No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
248 |
4. Check minimum number of eventsNone |
248 |
5. Include endpointsNone |
248 |
6. Filter based on genotype QC (FinnGen only) |
248 |
Control definitions (FinnGen only)
- Control exclude
- K11_INTESTOTH
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Impaction of intestines
based on the number of shared cases.
Similar with more cases:
- Paralytic ileus and intestinal obstruction
- Other diseases of intestines
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3077 | 1658 | 1372 |
| Only index persons | 1888 | 1071 | 817 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 66.50 | 69.86 | 62.39 |
| Only index persons | 59.60 | 63.66 | 54.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 248 | 135 | 113 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 59.06 | 54.02 | 65.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 227
- Matched controls
- 2269
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K56.4
ICD-10 Finland
Other impaction of intestine
1762.9
112.5
100
*
K56.3
ICD-10 Finland
Gallstone ileus
+∞
80.0
72
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
648.7
53.8
51
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
33.3
39.8
52
20
K56.7
ICD-10 Finland
Ileus, unspecified
+∞
34.2
32
*
UJF32
NOMESCO Finland
Coloscopy
7.5
32.3
88
177
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.8
25.9
116
405
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
+∞
23.3
22
*
56030
ICD-8 Finland
Intestinal obstruction without mention of hernia, Impaction of intestine
+∞
23.3
22
*
K59.0
ICD-10 Finland
Constipation
16.4
21.2
34
24
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
10.6
20.7
41
46
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.9
19.3
46
71
JFA00
NOMESCO Finland
Enterotomy
+∞
17.9
17
*
JFB00
NOMESCO Finland
Partial resection of small intestine
46.0
17.6
21
5
5603C
ICD-9 Finland
Intestinal obstruction without mention of hernia, Impaction of intestine[OBSTRUCTIO INTESTINALIS,KOVETTUNUT SUOLENSISÄLTÖ]
+∞
16.9
16
*
K59.09
ICD-10 Finland
Constipation, unspecified
14.3
16.7
28
22
ZXD05
NOMESCO Finland
Urgent procedure
3.4
15.8
98
410
A06AC01
ATC
ispaghula (psylla seeds); oral
3.7
14.1
70
241
JN3AD
NOMESCO Finland
Abdominal CT examination
7.4
13.7
33
51
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
+∞
13.7
13
*
K56.0
ICD-10 Finland
Paralytic ileus
+∞
13.7
13
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
13.2
83
339
JAH00
NOMESCO Finland
Laparotomy
13.4
12.9
22
18
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
15.8
12.0
19
13
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
126.1
11.5
12
*
UJF30
NOMESCO Finland
Ileoscopy through colon
7.9
11.1
25
35
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.7
10.3
26
43
N02AX02
ATC
tramadol; systemic, rectal
2.5
9.7
110
620
5603X
ICD-9 Finland
Intestinal obstruction without mention of hernia, Impaction of intestine[OBSTRUCTIO INTESTINALIS,MUU SUOLEN SISÄINEN SYY]
+∞
9.4
9
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.3
9.3
50
177
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
8.9
49
177
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.6
8.9
22
36
A06AD11
ATC
lactulose; oral
3.1
8.6
52
201
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.2
8.5
47
171
K56.2
ICD-10 Finland
Volvulus
+∞
8.4
8
*
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
34.7
8.1
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
8.1
65
297
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
7.9
7.8
17
23
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
46.6
7.8
9
*
N05AH04
ATC
quetiapine; oral
3.0
7.5
45
171
56096
ICD-8 Finland
Intestinal obstruction without mention of hernia, Ileus propter adhaesionem (functione laesa circulationis intestinalis non indicata)
+∞
7.3
7
*
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
+∞
7.3
7
*
45599
ICD-8 Finland
Haemorrhoids
+∞
7.3
7
*
6561
FHL
Removal of fasteners and related measures
+∞
7.3
7
*
P01AB01
ATC
metronidazole; oral, rectal
2.3
7.2
85
471
B01AB05
ATC
enoxaparin; parenteral
2.3
7.1
76
404
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
8.7
6.9
14
17
A02BC02
ATC
pantoprazole; systemic
2.1
6.9
144
1019
A07EC02
ATC
mesalazine; oral, rectal
6.2
6.8
17
29
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
6.7
51
227
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.1
6.6
13
15
N03AX16
ATC
pregabalin; oral
2.4
6.6
62
308
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
6.5
28
85
N02AA05
ATC
oxycodone; systemic
2.8
6.4
43
177
5608A
ICD-9 Finland
Intestinal obstruction without mention of hernia, Other specified intestinal obstruction[OBSTRUCTIO INTESTINALIS ,ADHESIONES INTRAABDOMINALE]
+∞
6.3
6
*
N06AX03
ATC
mianserin; oral
5.5
6.1
17
33
Mortality – FinRegistry
↥Association
Association between endpoint K11_IMPACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_IMPACT | 1.676 [1.35, 2.08] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.109 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 744 females with K11_IMPACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_IMPACT | 2.113 [1.56, 2.85] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 515 males with K11_IMPACT died.
Mortality risk
Mortality risk for people of age
years, who have K11_IMPACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.352% |
| 5 | 0.97% | 2.227% |
| 10 | 2.367% | 5.192% |
| 15 | 4.398% | 10.302% |
| 20 | 7.868% | 16.948% |
Relationships between endpoints
↥Index endpoint: K11_IMPACT – Impaction of intestines
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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