bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1533 |
4. Check minimum number of eventsNone |
1533 |
5. Include endpointsNone |
1533 |
6. Filter based on genotype QC (FinnGen only) |
1533 |
Control definitions (FinnGen only)
- Control exclude
- J10_LOWCHRON
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J40-J47
- Name in latin
- Bronchitis chronica non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified chronic bronchitis
based on the number of shared cases.
Similar with more cases:
- Chronic lower respiratory diseases
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
- Diseases of the respiratory system
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18442 | 6735 | 11129 |
| Only index persons | 8641 | 4155 | 4486 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.19 | 0.31 |
| Only index persons | 0.16 | 0.15 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 61.97 | 59.69 | 63.16 |
| Only index persons | 54.81 | 54.34 | 55.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1533 | 567 | 966 |
| Unadjusted period prevalence (%) | 0.34 | 0.19 | 0.43 |
| Median age at first event (years) | 57.22 | 53.52 | 59.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1419
- Matched controls
- 14185
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
106.5
323.0
472
66
J45.9
ICD-10 Finland
Asthma, unspecified
59.7
323.0
417
98
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
+∞
323.0
530
*
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
+∞
323.0
317
*
J42
ICD-10 Finland
Unspecified chronic bronchitis
1661.3
323.0
952
18
R03BB04
ATC
tiotropium bromide; inhalant
26.3
264.4
378
193
R03AC02
ATC
salbutamol; inhalant
7.1
252.3
947
3115
R03AK06
ATC
salmeterol and fluticasone; inhalant
15.2
206.0
362
313
R03DA04
ATC
theophylline; systemic, rectal
22.8
194.9
290
158
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
17.8
194.3
317
225
4919X
ICD-9 Finland
Chronic bronchitis, Unspecified chronic bronchitis
+∞
188.8
177
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
100.8
176.3
192
22
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
381.3
172.3
170
5
H02AB06
ATC
prednisolone; systemic
4.7
159.8
856
3481
R03BA02
ATC
budesonide; inhalant
9.2
157.6
360
503
R03BA05
ATC
fluticasone; inhalant
8.3
155.2
382
602
J45.1
ICD-10 Finland
Nonallergic asthma
285.3
152.6
153
6
R03BB01
ATC
ipratropium bromide; inhalant
17.8
152.0
246
165
R03AC12
ATC
salmeterol; inhalant
58.0
151.0
178
35
R03BA01
ATC
beclometasone; inhalant
9.7
143.7
316
408
J45.0
ICD-10 Finland
Predominantly allergic asthma
144.3
135.9
143
11
UGC12
NOMESCO Finland
Flexible bronchoscopy
8.6
131.2
309
443
R03AK07
ATC
formoterol and budesonide; inhalant
7.2
127.1
343
603
R03DC03
ATC
montelukast; oral
9.2
124.3
280
370
J47
ICD-10 Finland
Bronchiectasis
646.3
122.1
119
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
286.4
105.3
106
*
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
+∞
99.1
94
*
R03AC13
ATC
formoterol; inhalant
34.7
92.7
121
38
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.4
89.9
382
1096
49300
ICD-8 Finland
Asthma, bronchiale
+∞
83.1
79
*
R03AC03
ATC
terbutaline; inhalant
6.1
81.4
241
459
H02AB04
ATC
methylprednisolone; systemic
4.7
79.2
306
788
R03BA08
ATC
ciclesonide; inhalant
11.5
77.6
150
144
J45.8
ICD-10 Finland
Mixed asthma
120.9
74.7
80
7
J01AA02
ATC
doxycycline; systemic
3.1
73.7
1128
7846
R05
ICD-10 Finland
Cough
3.8
71.5
357
1155
J45
ICD-10 Finland
Asthma
14.7
71.0
122
90
J01FA06
ATC
roxithromycin; oral
2.8
69.2
639
3199
R03AK08
ATC
formoterol and beclometasone; inhalant
52.8
67.0
80
16
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
65.0
547
2557
R96
ICPC
Asthma
12.3
64.4
120
106
J01MA14
ATC
moxifloxacin; systemic
5.3
64.2
212
453
R06.0
ICD-10 Finland
Dyspnoea
3.1
61.9
428
1744
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
+∞
61.9
59
*
J46
ICD-10 Finland
Status asthmaticus
320.9
60.8
61
*
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
+∞
59.8
57
*
49099
ICD-8 Finland
Bronchitis, unspecified
+∞
58.7
56
*
H02AB07
ATC
prednisone; oral
3.7
55.1
277
882
J96.1
ICD-10 Finland
Chronic respiratory failure
21.1
53.7
80
40
R04.2
ICD-10 Finland
Haemoptysis
8.8
51.8
115
141
J01FA09
ATC
clarithromycin; systemic
2.7
51.4
445
2050
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
7.4
50.0
124
181
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
134.8
49.1
52
*
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
+∞
48.2
46
*
R03BB02
ATC
oxitropium bromide; inhalant
58.2
47.8
56
10
XG474
NOMESCO Finland
Exhalation nntrogen oxide
21.6
44.8
66
32
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
20.2
42.6
64
33
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.6
42.2
207
636
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
151.2
42.0
44
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.4
41.5
227
758
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
216.1
41.1
42
*
R95
ICPC
Chron obstructive pulmonary disease
22.7
40.8
59
27
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
39.8
627
3803
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.3
38.9
107
180
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
14.4
38.6
66
48
R06.2
ICD-10 Finland
Wheezing
8.0
36.6
85
112
J01FA10
ATC
azithromycin; systemic
2.1
36.5
664
4230
J01MA12
ATC
levofloxacin; systemic
2.5
35.6
324
1490
XG410
NOMESCO Finland
Flow-volume spirometry
7.3
35.5
88
128
J41.0
ICD-10 Finland
Simple chronic bronchitis
80.2
35.0
39
5
J01DA01
ATC
[U] cefalexin; systemic
2.0
34.6
880
6351
49101
ICD-8 Finland
Chronic bronchitis, Nonpurulenta (simplex)
+∞
34.5
33
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.7
33.2
73
88
R03AK11
ATC
formoterol and fluticasone; inhalant
21.5
32.8
48
23
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.2
32.2
401
2142
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
5.8
31.4
92
168
51899
ICD-8 Finland
Bronchiectasis
+∞
30.3
29
*
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
+∞
30.3
29
*
R01AD08
ATC
fluticasone; nasal
2.3
30.3
337
1700
R03DA05
ATC
aminophylline; systemic, rectal
25.4
30.2
42
17
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.1
30.0
439
2499
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
19.3
29.7
45
24
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
9.5
29.3
61
67
R05CB01
ATC
acetylcysteine; inhalant, oral
8.4
27.5
61
75
R03DC01
ATC
zafirlukast; oral
20.1
27.5
41
21
R02
ICPC
Shortness of breath/dyspnoea
3.0
27.1
168
605
J43.9
ICD-10 Finland
Emphysema, unspecified
61.2
26.0
30
5
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.0
25.7
106
278
R03BC03
ATC
nedocromil; inhalant
3.9
25.3
110
302
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
26.7
24.9
34
13
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.1
24.6
337
1839
R01AD09
ATC
mometasone; nasal
1.9
24.1
480
3023
J01FA15
ATC
telithromycin; oral
3.0
24.0
144
507
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
9.2
23.9
50
56
49102
ICD-8 Finland
Chronic bronchitis, Purulenta
+∞
23.0
22
*
C03CA01
ATC
furosemide; systemic
1.8
22.5
540
3605
A02BC01
ATC
omeprazole; systemic
1.9
22.3
409
2488
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
21.9
21
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.8
21.8
62
110
48609
ICD-8 Finland
Pneumonia, unspecified
8.0
21.6
49
63
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
50.8
21.2
25
5
A02BA02
ATC
ranitidine; systemic
2.0
20.9
319
1803
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
20.9
214
1018
4910A
ICD-9 Finland
Chronic bronchitis, Simple chronic bronchitis
+∞
20.9
20
*
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
30.5
20.6
27
9
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
20.3
557
3844
G47.3
ICD-10 Finland
Sleep apnoea
2.1
20.3
249
1289
R05FB02
ATC
cough suppressants and expectorants
1.7
20.2
527
3583
N02AX02
ATC
tramadol; systemic, rectal
1.7
20.1
561
3888
R03AC04
ATC
fenoterol; inhalant
74.5
19.7
22
*
A01AB09
ATC
miconazole; local oral
2.7
18.9
137
543
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
+∞
18.8
18
*
XQ800
NOMESCO Finland
Prick test
3.9
18.6
77
204
R05CB02
ATC
bromhexine; systemic
5.7
18.4
53
96
1240
FHL
Bronchoscopy
6.8
18.2
46
70
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.4
18.0
88
268
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
+∞
17.7
17
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.3
17.7
54
105
R05
ICPC
Cough
2.0
17.6
243
1313
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
21.2
17.3
25
12
R29
ICPC
Respiratory symptom/complaint other
3.4
16.9
82
248
J20
ICD-10 Finland
Acute bronchitis
2.7
16.9
119
464
TGC00
NOMESCO Finland
Bronchial lavation
5.0
16.9
54
111
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.7
16.7
48
87
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.5
16.5
78
231
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.3
16.5
86
275
R03AC18
ATC
indacaterol; inhalant
40.6
16.3
20
5
A02BC05
ATC
esomeprazole; systemic
1.7
16.1
480
3333
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
16.0
411
2737
J31.0
ICD-10 Finland
Chronic rhinitis
3.1
15.7
89
300
SPAT1059
SPAT
Spirometry at the office
3.7
15.7
68
188
R03DA54
ATC
theophylline, combinations excl. psycholeptics; systemic
6.1
15.7
42
70
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
+∞
15.6
15
*
A02BC03
ATC
lansoprazole; oral
1.7
15.6
391
2578
J01DA06
ATC
[U] cefuroxime; systemic
2.1
15.6
183
922
C01AA05
ATC
digoxin; systemic
2.0
15.4
200
1052
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.0
15.3
62
162
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
6.3
15.2
40
65
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.2
15.1
57
139
SPAT1058
SPAT
PEF monitoring instruction
3.0
15.0
87
300
A02BC02
ATC
pantoprazole; systemic
1.6
15.0
788
6290
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
32.0
14.8
19
6
XG460
NOMESCO Finland
Short time oxymetry
5.7
14.7
42
76
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
9.0
14.5
30
34
R03CC02
ATC
salbutamol; systemic
4.3
14.4
53
127
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
5.1
14.4
45
91
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
42.9
14.1
17
*
R01AD11
ATC
triamcinolone; nasal
2.5
14.0
108
444
Y0499
ICD-8 Finland
Investigation of respiratory system
6.3
13.8
36
58
R51.80
ICD-10 Finland
Headache
2.2
13.8
144
689
R05FA02
ATC
opium derivatives and expectorants; systemic
1.6
13.8
484
3480
48509
ICD-8 Finland
Bronchopneumonia, unspecified
7.4
13.8
32
44
J01CA04
ATC
amoxicillin; systemic
1.5
13.6
921
7721
4911A
ICD-9 Finland
Chronic bronchitis, Mucopurulent chronic bronchitis
+∞
13.6
13
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
13.2
116
511
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
13.2
250
1504
A07AA02
ATC
nystatin; oral
2.7
13.1
93
364
J37.0
ICD-10 Finland
Chronic laryngitis
4.3
13.1
48
115
R03AK
ATC
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
50.4
12.9
15
*
R01AD12
ATC
fluticasone furoate; nasal
1.8
12.8
255
1557
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
5.9
12.7
35
61
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.9
12.6
75
264
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
12.5
12
*
49309
ICD-8 Finland
Asthma, Unspecified
+∞
12.5
12
*
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
12.5
250
1529
N05CD07
ATC
temazepam; oral
1.8
12.3
228
1359
A01AB04
ATC
amphotericin B; local oral
2.8
12.3
80
297
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.4
12.3
109
482
N05CF01
ATC
zopiclone; oral
1.6
12.1
453
3281
3472A
ICD-9 Finland
Cataplexy and narcolepsy[OBSTRUKTIIVINEN UNIAPNEA]
5.5
12.1
35
65
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
12.1
330
2204
C08DA01
ATC
verapamil; systemic
2.9
12.1
74
265
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
18.2
12.1
18
10
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.6
12.0
53
150
SPAT1263
SPAT
Sampling
1.5
12.0
486
3591
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
11.9
63
206
XG405
NOMESCO Finland
Education on PEF monitoring
9.3
11.5
23
25
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
11.2
320
2162
J01FA01
ATC
erythromycin; systemic
2.0
11.2
145
760
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
11.1
354
2457
J32.4
ICD-10 Finland
Chronic pansinusitis
10.1
11.0
21
21
C07AB07
ATC
bisoprolol; oral
1.5
10.9
637
5058
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
10.9
95
417
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
4.3
10.9
39
92
N03AX12
ATC
gabapentin; oral
1.9
10.7
173
983
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
10.6
283
1874
J01FF01
ATC
clindamycin; systemic
1.6
10.6
302
2038
UDC00
NOMESCO Finland
Ear microscopy
2.3
10.5
95
424
Q32.21
ICD-10 Finland
Secondary congenital bronchomalacia
110.8
10.4
11
*
R03CC03
ATC
terbutaline; systemic
6.9
10.4
25
37
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
12.1
10.3
18
15
R5140
NOMESCO Finland
Monitoring the use of the aid
2.1
10.3
124
628
R09.3
ICD-10 Finland
Abnormal sputum
8.3
10.3
22
27
46699
ICD-8 Finland
Acute bronchitis and bronchiolitis
6.1
10.3
27
45
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
23.5
10.2
14
6
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
7.5
10.2
23
31
R05DA01
ATC
ethylmorphine; oral
2.2
10.1
103
489
R74
ICPC
Upper respiratory infection acute
1.7
10.1
224
1411
R06AE07
ATC
cetirizine; oral
1.5
10.0
421
3104
N06AA09
ATC
amitriptyline; systemic
2.0
10.0
126
653
N05BA04
ATC
oxazepam; oral
1.6
10.0
313
2158
J02AC01
ATC
fluconazole; systemic
1.5
9.9
372
2676
XG466
NOMESCO Finland
Sleep oxymetry
3.6
9.8
43
123
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.8
9.5
172
1015
R06AX13
ATC
loratadine; oral
1.9
9.5
138
755
E66.01
ICD-10 Finland
Obesity due to excess calories
2.6
9.4
67
264
P01AB01
ATC
metronidazole; oral, rectal
1.5
9.4
415
3085
49302
ICD-8 Finland
Asthma, Rhinitis allergica cum asthmate bronchiali
+∞
9.4
9
*
N03AX16
ATC
pregabalin; oral
1.6
9.3
251
1664
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
9.3
293
2021
WZC30
NOMESCO Finland
Teaching
1.9
9.3
147
829
Z72.0
ICD-10 Finland
Tobacco use
4.4
9.2
32
74
R81
ICPC
Pneumonia
3.3
9.2
45
140
R28
ICPC
Limited function/disability (R)
7.3
9.2
21
29
R01AD01
ATC
beclometasone; nasal
1.8
9.1
153
879
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
15.7
9.0
14
9
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
3.2
9.0
46
148
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
9.0
386
2851
R06.5
ICD-10 Finland
Mouth breathing
2.2
8.9
92
438
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
8.9
382
2819
UJF32
NOMESCO Finland
Coloscopy
1.5
8.9
302
2119
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
8.7
8.8
18
21
48601
ICD-8 Finland
More specifically, unspecified pneumonia and the pleural irritation caused by it
10.8
8.8
16
15
M54.5
ICD-10 Finland
Low back pain
1.5
8.7
320
2283
J01DC02
ATC
cefuroxime; systemic
2.5
8.7
64
260
R49.01
ICD-10 Finland
Functional dysphonia
3.7
8.7
36
99
R52.2
ICD-10 Finland
Other chronic pain
3.4
8.6
40
120
N05BA01
ATC
diazepam; systemic, rectal
1.7
8.6
174
1062
R05CB03
ATC
carbocisteine; oral
3.5
8.6
38
110
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.4
8.6
40
121
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
9.0
8.5
17
19
R01AD05
ATC
budesonide; nasal
2.3
8.5
74
326
A02BA03
ATC
famotidine; systemic
2.4
8.5
71
307
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
6.0
8.5
22
37
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
7.4
8.4
19
26
N06AB04
ATC
citalopram; systemic
1.6
8.4
248
1678
J43.8
ICD-10 Finland
Other emphysema
90.5
8.4
9
*
R11
ICD-10 Finland
Nausea and vomiting
2.1
8.4
97
487
J01DA08
ATC
[U] cefaclor; oral
2.1
8.4
95
474
A02BA04
ATC
nizatidine; systemic
1.9
8.3
119
645
J41.8
ICD-10 Finland
Mixed simple and mucopurulent chronic bronchitis
+∞
8.3
8
*
G44.2
ICD-10 Finland
Tension-type headache
1.9
8.2
116
629
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.9
8.2
112
601
L03
ICPC
Low back symptom/complaint
1.6
8.1
235
1583
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
9.0
8.0
16
18
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.7
8.0
51
190
J15.8
ICD-10 Finland
Other bacterial pneumonia
7.3
8.0
18
25
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.9
8.0
46
161
R06AX27
ATC
desloratadine; oral
1.6
7.9
213
1408
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.5
7.8
57
229
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
7.8
252
1742
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.7
92
467
A06AD11
ATC
lactulose; oral
1.6
7.7
237
1617
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
5.3
7.7
22
42
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
10.1
7.5
14
14
A03CA02
ATC
clidinium and psycholeptics; oral
2.0
7.5
88
444
R03AC19
ATC
olodaterol; inhalant
80.5
7.4
8
*
J20.0
ICD-10 Finland
Acute bronchitis due to Mycoplasma pneumoniae
6.5
7.4
18
28
SPAT1257
SPAT
Teaching of medicine inhalation technique
3.3
7.4
35
108
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
6.0
7.4
19
32
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
7.3
179
1153
4939A
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA SINE EXACERBATIONE]
+∞
7.3
7
*
J43.2
ICD-10 Finland
Centrilobular emphysema
+∞
7.3
7
*
M04AA01
ATC
allopurinol; systemic
1.6
7.3
195
1287
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.2
458
3615
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
7.2
322
2383
R07.3
ICD-10 Finland
Other chest pain
1.9
7.2
106
583
N06AX21
ATC
duloxetine; oral
1.9
7.1
100
541
D07AC13
ATC
mometasone; topical
1.5
7.1
312
2299
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
3.1
7.1
36
117
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.1
489
3914
C03DA01
ATC
spironolactone; oral
1.7
7.0
143
879
50300
ICD-8 Finland
Chronic sinusitis, Maxillaris cum empyemate
6.4
6.9
17
27
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
1.9
6.9
91
483
E66.00
ICD-10 Finland
Metabolic syndrome
2.4
6.9
53
222
R78
ICPC
Acute bronchitis/bronchiolitis
3.6
6.9
29
82
GD1AA
SPAT
NA
2.4
6.8
57
246
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
6.8
107
603
N06AA12
ATC
doxepin; systemic
2.1
6.8
77
386
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
5.3
6.8
19
36
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
6.7
156
993
D72.1
ICD-10 Finland
Eosinophilia
22.6
6.7
9
*
M01AE02
ATC
naproxen; oral, rectal
1.3
6.6
600
5006
30180
ICD-8 Finland
Personality disorders, Immatura
12.3
6.6
11
9
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.8
6.6
26
70
WX723
NOMESCO Finland
CPAP therapy
2.9
6.6
38
134
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
10.1
6.5
12
12
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.2
6.5
61
281
Z01.9
ICD-10 Finland
Special examination, unspecified
2.2
6.5
65
307
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
70.1
6.4
7
*
R03BB05
ATC
aclidinium bromide; inhalant
70.1
6.4
7
*
J98.1
ICD-10 Finland
Pulmonary collapse
7.4
6.4
14
19
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
6.4
74
373
R04
ICPC
Breathing problem other
2.8
6.4
38
138
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.4
105
602
C08DB01
ATC
diltiazem; oral
1.8
6.4
103
585
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.4
326
2472
ZX140
NOMESCO Finland
Intra articular
8.2
6.3
13
16
R05DB05
ATC
pentoxyverine; oral, rectal
2.4
6.3
51
218
N06AX03
ATC
mianserin; oral
2.2
6.3
60
280
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
6.3
99
560
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
3.9
6.3
24
63
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
6.3
120
724
J14
ICD-10 Finland
Pneumonia due to Haemophilus influenzae
+∞
6.3
6
*
4939B
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA CUM EXACERBATIONE]
+∞
6.3
6
*
5191A
ICD-9 Finland
Other diseases of respiratory system, Other diseases of trachea and bronchus, not elsewhere classified
+∞
6.3
6
*
348
Kela drug reimbursment
Roflumilast
+∞
6.3
6
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
3.4
6.2
28
84
M79.6
ICD-10 Finland
Pain in limb
1.4
6.2
344
2638
51900
ICD-8 Finland
Other diseases of respiratory system, Atelectasis pulmonis
26.8
6.2
8
*
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.3
6.2
56
254
N06AX11
ATC
mirtazapine; oral
1.4
6.2
331
2523
M09AA72
ATC
quinine, combinations with psycholeptics; systemic
2.2
6.2
61
288
M03BX02
ATC
tizanidine; oral
1.3
6.2
594
4984
R05DB20
ATC
other cough suppressants - combinations
2.1
6.2
68
337
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
6.2
63
302
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
6.1
173
1155
S82.4
ICD-10 Finland
Fracture of fibula alone
4.2
6.1
21
50
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
4.2
6.1
21
50
5645A
ICD-9 Finland
Functional digestive disorders, not elsewhere classified, Functional diarrhoea
12.6
6.1
10
8
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
6.1
44
180
M48.0
ICD-10 Finland
Spinal stenosis
1.6
6.1
145
930
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
3.1
6.0
31
103
D07XC01
ATC
betamethasone, combinations; topical
1.6
6.0
140
889
Mortality – FinRegistry
↥Association
Association between endpoint J10_BRONCHNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_BRONCHNAS | 1.856 [1.65, 2.08] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.249 |
During the follow-up period (1.1.1998 — 31.12.2019), 1058 out of 2991 females with J10_BRONCHNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_BRONCHNAS | 2.101 [1.86, 2.37] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1766 out of 3561 males with J10_BRONCHNAS died.
Mortality risk
Mortality risk for people of age
years, who have J10_BRONCHNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.175% | 0.429% |
| 5 | 0.997% | 2.609% |
| 10 | 2.501% | 6.064% |
| 15 | 5.092% | 10.933% |
| 20 | 8.903% | 18.446% |
Relationships between endpoints
↥Index endpoint: J10_BRONCHNAS – Unspecified chronic bronchitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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