
38
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
11.7
9.6
17
15
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
11.7
9.6
17
15
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
9.6
52
178
IGY02
NOMESCO Finland
Psychiatric monitoring contact
7.4
9.6
22
31
F39
ICD-10 Finland
Unspecified mood [affective] disorder
9.3
9.6
19
21
F06.0
ICD-10 Finland
Organic hallucinosis
+∞
9.4
9
*
9070A
ICD-9 Finland
Late effects of injuries to the nervous system, Late effect of intracranial injury without mention of skull fracture
+∞
9.4
9
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
22.1
9.4
13
6
F10.24
ICD-10 Finland
Alcohol depence active use
8.9
9.4
19
22
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
9.8
9.3
18
19
N06AG02
ATC
moclobemide; oral
4.2
9.2
34
85
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
9.3
9.1
18
20
N03AX12
ATC
gabapentin; oral
2.4
9.0
82
380
P99
ICPC
Psychological disorders other
5.7
9.0
25
46
S06.4
ICD-10 Finland
Epidural haemorrhage
24.5
8.9
12
5
N06AA06
ATC
trimipramine; systemic
5.8
8.8
24
43
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
9.7
8.8
17
18
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.2
8.8
32
79
N88
ICPC
Epilepsy
14.3
8.7
14
10
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.6
8.7
67
283
G31.0
ICD-10 Finland
Circumscribed brain atrophy
50.8
8.7
10
*
N05AH02
ATC
clozapine; systemic
6.0
8.7
23
40
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
11.8
8.6
15
13
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
28.0
8.5
11
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
20.4
8.5
12
6
S72.0
ICD-10 Finland
Fracture of neck of femur
4.5
8.4
29
68
G30.0
ICD-10 Finland
Alzheimer disease with early onset
91.4
8.4
9
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
91.4
8.4
9
*
N06DA04
ATC
galantamine; oral
91.4
8.4
9
*
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
91.4
8.4
9
*
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
13.0
8.4
14
11
N06AA09
ATC
amitriptyline; systemic
2.7
8.4
59
238
N06BA04
ATC
methylphenidate; oral
8.7
8.4
17
20
F05.0
ICD-10 Finland
Delirium not superimposed on dementia, so described
+∞
8.3
8
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
8.3
8
*
29320
ICD-8 Finland
Psychosis associated with other cerebral condition, Epilepsy
+∞
8.3
8
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
6.7
8.2
20
31
ZY010
NOMESCO Finland
Hospital outpatient
3.7
8.2
35
100
F20.9
ICD-10 Finland
Schizophrenia, unspecified
5.5
8.2
23
43
P29
ICPC
Psychological sympt/compl other
3.6
8.1
35
101
R42
ICD-10 Finland
Dizziness and giddiness
2.0
8.1
114
639
E8190
ICD-8 Finland
Motor vehicle traffic accident of unspecified nature, Driver of motor vehicle other than motorcycle
11.9
8.1
14
12
3459X
ICD-9 Finland
Epilepsy, unspecified
33.9
8.1
10
*
N06AA12
ATC
doxepin; systemic
3.6
8.1
35
102
Y09
ICD-10 Finland
Assault by unspecified means
22.4
8.0
11
5
S02.10
ICD-10 Finland
Fracture of base of skull, closed
22.4
8.0
11
5
F61.0
ICD-10 Finland
Mixed personality disorders
7.4
8.0
18
25
ZXD05
NOMESCO Finland
Urgent procedure
1.8
8.0
167
1077
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
7.9
7.9
17
22
Z3226
NOMESCO Finland
Physiotherapist
2.0
7.9
102
554
TAB00
NOMESCO Finland
Lumbar puncture
3.9
7.9
31
83
R51.80
ICD-10 Finland
Headache
2.3
7.9
75
355
WX892
NOMESCO Finland
Monitored bed care
2.9
7.9
47
173
F32.1
ICD-10 Finland
Moderate depressive episode
3.6
7.8
34
99
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
11.0
7.8
14
13
N05AA01
ATC
chlorpromazine; systemic, rectal
6.5
7.8
19
30
N03AX15
ATC
zonisamide; oral
45.6
7.7
9
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
7.7
37
814
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
7.6
87
449
EBA00
NOMESCO Finland
Extraction of tooth
1.8
7.6
160
1034
30180
ICD-8 Finland
Personality disorders, Immatura
18.7
7.6
11
6
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.4
7.6
35
107
N05AC01
ATC
periciazine; systemic
25.4
7.6
10
*
F60.2
ICD-10 Finland
Dissocial personality disorder
25.4
7.6
10
*
A86
ICD-10 Finland
Unspecified viral encephalitis
25.4
7.6
10
*
N06AB05
ATC
paroxetine; oral
3.3
7.6
36
113
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.2
7.6
39
130
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
7.4
48
186
ZY000
NOMESCO Finland
Hospital inpatient
9.5
7.3
14
15
F06.6
ICD-10 Finland
Organic emotionally labile [asthenic] disorder
+∞
7.3
7
*
3453A
ICD-9 Finland
Epilepsy, Grand mal status
+∞
7.3
7
*
K08.3
ICD-10 Finland
Retained dental root
2.9
7.3
43
157
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
7.3
86
448
F41.8
ICD-10 Finland
Other specified anxiety disorders
5.9
7.3
19
33
G40.89
ICD-10 Finland
Other epilepsy
16.0
7.2
11
7
N28
ICPC
Limited function/disability (N)
7.5
7.2
16
22
X58
ICD-10 Finland
Exposure to other specified factors
2.1
7.2
80
408
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.0
7.2
27
70
34510
ICD-8 Finland
Epilepsy, """"Grand mal""""
30.4
7.2
9
*
F99
ICD-10 Finland
Mental disorder, not otherwise specified
6.7
7.2
17
26
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
8.1
7.1
15
19
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
12.2
7.1
12
10
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
12.2
7.1
12
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
7.1
63
289
R47.0
ICD-10 Finland
Dysphasia and aphasia
8.9
7.1
14
16
B18.2
ICD-10 Finland
Chronic viral hepatitis C
8.9
7.1
14
16
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
10.2
7.1
13
13
R11
ICD-10 Finland
Nausea and vomiting
2.7
7.0
48
190
W10
ICD-10 Finland
Fall on and from stairs and steps
3.3
7.0
34
109
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.7
7.0
22
48
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
6.9
39
136
30000
ICD-8 Finland
Neuroses, Anxiety neurosis
14.0
6.9
11
8
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
14.0
6.9
11
8
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.0
6.9
39
138
WX730
NOMESCO Finland
Conventional respirator
5.4
6.8
19
36
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
9.5
6.8
13
14
S01.3
ICD-10 Finland
Open wound of ear
9.5
6.8
13
14
SPAT1229
SPAT
Assessment of need for aid
2.7
6.8
45
177
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
4.8
6.8
21
45
R45.1
ICD-10 Finland
Restlessness and agitation
40.5
6.8
8
*
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
40.5
6.8
8
*
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
40.5
6.8
8
*
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
40.5
6.8
8
*
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
40.5
6.8
8
*
N03AG04
ATC
vigabatrin; oral
40.5
6.8
8
*
AAK00
NOMESCO Finland
Cranioplasty
40.5
6.8
8
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.4
6.7
31
96
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
5.3
6.7
19
37
N05AL01
ATC
sulpiride; systemic
8.0
6.6
14
18
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
6.6
50
212
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
6.6
94
526
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.0
6.5
15
22
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
7.0
6.5
15
22
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
4.6
6.5
21
47
Y96.9
ICD-10 Finland
Unspecified type of accident
6.3
6.5
16
26
S60.2
ICD-10 Finland
Contusion of other parts of wrist and hand
3.4
6.5
30
93
A04
ICPC
Weakness/tiredness general
2.2
6.5
64
309
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
7.5
6.4
14
19
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
70.6
6.4
7
*
34598
ICD-8 Finland
Epilepsy, Alia definita
70.6
6.4
7
*
V03AA02
ATC
NA
70.6
6.4
7
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
6.4
51
222
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.0
6.4
36
127
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
6.4
65
318
R1260
NOMESCO Finland
Evaluation of communicative skills
6.1
6.3
16
27
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
6.1
6.3
16
27
R4120
NOMESCO Finland
Occupational therapy
2.8
6.3
40
151
T51.0
ICD-10 Finland
Toxic effect: Ethanol
18.3
6.3
9
5
29398
ICD-8 Finland
Psychosis associated with other cerebral condition, Alia definita
+∞
6.3
6
*
8510A
ICD-9 Finland
Cerebral laceration and contusion, Cortex (cerebral) contusion without mention of open intracranial wound[CONTUSIO CEREBRI NON COMP,EI TIETOA TAJUTTOMUUDESTA]
+∞
6.3
6
*
30188
ICD-8 Finland
Personality disorders, Alia definita
+∞
6.3
6
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
+∞
6.3
6
*
29330
ICD-8 Finland
Psychosis associated with other cerebral condition, Intercranial neoplasm
+∞
6.3
6
*
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
+∞
6.3
6
*
F06.33
ICD-10 Finland
Organic mood syndrome
+∞
6.3
6
*
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
7.2
6.2
14
20
V01.9
ICD-10 Finland
Pedestrian injured in collision with pedal cycle, Unspecified whether traffic or nontraffic accident
27.0
6.2
8
*
S06.8
ICD-10 Finland
Other intracranial injuries
27.0
6.2
8
*
W17
ICD-10 Finland
Other fall from one level to another
3.1
6.2
32
108
N30.0
ICD-10 Finland
Acute cystitis
2.2
6.2
60
288
S82.6
ICD-10 Finland
Fracture of lateral malleolus
3.0
6.2
33
114
OAB43
SPAT
NA
0.3
6.2
14
427
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
6.1
83
458
Y94.0
ICD-10 Finland
Accident at home
6.8
6.1
14
21

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERSBEHORG and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERSBEHORG 3.369 [2.8, 4.05] < 0.001
Birth year 0.998 [0.99, 1.01] 0.593

During the follow-up period (1.1.1998 — 31.12.2019), 534 out of 1449 females with F5_PERSBEHORG died.

Males

Parameter HR [95% CI] p-value
F5_PERSBEHORG 4.112 [3.58, 4.73] < 0.001
Birth year 0.984 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1321 out of 3047 males with F5_PERSBEHORG died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERSBEHORG.

N-year risk Females Males
1 0.306% 0.696%
5 2.45% 4.059%
10 5.875% 10.45%
15 10.264% 18.921%
20 17.597% 30.434%

Relationships between endpoints

↥

Index endpoint: F5_PERSBEHORG – Personality and behavioural disorders due to brain disease, damage and dysfunction

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data