asbestosis: A pneumoconiosis caused by inhalation and retention of asbestos fibers.
Pneumoconiosis due to asbestos and other mineral fibres
DOID EFO Endpoint Browser PheWeb
J10_ASBESTPNEUMOC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
824 |
4. Check minimum number of eventsNone |
824 |
5. Include endpointsNone |
824 |
6. Filter based on genotype QC (FinnGen only) |
824 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Asbestosis
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to asbestos and other mineral fibres
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6025 | 326 | 5496 |
| Only index persons | 3520 | 209 | 3311 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.01 | 0.15 |
| Only index persons | 0.12 | 0.01 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 71.18 | 71.89 | 71.13 |
| Only index persons | 71.74 | 71.88 | 71.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 824 | 32 | 792 |
| Unadjusted period prevalence (%) | 0.34 | 0.01 | 0.35 |
| Median age at first event (years) | 70.27 | 61.36 | 70.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 736
- Matched controls
- 7358
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
86.7
323.0
445
127
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
13226.5
323.0
676
5
5010A
ICD-9 Finland
Asbestosis[ASBESTOSIS]
+∞
85.1
80
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.9
77.6
158
180
XG410
NOMESCO Finland
Flow-volume spirometry
9.8
60.8
130
158
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
13.3
58.1
105
91
R03AC02
ATC
salbutamol; inhalant
3.4
54.0
424
2097
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.4
49.2
208
603
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
9.4
46.4
100
121
R03BB04
ATC
tiotropium bromide; inhalant
3.8
45.4
230
779
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.6
45.1
178
478
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.2
38.9
265
1104
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.7
37.4
115
231
H02AB06
ATC
prednisolone; systemic
2.5
31.0
409
2454
R06.0
ICD-10 Finland
Dyspnoea
2.7
30.2
264
1251
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
8.0
30.1
70
95
Z57.2
ICD-10 Finland
Occupational exposure to dust
24.0
29.0
41
18
J92.9
ICD-10 Finland
Pleural plaque without asbestos
9.7
28.2
58
64
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
16.4
26.2
42
27
TGC00
NOMESCO Finland
Bronchial lavation
7.3
26.0
64
95
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
16.4
24.4
39
25
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
3.1
24.3
155
590
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
24.0
88
212
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
23.3
160
638
J96.1
ICD-10 Finland
Chronic respiratory failure
5.1
23.0
75
159
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
21.1
375
2413
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
21.1
169
739
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
20.0
205
1017
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.1
19.5
115
411
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
6.5
18.6
49
80
R03BA05
ATC
fluticasone; inhalant
2.6
17.7
141
607
R03BA01
ATC
beclometasone; inhalant
2.7
17.6
129
529
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.1
17.2
55
115
J45.1
ICD-10 Finland
Nonallergic asthma
3.7
16.4
74
215
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
61.3
15.8
18
*
R03BB01
ATC
ipratropium bromide; inhalant
2.9
15.1
100
384
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
9.7
14.5
29
31
1240
FHL
Bronchoscopy
5.9
14.1
39
69
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
5.2
14.0
43
86
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
16.6
13.5
21
13
J01AA02
ATC
doxycycline; systemic
1.9
13.5
519
4134
R04.2
ICD-10 Finland
Haemoptysis
3.5
12.9
61
185
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
12.9
53
143
R03BA02
ATC
budesonide; inhalant
2.3
12.6
128
619
Z57.3
ICD-10 Finland
Occupational exposure to other air contaminants
71.1
12.6
14
*
J92
ICD-10 Finland
Pleural plaque
32.6
12.6
16
5
R03DA04
ATC
theophylline; systemic, rectal
2.4
12.6
111
500
51520
ICD-8 Finland
Pneumoconiosis due to silica and silicates, Asbestosis
+∞
12.5
12
*
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.2
12.3
46
114
R03AK07
ATC
formoterol and budesonide; inhalant
2.3
12.1
120
573
GAC00
NOMESCO Finland
Biopsy of pleura
21.7
12.0
17
8
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
11.4
98
435
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.0
11.3
67
240
R03AC03
ATC
terbutaline; inhalant
2.4
11.2
100
453
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
4.9
11.0
35
74
R05
ICD-10 Finland
Cough
2.2
10.9
127
649
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
10.3
297
2092
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
5.2
10.3
31
62
XG466
NOMESCO Finland
Sleep oxymetry
4.0
10.1
40
105
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.9
10.1
62
227
R06.2
ICD-10 Finland
Wheezing
3.6
9.8
44
129
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
10.8
9.8
18
17
R03BA08
ATC
ciclesonide; inhalant
3.2
9.8
51
168
R03AC13
ATC
formoterol; inhalant
3.0
9.6
56
199
J94.8
ICD-10 Finland
Other specified pleural conditions
4.8
9.4
30
64
R03AC12
ATC
salmeterol; inhalant
2.7
9.3
65
257
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
8.1
8.9
19
24
H02AB04
ATC
methylprednisolone; systemic
2.1
8.9
107
556
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
8.7
139
805
J47
ICD-10 Finland
Bronchiectasis
4.3
8.5
30
72
R02
ICPC
Shortness of breath/dyspnoea
2.1
8.4
95
480
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
8.3
260
1846
WX725
NOMESCO Finland
Noninvasive ventilation
3.3
8.2
39
121
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.5
8.1
37
111
C03CA01
ATC
furosemide; systemic
1.6
8.1
348
2669
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
8.3
8.1
17
21
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
6.4
8.0
20
32
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
9.5
7.8
15
16
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.7
7.6
160
1009
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
5.8
7.6
20
35
XX1XW
NOMESCO Finland
Extensive written report from radiologist
4.6
7.3
24
54
XG405
NOMESCO Finland
Education on PEF monitoring
5.9
7.3
19
33
5188X
ICD-9 Finland
Other diseases of lung
7.4
7.2
16
22
Y96.0
ICD-10 Finland
Work-related condition
20.2
7.1
10
5
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
4.1
7.1
26
65
J01FA06
ATC
roxithromycin; oral
1.6
7.1
246
1777
R99
ICPC
Respiratory disease other
5.7
7.1
19
34
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.9
116
683
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.7
6.9
44
167
R03DC03
ATC
montelukast; oral
2.2
6.9
70
340
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.8
288
2178
G47.3
ICD-10 Finland
Sleep apnoea
1.8
6.6
123
744
J96.0
ICD-10 Finland
Acute respiratory failure
4.6
6.5
21
47
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
+∞
6.3
6
*
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
+∞
6.3
6
*
R95
ICPC
Chron obstructive pulmonary disease
2.7
6.0
39
149
8041/3-C34.9
ICD-O-3
Small cell carcinoma, NOS, of lung, NOS
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASBESTPNEUMOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.687 [1.26, 2.25] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.642 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 200 females with J10_ASBESTPNEUMOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.879 [1.69, 2.09] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2029 out of 3332 males with J10_ASBESTPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASBESTPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.358% |
| 5 | 1.034% | 2.316% |
| 10 | 2.786% | 5.423% |
| 15 | 5.368% | 10.024% |
| 20 | 9.573% | 16.505% |
Relationships between endpoints
↥Index endpoint: J10_ASBESTPNEUMOC – Pneumoconiosis due to asbestos and other mineral fibres
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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