No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
134 |
4. Check minimum number of eventsNone |
134 |
5. Include endpointsNone |
134 |
6. Filter based on genotype QC (FinnGen only) |
134 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Pneumoconiosis ex aliis pulveribus inorganicis
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to other inorganic dusts
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1874 | 796 | 1036 |
| Only index persons | 1034 | 447 | 587 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 72.58 | 76.03 | 69.86 |
| Only index persons | 68.26 | 72.40 | 65.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 134 | 40 | 94 |
| Unadjusted period prevalence (%) | 0.03 | 0.01 | 0.04 |
| Median age at first event (years) | 68.26 | 65.91 | 69.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 127
- Matched controls
- 1269
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J63.3
ICD-10 Finland
Graphite fibrosis (of lung)
+∞
49.2
44
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
10.6
26.6
59
96
J63.8
ICD-10 Finland
Pneumoconiosis due to other specified inorganic dusts
+∞
24.8
23
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
12.4
23.0
44
52
J63.4
ICD-10 Finland
Siderosis
+∞
20.3
19
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
6.1
18.0
60
162
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
+∞
11.6
11
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
6.0
10.7
31
65
B01AC07
ATC
dipyridamole; systemic
5.1
9.1
30
73
J63.1
ICD-10 Finland
Bauxite fibrosis (of lung)
+∞
8.4
8
*
J63.0
ICD-10 Finland
Aluminosis (of lung)
+∞
8.4
8
*
51600
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other inorganic dust
+∞
7.4
7
*
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
13.1
7.2
12
10
AA1AD
NOMESCO Finland
CT of head and brain
3.0
7.2
50
226
B01AC04
ATC
clopidogrel; oral
3.2
7.1
44
180
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
6.8
58
296
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
5.8
6.6
18
35
H53.4
ICD-10 Finland
Visual field defects
15.4
6.5
10
7
5030A
ICD-9 Finland
Pneumoconiosis due to other inorganic dust[PNEUMOCONIOSIS ALIA DEFINITA]
+∞
6.3
6
*
J63.5
ICD-10 Finland
Stannosis
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint J10_INORGPNEUMOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_INORGPNEUMOC | 2.348 [1.93, 2.85] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.312 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 557 females with J10_INORGPNEUMOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_INORGPNEUMOC | 2.514 [2.05, 3.08] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 496 out of 715 males with J10_INORGPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_INORGPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.488% |
| 5 | 1.365% | 2.745% |
| 10 | 3.496% | 6.969% |
| 15 | 6.78% | 12.907% |
| 20 | 11.869% | 21.3% |
Relationships between endpoints
↥Index endpoint: J10_INORGPNEUMOC – Pneumoconiosis due to other inorganic dusts
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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