Risteys · I9_OTHINTRACRA

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I62 Cause of death: ICD-10 — I62 2 out of 7 registries used, show all original rules.	1124
4. Check minimum number of events None	1124
5. Include endpoints None	1124
6. Filter based on genotype QC (FinnGen only)	1124

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	10757	4015	6617
Only index persons	8357	3132	5225
Unadjusted period prevalence (%)
Whole population	0.16	0.12	0.18
Only index persons	0.17	0.12	0.20
Median age at first event (years)
Whole population	74.17	76.06	73.01
Only index persons	73.90	75.44	72.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1124	356	768
Unadjusted period prevalence (%)	0.27	0.12	0.34
Median age at first event (years)	72.47	69.31	73.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1013: Matched controls
10130

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

64.4

323.0

512

158

AAD10

NOMESCO Finland

Evacuation of chronic subdural haematoma

121.7

323.0

422

I62.0

ICD-10 Finland

Nontraumatic subdural haemorrhage

16384.0

323.0

770

I62.9

ICD-10 Finland

Intracranial haemorrhage (nontraumatic), unspecified

+∞

237.0

218

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

139.8

193.4

202

AA1AD

NOMESCO Finland

CT of head and brain

8.0

190.0

572

1414

I62.1

ICD-10 Finland

Nontraumatic extradural haemorrhage

+∞

115.9

109

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

58.9

110.0

129

I61.9

ICD-10 Finland

Intracerebral haemorrhage, unspecified

+∞

76.0

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.6

75.4

490

2096

X59

ICD-10 Finland

Exposure to unspecified factor

4.4

74.4

321

958

W19

ICD-10 Finland

Unspecified fall

5.6

66.9

218

475

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

332.5

62.1

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

19.2

60.2

K90

ICPC

Stroke/cerebrovascular accident

29.2

59.7

AAD05

NOMESCO Finland

Evacuation of acute subdural haematoma

85.3

57.7

I69.1

ICD-10 Finland

Sequelae of intracerebral haemorrhage

589.6

57.2

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

+∞

56.8

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

273.9

51.6

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

7.4

42.2

105

156

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.1

41.5

283

1140

AAC00

NOMESCO Finland

Ligature of intracranial aneurysm

+∞

40.9

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

+∞

40.9

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

413.0

40.4

I61.0

ICD-10 Finland

Intracerebral haemorrhage in hemisphere, subcortical

413.0

40.4

N03AX14

ATC

levetiracetam; systemic

13.0

40.2

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

10.9

38.9

R51.80

ICD-10 Finland

Headache

3.7

35.2

168

512

I69.2

ICD-10 Finland

Sequelae of other nontraumatic intracranial haemorrhage

+∞

33.5

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.8

31.4

230

948

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

25.1

29.4

AAF00

NOMESCO Finland

Ventriculostomy

58.5

29.3

G91.0

ICD-10 Finland

Communicating hydrocephalus

28.9

29.1

B01AA03

ATC

warfarin; systemic

2.3

29.0

356

1936

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.7

28.1

226

K91

ICPC

Cerebrovascular disease

23.1

28.0

I63.0

ICD-10 Finland

Cerebral infarction due to thrombosis of precerebral arteries

277.9

26.8

PA2BC

NOMESCO Finland

Cerebral extensive angiography with X-ray

99.4

26.8

I60.2

ICD-10 Finland

Subarachnoid haemorrhage from anterior communicating artery

+∞

26.1

G40.9

ICD-10 Finland

Epilepsy, unspecified

7.3

25.5

AAD12

NOMESCO Finland

Drainage of subdural fluid

51.4

25.3

I48

ICD-10 Finland

Atrial fibrillation and flutter

2.1

25.0

377

2214

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

245.4

23.7

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

10.2

22.7

G45.9

ICD-10 Finland

Transient cerebral ischaemic attack, unspecified

3.5

22.7

114

358

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.9

22.4

269

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.4

22.4

221

1057

R42

ICD-10 Finland

Dizziness and giddiness

2.2

21.7

263

1387

I65.2

ICD-10 Finland

Occlusion and stenosis of carotid artery

117.5

21.6

XA800

NOMESCO Finland

Neuropsychological investigation

7.8

21.6

T90.5

ICD-10 Finland

Sequelae of intracranial injury

11.5

21.6

WX002

NOMESCO Finland

Sedation and analgesia

2.3

21.5

243

1240

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.4

21.3

107

336

I61.1

ICD-10 Finland

Intracerebral haemorrhage in hemisphere, cortical

+∞

20.9

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

9.7

20.7

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

9.1

20.0

R53

ICD-10 Finland

Malaise and fatigue

2.2

19.3

238

1255

N02BE01

ATC

paracetamol; systemic, rectal

2.1

19.0

832

6979

I10

ICD-10 Finland

Essential (primary) hypertension

1.8

19.0

658

5072

N03AF02

ATC

oxcarbazepine; oral

6.3

18.7

AA5BD

NOMESCO Finland

CT of cerebral ischaemia

14.5

18.6

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

3.8

18.4

223

PA7AD

NOMESCO Finland

CT angiography of head and neck vasculature

7.8

18.3

N03AB02

ATC

phenytoin; systemic

10.9

18.0

R41.0

ICD-10 Finland

Disorientation, unspecified

4.3

17.8

164

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

12.7

17.7

N03AG01

ATC

valproic acid; systemic, rectal

4.3

17.7

165

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

29.3

17.5

R56.8

ICD-10 Finland

Other and unspecified convulsions

4.2

17.4

172

I60.1

ICD-10 Finland

Subarachnoid haemorrhage from middle cerebral artery

+∞

16.7

C07AB07

ATC

bisoprolol; oral

1.7

16.3

555

4152

N19

ICPC

Speech disorder

13.8

16.0

N18

ICPC

Paralysis/weakness

9.7

16.0

S06.0

ICD-10 Finland

Concussion

2.7

15.8

116

468

S06.3

ICD-10 Finland

Focal brain injury

8.5

15.8

AA1AA

NOMESCO Finland

Head X-ray examination

10.6

15.8

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

26.7

15.6

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

4.7

15.1

112

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

2.6

15.1

117

488

N05AH04

ATC

quetiapine; oral

2.3

15.0

146

685

R47.0

ICD-10 Finland

Dysphasia and aphasia

25.4

14.7

I63.1

ICD-10 Finland

Cerebral infarction due to embolism of precerebral arteries

+∞

14.6

I60.0

ICD-10 Finland

Subarachnoid haemorrhage from carotid siphon and bifurcation

+∞

14.6

PA2AD

NOMESCO Finland

CT angiography of brain

43.1

14.1

R4120

NOMESCO Finland

Occupational therapy

3.6

14.0

182

XF400

NOMESCO Finland

ECG with 12 standard connections

2.0

13.9

202

1127

SPAT1216

SPAT

Assessment of functional ability

2.0

13.9

200

1111

N80

ICPC

Head injury other

6.7

13.6

I61.8

ICD-10 Finland

Other intracerebral haemorrhage

+∞

13.6

S06.9

ICD-10 Finland

Intracranial injury, unspecified

16.4

13.5

WX110

NOMESCO Finland

Local anesthesy

1.6

13.3

567

4412

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

3.1

13.1

251

ZSA00

NOMESCO Finland

Procedure related to previous procedure classified in chapter A

19.3

12.9

P20

ICPC

Memory disturbance

2.0

12.9

176

953

SPAT1222

SPAT

Counselling/guidance promoting independent living

1.9

12.8

196

1110

H53.4

ICD-10 Finland

Visual field defects

7.3

12.8

SPAT1234

SPAT

Support of social functional capacity

2.8

12.6

300

R4150

NOMESCO Finland

Neuropsychological rehabilitation

70.7

12.6

SPAT1229

SPAT

Assessment of need for aid

2.4

12.6

110

488

G91.1

ICD-10 Finland

Obstructive hydrocephalus

20.3

12.5

N06AX11

ATC

mirtazapine; oral

1.7

12.3

279

1807

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

3.6

12.0

156

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.6

11.9

460

3448

PAF14

NOMESCO Finland

Thrombendarterectomy of internal carotid artery

47.2

11.9

S06.6

ICD-10 Finland

Traumatic subarachnoid haemorrhage

9.1

11.8

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

5.3

11.7

I63.8

ICD-10 Finland

Other cerebral infarction

+∞

11.5

I63.5

ICD-10 Finland

Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries

+∞

11.5

X58

ICD-10 Finland

Exposure to other specified factors

2.2

11.4

122

597

I64

ICD-10 Finland

Stroke, not specified as haemorrhage or infarction

35.4

11.3

L28

ICPC

Limited function/disability (L)

1.9

11.1

191

1126

Y96.9

ICD-10 Finland

Unspecified type of accident

5.8

10.9

N05AX08

ATC

risperidone; systemic

2.3

10.6

100

461

I60.8

ICD-10 Finland

Other subarachnoid haemorrhage

+∞

10.4

TKC20

NOMESCO Finland

Catheterisation of bladder

2.3

10.4

458

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.8

10.4

188

1124

I67.9

ICD-10 Finland

Cerebrovascular disease, unspecified

32.9

10.3

PA7BD

NOMESCO Finland

CT angiography of neck and brain

7.2

10.3

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

2.7

10.2

261

N05CF01

ATC

zopiclone; oral

1.6

10.1

339

2423

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.0

10.1

139

755

AA5PD

NOMESCO Finland

CT examination of brain pefusion

40.5

10.0

C09AA02

ATC

enalapril; systemic

1.7

9.9

240

1568

G40.10

ICD-10 Finland

Simple partial seizures

11.5

9.6

SPAT1053

SPAT

Memory test

1.7

9.5

215

1377

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.6

9.4

276

1900

I60.7

ICD-10 Finland

Subarachnoid haemorrhage from intracranial artery, unspecified

+∞

9.4

I69.8

ICD-10 Finland

Sequelae of other and unspecified cerebrovascular diseases

+∞

9.4

I62

ICD-10 Finland

Other nontraumatic intracranial haemorrhage

+∞

9.4

4340A

ICD-9 Finland

Occlusion of cerebral arteries, Cerebral thrombosis

+∞

9.4

I60.3

ICD-10 Finland

Subarachnoid haemorrhage from posterior communicating artery

+∞

9.4

R11

ICD-10 Finland

Nausea and vomiting

2.4

9.4

345

G40.19

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures

21.9

9.4

WX892

NOMESCO Finland

Monitored bed care

2.3

9.3

381

SPAT1215

SPAT

Assessment of need for medical rehabilitation

2.8

8.9

206

WX882

NOMESCO Finland

High dependency care

3.5

8.9

117

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

18.8

8.9

FFW96

NOMESCO Finland

Other operation on atria

24.2

8.9

G45.1

ICD-10 Finland

Carotid artery syndrome (hemispheric)

3.2

8.9

145

TPH04

NOMESCO Finland

Cathetrisation of vein

1.7

8.9

203

1300

NA1AD

NOMESCO Finland

Cervical spine CT examination

3.0

8.7

159

N03AF01

ATC

carbamazepine; oral, rectal

2.7

8.6

224

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.6

8.6

309

2229

N05BA04

ATC

oxazepam; oral

1.6

8.5

221

1466

S01.0

ICD-10 Finland

Open wound of scalp

2.2

8.4

413

ABB40

NOMESCO Finland

Evacuation of spontaneous haematoma of spinal canal

90.7

8.4

AAD15

NOMESCO Finland

Evacuation of traumatic intracerebral haematoma

90.7

8.4

N29

ICPC

Neurological sympt/complt other

4.5

8.4

F05.9

ICD-10 Finland

Delirium, unspecified

3.7

8.4

A28

ICPC

Limited function/disability NOS

1.7

8.4

188

1198

AAL00

NOMESCO Finland

Endovascular occlusion of intracranial aneurysm

+∞

8.3

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

33.6

8.1

G41.9

ICD-10 Finland

Status epilepticus, unspecified

9.0

8.0

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

2.1

8.0

414

SPAT1254

SPAT

Administration of medicine

1.7

8.0

163

1007

C10AA01

ATC

simvastatin; oral

1.5

7.9

472

3783

R50.9

ICD-10 Finland

Fever, unspecified

1.8

7.8

137

808

G81.9

ICD-10 Finland

Hemiplegia, unspecified

9.5

7.8

W00

ICD-10 Finland

Fall on same level involving ice and snow

2.1

7.7

463

B01AC07

ATC

dipyridamole; systemic

2.3

7.6

320

R55

ICD-10 Finland

Syncope and collapse

1.8

7.6

128

744

S06.4

ICD-10 Finland

Epidural haemorrhage

25.2

7.6

N99

ICPC

Neurological disease other

6.2

7.6

G72.8

ICD-10 Finland

Other specified myopathies

4.2

7.5

J01MA02

ATC

ciprofloxacin; systemic

1.5

7.5

394

3064

WX408

NOMESCO Finland

General anesthesy, balanced

1.6

7.5

236

1640

SPAT1226

SPAT

Implementation of occupational therapy rehabilitation plan

3.3

7.4

108

F00.20*G30.8

ICD-10 Finland

Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms

3.3

7.4

108

Z98.2

ICD-10 Finland

Presence of cerebrospinal fluid drainage device

80.6

7.4

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

1.9

7.3

112

629

I60.6

ICD-10 Finland

Subarachnoid haemorrhage from other intracranial arteries

+∞

7.3

PA2KT

NOMESCO Finland

Endovascular closure of brain aneurysm

+∞

7.3

PA2LT

NOMESCO Finland

Endovascular closure of extensive brain aneurysm

+∞

7.3

PA2VT

NOMESCO Finland

Intravascular evacuation of brain artery embolus

+∞

7.3

R1230

NOMESCO Finland

Neuropsychological evaluation of need and possibilities to rehabilitation

9.4

7.3

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

1.9

7.3

104

570

X57

ICD-10 Finland

Unspecified privation

3.7

7.1

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

2.5

7.1

219

XX3XW

NOMESCO Finland

12.1

7.1

A04

ICPC

Weakness/tiredness general

1.8

7.1

124

732

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

10.1

7.0

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

7.0

G40.20

ICD-10 Finland

Complex partial seizures with only alteration of consciousness

6.4

6.9

W10

ICD-10 Finland

Fall on and from stairs and steps

2.6

6.9

197

N03AX18

ATC

lacosamide; systemic

13.9

6.9

B01AB05

ATC

enoxaparin; parenteral

1.5

6.9

285

2103

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

1.7

6.8

148

931

SPAT1360

SPAT

Extensive global examination

2.0

6.8

416

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

3.8

6.8

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

5.4

6.8

ZXA05

NOMESCO Finland

Left side

1.5

6.8

256

1850

Z43.0

ICD-10 Finland

Attention to tracheostomy

40.3

6.8

G41.0

ICD-10 Finland

Grand mal status epilepticus

40.3

6.8

F00.20

ICD-10 Finland

Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms

5.0

6.7

Q28.2

ICD-10 Finland

Arteriovenous malformation of cerebral vessels

22.7

6.7

G30.8

ICD-10 Finland

Other Alzheimer disease

3.0

6.6

124

PA6AD

NOMESCO Finland

CT of neck arteries

8.8

6.6

N28

ICPC

Limited function/disability (N)

4.4

6.6

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.7

6.5

146

927

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.1

6.5

333

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

1.6

6.4

188

1279

T24.3

ICD-10 Finland

Burn of third degree of hip and lower limb, except ankle and foot

70.2

6.4

SPAT1245

SPAT

Provision of support and information to patient’s family members

2.2

6.3

307

A41.9

ICD-10 Finland

Sepsis, unspecified

2.5

6.3

201

J01DB01

ATC

cefalexin; oral

1.4

6.3

708

6271

N88

ICPC

Epilepsy

18.1

6.3

F03

ICD-10 Finland

Unspecified dementia

2.1

6.3

349

I63.2

ICD-10 Finland

Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries

+∞

6.3

I61.4

ICD-10 Finland

Intracerebral haemorrhage in cerebellum

+∞

6.3

I67.6

ICD-10 Finland

Nonpyogenic thrombosis of intracranial venous system

+∞

6.3

C03AA03

ATC

hydrochlorothiazide; oral

1.8

6.2

108

635

K78

ICPC

Atrial fibrillation/flutter

1.8

6.2

106

619

N05CD07

ATC

temazepam; oral

1.6

6.2

146

942

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

5.8

6.2

C03CA01

ATC

furosemide; systemic

1.4

6.1

381

3035

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.6

6.1

172

G40.89

ICD-10 Finland

Other epilepsy

12.6

6.1

XXA00

NOMESCO Finland

Clinical examination requiring general anaesthesia

12.6

6.1

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

12.6

6.1

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

2.1

6.1

321

SPAT1252

SPAT

Overall medication plan or its review

1.9

6.0

450

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

4.2

6.0

R1250

NOMESCO Finland

Evaluation of functional capability

3.6

6.0

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.7

6.0

126

785

N05AA02

ATC

levomepromazine; systemic

2.7

6.0

149

Mortality – FinRegistry

↥

Association

Association between endpoint I9_OTHINTRACRA and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_OTHINTRACRA	2.148 [1.85, 2.49]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.346

During the follow-up period (1.1.1998 — 31.12.2019), 1445 out of 2816 females with I9_OTHINTRACRA died.

Males

Parameter	HR [95% CI]	p-value
I9_OTHINTRACRA	2.024 [1.74, 2.35]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 2569 out of 4843 males with I9_OTHINTRACRA died.

Mortality risk

Mortality risk for people of age

years, who have I9_OTHINTRACRA.

N-year risk	Females	Males
1	0.205%	0.342%
5	1.286%	2.021%
10	3.13%	5.194%
15	6.112%	10.143%
20	10.484%	17.079%

Relationships between endpoints

↥

Index endpoint: I9_OTHINTRACRA – Other intracranial haemorrhages

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	I9_OTHINTRACRA
CONTROL_EXCLUDE	I9_CEREBVASC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I62
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I62
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other intracranial haemorrhages

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints