Risteys · K11_MALABSORB

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K90 Hospital discharge: ICD-9 — 579 Hospital discharge: ICD-8 — 269[1-2] Hospital discharge: excluded ICD-10 — K90.0 Hospital discharge: excluded ICD-9 — 5790A\|5793 Cause of death: ICD-10 — K90 Cause of death: ICD-9 — 579 Cause of death: ICD-8 — 269[1-2] Cause of death: excluded ICD-10 — K90.0 Cause of death: excluded ICD-9 — 5790A\|5793 2 out of 7 registries used, show all original rules.	1731
4. Check minimum number of events None	1731
5. Include endpoints None	1731
6. Filter based on genotype QC (FinnGen only)	1731

	All	Female	Male
Number of individuals
Whole population	11847	6237	5568
Only index persons	10703	5689	5014
Unadjusted period prevalence (%)
Whole population	0.17	0.18	0.16
Only index persons	0.20	0.21	0.19
Median age at first event (years)
Whole population	43.35	44.21	42.26
Only index persons	40.87	42.42	39.10

	All	Female	Male
Number of individuals	1731	1029	702
Unadjusted period prevalence (%)	0.33	0.35	0.31
Median age at first event (years)	49.17	44.82	55.55

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1556: Matched controls
15560

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K90.9

ICD-10 Finland

Intestinal malabsorption, unspecified

2749.4

323.0

433

133

Kela drug reimbursment

Severe chronic pancreatic insufficiency

139.1

323.0

426

K90.3

ICD-10 Finland

Pancreatic steatorrhoea

1536.8

323.0

516

K90.0

ICD-10 Finland

Coeliac disease

151.4

323.0

370

A09AA02

ATC

multienzymes (lipase, protease etc.)

83.9

323.0

475

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

7.5

276.5

889

2358

C10AC01

ATC

colestyramine; oral

24.7

200.4

290

143

26910

ICD-8 Finland

Other nutritional deficiency, Malabsorption syndrome, unspecified

+∞

199.3

187

K90.4

ICD-10 Finland

Malabsorption due to intolerance, not elsewhere classified

+∞

193.9

182

UJF32

NOMESCO Finland

Coloscopy

4.1

124.4

624

2169

K90.8

ICD-10 Finland

Other intestinal malabsorption

375.3

106.6

106

601

Kela drug reimbursment

Severe malabsorption of nutrients, mainly fats

52.6

105.1

126

K86.1

ICD-10 Finland

Other chronic pancreatitis

36.4

91.4

118

E13.9

ICD-10 Finland

Other specified diabetes mellitus, without complications

29.1

74.2

101

5798A

ICD-9 Finland

Intestinal malabsorption, Other specified intestinal malabsorption[RUOKA-AINEALLERGIAAN LIITTYVÄ MALABSORPTIO]

+∞

71.4

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

5.1

68.5

235

523

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.7

68.4

707

3713

A10AE04

ATC

insulin glargine; parenteral

4.6

67.7

260

652

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.6

65.2

337

1102

T89

ICPC

Diabetes insulin dependent

6.9

61.7

162

257

JN3BD

NOMESCO Finland

Extensive abdominal CT

4.0

60.8

274

794

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.5

60.2

751

4277

K59.1

ICD-10 Finland

Functional diarrhoea

5.8

58.2

175

331

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.6

57.8

582

2936

K86.00

ICD-10 Finland

Acute pancreatitis caused by alcohol

21.3

57.2

K92.1

ICD-10 Finland

Melaena

15.4

55.0

UJK02

NOMESCO Finland

ERCP

10.0

54.8

113

121

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.0

52.5

230

644

JN3AD

NOMESCO Finland

Abdominal CT examination

4.3

52.5

211

546

A02BC02

ATC

pantoprazole; systemic

2.3

51.7

1056

7431

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

5.7

51.0

156

300

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.9

50.9

356

1422

K86.08

ICD-10 Finland

Alcohol-induced chronic pancreatitis

40.3

49.4

K90

ICD-10 Finland

Intestinal malabsorption

+∞

48.2

K58.0

ICD-10 Finland

Irritable bowel syndrome with diarrhoea

4.7

47.6

173

403

K52.9

ICD-10 Finland

Noninfective gastroenteritis and colitis, unspecified

6.2

47.0

133

232

UJF30

NOMESCO Finland

Ileoscopy through colon

3.6

46.6

230

710

UJF92

NOMESCO Finland

Capsular endoscopy

10.4

46.0

SPAT1262

SPAT

Handing over of treatment supplies

2.8

45.9

353

1485

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.7

44.0

344

1460

A06AC01

ATC

ispaghula (psylla seeds); oral

2.5

43.6

440

2152

A07EA06

ATC

budesonide; oral, local oral

6.7

42.9

113

179

JLC30

NOMESCO Finland

Pancreatoduodenectomy

36.5

41.5

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

4.9

41.0

141

309

A02BC05

ATC

esomeprazole; systemic

2.1

40.9

684

4213

103

Kela drug reimbursment

Diabetes, insulin-treated

2.4

40.8

453

2313

K52.88

ICD-10 Finland

Other specified noninfective gastroenteritis and colitis

8.4

40.8

115

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.4

40.8

427

2119

501

Kela drug reimbursment

Cow's milk and / or soy protein allergy in young children

16.5

40.2

K92.0

ICD-10 Finland

Haematemesis

66.1

39.3

J01MA12

ATC

levofloxacin; systemic

2.6

38.7

334

1488

C25.0

ICD-10 Finland

Malignant neoplasm: Head of pancreas

15.5

38.6

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

6.1

38.2

108

188

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

3.7

38.1

180

532

K86.8

ICD-10 Finland

Other specified diseases of pancreas

46.2

37.0

JKE18

NOMESCO Finland

Endoscopic internal drainage of bile duct

17.2

36.5

K85

ICD-10 Finland

Acute pancreatitis

9.8

35.5

A02BC03

ATC

lansoprazole; oral

2.1

35.4

489

2733

N02AX02

ATC

tramadol; systemic, rectal

2.0

34.9

677

4344

N06AX21

ATC

duloxetine; oral

3.0

33.5

216

800

J01MA02

ATC

ciprofloxacin; systemic

2.0

33.1

615

3855

B03BA03

ATC

hydroxocobalamin; parenteral

4.3

33.0

130

326

A03FA01

ATC

metoclopramide; systemic, rectal

2.3

32.8

368

1859

JL5SB

NOMESCO Finland

Endoscopic retrograd cholangiopancreaticography

10.1

32.8

K86.9

ICD-10 Finland

Disease of pancreas, unspecified

38.2

32.6

UJD02

NOMESCO Finland

Gastroscopy

4.5

32.3

120

284

A10AE05

ATC

insulin detemir; parenteral

3.9

32.2

141

389

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

5.2

32.1

104

213

A07EC02

ATC

mesalazine; oral, rectal

4.0

31.9

136

367

K85.9

ICD-10 Finland

Acute pancreatitis, unspecified

8.0

31.7

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.6

31.4

258

1107

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

6.5

30.9

131

D37.7

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Other digestive organs

6.3

30.9

139

R11

ICD-10 Finland

Nausea and vomiting

3.2

30.9

173

581

N03AX16

ATC

pregabalin; oral

2.2

30.4

392

2098

Z01.8

ICD-10 Finland

Other specified special examinations

2.2

30.3

376

1979

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

4.4

30.2

114

274

ZXD05

NOMESCO Finland

Urgent procedure

2.0

30.1

515

3099

L04AX01

ATC

azathioprine; systemic

4.3

29.7

114

279

H02AB06

ATC

prednisolone; systemic

1.9

29.5

734

5048

A02BC01

ATC

omeprazole; systemic

2.0

29.4

452

2601

JN1DG

NOMESCO Finland

Very extensive MRI examination of upper part of abdomen with high intensity magnet

8.2

29.1

K83.1

ICD-10 Finland

Obstruction of bile duct

10.2

28.6

N05BA04

ATC

oxazepam; oral

2.0

27.4

412

2341

WX302

NOMESCO Finland

Thoracal epidural anesthesy

4.0

27.4

115

306

107

Kela drug reimbursment

Pernicious anaemia

7.7

27.3

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

4.5

26.9

228

N02AA05

ATC

oxycodone; systemic

2.5

26.5

231

1018

K90.2

ICD-10 Finland

Blind loop syndrome, not elsewhere classified

+∞

26.1

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

3.4

26.1

132

410

C03CA01

ATC

furosemide; systemic

2.0

25.8

385

2171

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

2.3

25.6

269

1301

A10AE06

ATC

insulin degludec; parenteral

4.9

25.4

181

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.8

25.1

544

3515

R50.9

ICD-10 Finland

Fever, unspecified

2.4

25.1

245

1143

5799X

ICD-9 Finland

Intestinal malabsorption, Unspecified intestinal malabsorption

+∞

25.1

TPH04

NOMESCO Finland

Cathetrisation of vein

2.1

25.0

335

1806

WZC30

NOMESCO Finland

Teaching

2.4

25.0

234

1068

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.9

24.9

451

2735

E14.9

ICD-10 Finland

Unspecified diabetes mellitus, without complications

6.3

24.9

110

K91.2

ICD-10 Finland

Postsurgical malabsorption, not elsewhere classified

254.0

24.7

208

Kela drug reimbursment

Ulcerative colitis and Crohn's disease

3.8

24.7

107

293

JL5BG

NOMESCO Finland

MRI examinaiton of bile and pancreas ducts with high intesity magnet

5.8

24.5

128

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

2.7

24.2

180

724

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.4

24.1

221

995

5790A

ICD-9 Finland

Intestinal malabsorption, Coeliac disease

+∞

24.0

E0000UV

ATC

1.8

23.8

613

4171

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

6.5

23.7

E10

ICD-10 Finland

Type 1 diabetes mellitus

6.6

23.6

K86.3

ICD-10 Finland

Pseudocyst of pancreas

18.4

23.5

N06AX11

ATC

mirtazapine; oral

1.8

23.3

494

3152

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

8.7

23.2

5770D

ICD-9 Finland

Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICA NONHAEMORHAGICA]

25.1

23.1

WX408

NOMESCO Finland

General anesthesy, balanced

1.9

23.0

433

2648

A07DA03

ATC

loperamide; oral

4.5

22.9

188

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

3.4

22.6

116

364

WX002

NOMESCO Finland

Sedation and analgesia

2.1

22.6

312

1694

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

5.1

22.5

146

A10AA01

ATC

4.8

22.5

168

K86.01

ICD-10 Finland

Late effects of pancreatitis caused by alcohol

45.7

22.4

AA1AD

NOMESCO Finland

CT of head and brain

2.0

22.2

350

1999

JAH00

NOMESCO Finland

Laparotomy

5.1

22.2

144

A02BA02

ATC

ranitidine; systemic

2.0

21.8

310

1701

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.3

21.5

222

1059

ZXE00

NOMESCO Finland

One hour or less

1.7

21.4

623

4357

JN4BD

NOMESCO Finland

Extensive body CT

2.5

21.4

184

801

K51.9

ICD-10 Finland

Ulcerative colitis, unspecified

4.8

21.4

159

JF1AB

NOMESCO Finland

Passage examination of small bowell with X-ray

9.1

21.4

N05CF01

ATC

zopiclone; oral

1.8

21.3

469

3010

D99

ICPC

Disease digestive system other

10.8

20.9

K50.1

ICD-10 Finland

Crohn disease of large intestine

9.0

20.9

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

9.8

20.9

A11CC03

ATC

alfacalcidol; systemic

5.6

20.8

112

N05AH04

ATC

quetiapine; oral

2.1

20.8

269

1418

UJF02

NOMESCO Finland

Peroral enteroscopy

15.1

20.7

K30

ICD-10 Finland

Functional dyspepsia

2.4

20.7

189

847

26900

ICD-8 Finland

Other nutritional deficiency, Sprue and steatorrhoea

212.6

20.6

K50.8

ICD-10 Finland

Other Crohn disease

7.0

20.6

H04AA01

ATC

glucagon; nasal, parenteral

4.7

20.5

157

K50.0

ICD-10 Finland

Crohn disease of small intestine

6.6

20.5

SPAT1249

SPAT

Treatment-related counselling outside office

1.7

20.2

605

4245

N03AX12

ATC

gabapentin; oral

2.1

20.2

243

1240

N02BE01

ATC

paracetamol; systemic, rectal

1.9

20.1

1290

11247

K50.9

ICD-10 Finland

Crohn disease, unspecified

6.7

20.0

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

2.8

20.0

137

523

P01AB01

ATC

metronidazole; oral, rectal

1.7

19.9

596

4179

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

4.3

19.8

177

A10AA02

ATC

4.0

19.8

216

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.4

19.8

181

811

K85.0

ICD-10 Finland

Idiopathic acute pancreatitis

12.3

19.6

Y0599

ICD-8 Finland

Investigation of digestive system

6.4

19.4

JKE02

NOMESCO Finland

Transduodenal endoscopic incision of common bile duct orifice

7.4

19.3

JN4CD

NOMESCO Finland

Very extensive body CT

3.9

19.3

211

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.7

19.3

469

3084

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.7

19.3

615

4380

ZXE10

NOMESCO Finland

More than one and less than three hours

1.7

19.3

540

3705

K92.2

ICD-10 Finland

Gastrointestinal haemorrhage, unspecified

11.1

19.2

R63.4

ICD-10 Finland

Abnormal weight loss

3.9

19.2

212

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.5

19.0

158

675

RD210

NOMESCO Finland

5.7

19.0

100

R4190

NOMESCO Finland

Nutritional therapy

4.0

18.9

205

K58.9

ICD-10 Finland

Irritable bowel syndrome without diarrhoea

4.0

18.9

205

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

4.8

18.8

135

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

3.0

18.8

115

409

R53

ICD-10 Finland

Malaise and fatigue

1.9

18.8

310

1789

K90.1

ICD-10 Finland

Tropical sprue

+∞

18.8

S18

ICPC

Laceration/cut

1.7

18.7

612

4379

J01DB01

ATC

cefalexin; oral

1.8

18.6

1247

10824

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

2.3

18.6

189

893

TPX10

NOMESCO Finland

Implantation of vascular injection port

4.6

18.6

146

A03CA02

ATC

clidinium and psycholeptics; oral

3.1

18.5

106

360

SPAT1263

SPAT

Sampling

1.6

18.5

650

4737

J02AC01

ATC

fluconazole; systemic

1.7

18.4

600

4283

E87.6

ICD-10 Finland

Hypokalaemia

4.3

18.2

163

K83.0

ICD-10 Finland

Cholangitis

7.5

18.0

J01FF01

ATC

clindamycin; systemic

1.8

17.9

411

2647

130

Kela drug reimbursment

Malignant tumour

2.6

17.8

132

528

E10.6

ICD-10 Finland

Type 1 diabetes mellitus, With other specified complications

10.5

17.7

JK3MN

NOMESCO Finland

Bile absorbtion isotope examination

96.1

17.6

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.0

17.3

259

1439

XJD02

NOMESCO Finland

Peroral endoscopic ultrasonography

12.1

17.3

A03FA02

ATC

cisapride; oral, rectal

2.6

17.3

132

537

K56.6

ICD-10 Finland

Other and unspecified intestinal obstruction

4.3

17.3

157

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

2.4

17.2

154

680

WX110

NOMESCO Finland

Local anesthesy

1.6

17.2

1047

8718

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

2.5

17.2

141

598

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

1.9

17.1

305

1805

25000

ICD-8 Finland

Diabetes mellitus, Sine complicatione

4.8

17.0

123

SPAT1260

SPAT

Consultation of another employee

1.9

16.8

281

1621

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.6

16.7

626

4601

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.8

16.5

312

1881

D64.9

ICD-10 Finland

Anaemia, unspecified

2.4

16.5

144

627

J01DA01

ATC

[U] cefalexin; systemic

1.6

16.3

929

7553

JKA21

NOMESCO Finland

Laparoscopic cholecystectomy

2.2

16.3

176

854

D11

ICPC

Diarrhoea

2.1

16.2

190

952

8140/3-C25.9

ICD-O-3

Adenocarcinoma, NOS, of pancreas, NOS

15.5

16.2

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.1

16.1

204

1058

D07AA02

ATC

hydrocortisone; topical

2.0

16.1

229

1243

XCK10

NOMESCO Finland

Photography of fundus of eye

2.3

16.1

163

768

H02AB09

ATC

hydrocortisone; systemic

4.7

16.1

117

ZXE20

NOMESCO Finland

More than three and less than five hours

2.0

16.0

215

1140

2500B

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]

4.6

16.0

122

JK3NB

NOMESCO Finland

Percutaneous transhepatic cholangiography

21.2

16.0

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.1

15.9

288

K85.2

ICD-10 Finland

Alcohol-induced acute pancreatitis

12.4

15.9

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.9

15.8

241

1345

C25.9

ICD-10 Finland

Malignant neoplasm: Pancreas, unspecified

9.9

15.7

SPAT1139

SPAT

Nutrition survey

3.7

15.7

193

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.3

15.6

150

689

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.7

15.6

366

2355

JK4ZT

NOMESCO Finland

Percutaneous transhepatic implantation of bile duct prothesis

85.9

15.6

H3603, E103

ICD-10 Finland

7.3

15.6

M05BA04

ATC

alendronic acid; oral

2.5

15.6

122

505

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.2

15.5

173

851

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.2

15.4

167

809

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.9

15.4

265

1544

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

5.5

15.3

N06AB04

ATC

citalopram; systemic

1.8

15.3

323

2012

K56.5

ICD-10 Finland

Intestinal adhesions [bands] with obstruction

6.5

15.2

M81.9

ICD-10 Finland

Osteoporosis, unspecified

3.6

15.2

203

K85.8

ICD-10 Finland

Other acute pancreatitis

10.5

15.2

N02AB03

ATC

fentanyl; nasal, sublingual, transdermal

3.8

15.2

178

SPAT1312

SPAT

General health counselling

1.6

15.1

484

3393

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.5

15.1

125

532

T90

ICPC

Diabetes non-insulin dependent

1.8

15.0

313

1939

B81

ICPC

Anaemia vit B12/folate deficiency

3.4

15.0

216

JN4AD

NOMESCO Finland

Body CT examination

2.4

14.9

126

541

SPAT1153

SPAT

Removal of sutures

1.6

14.9

450

3104

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

2.8

14.9

371

JFB00

NOMESCO Finland

Partial resection of small intestine

6.1

14.9

E86

ICD-10 Finland

Volume depletion

4.8

14.8

105

A12AA04

ATC

calcium carbonate; oral

6.5

14.8

R51.80

ICD-10 Finland

Headache

1.9

14.7

233

1315

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.2

14.7

155

740

JF1CG

NOMESCO Finland

Extensive MRI of small bowel

9.8

14.7

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

2.7

14.6

105

412

R13

ICD-10 Finland

Dysphagia

2.6

14.5

105

415

E10.1

ICD-10 Finland

Type 1 diabetes mellitus, With ketoacidosis

6.5

14.5

JK3BT

NOMESCO Finland

Catherisation of bile duct with X-ray guidance

15.5

14.4

N05CD07

ATC

temazepam; oral

2.1

14.4

173

878

P01BA02

ATC

hydroxychloroquine; oral

2.3

14.3

133

599

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.5

14.3

798

6366

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.6

14.3

460

3222

N05BA01

ATC

diazepam; systemic, rectal

2.0

14.3

204

1110

JL5CG

NOMESCO Finland

Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet

8.7

14.2

G63.2*E10.4

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic polyneuropathy

19.3

14.2

K86.2

ICD-10 Finland

Cyst of pancreas

10.5

14.2

OAB74

NOMESCO Finland

Nutritional guidance related to treatment and rehabilitation for medical condition

9.2

14.2

L13.0

ICD-10 Finland

Dermatitis herpetiformis

13.5

14.2

E000001

ATC

1.7

14.1

307

1925

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.1

14.1

177

911

A06AC51

ATC

ispaghula, combinations; systemic

2.9

14.1

318

H36.09*E10.3

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic retinopathy

7.9

13.9

M79.6

ICD-10 Finland

Pain in limb

1.6

13.9

509

3676

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.0

13.8

191

1026

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

3.6

13.8

172

K29.1

ICD-10 Finland

Other acute gastritis

7.4

13.7

177

Kela drug reimbursment

Insulin glargine 300 U / ml

4.5

13.7

109

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.7

13.7

295

1841

N06AX16

ATC

venlafaxine; oral

1.9

13.7

216

1219

N06AB10

ATC

escitalopram; oral

1.7

13.5

309

1963

K29.3

ICD-10 Finland

Chronic superficial gastritis

3.6

13.5

170

WX290

NOMESCO Finland

Other blockade of nerve

1.5

13.5

669

5173

K51.5

ICD-10 Finland

Left sided colitis

4.0

13.5

135

C07AB07

ATC

bisoprolol; oral

1.5

13.4

601

4545

E13

ICD-10 Finland

Other specified diabetes mellitus

26.0

13.4

E13.8

ICD-10 Finland

Other specified diabetes mellitus, with unspecified complications

26.0

13.4

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

4.5

13.3

108

E10.4

ICD-10 Finland

Type 1 diabetes mellitus, With neurological complications

8.6

13.3

R06AE07

ATC

cetirizine; oral

1.5

13.2

637

4891

A01AB09

ATC

miconazole; local oral

2.2

13.1

142

687

SPAT1254

SPAT

Administration of medicine

1.9

13.1

208

1174

N06AA09

ATC

amitriptyline; systemic

2.1

13.1

153

765

SPAT1310

SPAT

Counselling related to known health issue

1.6

13.1

473

3397

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

2.3

13.0

122

555

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

3.3

12.9

198

UJF12

NOMESCO Finland

Enteroscopy through intestinal stoma

22.7

12.9

K65.0

ICD-10 Finland

Acute peritonitis

7.8

12.9

A06AD11

ATC

lactulose; oral

1.9

12.9

189

1036

SPAT1149

SPAT

Suture or treatment of traumatic wound

1.9

12.8

189

1038

D07AC01

ATC

betamethasone; topical

1.6

12.8

467

3355

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.5

12.7

654

5077

K29.5

ICD-10 Finland

Chronic gastritis, unspecified

3.9

12.7

133

JFF13

NOMESCO Finland

Terminal enterostomy

24.5

12.5

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

5.7

12.4

Z49.1

ICD-10 Finland

Extracorporeal dialysis

6.9

12.4

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

6.9

12.4

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

4.0

12.4

126

Z04.9

ICD-10 Finland

Examination and observation for unspecified reason

2.9

12.3

257

SPAT1240

SPAT

Therapeutic discussion

2.0

12.3

169

903

XX3DW

NOMESCO Finland

Time consuming IT work

2.1

12.2

149

762

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.1

12.2

138

683

ZX120

NOMESCO Finland

Intravenous

2.1

12.2

136

670

E10.8

ICD-10 Finland

Type 1 diabetes mellitus, With unspecified complications

5.5

12.1

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.6

12.1

326

2165

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

3.0

12.1

242

JLB28

NOMESCO Finland

Endoscopic internal drainage of pancreatic duct

21.5

12.0

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

2.3

12.0

110

493

JKE22

NOMESCO Finland

Endoscopic extraction of foreign body from bile duct

13.5

11.9

A10AB06

ATC

insulin glulisine; parenteral

6.8

11.9

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.6

11.9

397

2785

E13.7

ICD-10 Finland

Other specified diabetes mellitus, with multiple complications

47.0

11.9

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

2.6

11.8

335

H3601, E103

ICD-10 Finland

7.1

11.8

H04.10

ICD-10 Finland

Dry eye syndrome

2.1

11.8

144

735

A07EC01

ATC

sulfasalazine; oral, rectal

2.2

11.8

126

608

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.3

11.7

113

518

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.0

11.7

151

786

NF1AA

NOMESCO Finland

Hip X-ray examination

2.2

11.7

116

541

JDW98

NOMESCO Finland

Other transluminal endoscopic operation on stomach or duodenum

6.1

11.7

JL1AT

NOMESCO Finland

Biopsy of pancreas with ultrasound guidance

30.3

11.6

N17.9

ICD-10 Finland

Acute renal failure, unspecified

3.2

11.6

192

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.0

11.6

163

880

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.3

11.6

108

489

E16.9

ICD-10 Finland

Disorder of pancreatic internal secretion, unspecified

65.4

11.6

XFP96

NOMESCO Finland

Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation

4.7

11.5

SPAT1301

SPAT

No procedures

1.5

11.5

439

3172

5798X

ICD-9 Finland

Intestinal malabsorption, Other specified intestinal malabsorption[MALABSORPTIO ALIA DEFINITA]

+∞

11.5

M01AE03

ATC

ketoprofen; systemic, rectal

1.5

11.4

520

3908

A02BC04

ATC

rabeprazole; oral

2.1

11.4

128

632

1300

FHL

Esophagogastroduodenoscopy (also includes staining)

7.9

11.4

A07AA02

ATC

nystatin; oral

2.5

11.4

369

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

2.9

11.3

236

TPH07

NOMESCO Finland

Cathetrisation of artery

2.0

11.3

140

718

R42

ICD-10 Finland

Dizziness and giddiness

1.7

11.3

279

1804

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

3.0

11.3

230

M54.5

ICD-10 Finland

Low back pain

1.5

11.3

461

3380

XF600

NOMESCO Finland

Bloodpressure measurement

2.4

11.3

401

TK800

NOMESCO Finland

Hemodialysis

4.2

11.2

103

F10.29

ICD-10 Finland

Addiction caused by alcohol UNS

3.8

11.2

128

X59

ICD-10 Finland

Exposure to unspecified factor

1.7

11.2

263

1677

R73.9

ICD-10 Finland

Hyperglycaemia, unspecified

3.5

11.2

149

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

2.0

11.2

145

758

A04AA01

ATC

ondansetron; systemic, rectal

2.3

11.1

102

458

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.3

11.1

104

470

SPAT1138

SPAT

Guidance concerning bowel function

5.2

11.1

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

1.8

11.1

186

1071

JA3AT

NOMESCO Finland

Cathetrisation of abdominal cavity with ultrasound guidance

5.4

11.0

R03AC02

ATC

salbutamol; inhalant

1.4

11.0

752

6120

R06.0

ICD-10 Finland

Dyspnoea

1.6

11.0

328

2230

JF1BD

NOMESCO Finland

Very extensive small bowel CT

10.1

11.0

K29.8

ICD-10 Finland

Duodenitis

9.3

11.0

M01AH02

ATC

rofecoxib; oral

1.9

11.0

181

1032

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

6.3

10.9

UKC02

NOMESCO Finland

Cystoscopy

1.8

10.9

197

1161

A10AD01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)

4.3

10.9

D82

ICPC

Teeth/gum disease

1.5

10.9

503

3783

N18.8

ICD-10 Finland

Other chronic renal failure

3.8

10.8

122

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.5

10.8

394

2815

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.5

10.7

536

4097

JLC10

NOMESCO Finland

Distal pancreatectomy

17.9

10.7

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

4.0

10.7

108

E16.89

ICD-10 Finland

Other specified disorders of pancreatic internal secretion

60.4

10.6

5770F

ICD-9 Finland

Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICA RECIDIVANS]

60.4

10.6

R01AD08

ATC

fluticasone; nasal

1.5

10.6

405

2916

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

10.6

741

6043

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.1

10.6

115

558

L04AD01

ATC

ciclosporin; systemic

4.2

10.6

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

2.3

10.5

411

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.7

10.5

243

1541

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.6

10.4

291

1944

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

3.6

10.4

126

EBA00

NOMESCO Finland

Extraction of tooth

1.5

10.4

467

3483

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.8

10.4

178

1028

A07EA02

ATC

hydrocortisone; rectal

3.6

10.3

127

JL5AG

NOMESCO Finland

Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet

6.4

10.3

J01MA14

ATC

moxifloxacin; systemic

2.0

10.3

129

666

K56.0

ICD-10 Finland

Paralytic ileus

8.2

10.3

QXB99

NOMESCO Finland

Other procedure to treat skin wound, unspecified location

4.3

10.3

M79.7

ICD-10 Finland

Fibromyalgia

3.0

10.3

193

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

1.8

10.3

172

986

WVC10

NOMESCO Finland

Subcutaneous infusion of drugs

10.7

10.3

JKE98

NOMESCO Finland

Other transduodenal endoscopic operation on bile duct or ampulla of Vater

4.8

10.3

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.0

10.2

136

718

K29.9

ICD-10 Finland

Gastroduodenitis, unspecified

6.7

10.2

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

2.8

10.2

234

H3600, E103

ICD-10 Finland

5.1

10.2

UDQ12

NOMESCO Finland

Flexible laryngoscopy

2.4

10.2

386

JJ1CE

NOMESCO Finland

Liver, bile duct and pancreas endoscopic ultrasound examination

13.2

10.2

N06AB06

ATC

sertraline; oral

1.9

10.1

155

863

M25.5

ICD-10 Finland

Pain in joint

1.5

10.1

393

2836

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.5

10.1

380

2723

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.7

10.1

239

1524

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.5

10.1

393

2839

R15

ICD-10 Finland

Faecal incontinence

3.5

10.1

130

320

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

11.4

10.1

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

2.9

10.0

223

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

2.5

10.0

324

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.4

10.0

689

5584

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

7.3

10.0

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

2.2

10.0

100

471

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

2.5

10.0

299

K29.7

ICD-10 Finland

Gastritis, unspecified

2.9

9.9

203

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

6.8

9.9

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.8

9.9

162

923

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

2.4

9.9

346

H03AA01

ATC

levothyroxine sodium; systemic

1.6

9.9

327

2275

F43.29

ICD-10 Finland

Adaptation disorder UNS

3.5

9.9

132

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.0

9.9

123

631

M79.0

ICD-10 Finland

Rheumatism, unspecified

2.9

9.9

204

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.0

9.8

125

650

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

2.0

9.7

129

682

H02AB04

ATC

methylprednisolone; systemic

1.7

9.7

198

1210

A08.4

ICD-10 Finland

Viral intestinal infection, unspecified

2.8

9.7

224

Z93.2

ICD-10 Finland

Ileostomy status

13.5

9.7

WX402

NOMESCO Finland

General anaesthesia

1.6

9.7

242

1566

M14.6*E10.6

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic neuropathic

55.3

9.7

JDE00

NOMESCO Finland

Gastrojejunostomy

55.3

9.7

JLC40

NOMESCO Finland

Total pancreatoduodenectomy

55.3

9.7

K02.1

ICD-10 Finland

Caries of dentine

1.4

9.6

828

6968

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.0

9.6

119

610

WX882

NOMESCO Finland

High dependency care

3.2

9.6

157

R55

ICD-10 Finland

Syncope and collapse

1.9

9.6

139

759

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

2.1

9.6

108

534

M05BX04

ATC

denosumab; parenteral

2.6

9.6

268

R4180

NOMESCO Finland

Podiatric therapy

6.4

9.6

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

1.9

9.5

133

716

SPAT1211

SPAT

Application of soft bandage

1.9

9.5

131

702

JLW98

NOMESCO Finland

Other transluminal endoscopic operation on pancreas

15.1

9.5

JN1BD

NOMESCO Finland

Extensive CT examination of upper part of abdomen

7.2

9.5

A41.9

ICD-10 Finland

Sepsis, unspecified

3.0

9.5

184

JKA20

NOMESCO Finland

Cholecystectomy

3.2

9.4

148

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

2.7

9.4

238

SAA02

NOMESCO Finland

Basic examination of mouth

1.4

9.4

932

8025

SPAT1222

SPAT

Counselling/guidance promoting independent living

1.7

9.4

190

1157

K86.0

ICD-10 Finland

Alcohol-induced chronic pancreatitis

30.2

9.4

JF1DG

NOMESCO Finland

Small bowel very extensive MRI with with high intensity magnet

21.8

9.4

JLB35

NOMESCO Finland

Transduodenal endoscopic extraction of foreign body from pancreatic duct

21.8

9.4

D07AC13

ATC

mometasone; topical

1.5

9.4

393

2880

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.6

9.3

264

1765

R07.4

ICD-10 Finland

Chest pain, unspecified

1.5

9.3

350

2502

JA2AT

NOMESCO Finland

Abdominal puncture with ultrasound guidance

7.0

9.3

C09AA05

ATC

ramipril; oral

1.6

9.3

297

2047

R01AD09

ATC

mometasone; nasal

1.4

9.3

634

5107

K51.1

ICD-10 Finland

Ulcerative (chronic) ileocolitis

7.3

9.2

R01BA52

ATC

pseudoephedrine, combinations; oral

1.5

9.2

419

3120

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.7

9.2

183

1111

N06AA12

ATC

doxepin; systemic

2.4

9.2

327

K10.3

ICD-10 Finland

Alveolitis of jaws

2.4

9.2

319

N02AC04

ATC

dextropropoxyphene; oral

3.0

9.1

169

C07AA05

ATC

propranolol; systemic

1.6

9.1

274

1858

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

1.7

9.0

190

1172

26998

ICD-8 Finland

Other nutritional deficiency, Aliae definitae

36.9

9.0

E10.00

ICD-10 Finland

Insulin-dependent diabetes diabetic hypoglycemic coma

4.9

9.0

T81.9

ICD-10 Finland

Unspecified complication of procedure

4.0

9.0

T81.8

ICD-10 Finland

Other complications of procedures, not elsewhere classified

3.7

8.9

101

K29.2

ICD-10 Finland

Alcoholic gastritis

18.7

8.9

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

8.9

779

6535

K51.8

ICD-10 Finland

Other ulcerative colitis

5.3

8.9

M01AB55

ATC

diclofenac, combinations; oral

2.1

8.9

475

B03XA02

ATC

darbepoetin alfa; parenteral

4.1

8.9

B01AB05

ATC

enoxaparin; parenteral

1.5

8.8

382

2813

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

2.3

8.8

365

SAA01

NOMESCO Finland

Simple examination of mouth

1.4

8.8

1028

9058

JN3DE

NOMESCO Finland

Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation

8.7

8.8

C03DA01

ATC

spironolactone; oral

1.9

8.8

129

709

M01AC06

ATC

meloxicam; systemic, rectal

1.4

8.8

478

3684

JN1BG

NOMESCO Finland

MRI examination of upper part of abodmen with high intensity magnet

6.0

8.8

N02AJ06

ATC

codeine and paracetamol; systemic

1.4

8.7

512

3999

J45.9

ICD-10 Finland

Asthma, unspecified

1.6

8.7

236

1559

F51.0

ICD-10 Finland

Nonorganic insomnia

1.7

8.7

182

1118

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

2.4

8.7

297

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

6.6

8.7

SPAT1097

SPAT

Recording of ECG

1.7

8.7

188

1171

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

2.1

8.6

493

SPAT1225

SPAT

Implementation of podiatry rehabilitation plan

3.3

8.6

131

E83.51

ICD-10 Finland

Hypocalcemia

8.3

8.6

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

4.5

8.6

602

Kela drug reimbursment

Children's severe malnutrition

16.4

8.6

J01AA02

ATC

doxycycline; systemic

1.4

8.5

1091

9735

K72.9

ICD-10 Finland

Hepatic failure, unspecified

10.1

8.5

K80.5

ICD-10 Finland

Calculus of bile duct without cholangitis or cholecystitis

3.3

8.5

127

F10.24

ICD-10 Finland

Alcohol depence active use

4.6

8.5

A07AA09

ATC

vancomycin; oral

5.7

8.4

N03AX09

ATC

lamotrigine; oral

2.3

8.4

340

K56.7

ICD-10 Finland

Ileus, unspecified

4.7

8.4

5583A

ICD-9 Finland

Other non-infective gastro-enteritis and colitis[ALLERGINEN SUOLISAIRAUS]

90.5

8.4

Z2446

NOMESCO Finland

Social worker

2.1

8.4

484

K91.8

ICD-10 Finland

Other postprocedural disorders of digestive system, not elsewhere classified

+∞

8.3

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.0

8.3

501

F10.26

ICD-10 Finland

Alcohol dependence periodic alcoholism

4.3

8.3

N05AB01

ATC

dixyrazine; systemic

5.5

8.3

C10AC02

ATC

colestipol; oral

10.8

8.3

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

1.7

8.3

189

1192

D37.9

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified

9.5

8.3

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

4.0

8.3

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.4

8.3

810

6893

WW500

NOMESCO Finland

Blood transfusion

2.7

8.2

215

A02BX02

ATC

sucralfate; oral

2.5

8.2

241

B01AB10

ATC

tinzaparin; parenteral

2.0

8.2

495

F10.20

ICD-10 Finland

Alcohol dependence currently independent

3.5

8.2

109

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

2.8

8.2

192

D80.1

ICD-10 Finland

Nonfamilial hypogammaglobulinaemia

14.5

8.2

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

2.6

8.2

224

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.4

8.2

280

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

2.4

8.2

280

N05CF02

ATC

zolpidem; oral

1.6

8.2

237

1591

127

Kela drug reimbursment

Transplant complication

3.9

8.2

N05BA12

ATC

alprazolam; oral

1.8

8.1

140

811

L04AB04

ATC

adalimumab; parenteral

3.4

8.1

110

Z51.5

ICD-10 Finland

Palliative care

2.3

8.1

342

J01FA10

ATC

azithromycin; systemic

1.4

8.1

816

6960

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

2.1

8.1

414

A05AA02

ATC

ursodeoxycholic acid; oral

3.5

8.1

105

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

2.4

8.1

293

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.4

8.1

548

4378

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.6

8.1

207

1348

QXA20

NOMESCO Finland

Skin abrasion, unspecified location

11.8

8.1

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

1.7

8.0

174

1082

D80.9

ICD-10 Finland

Immunodeficiency with predominantly antibody defects, unspecified

22.1

8.0

TKC20

NOMESCO Finland

Catheterisation of bladder

2.1

8.0

432

3AC01

NOMESCO Finland

5.9

8.0

G44.2

ICD-10 Finland

Tension-type headache

1.7

8.0

186

1178

J05AB01

ATC

aciclovir; systemic

1.5

8.0

284

2002

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.0

8.0

473

B99

ICD-10 Finland

Other and unspecified infectious diseases

3.8

8.0

D13.1

ICD-10 Finland

Benign neoplasm: Stomach

3.4

8.0

112

N03AE01

ATC

clonazepam; systemic

2.2

7.9

386

UGC12

NOMESCO Finland

Flexible bronchoscopy

2.0

7.9

504

V03AE01

ATC

polystyrene sulfonate; oral

5.0

7.9

R10.0

ICD-10 Finland

Acute abdomen

2.7

7.9

199

K83.9

ICD-10 Finland

Disease of biliary tract, unspecified

13.1

7.9

K52.2

ICD-10 Finland

Allergic and dietetic gastroenteritis and colitis

7.8

7.9

D62

ICD-10 Finland

Acute posthaemorrhagic anaemia

7.8

7.9

Z3226

NOMESCO Finland

Physiotherapist

1.6

7.9

244

1666

A41.8

ICD-10 Finland

Other specified sepsis

4.3

7.8

UDH02

NOMESCO Finland

Rhinopharyngoscopy

2.0

7.8

471

E000006

ATC

2.0

7.8

101

528

XF400

NOMESCO Finland

ECG with 12 standard connections

1.6

7.8

204

1336

JLB42

NOMESCO Finland

Transduodenal endoscopic dilatation of pancreatic duct

45.2

7.7

120

Kela drug reimbursment

Hypogammaglobulinaemia

15.1

7.7

N06CA01

ATC

amitriptyline and psycholeptics; systemic

1.8

7.7

133

773

D13.6

ICD-10 Finland

Benign neoplasm: Pancreas

6.4

7.7

R35

ICD-10 Finland

Polyuria

2.2

7.7

377

GD1AD

NOMESCO Finland

Thorax CT examination

2.4

7.7

251

JFA15

NOMESCO Finland

Endoscopic polypectomy in colon

2.3

7.7

301

Z01.2

ICD-10 Finland

Dental examination

1.4

7.7

578

4692

N06AX12

ATC

bupropion; oral

2.0

7.6

470

N04BC05

ATC

pramipexole; oral

2.0

7.6

470

C01CA24

ATC

epinephrine; parenteral

2.0

7.6

471

NA1AD

NOMESCO Finland

Cervical spine CT examination

2.5

7.6

245

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

2.1

7.6

434

JMA10

NOMESCO Finland

Transabdominal total splenectomy

6.7

7.6

JAH01

NOMESCO Finland

Laparoscopy

2.2

7.6

338

M54.4

ICD-10 Finland

Lumbago with sciatica

1.6

7.6

218

1460

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

1.9

7.6

104

559

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

1.9

7.6

110

604

Z54.0

ICD-10 Finland

Convalescence following surgery

3.8

7.6

D07AB02

ATC

hydrocortisone butyrate; topical

1.4

7.6

367

2753

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

2.4

7.6

274

BEF00

NOMESCO Finland

Continuous subcutaneous glucose monitoring

5.2

7.6

JF1AD

NOMESCO Finland

Small bowel CT

8.9

7.5

Z00.0

ICD-10 Finland

General medical examination

1.5

7.5

251

1740

R60.9

ICD-10 Finland

Oedema, unspecified

2.3

7.5

299

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

3.1

7.5

129

SGA02

NOMESCO Finland

Opening and dilatation of root canal of tooth

1.7

7.5

170

1071

H02AB07

ATC

prednisone; oral

1.6

7.4

181

1163

CL2S4

NOMESCO Finland

Ocular fundus photography for diabetic retinopathy screening

3.4

7.4

102

JLD00

NOMESCO Finland

Pancreaticojejunostomy

80.4

7.4

C24.1

ICD-10 Finland

Malignant neoplasm: Ampulla of Vater

80.4

7.4

JLA00

NOMESCO Finland

Exploration of pancreas

80.4

7.4

J01MA06

ATC

norfloxacin; oral

1.7

7.4

168

1057

D94

ICPC

Chronic enteritis/ulcerative colitis

7.7

7.4

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

2.5

7.4

225

C07AB02

ATC

metoprolol; systemic

1.5

7.4

244

1688

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

3.8

7.4

L95

ICPC

Osteoporosis

2.9

7.3

153

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

3.0

7.3

131

E84.9

ICD-10 Finland

Cystic fibrosis, unspecified

+∞

7.3

E84.1

ICD-10 Finland

Cystic fibrosis with intestinal manifestations

+∞

7.3

5770E

ICD-9 Finland

Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICAHAEMORRHAGICA]

+∞

7.3

R05CB13

ATC

dornase alfa (desoxyribonuclease); inhalant

+∞

7.3

JK3NT

NOMESCO Finland

Percutaneous transhepatic dilatation of bileducts

+∞

7.3

304

Kela drug reimbursment

Dornase alfa

+∞

7.3

E84.0

ICD-10 Finland

Cystic fibrosis with pulmonary manifestations

+∞

7.3

E13.2

ICD-10 Finland

Other specified diabetes mellitus, with renal complications

+∞

7.3

Z94.0

ICD-10 Finland

Kidney transplant status

4.5

7.3

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.3

7.3

610

5028

SPAT1104

SPAT

Monitoring of emergency patient

2.0

7.3

471

E16.2

ICD-10 Finland

Hypoglycaemia, unspecified

4.3

7.2

M75.0

ICD-10 Finland

Adhesive capsulitis of shoulder

2.1

7.2

396

0093A

ICD-9 Finland

Ill-defined intestinal infections, Diarrhoea of presumed infectious origin

4.1

7.2

R20.2

ICD-10 Finland

Paraesthesia of skin

2.0

7.2

461

NH3EA

NOMESCO Finland

Feet X-ray examination with load

3.3

7.2

105

TGC00

NOMESCO Finland

Bronchial lavation

3.0

7.2

133

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

1.7

7.2

161

1010

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.8

7.2

116

661

K80.8

ICD-10 Finland

Other cholelithiasis

3.7

7.2

SGC00

NOMESCO Finland

Local medication of root channels of tooth

1.7

7.2

150

926

SPAT1130

SPAT

Esophagoscopy, gastroscopy and duodenoscopy

2.6

7.1

187

J45.1

ICD-10 Finland

Nonallergic asthma

1.9

7.1

526

K26.9

ICD-10 Finland

Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation

6.6

7.1

D93

ICPC

Irritable bowel syndrome

5.1

7.1

T36

ICD-10 Finland

Poisoning by systemic antibiotics

2.2

7.1

308

S72.0

ICD-10 Finland

Fracture of neck of femur

2.8

7.1

151

JN5DR

NOMESCO Finland

PET-CT of upper body metabolism

3.6

7.1

Z72.1

ICD-10 Finland

Alcohol use

4.0

7.1

K03.80

ICD-10 Finland

Irradiated enamel

2.2

7.1

330

1310

FHL

Esophagogastroscopy

12.1

7.1

137

Kela drug reimbursment

Uraemia requiring dialysis

5.6

7.1

L04AA06

ATC

mycophenolic acid; systemic

3.4

7.0

R07.3

ICD-10 Finland

Other chest pain

1.8

7.0

123

716

J01FA09

ATC

clarithromycin; systemic

1.4

7.0

423

3296

K76.9

ICD-10 Finland

Liver disease, unspecified

4.1

7.0

WX610

NOMESCO Finland

Patient controlled analgesia

7.0

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

2.7

7.0

169

SAA04

NOMESCO Finland

Special inverstigation of mouth

2.1

7.0

395

SPAT1325

SPAT

Vaccination

1.4

7.0

436

3418

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.9

7.0

139

N30.9

ICD-10 Finland

Cystitis, unspecified

2.1

7.0

360

SPAT1281

SPAT

Other administrative function

1.8

7.0

110

620

V700A

ICD-9 Finland

General medical examination, Routine general medical examination at a health care facility

2.9

6.9

140

M48.0

ICD-10 Finland

Spinal stenosis

1.7

6.9

141

860

N05AA02

ATC

levomepromazine; systemic

2.3

6.9

253

JA3BT

NOMESCO Finland

Cathetrisation of abdominal cavity with X-ray guidance

7.6

6.9

J06BA01

ATC

immunoglobulins, normal human, for extravascular adm.; systemic

13.8

6.9

L04AA01

ATC

[U] ciclosporin; systemic

3.6

6.9

K20

ICD-10 Finland

Oesophagitis

3.7

6.9

I84.2

ICD-10 Finland

Internal hemorrhoids without complication

1.9

6.9

100

549

A01AB04

ATC

amphotericin B; local oral

2.2

6.9

295

L28

ICPC

Limited function/disability (L)

1.6

6.9

172

1114

K04.0

ICD-10 Finland

Pulpitis

1.7

6.8

137

834

L08

ICPC

Shoulder symptom/complaint

1.5

6.8

245

1727

SPAT1255

SPAT

Intravenous administration of medicine

2.0

6.8

434

R03BA02

ATC

budesonide; inhalant

1.5

6.8

235

1638

M54.2

ICD-10 Finland

Cervicalgia

1.9

6.8

521

SPAT1216

SPAT

Assessment of functional ability

1.6

6.8

182

1194

F43.22

ICD-10 Finland

Adaptation disorder with mixed anxiety and depression

2.3

6.8

276

M03BX02

ATC

tizanidine; oral

1.3

6.8

860

7512

56310

ICD-8 Finland

Chronic enteritis and ulcerative colitis, Ulcerative colitis

11.0

6.8

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

2.0

6.8

398

R19.5

ICD-10 Finland

Other faecal abnormalities

4.0

6.8

A04AA02

ATC

granisetron; systemic, transdermal

2.0

6.8

440

J45.0

ICD-10 Finland

Predominantly allergic asthma

1.8

6.8

119

694

A07AA11

ATC

rifaximin; oral

40.2

6.8

V03AG01

ATC

sodium cellulose phosphate; systemic

40.2

6.8

ND1AA

NOMESCO Finland

Wrist X-ray examination

2.0

6.8

441

JAH33

NOMESCO Finland

Opening of laparostomy

16.8

6.7

M03BC01

ATC

orphenadrine (citrate); systemic

1.4

6.7

312

2316

K04.4

ICD-10 Finland

Acute apical periodontitis of pulpal origin

1.8

6.7

115

665

N03AX14

ATC

levetiracetam; systemic

2.8

6.7

145

JFB30

NOMESCO Finland

Right hemicolectomy

4.1

6.7

SGA01

NOMESCO Finland

Tooth opening as first aid

1.5

6.7

214

1469

M54.6

ICD-10 Finland

Pain in thoracic spine

1.9

6.7

519

E87.5

ICD-10 Finland

Hyperkalaemia

3.8

6.7

E89.1

ICD-10 Finland

Postprocedural hypoinsulinaemia

22.6

6.7

6918B

ICD-9 Finland

Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]

4.4

6.7

J01EA01

ATC

trimethoprim; systemic

1.4

6.6

316

2354

ICD-10 Finland

2.9

6.6

132

R56.8

ICD-10 Finland

Other and unspecified convulsions

2.1

6.6

346

A06AH03

ATC

naloxegol; oral

5.5

6.6

D12.2

ICD-10 Finland

Benign neoplasm: Ascending colon

2.7

6.6

153

SPAT1229

SPAT

Assessment of need for aid

1.9

6.6

527

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.6

6.6

174

1142

J01CA04

ATC

amoxicillin; systemic

1.4

6.6

1173

10758

M03BC51

ATC

orphenadrine, combinations; systemic

1.4

6.6

363

2781

ZY010

NOMESCO Finland

Hospital outpatient

2.1

6.6

347

S72.1

ICD-10 Finland

Pertrochanteric fracture

3.5

6.6

E11

ICD-10 Finland

Type 2 diabetes mellitus

1.6

6.6

184

1222

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

2.2

6.6

278

H01CB02

ATC

octreotide; parenteral

12.3

6.6

TJD00

NOMESCO Finland

Insertion of nasogastric or naso-gastroduodenal tube

3.9

6.6

R52.9

ICD-10 Finland

Pain, unspecified

1.8

6.6

107

611

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.4

6.5

289

2121

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

2.0

6.5

442

E000003

ATC

2.1

6.5

314

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

1.8

6.5

114

666

TBW99

NOMESCO Finland

Other minor procedure in endocrine surgery

10.1

6.5

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

1.7

6.5

119

705

G04BD04

ATC

oxybutynin; oral, transdermal

2.1

6.5

341

D02AX

ATC

Other emollients and protectives

2.5

6.5

184

B80

ICPC

Iron deficiency anaemia

3.3

6.5

K08.80

ICD-10 Finland

Toothache NOS

1.8

6.5

106

606

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

2.4

6.5

211

EP1AE

NOMESCO Finland

Neck ultrasound examination

2.0

6.4

385

ZXD00

NOMESCO Finland

Emergency procedure

2.5

6.4

186

M01AE02

ATC

naproxen; oral, rectal

1.3

6.4

786

6809

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

2.3

6.4

256

WX892

NOMESCO Finland

Monitored bed care

1.8

6.4

535

GA4AT

NOMESCO Finland

Cathetrisation of pleural cavity with ultrasound guidance

4.9

6.4

S92.3

ICD-10 Finland

Fracture of metatarsal bone

2.4

6.4

206

A04

ICPC

Weakness/tiredness general

1.6

6.3

165

1077

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

2.5

6.3

180

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

1.7

6.3

139

870

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.4

6.3

405

3179

A01

ICPC

Pain general/multiple sites

1.8

6.3

103

589

D02

ICPC

Abdominal pain epigastric

2.0

6.3

405

XF404

NOMESCO Finland

Ambulatory ECG

1.7

6.3

115

679

J01FA06

ATC

roxithromycin; oral

1.3

6.3

535

4391

N25.8

ICD-10 Finland

Other disorders resulting from impaired renal tubular function

6.0

6.3

XX9TE

NOMESCO Finland

Compementary ultrasound examination

5.5

6.3

R19.8

ICD-10 Finland

Other specified symptoms and signs involving the digestive system and abdomen

3.7

6.3

N06AX03

ATC

mianserin; oral

2.1

6.3

306

TQW11

NOMESCO Finland

Vacuum treatment of wound

3.1

6.3

100

N19

ICD-10 Finland

Unspecified kidney failure

2.6

6.3

164

G43.9

ICD-10 Finland

Migraine, unspecified

1.9

6.3

436

P06

ICPC

Sleep disturbance

1.7

6.3

128

783

8240/3-C25.9

ICD-O-3

Neuroendocrine tumor, NOS, of pancreas, NOS

+∞

6.3

2770A

ICD-9 Finland

Other and unspecified disorders of metabolism, Cystic fibrosis

+∞

6.3

C24.02

ICD-10 Finland

Common bile duct

+∞

6.3

JFC10

NOMESCO Finland

Ileotransversostomy

+∞

6.3

E42

ICD-10 Finland

Marasmic kwashiorkor

+∞

6.3

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

1.8

6.2

104

598

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

1.5

6.2

247

1773

NE1AA

NOMESCO Finland

Pelvis X-ray examination

1.9

6.2

440

I49.9

ICD-10 Finland

Cardiac arrhythmia, unspecified

1.6

6.2

147

935

XX1XW

NOMESCO Finland

Extensive written report from radiologist

3.2

6.2

C25

ICD-10 Finland

Malignant neoplasm of pancreas

26.8

6.2

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

3.0

6.2

112

ZXD10

NOMESCO Finland

Scheduled procedure

1.3

6.2

495

4024

N05BA02

ATC

chlordiazepoxide; systemic

3.1

6.2

101

D01

ICPC

Abdominal pain/cramps general

1.6

6.2

140

881

H02BX01

ATC

methylprednisolone, combinations; systemic

2.1

6.2

324

J04BA02

ATC

dapsone; oral

5.4

6.2

Z49.2

ICD-10 Finland

Other dialysis

5.8

6.1

SAA03

NOMESCO Finland

Extended examination of mouth

1.3

6.1

530

4359

N30.0

ICD-10 Finland

Acute cystitis

1.6

6.1

179

1203

D07CA01

ATC

hydrocortisone and antibiotics; topical

1.6

6.1

166

1098

1370

FHL

Colonoscopy, whole colon

7.7

6.1

Z51.88

ICD-10 Finland

Other specified medical care

3.1

6.1

102

N18.0

ICD-10 Finland

End-stage renal disease

4.7

6.1

K04.5

ICD-10 Finland

Chronic apical periodontitis

1.4

6.1

320

2426

0092A

ICD-9 Finland

Ill-defined intestinal infections, Infectious diarrhoea

4.0

6.1

Z53.2

ICD-10 Finland

Procedure not carried out because of patient's decision for other and unspecified reasons

3.9

6.1

R63.8

ICD-10 Finland

Other symptoms and signs concerning food and fluid intake

12.6

6.1

E73.8

ICD-10 Finland

Other lactose intolerance

8.6

6.1

E27.3

ICD-10 Finland

Drug-induced adrenocortical insufficiency

8.6

6.1

K62.5

ICD-10 Finland

Haemorrhage of anus and rectum

2.1

6.1

319

326

Kela drug reimbursment

Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)

4.9

6.0

K29.6

ICD-10 Finland

Other gastritis

4.9

6.0

WX730

NOMESCO Finland

Conventional respirator

3.4

6.0

M70.6

ICD-10 Finland

Trochanteric bursitis

1.6

6.0

142

904

K70.1

ICD-10 Finland

Alcoholic hepatitis

6.7

6.0

NA1BA

NOMESCO Finland

Cervical spine extensive X-ray examination without contrast

5.2

6.0

XW000

NOMESCO Finland

Bone marrow biopsy

2.3

6.0

231

XKD00

NOMESCO Finland

Uroflowmetry

1.6

6.0

166

1101

NAME	K11_MALABSORB
CONTROL_EXCLUDE	K11_OTHDIG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K90
HD_ICD_9	579
HD_ICD_8	269[1-2]
HD_ICD_10_EXCL	K900
HD_ICD_9_EXCL	5790A\|5793
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K90
COD_ICD_9	579
COD_ICD_8	269[1-2]
COD_ICD_10_EXCL	K900
COD_ICD_9_EXCL	5790A\|5793
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
K11_MALABSORB	1.991 [1.74, 2.28]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.281

Parameter	HR [95% CI]	p-value
K11_MALABSORB	2.141 [1.85, 2.47]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.094

N-year risk	Females	Males
1	0.129%	0.445%
5	1.108%	2.958%
10	2.833%	6.885%
15	5.54%	13.216%
20	9.893%	22.331%

Intestinal malabsorption

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints